A new study published in the Journal of Hazardous Materials found that small home appliances with electric heating coils and brushed DC motors emit large quantities of ultrafine particles, posing significant health hazards. The study suggests that children are at a higher risk due to their smaller airway diameters.
Simulations predict a 22-26% and 37-43% increase in extreme floods on the Karnali River between 2020 and 2099, with high emissions expected to see a 73-84% increase. The study highlights the urgent need to reduce greenhouse gas emissions to mitigate flood hazards.
Scientists developed a wireless device that uses light to send information directly to the brain, bypassing natural sensory pathways. The soft device delivers precise patterns of light through the bone to activate neurons across the cortex, allowing mice to learn and interpret meaningful signals.
A new generation of brain-computer interface offers high-throughput information link to and from the brain, transforming treatment possibilities for neurological conditions like epilepsy and ALS. The single silicon chip implant is orders of magnitude faster and smaller than today's state-of-the-art devices.
Next Steps: Rebuilding Indigenous Law is a new research initiative that empowers Indigenous communities to renew and rebuild their own legal systems. The project, supported by a $10 million investment, aims to rebuild entire Indigenous legal orders and revitalize traditional legal traditions.
Researchers have uncovered a microbial metabolite called trimethylamine (TMA) that can block a key immune pathway and improve blood sugar control. TMA, produced by gut bacteria from dietary choline, targets IRAK4, a protein that triggers inflammation and insulin resistance in diabetic individuals.
A study of over 70,000 people found that fewer than 13% meet recommended sleep and physical activity targets. Improving sleep quality was associated with higher daily activity levels. The findings suggest prioritizing sleep may be the first step toward a healthier, more active life.
Researchers at Hokkaido University developed an environmentally friendly method to synthesize organosodium reagents using ball-milling mechanochemistry. This approach replaces traditional methods using highly reactive and toxic materials, offering a sustainable alternative in organic synthesis.
Researchers have developed a new acoustic wave-producing technology on an electronic chip, enabling customizable curved waves for trapping objects, routing wave information, and transporting fluids. This innovation has significant potential in medical applications, such as noninvasive surgery and biosensors.
Researchers at Stockholm School of Economics and Harvard University found that localized messaging can boost climate resilience in vulnerable communities. Homeowners who received emails mentioning their suburbs were twice as likely to seek more information on protective measures compared to those who received generic communications.
A new study using advanced computer simulations has shed light on the mysterious chemical history of the Milky Way. Researchers found that galaxies like the Milky Way can develop two distinct chemical sequences through various mechanisms, challenging previous assumptions about the role of cosmic gas flows and galaxy mergers.
Researchers found that patients who received immunochemotherapy before 3:00 pm experienced significantly longer progression-free survival and overall survival compared to those treated later. Earlier administration of immunotherapy was also associated with lower risks of cancer progression and death.
Researchers developed a dry-process technology for secondary battery electrodes with a dual-fiber structure, addressing mixing strength and performance degradation issues. The technology resulted in high areal capacity and energy density values, outperforming commercial electrodes.
Children who spend a significant amount of time on social media platforms experience a gradual decline in their ability to concentrate. The study found no association between TV watching or video game playing and attention symptoms.
The University of Hong Kong's Faculty of Arts has launched a pioneering postdoctoral fellowship project to recruit global experts in art conservation, with the goal of advancing cultural and scientific excellence. The fellowship will benefit both HKMoA and HKU, enabling the advancement of collection research and exhibitions.
Researchers from HKUMed identified ACACA and LSS as key factors in lipid metabolism that fuel gastric cancer growth. Targeting these vulnerabilities with cholesterol inhibitors killed cancer cells 6.3-fold, opening new avenues for personalized therapies.
The journal prioritizes research on emerging contaminants, water-carbon-nutrient interplay, and advanced modeling technologies to inform policy and optimize multi-objective management strategies. The new leadership aims to steer the field toward a more sustainable and resilient future for our planet's essential water systems.
A new study by University of Texas M.D. Anderson Cancer Center researchers identified CD40 overexpression as a potential biomarker associated with improved overall survival in angioimmunoblastic T cell lymphoma (AITL). This discovery could lead to therapeutic strategies to improve outcomes for this challenging disease.
Researchers mapped accessible routes to 59 surviving pillboxes along the Gin Drinker's Line in the New Territories, providing guides for visiting British and Japanese military sites. The study highlights the importance of these structures as a unique part of Hong Kong's WWII history and potential tourism assets.
HKU Professor Max Shen has been elected as an International Member of the Chinese Academy of Engineering in recognition of his contributions to artificial intelligence and supply chain optimization. He is advancing AI and supply chain technologies through collaboration with industry, academia, and research institutions.
Researchers from HKU identified six distinct tectonic regimes on terrestrial planets, including a novel 'Episodic-Squishy Lid' regime. This discovery provides clues to the origin of Earth's plate tectonics and offers a robust theoretical framework for deciphering Venus' enigmatic geological features.
Researchers engineered a single-layer color-tunable QLEDs technology where color emission is dynamically tunable through voltage modulation, enabling precise control over color transitions. The innovation achieved a record-breaking 5% external quantum efficiency and delivers three pivotal advantages—enhanced color gamut, simplified man...
A cross-disciplinary research team at HKU successfully applied NIR-II fluorescence video imaging during esophagectomy to reduce anastomotic leakage rate. The technique enables precise guidance for resection and reconstruction by delineating well-perfused and poorly perfused regions of the gastric conduit.
Researchers propose AI-based surrogate brain framework that integrates forward modeling, inverse problem solving, and evaluation to build next-generation data-driven models. The framework enables applications such as predicting future whole-brain activity, performing dynamical systems analysis, and guiding neurostimulation strategies.
Patients with lower-risk myelodysplastic syndromes experienced strong responses with fewer side effects when treated with a five-day azacitidine compared to shorter durations. The five-day regimen offered the best balance of safety and efficacy, demonstrating improved event-free survival and overall survival.
A joint research team from DGIST and Caltech developed a highly efficient photocatalyst that converts carbon dioxide into methane using sunlight. The new structure improves light energy usage, allowing for a fivefold increase in performance compared to ordinary conditions.
This review systematically outlines deubiquitinases' roles in various liver diseases, including metabolic dysfunction-associated steatotic liver disease, liver fibrosis, viral hepatitis, and hepatocellular carcinoma. It highlights their potential as therapeutic targets and emerging technologies for targeting DUBs.
The University of Hong Kong (HKU) has established the James M. and Cathleen D. Stone Center on Socio-Economic Inequality in Asia, a leading research hub addressing wealth inequality in Asia. The center aims to develop evidence-based solutions to inform public policy and discourse.
The TRANSCEND FL trial demonstrates the effectiveness of lisocabtagene maraleucel in achieving durable remissions and favorable safety profiles in patients with relapsed or refractory follicular lymphoma. The therapy produced a 97% overall response rate, with most patients remaining in remission after three years.
A new computational tool has discovered a previously unknown protein pathway that triggers the death of blood cancer cells when blocked. This finding could lead to new treatments and improved survival rates for patients with aggressive acute myeloid leukaemia (AML).
Researchers developed a new formulation for neutral triple gauge couplings, ensuring compatibility with the Standard Model Effective Field Theory. They estimated that future electron-positron colliders can probe these effects, outperforming the LHC and a future 100-TeV proton-proton collider
Research reveals that Methanogenic archaea, particularly M. smithii, play a crucial role in postnatal growth retardation by depleting β-hydroxybutyrate levels and inducing liver inflammation. Transplanting fecal microbiome from PGR piglets to mice confirms the same phenotypes.
The Battery Large Model system revolutionizes battery design, manufacturing, operation, and recycling through AI-simulation synergy. It provides a novel technological path for the industry's intelligent upgrade, enabling autonomous design scheme generation, accurate performance prediction, and intelligent defect detection.
Researchers discovered that locusts regurgitate to repel ant attacks, and the mixture of diethyl glutarate, 3-methylindole, and 2-(formylamino)benzoic acid stimulates ant gustation, leading to aversion
A new study by researchers at Karolinska Institutet found that lower doses of approved immunotherapy drugs can give better results against tumours, while reducing side effects. The regimen with the lower dose of ipilimumab was more effective, with a higher proportion of patients responding to treatment and longer overall survival.
Research finds that standard road crossing intervals are too short for older adults with limited mobility, resulting in a need for slower crossings. The study analyzed walking speeds of 1,110 adults aged 65 and over and found that just 1.5% can cross the road within the typical time allowed by pedestrian signals.
Experts discuss GLP-1 drug efficacy in treating obesity and its associated health issues. Key findings include the neurobehavioral links between mental health and obesity, as well as policy implications for access to these treatments.
A new study presented at ASH 2025 suggests that a virtual program focusing on diet and exercise can help reduce the severity of side effects associated with lymphoma treatment. The program, LIFE-L, showed significant improvements in symptoms such as anxiety, depression, pain, fatigue, and constipation among participants.
In a study published in the Journal of Experimental Biology, researchers from Kobe University found that hawkmoth larvae and pupae produce defensive sounds when stimulated. These sounds are released through respiratory openings and resemble snake warning signals, potentially helping the insects evade predators.
A new study found that a chemo-free combination treatment outperformed targeted therapy and chemotherapy in patients with Ph+ acute lymphoblastic leukemia, achieving higher rates of event-free survival and complete remission. Researchers recommend this approach as the new standard of care for this patient group.
The azacitidine-venetoclax combination significantly improves event-free survival and overall response rates compared to intensive chemotherapy. Patients in the aza-ven arm also experience lower symptom burdens, reduced depression, and improved quality of life.
A new study shows that adding epcoritamab to standard second-line therapy significantly improves follicular lymphoma outcomes, including a nearly 80% reduction in risk of death or disease progression. The treatment was also found to be effective for patients who received it on an outpatient basis.
Pirtobrutinib, a non-covalent Bruton tyrosine kinase (BTK) inhibitor, met its primary endpoint in terms of overall response rate compared to covalent BTK inhibitor ibrutinib. The study suggests pirtobrutinib shows promise as initial BTK inhibitor therapy for patients with CLL and SLL.
The Phase II trial of anito-cel demonstrated a high overall response rate of 97% and complete response rate of 68% in patients with refractory multiple myeloma. The therapy also showed a favorable safety profile, with manageable side effects.
Researchers developed an antibody therapy called 77A that targets HSP70, a heat shock protein helping tumors evade the immune system. The treatment showed strong antitumor effects by enhancing immune cell activity in laboratory models of multiple cancer types.
This study analyzed 57 variables across 18 kebeles in Ethiopia's Gedeo Zone to identify key factors affecting coffee production. The research revealed unique combinations of environmental and management characteristics among five distinct clusters, providing practical recommendations for farmers and policymakers.
Researchers at the University of Cincinnati present a new BTK degrader called Bexobrutideg, showing an 83% overall response rate in relapsed CLL patients. The treatment also shows efficacy in patients with CNS involvement and those with BTK mutations that none of currently approved BTK inhibitors are effective against.
A clinical trial found that linvoseltamab, a bispecific antibody, eliminated 90% of tumor cells in patients with residual disease. The treatment allows patients to bypass high-dose chemotherapy and bone marrow transplants, potentially improving long-term outcomes.
Patients with B-acute lymphoblastic leukemia who have no evidence of remaining cancer cells experienced comparable outcomes whether they received chemotherapy-based conditioning or total body irradiation. The study's findings could allow more patients to avoid TBI and its associated long-term side effects.
Researchers found that measurable residual disease (MRD) is strongly associated with long-term outcomes in AML patients, providing a reliable indicator of treatment response. MRD testing may help refine how physicians assess treatment efficacy and personalize post-remission care.
A new study presented at the 2025 American Society of Hematology meeting revealed that subtle disruptions in genome architecture can predispose individuals to lymphoma. The research found that damaged 3D genome architecture can silence key tumor suppressor genes, creating fertile ground for malignancy.
Researchers have found that patients with blood cancers can safely receive stem cell transplants from mismatched, unrelated donors using a protective regimen. The study's findings could make transplants accessible to nearly all patients with blood cancers, regardless of ancestry.
A new trial comparing continuous and fixed-duration treatments for CLL found equivalent outcomes in terms of risk of death or disease progression. Fixed-duration treatment was non-inferior to continuous treatment, suggesting clinically equal efficacy.
Researchers have discovered that a chemotherapy drug can improve outcomes in stem cell transplants when donors and recipients are unrelated and have significant genetic differences. The study showed comparable survival rates and lower risks of complications among patients receiving transplants with more or less extensive genetic mismat...
A multidisciplinary project resulted in a significant rise in iron deficiency screening and treatment for pregnant patients. The project standardized ferritin testing and prescribed oral or IV iron supplements to address low ferritin levels, leading to improved median hemoglobin levels among those who received IV infusions.
A study assessing the commercial roll-out of gene therapies for sickle cell disease and beta thalassemia reveals operational differences between two treatments. The median time to complete treatment was around 9-10 months, with most patients requiring only one cell collection procedure.
Black patients with acute myeloid leukemia are diagnosed at younger ages and have worse outcomes compared to white patients, according to a study analyzing data from 10 clinical trials over 34 years. The study found that Black patients had a higher risk of dying from AML and any cause, even when treated with similar mutations.
Preliminary results from trials of gene therapy exa-cel suggest the therapy offers an effective cure for beta-thalassemia and sickle cell disease in children younger than 12. The therapy's potential to prevent irreversible complications makes it potentially more beneficial in children than adults.
Nearly one-third of families with children being treated for acute lymphoblastic leukemia (ALL) experience serious financial difficulties, including losing 25% or more of their household income. The study, led by Dr. Daniel Zheng, found that nearly a third of families struggled to meet basic living costs during their child's treatment.
Researchers found that taking hydroxyurea during or shortly before pregnancy does not appear to cause specific issues in newborns, but recommend discontinuing the drug before conception due to potential risks. The study included data from 245 pregnancies involving hydroxyurea exposure and showed no maternal deaths or hydroxyurea-relate...