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Ecole Polytechnique Fédérale de Lausanne


Engineering molecular interactions with machine learning

Researchers at EPFL have computationally designed novel protein binders that attach seamlessly to key targets, including the SARS-CoV-2 spike protein, using deep learning-generated 'fingerprints' to characterize millions of protein fragments. This method demonstrates therapeutic potential for rapidly designing protein-based therapeutics.

SourceEcole Polytechnique Fédérale de Lausanne·JournalNature·TypeComputational simulation/modeling·DateMay 4, 2023

Testing antibiotic resistance with a fast, cheap, and easy method

Researchers have developed a fast, cheap, and easy method to test antibiotic resistance in bacteria, using optical nanomotion detection. The technique can determine sensitivity or resistance of bacterial cells to antibiotics in under two hours, with significant implications for clinical and research applications.

SourceEcole Polytechnique Fédérale de Lausanne·JournalProceedings of the National Academy of Sciences·DateApr 24, 2023

Nanoplasmonic imaging reveals real-time protein secretion

Researchers developed a novel optical imaging approach to observe cell secretions in space and time, revealing key heterogeneity and potential for pharmaceutical development. The method has tremendous potential for high-throughput screening of individual cells and studying delicate antibody-secreting human donor B-cells.

SourceEcole Polytechnique Fédérale de Lausanne·JournalNature Biomedical Engineering·TypeImaging analysis·DateApr 11, 2023

New circuit model offers insights into brain function

A new computational model of the thalamic microcircuit in mouse brains offers detailed insights into its role in brain function and dysfunction, particularly in relation to sensory processing and spindles. The model replicates network-level experimental findings across different brain states, shedding light on inhibitory rebound and th...

SourceEcole Polytechnique Fédérale de Lausanne·JournalCell Reports·TypeComputational simulation/modeling·DateMar 30, 2023

3D printing with bacteria-loaded ink produces bone-like composites

EPFL researchers have created a 3D printing ink containing calcium carbonate-producing bacteria that produces bone-like composites. The resulting bio-composite is exceptionally strong, light, and environmentally friendly. This innovation has potential applications in art restoration, coral reef regeneration, and biomedical fields.

SourceEcole Polytechnique Fédérale de Lausanne·JournalMaterials Today·TypeExperimental study·DateFeb 23, 2023

Integrated photonic circuits could help close the 'terahertz gap'

Researchers at EPFL have developed a new thin-film circuit that produces finely tailorable terahertz-frequency waves, enabling precise control over frequency, wavelength, amplitude, and phase. This breakthrough has significant implications for future electronics, telecommunications, spectroscopy, and quantum applications.

SourceEcole Polytechnique Fédérale de Lausanne·JournalNature Communications·TypeExperimental study·DateJan 12, 2023

A step towards solar fuels out of thin air

Scientists at EPFL have created a device that combines semiconductor-based technology with novel electrodes to harness water from the air and produce hydrogen gas powered by sunlight. The transparent, porous, and conductive electrodes mimic the properties of plant leaves, which convert sunlight into chemical energy through photosynthesis.

SourceEcole Polytechnique Fédérale de Lausanne·JournalAdvanced Materials·TypeExperimental study·DateJan 4, 2023