A retrospective cohort study found that outpatient early methadone dose titration is associated with improved treatment retention in individuals using fentanyl. This approach also lowers the risk of opioid toxicity, according to Canadian and US clinical guidance.
The discovery of an ancient egg containing the embryo of Lystrosaurus reveals that its ancestors laid eggs, and offers insights into their reproductive strategy. The large eggs suggest that Lystrosaurus did not produce milk for its young, and its precocial hatchlings were capable of feeding themselves.
Lauer and Barnes advocate for a national scientist databank, like the National Practitioner Data Bank, to promote transparency on staff misconduct. This approach could help institutions avoid problematic hires while allowing preventive steps to be taken by new employers.
A team of researchers discovered that the way cells sense oxygen determines if regeneration can even begin in mammalian limbs. They found that regenerative-competent amphibians show reduced oxygen-sensing capacity, while mammals respond strongly to oxygen and switch off regenerative programs.
Researchers found that Vibrio cholerae can efficiently acquire new sedentary chromosomal integron (SCI) gene cassettes from extracellular DNA. This process allows the bacteria to diversify its antiviral defenses and potentially expand its protection against viruses in different environments.
Researchers document a decades-long study of wild chimpanzee behavior, revealing a rare permanent split and subsequent lethal conflict within the Ngogo chimpanzee group. The study suggests that shifting social ties, competition over resources, and leadership changes can contribute to group divisions and violence.
A Swedish study found that high prenatal PFAS exposure is associated with a higher incidence of asthma in childhood. The research used a register-based cohort of children born between 2006 and 2013 to assess the relationship between maternal exposure and asthma outcomes.
A study led by Cleo Bertelsmeier found that wild mammals traded for pets, meat, or fur are 1.5 times more likely to share infectious agents with humans. The risk is higher when species are traded illegally or alive.
A recent study led by Cedars-Sinai Health Sciences University found that the same brain neurons are activated when people perceive and imagine objects. The research provides a detailed understanding of the neural mechanism underlying visual perception and creation of mental images in the human brain.
A new study links global wildlife trade to increased transmission of human-infecting pathogens, with traded mammals 40% more likely to harbor these diseases. The duration of species in trade amplifies this risk, suggesting cross-species transmission is inherent to the trade.
A large-scale experiment found that punishment consistently increases cooperation, but its effect on collective welfare varies depending on factors such as communication, contribution framing, and interaction duration. The study suggests that these elements interact in complex ways, with communication being the most influential factor.
A new analysis from UC San Francisco argues that diagnostics are being overlooked, slowing progress against major diseases despite advances in targeted therapies. The study suggests that nearly half of the world's population lacks adequate access to diagnostics due to inadequate investment and insurance reimbursement.
Researchers at the University of Texas at Austin observe permanent fission in wild chimpanzees, resulting in sustained intergroup violence. The findings suggest that relational dynamics can drive polarization and lethal conflict in chimps without language, ethnicity, or ideology.
A team led by Jiefu Li developed a new method to examine proteins lining the inside surface of blood vessels, revealing two proteins and pathways that play a role in opening and closing the blood-brain barrier. This discovery could help scientists understand how the barrier functions and develop better ways to deliver medicines for neu...
A new study by University Hospitals Harrington Heart & Vascular Institute highlights the long-term impact of preventive heart and vascular care. The study shows a significant decline in cardiovascular mortality rates after investments in local cardiac care, with notable reductions among older age groups.
A new multi-layer ionospheric mapping function for PPP-AR has been validated, improving convergence times by 4-10% and early-stage positioning. The method outperforms conventional Single Layer Model (SLM) in equatorial regions where ionospheric gradients are hardest to tame.
Researchers at UT MD Anderson have made significant advancements in cancer care, including a blood-based biomarker for cancer risk in people with Lynch Syndrome and a new target to sensitize pancreatic tumors to immunotherapy. The studies also identified a strategy to overcome radiation therapy resistance in lung cancer.
A mathematical model identifies universal patterns in competitive systems, revealing an optimal 'sweet spot' where excellence and opportunity coexist. The study found that high-performing systems strike a delicate balance between demand and opportunity.
Researchers have created a 3D experimental system to study the response of low-grade gliomas to drugs, providing a more realistic environment for testing treatments. The system uses organoids from pluripotent stem cells to replicate glioma development and characteristics.
Researchers developed an analytic tool using machine learning to predict how CPAP affects cardiovascular disease risk in patients with obstructive sleep apnea. The study found significant variation in treatment response across the cohort, identifying subgroups who benefited or were harmed by the therapy.
The conference discusses how funded literary translations represent cultural diversity and impact global circulation of texts, publishing market, and cultural policies. It is part of the research project Translating diversity: institutional agents and literary translation policies in Ibero-America.
A McGill-led study found that non-producing oil and gas wells emit microbial methane at rates roughly three times higher than earlier estimates. The team collected samples from 401 non-producing wells across Canada and detected traces of microbial methane in over 50% of them.
Researchers at UTIA are studying the genetic, cellular and microbial factors that influence feed efficiency in cattle. By identifying cell types, characterizing microbes and determining genetic influences, they aim to develop practical improvements for producers.
Researchers at BESSY II discovered a new method to investigate hydroxyl radicals, gaining surprising insights into their reaction pathway. They found that the proton of the hydroxyl radical reacts with TEMPO first, revealing an unexpected intermediate state.
A recent study published in Ecological Applications found that habitat restoration efforts in Forest Park have increased native bird diversity, with increases mostly seen in native species. The research also highlights the importance of access to water and varied habitats for boosting biodiversity.
Several open-source AI models consistently produced summaries that were more comprehensive than physician-written versions, particularly in capturing molecular and genetic findings. The study found that Llama 3.1 and DeepSeek performed best among the six evaluated models.
A new framework was developed to enable SMEs to systematically assess their supply chain risks and take proactive steps to build resilience. The integrated approach combines expert knowledge with established methods, identifying 11 key hazards across the supply chain.
Researchers found that orangutans and chimpanzees exhibit exactness in mimicking each other's facial expressions, particularly laugh faces, with a level of precision similar to humans. The study suggests that this ability may have given great apes important advantages in social interactions.
Researchers have developed an integrated reiterative pipeline that uses machine learning and structural biology to identify promising vaccine targets across multiple related viruses simultaneously. The system evaluates viral proteins to identify short fragments called epitopes that can trigger a strong immune response.
Researchers have developed a lead-free thin film that significantly improves the efficiency of microdevices in harvesting energy from ambient motion. The Mn-doped bismuth ferrite film exhibits stronger piezoelectric behavior, lower dielectric loss, and improved device-level performance.
A majority of Americans value U.S. membership in NATO and consider it a meaningful security asset, but views are sharply divided along partisan lines. Democrats are more supportive of NATO than Republicans, who hold less favorable views on the alliance's benefits to U.S. security.
A new study reveals that street greenery can reduce heat stress in cities, but its benefits depend on local conditions. The cooling effect is stronger in tropical and continental climates, but weaker in dry and temperate climates.
SKP2 functions as a signaling hub orchestrating metabolic reprogramming, DNA damage response, stem cell maintenance, and synaptic plasticity. Dysregulation contributes to human diseases, including cancer and neurodegenerative conditions.
A new study from Finland found that receiving an ADHD diagnosis earlier is associated with better academic performance and lower school dropout rates. Young people diagnosed earlier had a higher grade point average at age 16 and were more likely to pursue academic degrees.
Researchers at the University of Waterloo have discovered a safer and more effective way to treat Alzheimer's disease by combining anti-amyloid antibodies with molecules found in grapes, berries, peanuts, and turmeric. This combination approach neutralizes amyloid protein clumping in the brain, leading to better outcomes.
A recent study proposes an AI-enhanced evaluation framework to optimize city-scale municipal living plastic waste (MLPW) management. The framework addresses complex interplay of physical material flows, spatial infrastructure, and socio-economic factors, achieving a 96.3% reduction in annual greenhouse gas emissions by 2060.
UCLA investigators present new research on targeted drug delivery for colorectal cancer, COVID-19's impact on breast cancer outcomes, and AI in cancer diagnosis. These studies offer insights into overcoming drug resistance, enhancing immune responses, and improving outcomes for patients with difficult-to-treat cancers.
The INSPIRE Conference will discuss key project findings, tools, and resources on inclusive gender equality in research and innovation. The event aims to sustain change and address future challenges through dialogue among policymakers, researchers, and stakeholders.
Researchers focus on developing transformer efficiency and heat recovery to enhance hydrogen production energy efficiency. The goal is to significantly reduce electricity consumption by up to 35% and increase net efficiency to 85%.
Scientists develop a new generation of energy-efficient transistors made from thin, lightweight electrically conducting films. The film-based switch can control the flow of electric current with high precision, enabling complex motion sequences or fixed positions.
The study found that ATF5 plays a critical role in coordinating mitochondrial quality control and adaptive stress signaling in skeletal muscle. Absence of ATF5 resulted in increased muscle fatigability and elevated ROS production, highlighting its importance in maintaining muscle function with age.
Researchers have mapped the molecular mechanism behind allergic reactions and developed tailored antibodies to block life-threatening responses. The findings suggest a new approach to targeting the most important allergens and provide a starting point for developing more precise treatments for severe allergy.
A randomized, open-label bridging clinical trial was conducted to evaluate the immunogenicity and safety of a 9-valent HPV vaccine in adolescents aged 9-17 years compared to young women. The study found non-inferior immune responses with seroconversion rates comparable to those in young women receiving three doses.
Mount Sinai ophthalmologist has developed a groundbreaking device enabling precise measurement of aqueous outflow during eye surgery. The technology offers improved accuracy and reduced complications, potentially transforming the field of ophthalmology.
Researchers found that far-right influencer Tommy Robinson used his Telegram channel to comment on events and legitimise violence during anti-immigration protests in 2024, shaping followers' interpretations of events without issuing direct instructions. The study identifies key tactics used by influencers to create emotional conditions...
A new study by IIASA researchers reveals that China's economic growth is being driven by the skills of its workforce, not just its large working-age population. Improvements in skill composition have become a key driver of economic expansion, and a more favorable age structure enhances economic returns to workforce skills.
The clinical guideline emphasizes personalized care, recommending pre-exercise cardiovascular risk assessment and individualized exercise prescriptions. Adults with T2D are advised to engage in at least 150 minutes of moderate-intensity aerobic exercise per week, or a combination of aerobic and resistance training.
A proposed embedded ethics approach facilitates ethically responsible research with human stem-cell-based embryo models by integrating continuous dialogue among scientists, ethicists, and regulators. This framework helps build trust and serves as a public policy tool to ensure that research meets both scientific and societal values.
A team-based program in community health clinics helped low-income patients reduce their blood pressure more than standard care alone. After 18 months, patients in the team-based program saw a significant drop in systolic blood pressure and showed better adherence to hypertension treatment.
Researchers found that watching an online performance in real time boosts several aspects of the viewing experience, including a common factor of heightened sense of presence. The liveness effect weakens when viewers cannot see a performer's face, but going live can benefit streamers by motivating audience engagement.
The research team will analyze mouse models and human brain tissue to identify cell types that show early signs of stress before neurons die. The multiscale model simulates how the progressive loss or disconnection of specific neurons disrupts memory-related brain networks.
Adults aged 75 or older without adenoma on prior colonoscopy have lower risk of subsequent colorectal cancer and CRC death. Despite this, those with prior adenoma may consider deprioritizing surveillance colonoscopy relative to other health concerns.
A study found that children who need dental care the most are less likely to participate in school-based cavity prevention programs, which can lead to significant savings for state Medicaid programs. Improving participation among high-risk children could save up to $2.4 million annually.
A national study found that unmet health-related social needs are associated with lower colorectal cancer screening rates, particularly among adults aged 50-64. Addressing these needs may support age-specific strategies to improve screening rates.
Scientists used CAR-T cell therapy to treat a patient with severe autoimmune hemolytic anemia, immune thrombocytopenia, and antiphospholipid antibody syndrome. The treatment achieved lasting remission without additional treatment for over a year.
Researchers identify previously unknown microbe living in close partnership with another organism inside stromatolites, providing insights into how complex life began. The discovery sheds light on the evolution of eukaryotes and the emergence of mitochondria.
A new machine-learning method detects sudden changes in fluid behavior, improving simulation capabilities for everyday applications like weather prediction and nuclear reactor safety. This enables faster design testing, real-time adjustments, and reduced computational burden.
A new study uses an AI model to predict type 2 diabetes risk based on behavioral and psychosocial information. The digital twin model found that loneliness, insomnia, and poor mental health substantially raise a person's future risk of developing the disease.
A new study found that nearly half of young survivors of the October 7 attacks developed atypical sensory patterns, causing everyday stimuli to be perceived as overwhelming threats. This altered sensory processing is directly tied to emotional distress and anxiety in children.
Researchers compare viral and MASLD cirrhosis pathogenic mechanisms, identifying shared pathways and diagnostic differences. The study aims to establish a framework for prevention, diagnosis, treatment, and monitoring of MASLD cirrhosis.