A groundbreaking framework for predicting drug safety in liver injury (DILI) has been published by Cellularity in Nature Communications. The ToxPredictor model demonstrates high sensitivity and specificity in identifying phase 3 clinical safety failures, offering improved clarity on hepatotoxic pathways.
A multidisciplinary team of researchers used genomic technology to decode the DNA of non-flowering seed plants, including gymnosperms, to identify genes involved in seed development. The study, published in Nature Communications, may aid scientists in improving crop production and conserving these ancient endangered seed plants.
A new study has analyzed a rare flooding event in the Maldives in July 2022 and found it could become a far more common occurrence in the future. By 2050, predicted rises in sea levels, coupled with increased extreme weather events, may result in such flooding happening every two to three years.
A recent study published in Nature Genetics found that depression beginning before age 25 has a stronger hereditary component and is associated with a higher risk of suicide attempts. The research identified 12 genetic regions linked to early-onset depression, highlighting the potential for precision medicine in psychiatry.
New research reveals that oceanic upwelling systems amplify acidification, posing existential threats to fisheries and coastal economies. The study used historic coral samples and regional ocean models to predict future changes.
The American Psychological Association's new health advisory emphasizes that generative AI chatbots and wellness applications lack scientific evidence to ensure user safety. Despite their low cost and accessibility, these tools are not a substitute for systemic solutions to the mental health crisis.
Eric Nestler receives the UNIGE Synapsy Prize 2025 for his pioneering work in linking fundamental neuroscience research to clinical advances in mental health. His career has shown how stress and addictive substances alter gene expression, affecting neural circuits involved in reward and mood.
Keck Hospital of USC and USC Verdugo Hills Hospital earned a Fall 2025 'A' Hospital Safety Grade from The Leapfrog Group, recognizing their rigorous commitment to patient safety. This is the first time Keck Medicine has received two 'A's simultaneously.
A 7-week randomized controlled trial found that a train fare subsidy program significantly increased daily walking steps among prime-aged adults by 711.43 steps/day for those subsidized with 1000 points. However, middle-aged and older adults did not experience significant increases in step count.
Researchers have developed phytochemical-engineered vesicles that combine Ginsenoside Rg1 priming with nanoscale engineering, offering a scalable and innovative strategy for mitigating myocardial ischemia/reperfusion injury. These nanovesicles demonstrated dual efficacy in scavenging mitochondrial reactive oxygen species and repairing ...
A new synthesis method allows for the scalable direct synthesis of short-wavelength infrared PbS quantum dot inks, yielding over 10 grams of QD solids per batch. The results achieve a power conversion efficiency of nearly 9% in solar cells fabricated using the inks.
Researchers have developed a compact device that can detect light intensity, wavelength, and polarization, addressing a critical bottleneck in optoelectronics. The perovskite-based photodetector enables precise control over polarization states through pulsed-voltage-driven ion migration.
Researchers examined single event effects in carbon nanotube devices and found they exhibited outstanding radiation tolerance, outperforming silicon-based devices. The study suggests that CNTs can serve as an excellent radiation-hard technology for future electronic applications.
Researchers develop a technology to boost natural photosynthesis efficiency by combining Ru-Oxo clusters with g-C3N4 nanosheets, leading to improved crop yields. The system promotes plant growth by up to 36% and improves sunlight utilization, paving the way for sustainable agricultural technologies.
Researchers developed a Mo-MXene/MoO2-N/Ce composite system to regulate dielectric polarization response. The system achieves precise regulation of dielectric loss, with optimal reflection loss reaching -57.46 dB at 13.43 GHz and 4.685 mm thickness.
Researchers have developed a new class of ultrafast nanomotors powered by near-infrared (NIR) light, capable of reaching velocities up to 100 body lengths per second. The hybrid nanomotors operate through a simple photothermal mechanism and demonstrate precise nanoscale transport without the need for chemical fuels.
Researchers developed a new oral taste-masking agent using mesoporous molecular sieves, which successfully masked the bitter taste of cetirizine and achieved high drug loading rates. The agent showed significant shielding effects and is expected to become a high-efficiency taste masking agent for improved oral administration.
The newly released expert consensus systematically reviews epidemiological characteristics, laboratory diagnostic methods, and optimized treatment pathways for managing ESBL-E infections. It provides individualized, evidence-based antimicrobial therapy based on infection severity, pathogen characteristics, and pharmacokinetic–pharmacod...
A new study identifies fatty acid elongase ELOVL5 as a key promoter of inflammation resolution in the lungs. The research reveals that ELOVL5 works through a dual mechanism to dampen inflammatory pathways and generate pro-resolving lipid signals.
High-resolution label-free imaging reveals stable organelle dynamics and spatial organization, overcoming phototoxicity and halo artifacts. ExAPC microscopy captures biomolecular condensate-like structures and cellular responses to drugs.
The University of Osaka and NEC have demonstrated a wide-area distributed campus AI processing platform, enabling on-demand use of GPUs from compute servers via an optical network. This platform leverages NEC's ExpEther technology to connect and disconnect devices across campus, improving efficiency and optimizing GPU utilization.
A decade-long study by Chinese Academy of Sciences researchers found that soil microbial communities reorganize to form more stable networks, reducing carbon emissions. Microbial thermal adjustment and efficient microorganisms mitigate the effects of climate warming.
Headache disorders affect nearly one in every three people, causing significant disability and health loss. Migraine and medication overuse drive most of the global burden, emphasizing the need for improved prevention, management, and access to care.
The 2025 Global Carbon Budget projects a record high of 38.1 billion tonnes of fossil CO2 emissions, with decarbonisation efforts not enough to offset growing energy demand. Climate change is weakening the land and ocean carbon sinks, reducing the remaining carbon budget to limit global warming to 1.5°C.
Researchers create new prediction model combining age, sex, genetic risk, and brain amyloid levels to calculate lifetime risk of developing memory problems. The study, published in The Lancet Neurology, found women have a higher lifetime risk than men, with the common APOE ε4 variant increasing risk.
A new study reveals that 16% of the Arctic Ocean's dissolved organic carbon comes from land, primarily from thawing permafrost and coastal erosion. This finding has significant implications for understanding how terrestrial organic matter affects Arctic marine ecosystems and the ocean's ability to store CO2.
A novel methylation analysis method, called UMBS-seq, achieves both accuracy and gentleness, unlocking more reliable cancer biomarker detection. The method outperforms existing methods for 5-methylcytosine detection with low input DNA, preserving DNA integrity.
Researchers discovered a cellular protein, FGD3, that enhances the effectiveness of breast cancer chemotherapy and immunotherapies. FGD3 weakens cancer cells when attacked by drugs like ErSO or doxorubicin, causing them to rupture and alert the immune system.
A study from the University of Victoria suggests that humans can smell testosterone and associate it with dominance. The research found that participants rated men with higher testosterone levels as more dominant than those with lower levels, indicating a link between body odour and perceptions of social status.
In a study by Michelle Miner at UC Riverside, bumble bees were found to avoid foraging near ant colonies due to the risk of being bitten. However, aggressive bees who fought back were victorious in individual fights but may ultimately harm their colony by wasting energy.
Researchers developed a reconfigurable bioinspired vision sensor using GaN/AlN quantum-disk-in-nanowires, emulating the human retina's dual-cell system. The QD-NW platform enables real-time, low-power high-accuracy visual perception and opens pathways for neuromorphic vision systems.
A Cochrane review found that low-dose colchicine reduced heart attacks and strokes in people with a history of heart disease or stroke. The study involved nearly 23,000 participants and showed that taking colchicine could prevent about two of each heart attack and stroke among those with cardiovascular disease.
The Phase 3 study demonstrated the safety and non-inferiority of EuTYPH-C Inj.® Multi-dose compared to a World Health Organization (WHO) prequalified comparator TCV, Typbar TCV®. The vaccine was shown to be well-tolerated across all age groups with no serious adverse events.
Experts argue that e-cigarette regulation should prioritize children's best interests, citing the WHO Framework Convention on Tobacco Control and the UN Convention on the Rights of the Child. The authors recommend strict measures to reduce e-cigarette appeal, availability, and affordability among children.
Researchers developed a bioinspired dual-mechanism iontronic pressure sensor (FIPS) that mimics human skin structure, achieving high sensitivity and full-range linearity for real-time musculoskeletal load monitoring. The FIPS platform opens new avenues for wearable biomechanics, sports medicine, and rehabilitation robotics.
Researchers developed a biochar-based material that dramatically improves nitrate removal from agricultural soils and water, maximizing both nitrate adsorption and ammonium retention. The optimized composite achieved nitrate reduction rates as high as 71 percent and increased ammonium retention by 53 percent compared to biochar alone.
The prevalence of high blood pressure among children and adolescents increased from 3.2% to 6.2% between 2000 and 2020, with obesity identified as a substantial driver. Early detection and prevention efforts are crucial to control high blood pressure in children and reduce the risks of future health complications.
A newly discovered carnivorous lizard, Tainrakuasuchus bellator, lived 240 million years ago and resembled a dinosaur due to its armour-plated body. The species was among the top predators of its time in Brazil during the Triassic Period.
Researchers have presented a comprehensive review on synergistic ferroptosis–immunotherapy nanoplatforms to overcome TME resistance and enhance antitumor immunity. The work offers a systematic roadmap for integrating ferroptosis induction with immunotherapy.
A new report from the Higher Education Policy Institute calls for a fundamental rethink of NHS clinical placement provision. The paper proposes practical interventions to make placements more effective and sustainable, including greater use of simulation and digital learning, new supervision frameworks, and community-based models.
A US study found that extending anti-clotting treatment beyond 90 days reduces recurrent VTE rates by 81% and death rates by 26%, while increasing major bleeding risk. The overall 'net clinical benefit' persists even after three years of treatment.
A systematic review examines the current landscape in data processing flow, multimodal fusion strategy, and model architecture for affective computing. Deep learning methods are shown to extract feature representations with high consistency across public datasets and self-collected data.
Scientists successfully measured electric potential in plasmas using a non-contact diagnostic technique, enabling the detection of temporal transitions in internal plasma potential distribution. The method allows for improved predictive models of plasma behavior and confinement frameworks in fusion research.
Researchers at Stanford University found that very old mice are less prone to cancer, with significantly fewer lung tumors than younger animals. This contradicts the long-held assumption that cancer risk increases with age, suggesting a deeper biological cause.
The Canadian Fermented Foods Initiative (CFFI) launches with a shared network of research and industry experts to share trusted information on fermented foods. Large population studies show that people who eat fermented foods are generally healthier.
The institute has opened its first specialized angiography-CT suite, integrating two forms of imaging equipment in one dedicated space. This allows interventional radiologists to perform both angiography and CT scans on the same day, reducing travel burdens for patients and improving treatment outcomes.
A new report from Northwestern University offers six practical strategies to improve the doctor-patient bedside encounter in an era dominated by AI. By employing these strategies, clinicians can strengthen patient-physician relationships, combat inequities, and reduce burnout, ultimately leading to better patient outcomes.
Research from ESA's journals reveals that tiger populations are limited by prey scarcity, not protection. Invasive grasses also boost tick survival in Florida's longleaf pine forests.
Researchers have developed a new surgical instrument called the CAP-LIFT cannula that completely transforms arthroscopic procedures in the hip region. The device solves existing problems with limited space and allows for easier maneuverability of tools, reducing complications and recovery time.
Researchers at Tohoku University shared key findings from their 10-year genome cohort study, highlighting effective techniques for analyzing and managing genomic data. The study's unique approaches to whole-genome sequencing, including qMiSeq and iDeal protocols, have been widely adopted by institutions worldwide.
A team of scientists has imaged bacterial symbionts inside the ovaries of tiny crustaceans, discovering that these bacteria manipulate host reproduction and are transmitted from mothers to offspring. This finding provides a unique model for studying endosymbiosis in an aquatic arthropod.
Matricelf is manufacturing the world's first engineered nerve tissues for paraplegics, aiming to enable patients to walk again. The company partnered with Tel Aviv Sourasky Medical Center (Ichilov) to produce the implants in cleanrooms, meeting regulatory requirements.
Tufts University faculty Chunmei Li, Renata Micha, and Dariush Mozaffarian are among the world's most highly cited researchers. Their research has been published in leading journals and cited over 160,000 times.
The conference examines the practices of responsibility in design, highlighting how women designers foster collaboration, reimagine design as a vehicle for storytelling, and shape cultural memory. The event features five thematic panels discussing topics such as social challenges, material storytelling, collecting, and pedagogy.
The ESMO Congress on Artificial Intelligence and Digital Oncology features a diverse range of presentations on multimodal AI for clinical decision support, AI-based biomarkers for precision oncology, and digital health in practice. The congress also explores ethics, regulation, and patient perspectives.
Researchers have made significant advances in genetically modified plants that produce alpha-amylase inhibitor proteins, making them indigestible to pests like bedbugs, beetles, weevils, and woodworms. Gene editing techniques, such as CRISPR, offer a promising solution to combat insect pests without compromising human consumption.
Climate change is expected to lead to a significant increase in methane emissions from lakes and reservoirs, with current emissions potentially doubling by the end of the century. This would contribute to faster climate change than currently predicted, highlighting the urgent need for reduced greenhouse gas emissions.
Researchers will explore new theories and methods for modelling complex energy systems, enabling simulation of the future energy system before building it. The project aims to investigate key challenges such as cyber physical dynamics, hidden instability modes, and cyber vulnerabilities.
The Rhine-Main Universities have submitted a joint proposal to be recognized as a University Excellence Consortium, highlighting the shared goal of transforming into an internationally leading center for cutting-edge research. The alliance aims to foster a research culture that strengthens the connection between science and society.
Researchers have identified a new species of ancient symbiotic fungus preserved within a 407-million-year-old plant fossil from Scotland. The discovery provides unprecedented three-dimensional insight into one of the earliest known plant–fungus partnerships, known as mycorrhiza.