Researchers at Cedars-Sinai Medical Center found that multifocal glioblastoma patients have significantly shorter overall survival compared to those with single tumors, even when treated with the same therapies. Median overall survival for multifocal patients was six months, while single-tumor patients survived 11 months.
A new experimental immune-based therapy has more than doubled median survival of patients diagnosed with the most aggressive malignant brain tumor. The vaccine targets six antigens involved in glioblastoma cell development and shows promise in attacking cancer stem cells.
Researchers at Cedars-Sinai Medical Center are developing a new treatment for ALS using a combination of stem cells and gene therapy. The grant will fund an 18-patient clinical trial for ALS in four years, with the potential to protect damaged motor neurons and deliver the protein GDNF exactly where it's needed.
Cedars-Sinai researchers found a strong connection between Kawasaki Disease and accelerated atherosclerosis, a leading cause of adult heart disease. Children with Kawasaki Disease are at increased risk of developing early-onset atherosclerosis, which can lead to hardening of the arteries.
Cedars-Sinai researchers created a laboratory model for Huntington's disease using induced pluripotent stem cells from patients' skin cells. The 'disease in a dish' model allows scientists to test therapies directly on human Huntington's neurons, offering a new pathway to identifying treatments.
Researchers employ pluripotent stem cells to model spinal muscular atrophy, revealing cell death mechanisms and identifying potential pharmaceutical treatments. The study provides an important clue for developing medicines to reverse or prevent motor neuron cell death in patients with the disease.
Researchers discovered that fungi inhabit the large intestine and play a role in inflammatory diseases like ulcerative colitis. The study identified a protein called Dectin-1, which helps protect against inflammation caused by indigenous fungi.
A new study definitively links Irritable Bowel Syndrome (IBS) to bacterial overgrowth in the gut, finding that over 30% of patients with IBS also have small intestinal bacterial overgrowth. Antibiotics are an effective treatment for IBS, according to previous clinical trials and this study
Researchers have identified a genetic mutation in the DYNC1H1 gene as the cause of rare form of spinal muscular atrophy with lower extremity predominance. This disease affects nerve cells controlling muscles of the legs and has a good prognosis, although patients are moderately disabled.
Patients diagnosed with aortic stenosis who are too sick for open-heart surgery have better survival rates and an improved quality of life after undergoing catheter-based heart valve replacement. The minimally invasive procedure adds years to life and life to years, according to a study published in the New England Journal of Medicine.
Cedars-Sinai researchers found that rifaximin and lubiprostone are effective treatments for irritable bowel syndrome (IBS) with low side-effect profiles. The study analyzed over two dozen clinical trials and compared various drug therapies, concluding that these two drugs offer the best options for IBS patients.
Two Cedar-Sinai Heart Institute physicians, Prediman K. Shah and C. Noel Bairey Merz, receive American College of Cardiology's highest honors for groundbreaking work in cardiovascular disease research and clinical care. The accolades recognize their pioneering efforts to develop innovative treatments and improve heart health outcomes.
Cedars-Sinai researchers identified the mechanism that leads to interleukin-1beta production, a major contributor to inflammation in conditions like atherosclerotic heart disease and strokes. This discovery could lead to treatments that prevent its production, resulting in more effective medications for inflammatory diseases.
Researchers at Cedars-Sinai are exploring new treatments for Alzheimer's disease by targeting the immune system and amyloid plaques in the brain. The goal is to identify drugs that can stimulate macrophages to clean up these plaques, allowing brain regeneration.
A Cedars-Sinai Heart Institute clinical trial has demonstrated that treating heart attack patients with their own heart-derived cells can help damaged hearts regrow healthy muscle. The study found a significant reduction in scar size and an increase in healthy heart muscle following the stem cell treatments.
Cedars-Sinai neurology researchers present research updates at the International Stroke Conference, including the use of therapeutic cooling to reduce neurological damage after stroke. Thrombin leaks into healthy brain cells after ischemic stroke, but injecting a drug to counter its effects can improve symptoms.
A Cedars-Sinai study reveals that a normal protein involved in blood clotting can harm healthy brain cells after an ischemic stroke. The researchers will investigate the source of this protein and its interactions with other molecules to develop new treatments for stroke patients.
A new study by Cedars-Sinai researchers found a targeted antibiotic to be the safest treatment option for irritable bowel disease, with fewer adverse side effects compared to other therapies. Rifaximin was shown to have a significantly lower number needed to harm than other commonly used treatments.
Future-Directed Therapy has been shown to significantly improve depression and anxiety symptoms in patients by teaching them skills to think positively about the future. The new treatment approach focuses on helping individuals set goals, problem-solve, and plan for future events, leading to improved overall quality of life.
Dr. Giuliano was awarded the Brinker Award for Scientific Distinction for his pioneering findings on lymph node removal and his contributions to less invasive breast surgery. His research has led to improved quality of life for women with breast cancer and reduced side effects from breast surgery.
The Cedars-Sinai Regenerative Medicine Institute has opened a new facility to produce induced pluripotent stem cells, which can be used to study human diseases and develop new treatments. Cells produced by the core will be critical for innovative research aimed at increasing our understanding of human diseases and genetic disorders.
A new study published in the New England Journal of Medicine found that approximately two-thirds of patients with hepatitis C can be cured in six months, rather than the standard 48-week treatment. The study showed that response-guided therapy is a successful strategy for individualizing treatment based on patient responses.
A recent brain stent study found aggressive medical treatment without stenting may be better for high-risk stroke patients, but experts at Cedars-Sinai Medical Center believe the procedure is appropriate for certain patients who haven't responded to medication. The study's limitations and exclusions have raised concerns among researchers.
Researchers found that while deep brain stimulation has increased acceptance among referring physicians for Parkinson's disease and other movement disorders, only half of recommended patients are appropriate candidates for immediate therapy. This suggests that physicians have become more aware and accepting of the treatment, but may re...
A commentary in New England Journal of Medicine suggests fibrates do not lower heart risk in diabetic patients taking statins; doctors recommend prescription only to high-risk patients after optimal LDL control achieved
Cedars-Sinai's COACH for Kids program will receive a $300,000 grant to expand its oral health services in 14 Los Angeles elementary schools. The program will conduct oral health screenings, education, and apply fluoride varnish to address the most common unmet need among children.
A new study published in Journal of the American Medical Association found that removing lymph nodes due to microscopic cancer cells has no impact on survival outcomes for women with early-stage breast cancer. The study, conducted by Cedars-Sinai Medical Center, challenged the common approach to treating early-stage breast cancer.
Deep brain stimulation is a therapy approved by the FDA for certain treatment-resistant dystonias and has shown sustained benefit for up to three years. Michele Tagliati, a movement disorders expert, led an international task force that reviewed current practice and research on DBS for dystonia.
A surgeon's behavior in the operating room affects patient outcomes, healthcare costs, medical errors, and staff-satisfaction. Civility in the surgical suite can lead to fewer post-operative deaths and complications, improved clinical outcomes, and reduced medical errors.
A genome-wide association study has identified a novel genetic variation in the BAZ2B gene linked to an increased risk of sudden cardiac arrest. This variation may predispose individuals to double their risk of having a sudden cardiac arrest, a disorder that is fatal in about 95% of cases.
A study by Cedars-Sinai surgeon Shirin Towfigh found that daily probing of wounds with a dry cotton swab after surgery dramatically reduced infections in post-operative incision sites. The technique resulted in significantly shorter hospital stays and better cosmetic healing.
A Phase I clinical trial found that the experimental vaccine ICT-107 targets six antigens found on glioblastoma cells and three on cancer stem cells, improving immune responses and progression-free survival rates in patients. The study also showed that targeting these antigens may be a viable strategy for treating glioblastoma.
Researchers at Cedars-Sinai Medical Center are developing gene therapy in corneal stem cells to alleviate damage to corneas caused by diabetes. The therapy aims to correct abnormal protein production and restore normal corneal cell turnover, preventing vision loss.
A two-year study published in Journal of Bone and Joint Surgery found that artificial disc replacement was comparable to fusion surgery in terms of outcomes, but showed individual patient advantages. Patients in the artificial disc group experienced less pain, reduced medication use, and higher satisfaction rates.
Researchers found that Irritable Bowel Syndrome is linked to an overgrowth of bacteria in the gut, as well as a connection to food poisoning. The study suggests that military personnel are at a higher risk for developing IBS due to their increased exposure to gastroenteritis.
Researchers have created a new model using striped zebrafish to screen drugs for Cushing disease, allowing for rapid identification of effective treatments. The model has already shown promise with one drug suppressing hormone secretion and cortisol levels.
Cedars-Sinai Medical Center has received a $500,000 grant from the California Community Foundation to fund primary healthcare and case management services for vulnerable children. The grant will support COACH for Kids and Their Families program, providing no-cost health services to over 10,500 individuals in underserved communities.
Cedars-Sinai researchers discovered how white blood cells identify invading fungi, using the molecular receptor Dectin-1. This finding sheds light on the immune system's ability to mount a response against pathogens.
A new nanodrug breaks down barriers to attack breast cancer cells by carrying multiple drugs that accumulate in tumor cells and strike cancer-specific molecular targets. This targeted approach shows promise as a more effective treatment method than standard treatment, with the potential to be tailored for various disorders.
Earlier deep brain therapy shows better, quicker results for patients with potentially crippling dystonia. A study found that those treated earlier have better general outcomes, while age at surgery influences the time necessary to achieve optimal benefit.
A new study found that coronary artery calcium scanning helps patients make heart-healthy lifestyle changes and lower their heart disease risk factors. The scan also showed significant improvement in several risk factors, such as blood pressure and cholesterol levels, after four years.
Cedars-Sinai's COACH for Kids program will provide comprehensive screenings, immunizations and early treatment to over 25,000 medically underserved children annually. The $20,000 grant expands vital healthcare services to homeless children in need.
Researchers at Cedars-Sinai Medical Center have created a new molecule from curcumin, a key spice in Indian and Southeast Asian cuisine, that affects mechanisms protecting and helping regenerate brain cells after stroke. The compound, CNB-001, crosses the blood-brain barrier and moderates critical pathways involved in neuronal survival.
A Cedars-Sinai research team has received a $1.9 million grant to develop a new pharmaceutical discovery process using pluripotent stem cells, aiming to find a treatment for Spinal Muscular Atrophy. Another team will create a new imaging system to monitor stem cell treatments in real-time, providing insights into tissue regeneration.
A new study by Michele Tagliati and colleagues found that patients with deep brain stimulation experienced no significant progression of motor symptoms over five years. The research suggests that the therapy may actually stabilize these symptoms, challenging previous assumptions about Parkinson's disease progression.
A new antibiotic therapy developed at Cedars-Sinai Medical Center has shown long-lasting relief from irritable bowel syndrome (IBS) symptoms, even after treatment is stopped. The study found that patients experienced significant relief from bloating, abdominal pain, and loose stools for up to 10 weeks.
A groundbreaking clinical trial is examining the safety of hypothermia in elderly stroke patients, aiming to improve outcomes and prevent neurological damage. The study, led by top researchers, will enroll 400 patients at multiple US and European sites and investigate the effectiveness of therapeutic brain cooling.
Researchers create a nanobioconjugate drug that specifically targets glioblastoma multiforme by blocking the production of laminin-411, promoting tumor cell death. Human clinical trials are anticipated to begin soon, offering new hope for brain cancer treatment.
A study from Cedars-Sinai Heart Institute shows that barbers can improve hypertension control in African-American men by conducting monitoring, education and physician-referral programs. The intervention resulted in 20% more patients with controlled blood pressure compared to the comparison group.
A team of researchers aims to develop a biological treatment for compression fractures, the most common type of bone fracture in osteoporosis patients. The goal is to promote healing and stimulate normal bone production.