A retrospective study of 40 immunocompromised ICU patients found associations between low CD4+T-cell counts and specific lung pathogens. Patients with severe CD4 depletion had higher proportions of fungal infections, while moderate immunosuppression was linked to Streptococcus pneumoniae.
The Heinz Maier-Leibnitz Prize is awarded annually by the Deutsche Forschungsgemeinschaft to recognize excellence in scientific research. This year's winners have made significant breakthroughs in various fields, including quantum computing and materials science.
Researchers develop method to model record correlations in synthetic data, preserving global and local distributions. This approach significantly outperforms current state-of-the-art methods, offering high utility and robust privacy protection.
A new software package called CREsted has been developed to analyze and design gene regulatory elements in a systematic and scalable way. The framework turns enhancer modeling from one-off analyses into a reusable workflow, enabling researchers to study enhancer logic across biological systems.
Dr. Cudjoe's research examines the influence of social connection on health and developing interventions to address social isolation in older adults. He is a recipient of several awards, including the National Institute on Aging GEMSSTAR award and the Robert Wood Johnson Foundation Amos award.
Researchers used supercomputer simulations to study how red blood cells deform under stress, shedding light on hemolysis risks in blood pump conditions. The study offers new insights that could lead to safer and more effective blood pump designs.
The oXiris membrane addresses complex sepsis by integrating diffusion, convection, and adsorptive properties to remove inflammatory mediators. Early physiological improvements and potential benefits for cardiac surgery-associated acute kidney injury and severe COVID-19 have been reported in observational studies.
A team of researchers from the IBMCP has discovered a new molecular mechanism that regulates the formation of vascular tissues in plants. Thermospermine acts as a biological switch to control the production of key proteins, influencing water transport and structural support.
Therapy-related myeloid neoplasms (t-MN) pose a significant threat to female cancer survivors, with limited treatment options and high mortality rates. New therapies and diagnostic approaches, such as CAR-T and hypomethylating agents, offer hope for improved treatment outcomes and prevention.
The team successfully developed a multifunctional catalyst incorporating palladium and copper complexes on mesoporous silica, enabling the efficient activation of ketones and allyl alcohols. This process accelerates the allylation reaction by up to a factor of 15.5 compared to previous catalysts.
A new framework called CH4Vision uses hyperspectral satellite imagery to estimate methane flux directly, improving accuracy and robustness. The method incorporates plume morphology and machine learning to infer emission rates, increasing reliability of satellite-based quantification.
The Association for Computing Machinery has published its inaugural issue of ACM AI Letters, a premier venue for rapid and timely AI research. The journal aims to bridge the gap between traditional conferences and journals, featuring short, peer-reviewed contributions that accelerate knowledge dissemination across academia and industry.
Researchers found that older adults exhibit higher BOLD variability in cerebellar lobule VIIIb and greater modulation across task conditions. This modulation predicts performance in an age-dependent manner, with increased modulation linked to better performance in older adults.
Researchers identified DMBT1 as a key target of Lentinus edodes-derived β-glucan in inhibiting cervical cancer progression. The compound's anti-cancer activity was shown to be closely correlated with DMBT1 expression levels, suggesting its potential as a prognostic marker or therapeutic target.
Researchers developed a new sensor called CAMEO to monitor electrical activity in human cerebral organoids, facilitating research into neurodevelopment and genetic disorders. The device is made of carbon nanotube strands, enabling low-cost and scalable monitoring.
Researchers identify Nipah virus's critical survival strategy by hijacking human protein NSUN2, facilitating viral replication. A dual-targeting antiviral strategy has been developed, combining an approved drug with an experimental inhibitor to effectively reduce virus levels and improve survival in animal models.
A randomized trial tested HabitWorks, a smartphone app offering personalized exercises to target interpretation bias. Participants reported significant improvements in interpretation bias, functioning, and overall mental health symptom severity.
A study by researchers from the University of Michigan and international institutions recommends prioritizing grid upgrades targeting long-term demand expectations to minimize total costs. By upgrading the grid first, utilities can create a more efficient infrastructure that leverages Vehicle-to-Grid (V2G) chargers more effectively.
A study published in The Lancet Regional Health – Americas found that carefully selected older adults can safely undergo surgery and achieve outcomes comparable to younger patients. The research challenges longstanding assumptions about age and cancer treatment, suggesting that older adults should not be excluded from potentially curat...
Researchers have developed a new artificial intelligence framework called CLAK that enables drones to localize themselves in GPS-denied environments using non-visual sensors such as LiDAR, barometric altitude, and inertial measurements. The model improves localization accuracy while remaining lightweight enough for practical deployment.
A large-scale study published in Nature found that hundreds of researchers reanalyzing the same data often reached divergent conclusions. The study highlighted the critical role of collaboration and exchange across disciplines in achieving robust results.
Children with rare food allergy FPIES exhibit atypical gut microbiota compared to healthy peers, according to a new Umeå University study. The analysis of stool samples revealed differences in bacterial composition associated with FPIES, which may contribute to the development of more individualized strategies for diagnosis and treatment.
The Mount Sinai Hospital has pioneered a new minimally invasive liver cancer treatment method that allows doctors to treat patients on more days of the week, improving access and reducing wait times. This breakthrough innovation, called TheraSphere Y-90 Any Day Dosing, enables flexible scheduling and seamless care coordination.
The University of Cincinnati has established a new Center for Public Health, led by Dr. Suzanne Judd, a renowned epidemiologist and expert in health disparities. The center aims to transform community health through innovative research, education, and strategic advocacy.
A large-scale study found a reciprocal relationship between sleep disturbance and the gut microbiome, improving dementia risk prediction accuracy. The protein-based model identified key proteins associated with dementia risk, offering potential therapeutic targets.
Calls to poison centers about kava, a plant-based drug promoted as a healthy alternative, rose 383% between 2011 and 2025. The number of exposures leading to severe health outcomes also increased, with 32% in 2025.
Researchers developed a blood-based test that analyzes circulating tumor HPV DNA to inform personalized treatment strategies for HPV-associated throat cancer. The study found that ctDNA levels change before and after surgery, influenced by tumor biology and kidney function.
MILCAnet, a dominant feature attention framework, enhances multimodal data analysis in depression detection by combining key feature extraction and feature fusion. This innovative approach offers a more efficient and accurate solution for non-contact depression screening.
This cross-sectional study found that direct care worker unionization and employer ownership are independently associated with workforce turnover rates. State policies facilitating DCW unionization or public employment of DCWs may improve retention rates, according to the study.
A new study proposes an innovative framework called SEA-SQL, which uses zero-shot prompts and GPT-3.5 to perform the Text-to-SQL task more effectively and economically. The method enhances database content with semantic information and eliminates biases in SQL queries.
A new class of ultra-high strength and ductility steel has been created using machine learning, achieving a rare balance of extreme strength and ductility. The resulting metal resists corrosion and degrades slowly in salt-water tests.
A new portable AI-powered scanning slit-light device makes low-cost eye disease screening more accessible, providing quantitative measurements and qualitative assessments of anterior-segment abnormalities. The lightweight AI model allows for on-device analysis, reducing operator dependence and improving portability.
A new virulence regulator called Fis is found to play a crucial role in regulating the virulence of Yersinia pseudotuberculosis, a diarrheal pathogen. The protein represses virulence genes at cooler temperatures outside the host.
A study using Arabidopsis revealed that germline segregation occurs earlier than previously thought, with some cells segregating during inflorescence meristem formation. This finding supports Weismann's germ plasm theory and provides insight into how plants balance developmental plasticity with safeguarding genetic integrity.
Researchers introduced a self-attention network to analyze micro-expression temporal features, improving recognition performance. The approach preserves richer variation features through complete sequence analysis, marking a technological breakthrough.
A lower semaglutide price could generate savings that offset the cost of treating an additional 550,000 to 3.6 million Medicare beneficiaries eligible for expanded obesity-indication coverage. This voluntary price agreement may lead to substantial savings for Medicare spending on semaglutide treatment.
A new Chinese pediatric dataset, PediaBench, evaluates large language models (LLMs) in medical question-answering tasks. The dataset consists of five question types and 12 disease groups, with an integrated scoring scheme to assess LLM performance comprehensively.
A new study suggests that electric vehicles can serve as a vast network of mobile batteries, storing excess energy and feeding it back into the grid when demand surges. This approach could ease grid strain, cut emissions, and create revenue, but only if paired with timely grid upgrades.
A new study highlights how geography and regulations limit methadone access in US jails, with over half of facilities located more than a 30-minute drive from the nearest opioid treatment program. This distance creates logistical challenges for providing this lifesaving medication to incarcerated individuals.
The MedFuse framework improves diabetic retinopathy lesion segmentation by aligning visual features with anatomical priors. This approach enhances the model's robustness and accuracy, particularly in low-contrast or artifact-heavy regions.
The renewed agreement allows eligible researchers at participating UK institutions to publish unlimited articles across JMIR's portfolio of journals without APCs. This simplifies the publication workflow and increases equity for researchers at all career stages.
Researchers found that influenza vaccination reduced the risk of heart attack and stroke by half for those who got infected, even if they didn't get vaccinated beforehand. The study's findings suggest prioritizing influenza vaccination among high-risk populations could have significant public health impact.
Researchers developed first-in-class dual HIF inhibitors that, when combined with immunotherapy, can completely eliminate breast, colorectal, melanoma, and prostate tumors in mice. The drugs target HIF-1/2 transcription factors, which are key regulators of cancer progression.
The article highlights the dangers of autonomous AI systems interacting within clinical environments, creating a 'digital ecosystem' that can operate beyond human oversight. The analysis warns of risks including the rapid propagation of errors, accelerated data leaks, and the spontaneous development of unintended hierarchies.
Researchers have developed a room-temperature drying technique that locks functional proteins into a stable, sugar-based 'glass', preserving their biological function. This method offers several advantages over conventional freeze-drying, including reduced processing time, lower energy consumption and no specialized equipment needed.
Researchers have developed a new measurement method to track the loss of information in qubits, resolving a major problem in quantum computing. The method enables fast and accurate measurements, allowing for real-time monitoring of information decay and identification of underlying causes.
A new international project will provide essential measurement equipment for two doughnut-shaped fusion devices, WEST and JT-60SA, to understand plasma behavior. PPPL's Luis Delgado-Aparicio leads the effort, adding powerful X-ray imaging systems to guide future fusion system design.
The NCCN Foundation recognizes five young investigators for their promising research on cancer innovation, providing $100,000 grants to advance their work and strengthen the pipeline for cancer success.
The Endocrine Society suggests that redefining obesity beyond BMI could complicate diagnosis and delay treatment. The proposed framework requires clinicians to prove organ dysfunction is caused by body fat for a clinical obesity diagnosis. This approach may hinder access to effective obesity treatment.
A study by Washington State University researchers found that the torpedo bat and traditional bat perform equally well in hitting power, with only a slight difference in sweet spot location. The researchers discovered that the ideal spot to hit the ball is closer on a torpedo bat, resulting in slower ball speed and distance.
A new study finds that people with metabolic dysfunction-associated steatotic liver disease face a significantly higher risk of liver fibrosis if they engage in episodic heavy drinking. Episodic heavy drinking is defined as four or more drinks for women and five or more drinks for men, at least once a month.
A Northwestern University study finds that disinfectants like chlorhexidine linger on surfaces for longer than previously known, allowing microbes to build tolerance. Chlorhexidine-tolerant bacteria were also detected spreading through touch and airborne dust across hospital rooms.
Scientists at Chiba University developed a simple method to generate high-quality optical bottle beams that remain concentrated over long distances. The technique uses a binary axicon and a flat multilevel diffractive lens to create sharp light structures.
Scientists have discovered two new species of fungi, Neohelicomyces coffeae and Neohelicomyces puerensis, growing on dead coffee branches in Yunnan Province. These saprophytic fungi play a vital role in the coffee ecosystem by decomposing organic matter and unlocking trapped nutrients.
A recent study by Bas Heerma van Voss found that governments are prone to cognitive biases when it comes to major risks like pandemics and climate change. Debiasing training for risk analysts can help recognize and avoid these biases, but such training is rarely implemented systematically.
A new system can map soil moisture tree by tree, allowing growers to water specific trees if they're dry. Maintaining the right moisture level is crucial for plant health, as too little water can stress trees, while too much water can deprive roots of oxygen.
A new study by MIT researchers provides a high-resolution picture of auto emissions in NYC, allowing for more effective transportation and decarbonization policies. The method produces detailed data that bridges the gap between citywide emissions inventories and individual vehicle analyses.
Researchers found that only the last few layers of a quantum circuit matter due to accumulating noise, which weakens earlier steps. This means that even deep noisy circuits can be adjusted or 'trained' for simple tasks.
Researchers from Kyushu University used ALMA to observe a baby star producing a giant ring of gas about 1,000 au in size, which helps the star release excess energy. The team found that this ring is slightly warmer than its surroundings and hypothesize it's produced through magnetic field threading.
Researchers uncover distinct patterns of Indigenous and European ancestry in urban Peruvian population, challenging common categorizations. The study's findings hold significant implications for precision medicine and health disparities among Latin Americans.