Scientists have found that six ligands arranged in a specific pattern are optimal for super-selective binding, while rigidity is crucial for controlling the binding interaction. This breakthrough could lead to new approaches for virus prevention and cancer detection.
A new study reveals that the protein fragile X mental retardation protein (FMRP) plays a crucial role in helping tumors evade immune destruction, leading to treatment resistance. FMRP regulates a network of genes and cells in the tumor microenvironment, contributing to its ability to hide from immune cells.
A study found that higher levels of glutathione in the nucleus accumbens correlate with better performance in motivation tasks. Nutritional interventions targeting GSH levels may improve motivation by modifying behavior and facilitating effortful endurance.
Scientists at EPFL have developed a method to enhance the packing of photosensitizer dye molecules, resulting in DSCs with power conversion efficiencies of up to 28.4% and long-term operational stability. This breakthrough offers promising prospects for applications as power supply and battery replacement for low-power electronic devices.
Researchers identified urolithin A as a compound that improves function of immune cells against cancer. The study found that urolithin A induces mitophagy in T cells, recycling and renewing mitochondria to enhance tumor-fighting capabilities.
Researchers developed a machine-learning model to predict heat capacity of MOFs, enabling more efficient applications in energy and climate change. The model's accuracy was improved by removing solvent from pores during synthesis.
The study found that the interaction between two organelles in the cell, the endoplasmic reticulum and Golgi apparatus, controls the transfer of cholesterol to the plasma membrane. This process is crucial for maintaining proper lipid composition at the cell surface.
Researchers have successfully inserted nanotubes into bacteria, allowing for the creation of
Scientists at EPFL have created an intelligent microscope that uses artificial neural networks to automate image acquisition and reduce sample stress. The technique can capture more detailed images of bacterial division and mitochondrial constrictions, leading to a better understanding of these rare biological events.
A new study reveals that exploiting mitohormesis, a biological phenomenon where mild cellular stress boosts health and viability, can induce tolerance to influenza infection. Researchers identified a novel molecule, 9-tert-butyldoxycycline, which triggers beneficial mitochondrial responses that reduce tissue damage and inflammation.
Neurobiologists identified mechanisms underlying atypical protein tangles that kill neurons in neurodegenerative disorders. Engineering Drosophila adults with human Tau revealed a 'traffic jam' effect, where reduced retromer activity accelerates neurodegeneration. Inhibiting the shortened form of Tau could stall neuron loss.
EPFL researchers have discovered a material called Vanadium Dioxide (VO2) that can remember its previous external stimuli for up to three hours. The material's structural memory is capable of anticipating future events, similar to how neurons in the brain function.
Scientists have developed Live-seq, an innovative approach that keeps cells alive during RNA extraction for further study. This technique uses FluidFM to manipulate tiny volumes of fluids in a sample under the microscope, allowing for the insertion and extraction of mRNA from single cells without killing them.
Researchers found that transcranial brain stimulation can improve accuracy and speed in older adults, facilitating the emergence of efficient motor chunks. The study suggests that this non-invasive technique may restore motor skill acquisition in individuals with diminished learning mechanisms.
Scientists have developed a biomass-derived plastic similar to PET that meets the criteria for replacing several current plastics. The new plastic can be produced in one step using inexpensive chemicals and retains its sugar structure, making it easy to degrade.
Researchers at EPFL have developed a photonic integrated circuit based erbium-doped amplifier that generates record output power and provides high gain, matching commercial EDFAs. This breakthrough enables new applications in optical communications, LiDAR, quantum sensing, and memories.
Researchers have developed a new protocol for differentiating human embryonic stem cells into retinal pigment epithelial (RPE) cells, which can be used to treat age-related macular degeneration. The study shows that the protocol produces a pure population of RPE cells that can continue maturing after transplantation, paving the way for...
A new time-resolved instrument measures circular dichroism changes in fractions of a picosecond, enabling the capture of photoexcited molecules' chirality and conformational motion. This resolves the deactivation mechanism of iron-based spin-crossover complexes, crucial for magnetic data storage.
A new method for 3D mapping uses artificial intelligence to detect correspondences and correct gaps in laser-point clouds, eliminating the need for manual data corrections. This approach enables faster, cheaper, and more accurate maps, with potential applications in construction, climate change monitoring, and road safety.
A new clinical study published in Cell Reports Medicine found that daily intake of postbiotic Urolithin A improved muscle strength by 12% in middle-aged adults. The supplement supported the cells' ability to renew their powerplants, the mitochondria, during the aging process.
A new mathematical theory explains how cells navigate the risk-speed tradeoff when dividing, balancing risk and speed to ensure survival. The theory applies broadly to all organisms, despite differences between yeast and mammalian cells.
Scientists have created nanomechanical resonators with extremely high quality factors using a regular polygon design, leading to compact devices for sensing weak forces. The new design allows for precision force sensing with sensitivity approaching state-of-the-art atomic force microscopes.
Researchers at EPFL's School of Life Sciences create a digital twin of Drosophila called NeuroMechFly, which uses biomechanical modeling and machine learning to simulate the fly's movements. The model is validated through experiments that demonstrate its accuracy in replicating real animal behaviors.
Researchers discovered a novel mutation in the alpha-synuclein gene that causes severe Lewy body pathology, revealing distinct mechanisms of neurodegeneration. The E83Q mutation influences alpha-synuclein's structure and aggregation properties, leading to increased pathology formation and toxicity.
Researchers have created a new solvothermal method to produce single-crystalline titanium dioxide nanoparticles that can enhance the scalability of perovskite solar cells. The resulting cells demonstrated improved power-conversion efficiency and operational stability, with values reaching up to 24.05% and 84.7% fill factor.
Researchers at EPFL's School of Life Sciences have identified a critical link between cellular lipids and the determination of cell fate. They found that changes in lipid composition can influence the behavior of cells in response to external stimuli, even if the original cell type is identical.
A study from EPFL and the University of Lausanne developed a method to calculate which jobs are at risk of being automated by robots. The team created an algorithm that predicts the risk of automation for hundreds of jobs and suggests alternative careers with minimal retraining requirements.
The study found two DNA defense systems in Vibrio cholerae bacteria that work together to eliminate plasmids and prevent the spread of antibiotic resistance. These defense systems, called DdmDE and DdmABC, are encoded within distinct pathogenicity islands and help the bacteria survive pandemics.
A team of scientists has developed a solar-powered water filter that can remove pathogens, pesticides, and micropollutants from contaminated water. The filter uses titanium dioxide (TiO2) nanowires and carbon nanotubes to produce reactive oxygen species that kill bacteria, viruses, and other microorganisms.
A groundbreaking system implanted directly on the spinal cord has restored blood pressure regulation in a patient with multiple system atrophy-parkinsonian type (MSA-P), enabling them to walk again after being bedridden for over a year. This innovative therapy paves the way for new clinical breakthroughs in treating degenerative diseases.
Researchers propose an open platform to integrate data collection, processing, and publication, ensuring FAIR (findable, accessible, interoperable, reusable) data and enabling machine-learning algorithms to learn from failed experiments. The platform aims to bridge the gap between data and machine learning in chemistry.
Researchers at EPFL and ETH Zurich propose a rational explanation for the deaths of nine hikers in 1959, attributing their injuries to a small slab avalanche. The team's work was met with intense media attention and criticism from conspiracy theorists before being accepted by the Russian scientific community.
A new study by EPFL researchers finds that stress during early adolescence leads to increased body fat and reduced sociability in males, but not females. The researchers identified a biological link between stress-induced fat gain and impaired brain function, specifically the NAD+/Sirtuin-1 pathway.
A recent study analyzed samples from eight research stations across the Arctic, revealing that organic aerosols come mainly from human activity in winter but from natural sources in summer. The researchers also mapped black carbon concentrations and origins in each region, providing insights for targeted pollution reduction measures.
Scientists at EPFL have created strained crystalline nanomechanical resonators with ultralow dissipation, enabling the creation of high-purity quantum states. These nanostrings could be used as precision force-sensors, taking advantage of interactions such as radiation pressure and magnetic fields.
According to a new EPFL study, Swiss rivers are at risk of overheating by the end of the century. If greenhouse gas emissions are reduced, river temperatures may only rise by 1°C and discharge decreases by 5% in mountain catchments. Inaction could lead to extreme consequences, including glacier loss and decreased biodiversity.
A new method called DisCo enhances the efficiency of single-cell RNA sequencing by actively detecting and capturing cells using machine-vision. This approach allows for continuous operation and high capture efficiency, making it suitable for processing small cell samples such as tissues or patient biopsies.
A team of scientists has developed a pioneering approach to combine advances in computer vision with ecological expertise to analyze wildlife populations. By leveraging AI and machine learning algorithms, researchers can extract key features from images and videos to quickly classify species, count individuals, and track behavior.
Localis-rex identifies 32 locale-specific sensor proteins sensing hydroxynonenal, a lipid-derived electrophilic-metabolite, revealing new information on electrophile signaling and its impact on biological processes. The study also highlights the potential for covalent drug design and profiling of drug-sensitive cells.
Researchers at EPFL's School of Life Sciences discovered that blocking sphingolipid synthesis can reverse the symptoms of Duchenne muscular dystrophy, including loss of muscle function and inflammation. This study identifies sphingolipid inhibition as a potential treatment for muscular dystrophies.
Scientists at EPFL have developed a novel method to convert banana peels into valuable hydrogen and solid-carbon biochar through flash pyrolysis using a Xenon lamp. This innovative technique generates around 100 liters of hydrogen per kg of dried biomass, making it a promising renewable energy solution.
Researchers replaced traditional electron-transport layers with quantum dot layers in perovskite solar cells, resulting in record power-conversion efficiencies of up to 25.7%. The use of quantum dots also enabled high operational stability and scalability, making them a promising solution for large-scale solar energy production.
Researchers have developed a promising treatment approach for chronic stroke patients using carefully tuned electrical stimulation of the neuromuscular system. This method has been shown to improve motor control, sensory capabilities, and body perception in patients with long-term disabilities.
Scientists successfully demonstrated efficient electron beam modulation using integrated photonic microresonators, paving the way for atomic-scale imaging and coherent spectroscopy.
Researchers have developed a computer program that can control a robot using electrical signals emitted by a patient's brain, allowing them to move the robot with their thoughts. The system uses an algorithm that can learn from the patient's brain activity and adjust the robot's movements accordingly.
The study found that exercise induces expression of long noncoding RNA CYTOR, which enhances myogenic differentiation and improves muscle morphology and function in aged muscles. CYTOR also re-configures chromatin accessibility at binding sites of other genes, shedding light on its mechanisms.
Researchers developed a molecular device that converts infrared light to visible light, expanding detection capabilities. The device uses tiny vibrating molecules and metallic nanostructures to enhance conversion efficiency.
A team of researchers has developed a deep-learning model that can count the number of seals in aerial photos considerably faster than manual identification, allowing for more efficient ecological surveys. The new approach eliminates the need for labeling individual animals and can be applied to various types of objects or animals.
Researchers have used advanced microscopy to study the ultrastructure of huntingtin inclusions, revealing different mechanisms of aggregation that lead to distinct biochemical properties. The findings suggest targeting inclusion growth as a potential therapeutic strategy for slowing Huntington's disease progression.
A study by EPFL researchers reveals that CTCF sites within the HoxD cluster contribute to organizing genes into topologically associated domains, helping to organize developmental complexity. The dual function of CTCF binding sites varies depending on tissue type.