A three-year clinical trial shows dutasteride delays prostate cancer disease progression by 38% compared to placebo, while also reducing anxiety. The study suggests a viable treatment option for men with low-risk disease, offering a safer alternative to aggressive local treatment.
Researchers at Wayne State University are investigating the role of c-kit in bone metastasis of prostate cancer. They aim to understand how factors from the bone stimulate the production of c-kit and its ligand in prostate cancer cells, facilitating their growth and survival.
Researchers Kari Tikkinen and Anssi Auvinen argue that 'overactive bladder' should be studied individually, rather than as an ambiguous constellation of symptoms. This approach could lead to better understanding of underlying causes and more effective treatments.
Researchers have identified a rare, inherited mutation linked to a significantly higher risk of developing prostate cancer. The mutation was found in 10-20 times more men who inherited it compared to the general population. Further studies may lead to genetic testing for inherited prostate cancer.
Researchers at Duke University Medical Center found that noise-cancelling headphones playing classical music reduce pain and anxiety during prostate biopsies. This simple and inexpensive method may help an estimated 700,000 US men who undergo a biopsy a year.
Researchers at Queen's University identified a new mechanism that could explain immune resistance in cancer cells, suggesting nitroglycerin may boost the body's natural immune response to cancer. The discovery sheds light on the role of hypoxia and ADAM10 enzyme production in cancer cell resistance.
Researchers suggest combining PSA testing with factors like prostate size, weight, and family history to identify aggressive cancers and avoid unnecessary biopsies. This approach could potentially save up to a quarter of men from undergoing biopsies and related risks.
A recent study published in the Journal of Urology found that prostate cancer patients who undergo radical prostatectomy experience fewer complications and shorter hospital stays at teaching hospitals compared to non-academic institutions. The study suggests that the characteristics of teaching hospitals, including higher subspecialty ...
Researchers found that patients with ANCA-associated vasculitis have elevated levels of the protein Flt1, which hinders blood vessel repair. This impairment contributes to disease progression and increases the risk of kidney failure in these patients. Inhibiting Flt1 may help improve blood vessel repair and reduce this risk.
A University of Rochester analysis found that older men are more likely to die from prostate cancer due to late-stage diagnosis. The study's lead author notes that overall health plays a significant role in life expectancy following a cancer diagnosis.
A Kaiser Permanente study found that antidepressants, diuretics, bronchodilators, antihistamines, and sympathomimetics can cause lower urinary tract symptoms (LUTS) in men. The study examined data from over 63,000 ethnically diverse men and found associations between specific medication classes and LUTS severity.
A study by UK researchers found parents of children with genital ambiguity experience shock, anxiety and a need to protect their child. The parents sought harmony between their child's ambiguity and the sex they raised them as.
A large-scale study found that saw palmetto extract did not improve lower urinary tract symptoms in men with prostate enlargement. The researchers tested up to three times the standard dose and discovered no measurable benefits or toxicity.
By 2018, an estimated 2.3 billion people worldwide will experience at least one lower urinary tract symptom, with increases expected in Africa, Asia, and South America. The study highlights the urgent need for public awareness, prevention, diagnosis, and management of these conditions to tackle the growing burden.
A large study led by Stanford urologist Michael Eisenberg found that childless men are more likely to die from cardiovascular disease than fathers. The study tracked over 135,000 male members and found a 17% increase in mortality risk among childless men compared to fathers.
A study by Johns Hopkins researchers found a significant rise in serious prostate biopsy complications requiring hospitalization among Medicare beneficiaries. Hospital admission rates were two-fold higher among those who underwent a biopsy compared to controls, with infection-related complications on the rise since 2000.
A study found that African-American men living in low-sunlight areas are more likely to have vitamin D deficiency. Researchers recommend stratified recommendations to consider group differences, as skin composition affects vitamin D production.
African-American men are up to 3.5 times more likely to have Vitamin D deficiency than Caucasian men, requiring higher supplementation doses. Skin color and sunlight exposure play a crucial role in Vitamin D production.
A recent study published in JAMA found that discussing sexuality with doctors can improve quality of life for prostate cancer survivors. Researchers used phone interviews and questionnaires to measure quality of life in over 2,900 men before and after treatment, including surgery, radiation, or brachytherapy. The study revealed that me...
Researchers found that high calcium intake increases prostate cancer risk among African-American men genetically predisposed to poor calcium absorption. This study provides insight into the link between diet and disease, suggesting personalized prevention strategies may be possible in the future.
The Division of Pain Medicine at University Hospitals Cleveland Medical Center received a 2011 Medical & Academic Partnerships Fellowship Award from Pfizer Inc. The Epilepsy Center also received an award for its nationally competitive research. The fellowships support patient-oriented research to improve healthcare outcomes.
A new urine-based test has been found to be more accurate than traditional prostate cancer screening methods, detecting the disease in 100% of cases while minimizing false positives. The PSA/SIA assay works by analyzing changes in PSA protein structure associated with cancer.
Researchers at Lund University have developed a new treatment option for advanced prostate cancer by targeting cancer stem cells with a STAT3-inhibitor. The study found that galiellalactone, a natural compound, has inhibitory effects on the growth of prostate cancer cells and prevents tumour growth and spreading.
Researchers at Beth Israel Deaconess Medical Center are receiving $1 million each from the Prostate Cancer Foundation to develop a vaccine that boosts patients' immune systems against prostate cancer. The goal of this treatment is to directly attack prostate-cancer cells and potentially be less expensive and more easily disseminated.
Child-centered approaches result in older toilet training ages, with key findings including negative outcomes associated with late start times and punishment-based methods. The Canadian Paediatric Society recommends starting toilet training at 18 months of age, with expert opinion guiding physicians for patients unlikely to cause harm.
Hospital Clínic of Barcelona applies the first minimally invasive technique in living donors, reducing scarring and improving donor quality of life. The technique uses natural orifices to extract a kidney without major scars.
A study by UC Davis researchers found that a significant proportion of men carry defective genes for the sperm coat protein DEFB126, which may significantly affect their fertility. The protein plays a crucial role in allowing sperm to swim through mucus and avoid the immune system.
A recent study by UCLA found that nearly all patients with high-grade, non-invasive bladder cancer are not receiving comprehensive care recommended by the American Urology Association and National Comprehensive Cancer Network. This is critical as it can significantly minimize the likelihood of patient death from their cancer.
A new minimally invasive procedure called hidden incision endoscopic surgery (HIdES) eliminates visible scarring in kidney surgeries. The technique, developed by Dr. Patricio Gargollo, offers greater technical flexibility than laparoscopic surgery and has been shown to provide higher satisfaction rates among patients.
Researchers at Johns Hopkins have identified two genes, ATRX and DAXX, that contribute to the lengthening of telomeres in cancer cells. The study found a correlation between mutations in these genes and alternative lengthening of telomeres in various types of tumors.
A recent study published in International Journal of Cancer found that boosting the production of a specific microRNA, miR-34a, increases sensitivity of bladder cancer cells to chemotherapy. The study suggests that miR-34a may be used as a predictor of response to chemotherapy and a target for new drugs.
A recent study published in BJUI found that homosexual men taking bicalutamide for prostate cancer reported significant reductions in all aspects of their sexual functioning and satisfaction, ranging from 23% to 54%. In contrast, heterosexual men reported fewer problems and were more satisfied with intercourse.
Researchers at UCLA have developed a patented test that uses methylation patterns in DNA to accurately predict a person's age within five years. This test could offer a new forensic tool for crime-scene investigations, as well as personalized medicine applications, such as tailoring medical interventions based on an individual's bio-ag...
Research by NewYork-Presbyterian/Weill Cornell Medical Center reveals varicoceles cause lower testosterone levels in men. Microsurgery significantly increases testosterone levels in patients with varicoceles.
A study published in the Journal of Pediatric Urology found that a surgical technique for repairing hypospadias in boys results in a postoperative success rate better than 95%. The procedure, called tubularized incised plate (TIP) repair, is effective regardless of anatomy, and offers a more natural appearance after surgery.
A multi-site study has shown that the new drug Cabozantinib is effective in treating prostate cancer that has spread to the bone, with three-quarters of patients experiencing partial or complete tumor shrinkage. Additionally, patients showed significant improvements in bone pain and reduced need for narcotic use.
A new experimental vaccine made from frozen immune cells has shown promise in extending the survival of metastatic prostate cancer patients. The vaccine, APC8015F, was found to increase median survival by approximately 10 months compared to those not treated with it.
A new non-invasive wireless near-infrared device has been shown to be as reliable as current invasive tests in determining bladder disease. The device uses light shone through the skin to monitor changes in bladder physiology, revealing consistent patterns of normal oxygen availability and blood supply in healthy subjects during urinat...
A new Canadian-made therapy, Urocidin, has shown promising results in treating superficial bladder cancer. Patients who received Urocidin became disease-free after one year, tolerating the treatment well.
A decade-long study demonstrates that holmium laser therapy is a safe and durable treatment option for Benign Prostatic Hyperplasia, reducing complications and recurrence rates compared to traditional TURP. Patients treated with HoLEP experience reduced pain, shorter hospital stays, and fewer sexual side effects.
A new study shows that nearly 70% of men with rising PSA levels and subsequent normal biopsies were eventually diagnosed with prostate cancer. Rising PSA velocity over several years should prompt clinicians to follow patients more closely, even with negative biopsy results.
A new alpha-blocker treatment, silodosin, has been shown to reduce symptoms and improve quality of life for men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). The study found that approximately 60% of men reported feeling better after treatment, compared to 30% on a placebo.
A new test measuring multiple parameters including PSA and six antibodies found in the blood of men with prostate cancer is more sensitive and specific than the conventional PSA test. The A+PSA assay reduces false-positives and shows great potential to improve prostate cancer diagnosis.
Researchers at Mayo Clinic found that patients diagnosed with advanced prostate cancer can enjoy long-term survival and a significant cancer-free interval. The study showed an 80% survival rate for patients with locally advanced prostate cancer at 20 years after surgery.
Patients with small kidney tumors are more likely to be offered partial nephrectomy based on surgeon's case volume and type of practice. Fellowship-trained surgeons in academic centers were 70-80% more likely to follow guidelines, while those in private practice saw fewer patients offered radical nephrectomy.
A new technology fusion of MRI with real-time 3D ultrasound improves targeted biopsy accuracy for prostate cancer diagnosis. The system identifies suspicious areas in the prostate and provides a roadmap for biopsy needle guidance, increasing cancer detection rates by five times compared to conventional biopsies.
A study published in PLoS ONE found that a shorter anogenital distance may indicate impaired testicular development and function. The research suggests that this non-invasive measurement could be used to evaluate patients with reduced reproductive potential, potentially linking gestational exposures to adult testicular function.
Researchers find increased MAN2C1 levels enhance prostate cancer recurrence and metastasis, highlighting a potential target for blocking tumor progression. The study could lead to the development of new treatments for patients with advanced prostate cancer.
The landmark event brought together pediatric urologists worldwide to share ideas and advance research. Key findings highlight the growing importance of pediatric urology as a global specialty.
A new study published in The Journal of Urology found that testosterone therapy does not cause rapid growth of prostate cancer in men with untreated or low-risk prostate cancer. Testosterone treatment was associated with improved symptoms and quality of life, without increasing the risk of cancer progression.
A large-scale study of 769 men with low-grade prostate cancer found that closely monitoring the disease without immediate treatment does not raise the risk of death. Men who undergo active surveillance are less likely to need subsequent surgery or radiation if their cancer progression is carefully monitored.
A new PSA test has been shown to detect aggressive prostate cancer more accurately than current tests and reduce unnecessary biopsies. The Pro-PSA test uses a specific PSA subform called (-2) Pro-PSA and can be analyzed with a mathematical formula to provide an overall Prostate Health Index.
A study published in the Journal of the American College of Surgeons found a 22% relative increase in women among USMG applicants to general surgery programs, with a corresponding 40% increase in those entering training. This trend aligns with increasing equal gender enrollment of medical students.
Researchers found that men using digoxin had a 24% lower risk of prostate cancer. The study also identified other approved drugs with anti-prostate cancer properties, paving the way for further research and potential new treatments.
A study by UC Davis researchers found that frequent CT scans for testicular cancer surveillance are associated with a higher risk of secondary malignancies in older men. The study suggests that alternative imaging techniques, such as ultrasound and MRI, may be more suitable.
A study of over 3,000 patients found robot-assisted prostate surgery to be safe, with a low major complication rate and no disease recurrence after five years for nearly 87 percent of patients. The study analyzed surgical outcomes from 2005 to 2009 and addressed the lack of standardized reporting in previous literature.
A new study shows that a surgical technique called microdissection testicular sperm extraction (TESE) can effectively locate and extract viable sperm in over one-third of adult male childhood cancer survivors who were previously considered sterile. This technique enabled many men to father children with the help of in vitro fertilization.
A new study published in Medical Care found that hospitals with robotic technology are more likely to perform radical prostatectomy surgeries. This is the first study to investigate the impact of surgical robot acquisition on surgery rates, and it concludes that technological adoption leads to increased surgical volume.
A UCLA research team has developed a device using Velcro-like nanoscale technology to efficiently identify and capture circulating tumor cells, or CTCs, in blood samples. The new approach captures a greater number of CTCs than existing methods and could enable early detection and diagnosis of cancer.
Men taking non-steroidal anti-inflammatory drugs (NSAIDs) three times a day are 2.4 times more likely to develop erectile dysfunction compared to non-users, according to a Kaiser Permanente study. Regular NSAID use is associated with a modest risk of ED, consistent across all age groups.