Researchers found that combining low doses of bortezomib with an oncolytic virus significantly improves the ability to kill cancer cells. The combination treatment suppressed tumor growth by 92% in a glioma model and improved survival rates, offering a novel therapeutic strategy for solid tumors.
Researchers have discovered a bird flu virus with pandemic potential, closely related to the 1918 Spanish flu. The virus, composed of eight gene segments, can cause flu-like symptoms in ferrets and has the potential to spread efficiently among humans if it acquires key mutations.
A team of researchers has identified eight genes from influenza viruses isolated from wild ducks that possess genetic similarities to the 1918 pandemic flu virus. The new study shows that these gene pools have the potential to cause a severe pandemic in the future if combined with other viral components.
A University of Nebraska-Lincoln team has developed a promising new approach for HIV vaccine development using an attenuated and genetically modified virus. The approach involves manipulating the virus' codons to rely on an unnatural amino acid, preventing the virus from replicating in the human body.
A study published in mBio found an unusual avian influenza virus in Adçie penguins from Antarctica, which is distinct from other circulating flu viruses. The virus was detected in adult and chick samples, and its genetic material showed high similarity to North American avian lineage viruses from the 1960s-80s.
Researchers reconstruct origins of 1918 H1N1 influenza A virus, finding it arose from bird flu virus acquired by human H1 virus before 1918. Childhood exposure to previous flu strains may predict susceptibility to future strains and inform vaccination strategies.
Researchers identified a novel antiviral agent that blocks influenza infection in cell culture without developing resistance. The study suggests the potential of small molecule MK2206 as an effective treatment option for Tamiflu-resistant pH1N1 virus infections.
Hepatitis C virus infects liver cells' energy centers, damaging mitochondria and recruiting proteins to eliminate damaged area. This process helps the virus persist in the body, making mitochondrial operations a potential therapeutic target.
A recent study has identified five essential mutations allowing the H5N1 bird flu virus to spread through the air between ferrets. These findings could provide crucial insights for future surveillance and early warning systems, potentially preventing future pandemics.
Quail and chickens are likely sources of infection for the H7N9 influenza virus, according to a study published in the Journal of Virology. The research found that quail efficiently transmitted the virus, while other poultry species were resistant or did not become infected.
Researchers at Mount Sinai Hospital have discovered how the Marburg virus interacts with host protein Keap1, allowing it to live longer and replicate better. This knowledge may lead to the development of targeted therapies to arrest the lethal virus.
Researchers at the University of Liverpool have created a WiFi virus called 'Chameleon' that can spread rapidly between homes and businesses, evading detection by encryption and passwords. The virus exploits weaknesses in WiFi networks to propagate quickly across densely populated areas.
Scientists have discovered that herpes virus proteins use their flexible arms to pass on viral building blocks to hijacked cell proteins, providing insight into the virus's ability to hijack cells. The study's findings may lead to new treatments for Kaposi's sarcoma, a type of cancer caused by the herpes virus.
A Chinese woman died from a new bird flu virus H10N8 after visiting a live poultry market, with the virus showing genetic characteristics allowing it to replicate efficiently in humans. The H10N8 strain has been previously isolated but never reported in humans before.
A new study reveals the 3D structure of HIV infection in the gut, showing how the virus infects immune cells and spreads through tissue. The researchers used electron tomography to visualize the architecture of infected parts of the gut, revealing details on viral transmission events.
Researchers discovered a stem-loop structure in viral RNA that blocks host cell immune proteins, allowing viruses to evade the immune system. By altering this structure, scientists hope to develop treatments that restore natural virus-fighting capabilities and stop or slow viral infections.
Researchers at the University of Pittsburgh have discovered a unique immune avoidance mechanism used by a deadly mosquito-borne virus to suppress human immunity. The discovery could lead to the development of vaccines and treatments for eastern equine encephalitis virus, which has a 30-70% fatality rate.
Researchers identified a novel avian-origin H6N1 virus that closely resembles chicken H6N1 viruses circulating in Taiwan since 1972. The virus has a mutation that could increase its preference for human SAα-2,6 receptors, making it more infectious to humans.
Researchers have identified a molecular invisibility cloak that enables HIV to hide in cells, but exposing it triggers an immune response. This discovery could lead to new treatments and improve existing therapies for HIV infection.
Danish researchers have discovered how the body's immune system responds to HIV infection, identifying key proteins and mechanisms that can be targeted for improved treatments. The study's findings aim to enhance the immune system's ability to defend against uncontrolled virus growth.
Researchers at University of Wisconsin-Madison have created a highly detailed structural model of the rhinovirus C, which is responsible for up to half of all childhood colds. The new model shows that the virus has distinct surface features that make it difficult for drugs to effectively target it.
Researchers identify Chinese strain as origin of emerging US swine virus with high mortality rates, emphasizing the need for strict biosecurity and sanitation procedures on farms. The study found that the US strains share 99.5% of their genetic code with their Chinese counterpart, indicating a possible evolutionary origin from bats.
Researchers at Whitehead Institute discovered that the flu virus infects host cells by killing off immune system's best-equipped cells that can neutralize the virus. This allows the virus to replicate efficiently before the immune system mounts a second wave of defense.
A large genetic analysis of MERS-CoV genomes suggests the virus has transmitted from animals to humans on multiple occasions. The study found that the virus evolved quickly and spread between locations, making it unlikely that a single transmission occurred. Further animal studies are needed to establish the source of the virus.
Researchers at the University of Edinburgh have found a link between cold sore susceptibility and a mutated gene, revealing why some people are more prone to the virus that causes them. The study identifies IL28b as the affected gene, which plays a crucial role in mounting an immune response against the herpes simplex virus.
A new study provides a clearer picture of how much time elapses between known infection, viral shedding, immune response, and onset of flu symptoms. Researchers found that a minimum dose of 10^7 TCID50 virus is needed to induce mild-to-moderate illness in 60% of volunteers.
Recent paper reviews treatment scenarios for SARS, suggesting similar treatments may work for MERS-CoV. The Middle East Respiratory Syndrome Coronavirus has been identified in over 90 patients, with approximately 50% mortality rate.
A novel avian-origin H7N9 influenza A virus has been found to attach moderately or abundantly to the epithelium of both the upper and lower respiratory tracts. This pattern suggests that the emerging H7N9 virus may transmit efficiently in humans and cause severe pneumonia.
Scientists have discovered a new strategy that cripples the dengue virus's ability to escape the host immune system. By introducing a genetic mutation to deactivate the MTase enzyme, researchers created a weakened virus that generates a strong protective immune response while preventing the virus from spreading in mosquitoes.
A study published in PNAS reveals that the human herpes virus uses histone proteins to package and store its genetic material, allowing it to remain dormant. Researchers identified a viral protein called IE1 as a potential target for new therapies to control the virus's activity.
A fatal case of raccoon rabies virus exposure has been linked to a kidney transplant 18 months earlier, suggesting a long incubation period. The study emphasizes the importance of increased awareness and modified organ donor screening and recipient monitoring for infectious encephalitis.
Researchers isolated Heartland virus in tick populations in northwestern Missouri, confirming its role as a human pathogen. The virus causes severe illness with fever, headaches, and low white blood cell counts, with no treatment available.
A study analyzed West Nile virus epidemics in Dallas County, Texas, finding that they begin early after warm winters and are predicted by the mosquito vector index. The analysis also revealed higher incidence rates of neuroinvasive disease in recent years compared to previous decades.
Researchers aim to identify genetic elements that enable animal hepatitis E strains to infect humans, with potential implications for fighting cross-species virus infections. The study will also investigate host immune factors that defend against the virus.
Researchers found that 'virus-negative' genital warts can harbor small amounts of more distantly related viruses that escaped previous detection. The study identified 23 new types of HPV and two known sequences, highlighting the diverse pool of previously unknown HPV types infecting humans.
A new study reveals the H7N9 avian influenza virus can infect and replicate in human cells, suggesting it has pandemic potential. The virus also transmits efficiently in ferrets and other mammalian species, raising concerns about a potential global outbreak.
Researchers have identified a new virus, CyCV-VN, in patients with severe brain infections in Vietnam. The virus was found in 28 out of 644 patients, but not in those with non-infectious brain disorders. Further research is needed to determine its role in causing the symptoms.
Researchers at Brandeis University have developed a sophisticated computational model that helps scientists understand how viruses spread by analyzing genomic data, virus structure, and capsid formation. The team's tool predicts key structural features of the virus genome and controls capsid assembly.
Researchers infected ferrets and pigs with the human-derived H7N9 virus, showing that both species can be infected and transmit the virus. While transmission was more efficient in ferrets, the study highlights potential public health implications of the avian virus.
A novel avian-origin H7N9 influenza virus was found to show rapid evolution, with several viruses circulating in Hangzhou. The virus's pathogenesis in humans remains unknown, but substitutions have been identified as potential pathogenicity factors.
Scientists have identified the minimum dose of dengue virus needed to infect mosquitoes when bitten. This finding has significant implications for preventing the spread of the disease. The study provides a target for experimental vaccines and drugs to prevent the virus from reaching humans.
Scientists at UCSF have developed a new gene sequencing technique that can identify the Lone Star virus in less than 24 hours, significantly faster than conventional methods. The ultra-rapid deep sequencing approach has the potential to democratize viral surveillance and could help prevent outbreaks.
Scientists studying the Human Coronavirus-Erasmus Medical Center have discovered a potential treatment strategy for the new Middle East virus. The researchers found that certain compounds could treat the infection by altering lung cells' response to infection, which might help prevent the virus from reproducing.
Research reveals Nipah virus can be carried by fruit bats on both sides of Wallace's line, which may have initially restricted the spread of avian flu to Australia. The finding extends the known regions where Nipah virus has been detected, including the island of Timor.
Researchers have discovered that rising temperature induces key changes in the dengue virus when it enters its human host, leading to a new approach for designing vaccines against the aggressive mosquito-borne pathogen. The study found that the virus's bumpy form is more efficient at infecting mammalian cells.
Researchers at MIT have developed a novel approach to protecting against the dengue virus using mutated antibodies. The new therapy has shown significant promise in neutralizing all four serotypes of the virus and could be ready for human trials within two to three years.
Researchers at the University of North Carolina discovered that hepatitis A virus acquires an envelope from infected cells when found in the environment, blurring the distinction between enveloped and non-enveloped viruses. This unique behavior allows the virus to evade host immune systems and survive longer periods between hosts.
Tracking an early immune response, researchers chart a new route for developing a long-sought HIV vaccine that boosts the body's ability to neutralize the virus. The study reveals the co-evolution of antibodies and virus in a person whose immune system mounted a broad attack against the pathogen.
The study reveals the precise structure of the mosquito-transmitted chikungunya virus pathogen bound to antibodies, showing how infection is likely neutralized. Antibodies stabilize the viral surface, hindering fusion and blocking infection. The findings could lead to effective vaccines against the infection.
A new vaccine has proven highly effective against the H5N1 avian influenza virus, when tested in mice and ferrets. The vaccine uses an attenuated version of the H9 virus with an added H5 gene, slowing viral replication and reducing the risk of successful reassortment.
Researchers monitored WNV in California Culex mosquitoes and found that the virus is passed vertically from females to eggs, but with significantly lower rates when transmission occurs from larvae to adults. This loss of infection during larval development remains unclear.
Researchers discover that defective viruses, once thought useless, increase the spread of disease by 'hitchhiking' with functional viruses. The presence of a defective DENV-1 virus may have led to large increases in dengue fever cases in Myanmar in 2001 and 2002.
A modified Newcastle disease virus has been developed to target prostate cancer cells without harming normal cells, offering a new treatment option for hormone-refractory patients. This oncolytic virus uses a retargeted design to minimize off-target losses and reduce the amount of virus needed for treatment.
Researchers from Beth Israel Deaconess Medical Center have discovered a second B-cell attachment receptor for the Epstein-Barr virus, which could lead to the development of a vaccine. The new finding also raises questions about the virus's possible relationship to malaria and autoimmune diseases.
A new class of influenza drug has been shown to prevent the flu virus from spreading and successfully treat mice with lethal strains. The drug works by attaching itself to the virus's molecular machinery, rendering it useless.
Researchers successfully measure and block a previously unstudied enzyme to stop the virus from replicating, potentially leading to a cure for patients. The breakthrough, which was aided by advances in HIV research, may lead to new hepatitis B drugs that can suppress the virus far enough to cure patients.
Researchers have discovered a link between West Nile virus in mosquitoes and birds, as well as the insects' ability to spread the virus to horses and people. Habitats with high disease prevalence in horses and birds also have more mosquitoes and certain bird species, which contribute to the transmission of the virus.
A Kansas State University doctoral student has received a USDA grant to research the relationship between the tomato spotted wilt virus and its vector, the western flower thrip. The goal is to develop a genetic tool to silence the thrip's protective genes, potentially stopping the disease's transmission.
Researchers at Mount Sinai have discovered that the flu virus can essentially tell time, with a clock that dictates when it multiplies, infects cells, and spreads. This finding provides a novel design platform for the flu vaccine and could lead to new antiviral drugs that target the virus's internal clock.
A recent study by EcoHealth Alliance found Ebola virus antibodies in approximately 4% of the bats screened in Bangladesh, indicating that Rousettus fruit bats may be a natural reservoir for Ebola virus. The study extends the known range of Ebola to mainland Asia.