Researchers at MIT have made significant progress in understanding the neural mechanisms of compulsive behavior by activating a specific brain circuit that controls compulsive behavior. By using optogenetics, they were able to block compulsive behavior in mice and demonstrate potential new approaches for treating diseases such as OCD.
A pioneering study demonstrates the benefit of MRI in identifying mental illnesses such as bipolar disorder. The advanced imaging technique was able to correctly distinguish patients from healthy individuals with a high degree of accuracy, promising a new approach to diagnosis.
Researchers have discovered similar brain structural abnormalities in dogs with canine compulsive disorder (CCD) as those found in humans with OCD. This study may lead to the development of new therapies for OCD and related conditions.
A new study found that a spike in acetylcholine in the right prefrontal cortex activates response to signals, suggesting a potential brain mechanism for switching between behaviors. The findings have implications for treating disorders such as obsessive-compulsive disorder and autism.
The Lancet Series on bipolar disorder offers a comprehensive overview of the condition, including its genetic basis, diagnostic challenges, and treatment limitations. The series highlights the need for more accurate diagnosis and personalized treatments, with neuroimaging research potentially transforming bipolar diagnosis.
Researchers found that theta brainwave activity in the prefrontal cortex is related to overcoming ingrained biases. The study used a custom-designed computer game to measure subjects' ability to repress Pavlovian biases, with those who performed better showing higher theta activity.
Researchers at UCLA found that individuals with body dysmorphic disorder (BDD) have abnormal brain connections, which may impair information processing. The study suggests that these patterns in the brain relate to impaired symptoms, particularly compulsive behaviors.
A new study by researchers at the University of Pennsylvania found that deep brain stimulation can curb binge eating in obese animals, leading to weight loss and improved glucose sensitivity. The therapy targets the dopamine type-2 receptor, providing therapeutic relief for obesity-related behaviors.
A new study found that Google searches for information on all major mental illnesses followed seasonal patterns, with winter queries consistently higher than summer ones. This suggests that mental illness may be more strongly linked to seasonal patterns than previously thought.
A NIH study found that stimulating the brain's prefrontal cortex can reduce compulsive cocaine-seeking behavior. The study, conducted in rats, suggests a promising treatment approach for addiction.
Researchers have discovered that stimulating one part of the brain with laser light can wipe away addictive behavior in rats and turn non-addicted rats into compulsive cocaine seekers. The study suggests a new therapy using transcranial magnetic stimulation could be effective for humans, offering hope for treating cocaine addiction.
A Mayo Clinic study found that men with dementia with Lewy bodies are five times more likely to have rapid eye movement (REM) sleep behavior disorder, which can appear decades before a diagnosis. The study suggests that screening for this sleep disorder could improve diagnosis and treatment of dementia with Lewy bodies.
The Brain & Behavior Research Foundation has awarded nearly $4 million in new NARSAD grants to 40 mid-career researchers pursuing innovative studies on depression, bipolar disorder, and other mental illnesses. The grants will focus on diagnostic tools, early intervention, new technologies, next-generation therapies, and basic research.
A study published in Psychopathology found that sports gamblers who believed they could control the outcome using knowledge of the game were actually no more successful than those with no prior experience or knowledge. Cognitive therapy may be a better approach for treating this type of addiction.
A new somatic symptom disorder in DSM-5 risks mislabeling many people as mentally ill due to a lack of specificity and high false-positive rate. The condition will classify excessive responses to distressing symptoms, potentially leading to inappropriate medical decision-making.
A study found that family-focused treatment improved mood symptoms in children and adolescents at risk for bipolar disorder, with significant benefits for those from high expressed emotion families. The treatment showed promise in stabilizing symptoms and improving long-term outcomes.
A new trial has shown that Deep Brain Stimulation (DBS) can help patients with chronic, severe Anorexia Nervosa achieve improvements in body weight, mood, and anxiety. Four of six patients experienced significant weight gain and simultaneous changes in mood and symptoms related to anorexia.
A pilot study found DBS to be effective in improving mood and BMI in severely anorexic patients. After surgery, patients began stabilizing or gaining weight, with three maintaining higher weights than before. Improvements in mood and obsessive-compulsive behavior were also observed.
Nicole Calakos studies synaptic defects in the basal ganglia that underlie compulsive behavior, including Huntington's and Parkinson's diseases. Mice with overactive metabotropic glutamate receptors exhibit impaired synaptic plasticity, leading to obsessive-like behaviors.
A new robot technology called RP-7 enables remote presence in programming brain and spine stimulators, allowing non-expert nurses to be guided by specialists. The study found no significant difference in accuracy or clinical outcomes between remote-presence and conventional programming.
Research finds heightened activity in brain circuits for negative emotions and reduced activation of emotion-suppressing circuits in borderline personality disorder, with reduced frontal brain activity unique to the condition. The study suggests improved emotion regulation skills may be normalized after successful treatment.
The Brain & Behavior Research Foundation has awarded $1.5M in NARSAD Distinguished Investigator Grants to 15 researchers studying depression, bipolar disorder, schizophrenia, autism, and anxiety disorders. The grants will support innovative research ideas with the potential to transform mental illness treatment and prevention.
Researchers found no correlation between Parkinson's disease itself and impulse control symptoms, contradicting previous studies. The study suggests that dopamine-related medications may be the primary cause of these disorders.
Research from King's College London reveals that individuals with mental health disorders are at a higher risk of experiencing domestic violence. Women with depressive disorders were 2.5 times more likely and those with PTSD were 7 times more likely to have been victims compared to women without mental health problems.
Researchers found that people with ADHD are impulsive risk-takers, while those with OCD are anxious about consequences, causing hesitancy in decision-making. Accurate diagnosis is crucial for effective treatment and well-being, as mistaking the two disorders can lead to wrong medication prescriptions.
Patients with depressive disorders and borderline personality disorder have significantly higher unemployment rates than those without the condition. Persistent unemployment poses a significant public health burden, with 13.4% of patients missing up to two years or more from work.
A Baylor University study found that materialism and impulsiveness drive cell phone addiction. Cell phones are used as a status symbol and can erode personal relationships.
Children with developmental coordination disorder can improve their fine motor skills through a unique virtual reality training program. The study, published in the Journal of Child Neurology, used a three-dimensional virtual reality device to help children with DCD overcome their motor skill impairments.
A new study from MIT neuroscientists has found that the brain's prefrontal cortex has a small region responsible for controlling which habits are switched on at a given time. The researchers used optogenetics to inhibit this region, allowing them to break and form new habits in rats.
Researchers found dopamine neurons release GABA, a neurotransmitter that lowers neuronal activity, which could explain why restoring only dopamine leads to waning improvements in Parkinson's patients. This discovery highlights the complex interplay between dopamine and GABA in brain disorders like depression and addiction.
A UCLA-led team of experts found the proposed criteria to be reliable and valid in helping mental health professionals diagnose hypersexual disorder. The study accurately classified 88% of patients as having the disorder, with significant consequences including job loss, relationship end, and emotional distress.
A team of MIT neuroscientists has created a way to monitor brain-cell activity by detecting calcium ions, which could provide insights into the origins of autism and obsessive-compulsive disorder. The technique allows for pinpointing specific cell types involved in psychiatric diseases.
A large genetic replication study found compelling evidence that the chromosome 3p21.1 locus contains a common genetic risk for bipolar disorder, specifically the PBRM1 gene. This replication distinguishes the heritable risk for bipolar disorder and schizophrenia, contrasting with previous studies.
Researchers have identified genetic variations in genes associated with bipolar disorder I and II, providing new insights into the complex biochemical pathway involved. The study found associations between variants in PDE10A, DISC1, and GNAS genes and an increased risk of developing the mental illness.
A study by Joseph Mazer and Andrew M. Ledbetter found that online self-disclosure and social connection attitudes predict compulsive internet use, leading to poor well-being outcomes. Excessive internet users are motivated by efficiency, not anxiety.
A recent study found that two-thirds of the variation in avoidant and dependent personality disorder traits can be explained by genes, highlighting the importance of genetic influences in their development. The study's use of both questionnaire and interview measures provided a more comprehensive understanding of heritability.
In 2011, Americans took a record 4.02 billion prescription drugs, with antidepressants and ADHD medicines showing notable increases in sales. The growth of prescriptions is attributed to the rising demand for CNS disorders medications.
Research shows that nearly 20% of young children with cancer develop posttraumatic stress disorder, exhibiting symptoms such as flashbacks and anxiety. The study highlights the need for child-friendly treatment procedures and psychological support to prevent prolonged disorders that impair development.
Research from the University of Cambridge suggests that a traumatic upbringing during childhood is linked to impulsive and compulsive personality traits, increasing the risk of drug dependence. The study examined 50 adults with cocaine dependence and their biological siblings, finding a direct relationship between traumatic childhoods ...
A new study suggests pregnancy could have a positive impact on bipolar disorder, with fewer and shorter episodes in pregnant women. The study's findings call for large, multicenter, prospective studies to better understand the natural course of the disorder.
A new study by Dr. Inti Pedroso and colleagues has identified key genes and neural signaling pathways involved in the development of bipolar disorder. The findings, published in Biological Psychiatry, provide insight into the complex biology of the disorder and highlight potential new avenues for treatment.
Researchers discovered similarities between compulsive behavior in dogs and humans, including early onset, recurrent behaviors, and nutritional supplements' beneficial effect. The study suggests that dogs can serve as an excellent animal model for studying the genetic background and environmental factors associated with human OCD.
The Brain & Behavior Research Foundation has awarded $11.9 million in NARSAD grants to support innovative brain and behavior research related to mental illnesses such as depression, bipolar disorder, and schizophrenia. The grants aim to advance treatments and therapies for these conditions.
Two GWAS studies have identified possible associations with genes related to obsessive-compulsive disorder (OCD) and Tourette syndrome. The studies found potential links to BTBD3, DLGAP1, COL27A1, and other SNPs, but further research is needed to confirm these findings.
A NIH-funded study reveals that hoarding disorder is associated with abnormal brain activity in areas processing error monitoring and weighing the value of possessions. Patients with hoarding disorder tend to over-activate these areas when deciding about their own possessions, but under-activate them when dealing with others' stuff.
Patients with hoarding disorder showed abnormal brain activity when deciding about possessions, with reduced activity for items not belonging to them and increased activity for items that did. The study found that these patients had difficulty discarding possessions, with fewer items discarded compared to healthy individuals.
A UCI study reveals that individuals with stellar autobiographical memory exhibit distinct brain variations and statistical evidence of obsessive-compulsive tendencies. These unique traits enable them to effortlessly recall every moment of their lives since age 10.
New study reveals that mephedrone activates brain's reward circuits similarly to cocaine, increasing addictive potential and compulsive drug taking. The findings justify maximum restriction of bath salts access by the FDA.
A study suggests that individuals with a family history of schizophrenia or bipolar disorder are at increased risk of developing autism spectrum disorder. The findings indicate shared etiologic risk factors among ASD, schizophrenia, and bipolar disorders.
Researchers at Mount Sinai Hospital found a link between increased risk of autism spectrum disorder (ASD) and family history of schizophrenia or bipolar disorder. The study suggests shared etiologic risk factors among these disorders, potentially leading to more similar understanding and treatment approaches.
A large Danish cohort study reveals that childless women who undergo fertility evaluations have a higher risk of hospitalizations for psychiatric disorders, particularly anxiety and depression. The study found significant correlations between childlessness and increased rates of substance abuse, schizophrenia, and eating disorders.
Researchers found that a combination of cognitive-behavioral therapy with a transdiagnostic approach significantly improved anxiety disorders such as fear of flying and public speaking. This approach treats patients with one set of principles across all types of anxiety disorders, leading to considerable improvement in comorbid diagnoses.
Research reveals that smoking, head injury, and pesticide exposure may increase the risk of REM sleep behavior disorder, a rare condition where people act out their dreams. The study also found that farming work and lower education levels were associated with a higher risk of developing the disorder.
Researchers identified a brain pathway imbalance linked to addictive behavior, which may also underlie less severe compulsive behaviors. The study's findings could lead to better understanding and monitoring of various compulsive behaviors.
Researchers discovered that the dorsal anterior cingulate cortex (dACC) optimizes behavioral responses by predicting task difficulty. The study used a complex task to evaluate dACC function, revealing that the structure speeds up responses when difficulty levels are constant but slows down response time when faced with changing demands.
A BUSM study found that blocking the Sigma-1 receptor reduced binge eating and caused eaters to eat more slowly, suggesting a potential therapeutic treatment target for binge eating disorder. The researchers also observed improved decision-making in experimental subjects.
Researchers at Rhode Island Hospital and Auburn University found a significant association between restrictive food intake and an increased number of suicide attempts in individuals with Body Dysmorphic Disorder (BDD). The study also suggests that those with a history of BDD-related excessive exercise had lower rates of suicide attempts.
Researchers at Michigan State University found that anxious girls' brains respond more intensely to mistakes, suggesting a potential link between worrying and brain function. The study may help identify girls prone to anxiety problems.
A study by University of Granada researchers found that immigrant women in Spain experience great stress during childbirth, with disorders such as obsessive compulsive disorder and depression common among them. The study also revealed differences in healthcare access and utilization between immigrant and Spanish women.
Researchers found a link between compulsive cell phone use and increased risk of motor vehicle crashes. A study showed that anticipating calls or messages can be an additional source of distraction contributing to crashes.