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Hokkaido University


Reusing waste energy with 2-D electron gas

Researchers at Hokkaido University developed a novel approach to improve thermoelectric material performance by harnessing high mobility two-dimensional electron gas. This enables efficient heat-to-electricity conversion, overcoming current limitations in industrial applications.

SourceHokkaido University·JournalAdvanced Science·DateNov 20, 2017

'Ion billiards' cue novel material synthesis method

Researchers at Hokkaido University have developed a novel material synthesis method that utilizes protons to introduce ions into host materials. This liquid-free process enables the homogenous introduction of various ions, such as lithium and sodium, into tantalum sulfide, maintaining its crystallinity.

SourceHokkaido University·JournalJournal of the American Chemical Society·DateNov 16, 2017

New way to prevent unfavorable intestinal microbiota

Researchers found that antimicrobial peptide R-Spondin1 stimulates intestinal stem cells to differentiate into Paneth cells, which secrete alpha-defensins with strong antimicrobial activity. Administration of R-Spondin1 restored gut microbiota in mice with graft-versus-host disease, preventing depletion of Paneth cells and dysbiosis.

SourceHokkaido University·JournalJournal of Experimental Medicine·DateOct 24, 2017

Virus hijacks cell's transportation system

A deadly tick-borne virus uses the host neuron's transportation system to move its RNA, resulting in local reproduction of the virus and severe neurological symptoms. The unique virus-host interaction reveals a pivotal non-coding sequence that hijacks the neuronal granule system.

SourceHokkaido University·JournalProceedings of the National Academy of Sciences·DateSep 1, 2017

New therapeutic antibody for dog cancers

Researchers at Hokkaido University have developed a chimeric anti-PD-L1 antibody that induces immune responses and tumor regression in dogs with malignant cancers. The antibody targets PD-L1-positive cancers, including oral malignant melanoma and undifferentiated sarcoma.

SourceHokkaido University·JournalScientific Reports·DateAug 24, 2017

Allergies: Cross-reactivity between cypress pollen and peaches/citrus fruits explained

Researchers have discovered a new family of proteins involved in cross-reactivity between cypress pollen and certain fruits, leading to improved allergy diagnosis and treatment. This finding, published in Journal of Allergy and Clinical Immunology, sheds light on the underlying mechanisms behind pollen food associated syndrome.

SourceHokkaido University·JournalJournal of Allergy and Clinical Immunology·DateAug 18, 2017

Mosses used to evaluate atmospheric conditions in urban areas

Researchers have developed a method using mosses (bryophytes) to evaluate atmospheric conditions in urban areas, including nitrogen pollution severity and drought stress. The study found that bryophytes can indicate the degree of nitrogen pollution and drought levels, making them a valuable tool for assessing environmental changes.

SourceHokkaido University·JournalLandscape and Urban Planning·DateAug 16, 2017

Countering atopic dermatitis immune reactions

Researchers from Hokkaido University successfully treated mice with atopic dermatitis using HLA-G1, a protein that inhibits immune responses. The treatment showed marked improvement in skin lesions and reduced immune response compared to untreated mice.

SourceHokkaido University·JournalInternational Immunopharmacology·DateAug 3, 2017

Native leech preys on invasive slug?

Invasive giant slug <i>Limax maximus</i> has spread to Hokkaido, Japan, where it is preyed upon by microphagous leech <i>Orobdella kawakatsuorum</i>. The study reveals that the invasive species feeds on various crops including cucumber and sweet potato.

SourceHokkaido University·JournalBioInvasions Records·DateJul 20, 2017

World's first success in asymmetric borylation of ketones

Researchers at Hokkaido University have successfully developed a method for the catalytic asymmetric borylation of ketones, a breakthrough expected to facilitate the development of new medicines and functional chemicals. The team has identified a suitable catalyst element called chiral NHC complex for efficient reaction with diboron.

SourceHokkaido University·JournalAngewandte Chemie International Edition·DateJun 8, 2017

When gold turns invisible

Researchers at Hokkaido University developed a gold compound that turns invisible when ground into a fine powder, emitting only infrared light. The substance's unique property has significant implications for bioimaging and the creation of invisible security inks.

SourceHokkaido University·JournalJournal of the American Chemical Society·DateMay 31, 2017

Identifying species from a single caviar egg

A new tool enables identification of high-end caviar from Beluga sturgeons by analyzing DNA from a single caviar egg, contributing to conservation and fair international trade. The development helps distinguish Beluga caviar from Bester and other species using targeted genetic variants.

SourceHokkaido University·JournalScientific Reports·DateMay 30, 2017

Diverse populations make rational collective decisions

Researchers at Hokkaido University discovered that individual ants with different preferences can lead to a collective rational decision when making binary choices. The team found that the middle group of ants, which preferred a higher sucrose concentration, was the key to the colony's decision-making process.

SourceHokkaido University·JournalRoyal Society Open Science·DateMay 16, 2017

Deciphering an embryo-protecting protein

A team of researchers at Hokkaido University has uncovered the structure of a protein called HLA-G2 that protects embryos from being attacked by their mothers' immune systems during pregnancy. The structure was found to be similar to another class of human leukocyte antigens, suggesting its evolutionary origin.

SourceHokkaido University·JournalThe Journal of Immunology·DateMay 9, 2017

Synchronized voltage rhythms could maintain the body's clock

A study by Hokkaido University researchers found that voltage rhythms are synchronized across the entire suprachiasmatic nucleus (SCN), maintaining a tissue-wide rhythm. This discovery suggests that inter-cellular interactions within the SCN may be responsible for synchronizing voltage changes, separate from asynchronous calcium rhythms.

SourceHokkaido University·JournalProceedings of the National Academy of Sciences·DateApr 23, 2017

Clues as to why cockroaches are so prolific

A study by Hokkaido University researchers found that grouping female American cockroaches promotes asexual egg production, with synchronized egg case delivery in synchrony. The females perceive female-specific chemosensory signals via their antennae, leading to increased fecundity and colony survival.

SourceHokkaido University·JournalZoological Letters·DateApr 19, 2017

Why don't fish freeze to death in icy water?

Researchers from Hokkaido University conducted microgravity experiments on the International Space Station to measure ice crystal growth rates. They found that glycoproteins in fish blood facilitate growth, but also lead to a slowing effect when flat faces are truncated by slower-growing faces.

SourceHokkaido University·JournalScientific Reports·DateApr 17, 2017

Atomic 're-packing' behind metallic glass mystery

Researchers have solved a decades-long puzzle about metallic glasses' atomic structure using a new method combining various techniques. The study revealed a hidden amorphous phase within a certain temperature range, linked to metals' ability to form glass and potentially enabling the development of stronger novel materials.

SourceHokkaido University·JournalNature Communications·DateMar 29, 2017

Building trust, not hate

When anonymity is lifted, cooperation increases significantly due to mutual understanding. Participants who knew each other were more likely to cooperate rather than engage in retaliatory sentiments or punishment.

SourceHokkaido University·JournalScience Advances·DateMar 29, 2017

New 'tougher-than-metal' fiber-reinforced hydrogels

Scientists at Hokkaido University have created 'fiber-reinforced soft composites' that combine the flexibility of hydrogels with the strength of glass fibers. These materials are 5 times tougher than carbon steel, making them suitable for various applications such as artificial ligaments and tendons.

SourceHokkaido University·JournalAdvanced Functional Materials·DateFeb 23, 2017

New RNAi treatment targets eye inflammation

A new RNAi treatment has shown significant improvement in mouse models of acute uveitis and chronic diabetic inflammation without apparent side effects. The therapy targets the receptor-associated prorenin system, involved in uveitis pathogenesis.

SourceHokkaido University·JournalMolecular Therapy — Nucleic Acids·DateFeb 13, 2017

Pure iron grains are rare in the universe

New research suggests that pure iron grains are extremely rare in the universe, contrary to previously thought, and may be forming invisible metal particles. A study published in Science Advances used a rocket-based experiment to simulate the formation of pure iron grains in space, revealing grain formation is highly unlikely.

SourceHokkaido University·JournalScience Advances·DateFeb 8, 2017

Manipulating gene expression precisely using light

Researchers at Hokkaido University have created a new technology that can precisely control gene expression by light illumination, overcoming existing limitations. The method uses ultraviolet and blue light to start and stop protein production in embryos, enabling precise timing and duration of gene expression.

SourceHokkaido University·JournalACS Chemical Biology·DateJan 23, 2017