A new study by Massachusetts General Hospital researchers has identified slowing brain rhythms as a biomarker for detecting delirium and predicting poor clinical outcomes. The study found that generalized EEG slowing was associated with longer patient hospitalizations, worse functional outcomes, and increased mortality.
A survey of European patients with lung cancer revealed that many were unaware of or had never heard of clinical trials. Despite positive experiences by over 50%, respondents identified difficulties in accessing trials, including language barriers, limited information, and disparities across Europe.
Researchers at Kessler Foundation will conduct a comprehensive five-year study on the effects of robotic exoskeleton-assisted gait training in patients with stroke. The study aims to improve recovery of lost mobility and understand the mechanisms underlying the effects of exoskeleton-assisted gait therapy.
The UCI Institute for Clinical & Translational Science will use the grant to initiate and extend efforts to translate biomedical research into new treatments, with a focus on diverse communities. The institute aims to partner with community partners to identify and resolve health needs in Orange County.
LSU Health New Orleans has been awarded a $13.6 million grant to expand its clinical trials network, providing cancer care and access to over 50% of newly diagnosed patients in the region. The new network will also increase minority patient participation in clinical trials.
The American College of Physicians (ACP) has developed a rigorous process for disclosing interests and managing conflicts of interest to ensure transparency, proportionality, and consistency in clinical guideline development. The process applies to all individuals involved in ACP's clinical guidelines and guidance statements.
Researchers at Cincinnati Children's Hospital Medical Center designed an AI-powered system to streamline clinical trial recruitment. The Automated Clinical Trial Eligibility Screener (ACTES) reduces patient screening time by 34 percent and improves enrollment by 11.1 percent compared to manual screening.
The Keck School of Medicine of USC has received a $4.5 million NIH grant to recruit underrepresented patients in cardiac surgery clinical trials. The grant aims to translate clinical research findings into clinical practice, addressing the No. 1 cause of mortality in the US.
The DFG is establishing ten new Research Units, two new Clinical Research Units, and one Centre for Advanced Studies to tackle topics such as stroke recovery, anti-allergy measures, and communication techniques. The funding will support researchers in pursuing pressing issues and advancing knowledge.
The foundation awarded Continuation Grants to five Damon Runyon Clinical Investigators, providing an additional two years of funding totaling $400,000. The recipients are conducting patient-oriented cancer research with the goal of finding cures for cancer diagnosis, prevention and treatment.
A new study found that stimulating the brain's dorsal anterior insula triggers an ecstatic aura in epileptic patients. This region is proposed to be a key area for elicit symptoms of altered consciousness and ecstasy-like experiences. The findings provide additional support for its role in human consciousness.
The American College of Physicians has released a new paper outlining its methods for developing high-quality, evidence-based clinical policy papers. The methodology ensures that recommendations are based on the best available scientific evidence, considering clinical benefits, harms, costs, and patient values. ACP's approach includes ...
Researchers found that an immunotherapy treatment, teplizumab, effectively delayed the progression to clinical type 1 diabetes in high-risk individuals. Participants who received teplizumab took longer to develop clinical disease, with a median time of 48 months compared to just over 24 months for those in the control group.
A phase III international clinical trial found that treatment with apalutamide significantly improved overall survival by 33% compared to standard-of-care therapy. The study also showed apalutamide delayed disease progression, increasing the time until chemotherapy was needed.
Researchers developed COXEN, a predictive tool that analyzes gene expression to predict response to chemotherapy in bladder cancer patients. The trial showed COXEN's ability to predict response using Gemcitabine-Cisplatin (GC) biomarker.
The Case Comprehensive Cancer Center has been selected as a Lead Academic Participating Site by the National Cancer Institute for a six-year grant worth $8.9 million. This renewal grant enables the center to provide patients with additional access to clinical trials through the National Clinical Trials Network.
A joint report from AMP and CAP provides evidence-based recommendations for designing and validating clinical CYP2C9 assays, promoting standardization and improving patient care. The report defines a minimum set of alleles and their variants that should be included in all clinical CYP2C9 genotyping tests.
Dr. Samuel Huang receives the Pfizer/ACMG Foundation Clinical Genetics Combined Residency Fellowship Award to enhance his clinical research training and expertise in biochemical genetics and therapeutics. He aims to improve patient care through translational genomics and policy changes.
A new study reveals that hippocampal neurons provide pointers to complete memories by firing strongly during recall. This process, called reinstatement, helps the brain reconstruct associated objects from memory, similar to initial learning. The discovery has implications for understanding memory deficits and potential treatments.
Dr. Bryce Seifert, Laboratory Genetics and Genomics Fellow at Duke University School of Medicine, has been awarded the 2019 Richard King Trainee Award for his outstanding research publications in Genetics in Medicine.
Researchers studied neural activity of thalamus and cerebral cortex to understand sensory perception of tactile stimuli. They found that functional interactions between neurons in these areas influence the decision on stimulus detection.
Researchers develop AI method to extract clinically important movement patterns from normal video recordings, enabling early CP detection and assessment of neurological development. The study shows promise for automated movement analyses in diverse applications, including out-of-hospital screening and therapeutic decision-making.
A new study explores the connection between poor sleep and Alzheimer's disease, revealing that sleep helps clear excess amyloid beta and tau proteins from the brain. Disruption of slow-wave sleep can cause a significant increase in these protein levels, suggesting that sleep plays a crucial role in preventing Alzheimer's development.
A PLOS Special Collection explores new steps in clinical research for optimal TB treatment, driven by WHO and IRD-France sponsorship. Experts outline best practices for future clinical trials to inform policy guidance.
The collaboration identifies leadership, patient engagement, and community engagement as crucial factors in increasing accrual of racial and ethnic minorities in cancer trials. High-recruiting centers like Henry Ford Cancer Institute excel in engaging providers, building trust, and seeking input from minority patients and caregivers.
A study found that pharmacists in accident and emergency departments can provide overall clinical care to patients, taking on roles such as examining and diagnosing patients. With their medicines expertise, they fill gaps in doctor and nurse practitioner rotas.
Researchers found that young women with a family history of hypertension have decreased baroreflex sensitivity, which can be a marker for hypertension and heart disease. This study suggests that these women may be at increased risk for developing high blood pressure later in life.
Research reveals distinct brain regions process concrete and abstract word meanings separately, with a network of areas working together in different languages. The findings provide new insights into how our brains represent word-meaning structure.
Researchers have identified specific brain cell types, areas and biological processes linked to the genetic risk of insomnia, a major step towards understanding its mechanisms. The study found that over 100 genes contribute to insomnia, with some influencing the functionality of axons and specific cell types in the frontal cortex.
A new study published in eNeuro found that Ritalin had no impact on neuronal activity in the prefrontal cortex of monkeys. The researchers observed improved performance in attention tasks at higher doses, but not in brain activity.
The lack of regulatory standards in clinical artificial intelligence poses concerns about safety and efficacy, according to a recent study. The authors propose five standards to guide evaluation and regulation of clinical predictive analytics, emphasizing the importance of established clinical standards and clinician agency.
Research at Fred Hutchinson Cancer Center found that patients face structural and clinical barriers to participating in clinical trials, with nearly 22% deemed ineligible. The team calls for policy changes such as expanding trial locations and proactively discussing options with patients to increase access and participation.
An investigational monoclonal antibody, mAb114, has been found to be safe and well-tolerated in an early-stage clinical trial involving adults. The treatment, which targets the Ebola virus's surface protein, demonstrated promising results, with all participants experiencing mild side effects.
A new SWOG Cancer Research Network study found that cancer patients with comorbidities such as hypertension or asthma are less likely to participate in clinical trials. The study suggests that allowing patients with manageable comorbidities to join trials could increase treatment opportunities for thousands of patients.
Research at Ruhr-University Bochum shows that blindness disrupts brain's organisation and memory ability in mice. After vision loss, other senses like touch, hearing, and smell become more sensitive over time.
A phase I/II trial found that combining nab-paclitaxel with gemcitabine significantly improved survival rates even among patients with reduced health status. The study's results suggest alternative treatment options for patients typically underrepresented in clinical trials.
Researchers at Dana-Farber Cancer Institute present positive results from clinical trials of CAR T-cell therapy and immunotherapy for patients with leukemia and lymphoma. The studies show that Yescarta provides durable benefit to lymphoma patients, while pembrolizumab achieves long-lasting responses in patients with an aggressive form ...
A team of researchers has identified a mechanism regulating the regeneration of neural pathway insulation. The discovery highlights the significance of the Vav3 exchange factor in controlling molecular switches that activate and deactivate signaling processes.
The 2019 International Brain Stimulation Award recognizes Mark Hallett's pioneering work in developing transcranial magnetic stimulation (TMS) and advancing the field of neuromodulation. His research has led to new treatments for neurological and psychiatric conditions, including depression and OCD.
A new system, CAMR-R, can measure antimicrobial resistant phenotypes at single-cell resolution from clinical samples in three hours without cell propagation. The instrument uses D2O-feeding Raman Microspectroscopy to quantify AMR levels and has potential applications in diagnosing clinical pathogens.
The journal publishes original research, reviews, brief communications, and case reports across various medical fields. All published articles will be freely accessible during the first two years of publication.
Llinás' research on membrane biophysics and the active neuron concept has significantly advanced our knowledge of neuronal function and behavior. He was recognized for his work on dendritic calcium spikes, electrotonic coupling, and subthreshold oscillations in mammalian neurons.
A study by Massachusetts Eye and Ear found that astronauts or pilots with higher vestibular thresholds are more likely to become disoriented during flight. The researchers also found a strong correlation between lower vestibular thresholds and improved manual control performance.
A new conceptual framework proposes examining exercise effects on brain connectivity, structure, and molecular mechanisms in multiple sclerosis. This systematic approach may lead to new strategies for rehabilitative care and treatment.
Researchers at MIT's Picower Institute discovered that SAP102 regulates synaptic AMPAR function differently than PSD-95, with distinct effects on current decay timing. This finding may contribute to the greater cognitive capacity of mammals and other vertebrates.
A study of teenage twins reveals that both genetic and environmental factors shape brain activity during sleep. The findings suggest that frontal regions are under stronger environmental control, while regions towards the back of the brain are more influenced by genetics.
Researchers at Universities of Bonn and Tübingen demonstrate that human neurons fire mainly for specific quantities, such as three or four points. The study also shows how we learn to handle number symbols in comparison to quantities, with digit neurons responding differently from quantity neurons.
The article discusses clinical early warning scores as new clinical tools to predict future clinical deterioration, particularly related to sepsis. It provides a critical review of the state-of-the-art in early warning algorithms and suggests further research initiatives.
Atrium Health Wake Forest Baptist will join nationwide clinical trial networks, NeuroNEXT and NIH StrokeNet, to develop new treatments for neurological diseases and improve stroke prevention. The institution aims to enroll patients from historically underserved groups and make meaningful contributions to both networks.
A new study published in Clinical Neurophysiology found that attention plays a key role in restoring vision in patients with hemianopia, a condition where half of the visual field is impaired. After five weeks of vision rehabilitation training, patients showed significant improvements in their visual function.
Researchers examined federal payment databases to determine payments made to oncologists who authored studies in high-impact journals. The study found that a substantial proportion of payments were not disclosed, which could lead to bias and influence clinical trial results.
The American College of Rheumatology has received two grants from the Office of Minority Health to increase minority participation in lupus clinical trials. The MIMICT and LuCTT programs will address challenges in recruiting minority populations affected by lupus, utilizing community health workers as referral sources.
Researchers at Marshall University Joan C. Edwards School of Medicine discovered dynamic signals from sense organs are crucial for normal leg movements. The findings suggest mechanisms to make prosthetic joints more adaptable, enabling more natural movements in amputees.
The Network for Excellence in Neuroscience Clinical Trials has been renewed for five more years, enabling the study of new treatments for brain disorders. Nine clinical trials are currently underway, demonstrating the potential of NeuroNEXT to expedite research and bring treatments to patients faster.
Researchers found that evolutionary changes occur deep in the fly brain, in a small cluster of neurons controlling mating behavior. The study overturned long-held beliefs about how evolution ensures animals perpetuate their species.
The foundation awarded six new Damon Runyon Clinical Investigators, who will receive $450,000 each to develop their cancer research programs. Three others received Continuation Grants totaling $300,000, supporting their ongoing research.
Clinical Trials in a Dish (CTiD) offers a novel strategy to test drugs on patient cells before moving into actual clinical trials. CTiD studies have opened up new avenues for screening cell-based safety and toxicity at the population level, enabling efficient testing with reduced costs.
The Second Xiangya Hospital of Central South University in Changsha, China has implemented a structured train-the-trainer program to train pharmacists in providing direct patient care. The program has resulted in comprehensive pharmaceutical care for all patients, demonstrating the positive impacts of this innovative training.
The collaboration aims to use clinical insights to fine-tune early device testing, focusing on preclinical support, proof of concept studies, de-risking medical device translation, and rapid prototyping. Tufts CTSI and MIT will provide resources and expertise to research teams to efficiently turn device concepts into testable prototypes.
The National Institutes of Health has awarded Tufts Clinical and Translational Science Institute (CTSI) $56 million to support its local, regional, and national research initiatives. The funding will accelerate the translation of research into clinical use, medical practice, and impact on health.