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Hokkaido University


Becoming promiscuous to ensure reproduction

In a study on Japanese great tits, researchers found that females became more promiscuous after failed breeding attempts, increasing the rate of extra-pair paternity by 40% in subsequent breeding attempts. This flexible behavior is thought to be an adaptive strategy to improve reproductive success.

SourceHokkaido University·JournalBehavioral Ecology·DateOct 9, 2018

Evolution: Genetics doesn't matter much in forming society

Researchers at Hokkaido University discovered that social behavior in eusocial species like sweat bees is more attributed to cooperative behavior than genetic similarity. This finding challenges previous theories and suggests that the benefit of grouping is a key factor in the evolution of cooperation, including among humans.

SourceHokkaido University·JournalScience Advances·DateOct 3, 2018

New micro-platform reveals cancer cells' natural behavior

Researchers developed a new cell culture platform to observe cancer cells' never-before-seen behaviors, revealing the mechanisms behind pancreatic cancer's clinical properties. The study shows that cancer cells can self-organize into micro-tumors and evade the immune system by releasing chemical markers on their surfaces.

SourceHokkaido University·JournalScientific Reports·DateSep 19, 2018

Mitochondria come together to kill cancer cells

Researchers at Hokkaido University identified a pathway that facilitates the dispersion of mitochondria towards the cell periphery, increasing cancer invasiveness. Blocking this pathway led to the aggregation of mitochondria and an increase in reactive oxygen species production, resulting in cancer cell death.

SourceHokkaido University·JournalNature Communications·DateSep 12, 2018

Methane to syngas catalyst: two for the price of one

Hokkaido University researchers have created an improved catalyst for the conversion of methane gas into syngas, overcoming challenges faced by previous studies. The new catalyst successfully generates syngas at a lower temperature than conventional methods, making it more efficient and cost-effective.

SourceHokkaido University·JournalCommunications Chemistry·DateSep 4, 2018

What's behind the retreating kelps and expanding corals?

A recent study by Hokkaido University reveals that climate warming, ocean currents, and deforestation by invasive fish are driving the expansion of tropical corals into temperate zones in Japan. This shift is linked to increased grazing by herbivorous fish, leading to a decline in macroalgae populations.

SourceHokkaido University·JournalProceedings of the National Academy of Sciences·DateAug 20, 2018

Hybrid catalyst with high enantiomer selectivity

Researchers at Hokkaido University have developed a hybrid catalyst that combines simple rhodium and organic catalysts to selectively produce molecules with high enantiomer selectivity. This technology is expected to assist in rapid and low-cost drug synthesis, particularly for nucleotide medicine.

SourceHokkaido University·JournalNature Catalysis·DateAug 9, 2018

Fish reproduction: Two times a lady

A DNA probing technique clarifies the mechanism behind clonal reproduction of female dojo loach fish, revealing how they double their chromosomes twice to ensure clonal reproduction. The study also provides insight into the ancestral origin of this population and suggests a method for developing clone fish with desirable characteristics.

SourceHokkaido University·JournalChromosome Research·DateAug 2, 2018

River complexity maintains regional population stability

A study by Hokkaido University researchers found that branching complexity of rivers, rather than ecosystem size, contributes to regional population stability in nature. This challenges current theories and highlights the importance of environmental diversity in maintaining stable populations.

SourceHokkaido University·JournalProceedings of the National Academy of Sciences·DateJul 31, 2018

Relational mobility may influence your interpersonal behaviors

A large-scale analysis found higher relational mobility in North America, Europe, and Latin America compared to Asia and the Middle East, associated with increased personal self-esteem, closeness in friendship, and proactive behavior. Societal threats and subsistence style also influenced relational mobility scores.

SourceHokkaido University·JournalProceedings of the National Academy of Sciences·DateJun 26, 2018

How do horses read human emotional cues?

Researchers found that horses can read human emotional cues through facial expressions and voice tones, regardless of familiarity. They used the expectancy violation method to investigate this phenomenon and observed significant responses in both familiar and unfamiliar settings.

SourceHokkaido University·JournalScientific Reports·DateJun 21, 2018

Electron sandwich doubles thermoelectric performance

A new study published in Nature Communications has more than doubled the ability of a material to convert heat into electricity, a significant step towards reducing wasted fossil fuel. By significantly narrowing the space through which spread electrons move, researchers improved thermoelectric energy conversion rates.

SourceHokkaido University·JournalNature Communications·DateJun 20, 2018

The right squeeze for quantum computing

Scientists at Hokkaido University have developed a theoretical approach to quantum computing that uses light squeezing to dramatically reduce errors. This new method is ten billion times more tolerant of errors than current experimental methods, bringing us closer to developing ultra-accurate quantum computers.

SourceHokkaido University·JournalPhysical Review X·DateMay 31, 2018

Key molecule for flu infection identified

A research team at Hokkaido University has discovered the key receptor molecule that enhances the infection of the influenza A virus. The Ca2+ channel is the critical component, and blocking it with calcium channel blockers can significantly suppress IAV infections.

SourceHokkaido University·JournalCell Host & Microbe·DateMay 29, 2018

Giant clams tell the story of past typhoons

Researchers at Hokkaido University have created a precise method to determine past typhoon occurrences from giant clam shells, which could help predict future cyclone activity. The team found that the shell's microstructure and chemical composition reveal data about typhoons occurring before written records were available.

The far-reaching effects of ocean floors on the sea surface

Research from Hokkaido University reveals that low rises on the ocean floor regulate surface flows, creating sharp SST fronts with significant impacts on climate and marine resources. The study found that Rossby wave propagation is deflected by eddy-driven flows over bottom rises, leading to thickness jumps and jet formation.

SourceHokkaido University·JournalNature Communications·DateMay 8, 2018

Unraveling the immunopathogenesis of Johne's disease

A study by Hokkaido University researchers has identified prostaglandin E2 (PGE2) as a key player in impairing the immune response of cattle affected by Johne's disease. The discovery offers hope for developing a method to control this chronic enteritis caused by Mycobacterium avium subsp. paratuberculosis.

SourceHokkaido University·JournalInfection and Immunity·DateApr 2, 2018

Calculating the impacts of natural events on wildlife

Researchers developed a new approach to measure the impact of natural disasters on wildlife populations, finding that frequent intense events exert strong selection pressures on species. The study suggests that the 2011 tsunami had a relatively small impact on organisms living in Japan's intertidal zone, comparable to a Pacific storm.

SourceHokkaido University·JournalScientific Reports·DateMar 30, 2018

Diet or Regular? Decoding behavioral variation in ant clones

Researchers found significant variation in the response threshold of cloned ants to sweetened water, with some preferring diet soda equivalents and others requiring stronger concentrations. This diversity may be driven by epigenetic modifications that allow for individualized adaptation and potentially enhance long-term colony survival.

SourceHokkaido University·JournalRoyal Society Open Science·DateFeb 20, 2018

Sniffing out a mate with precision

Researchers discovered how male cockroaches locate a sexual mate by detecting fine structures of odor plumes, thanks to their antennae and neural circuits. They identified twelve key interneurons that convey spatial information to the brain, ensuring complete coverage over the entire flagellum.

SourceHokkaido University·JournalCurrent Biology·DateFeb 8, 2018

An unbiased approach for sifting through big data

Researchers developed a novel probabilistic approach to mine big data, enabling the creation of an 'Optimal Information Network' (OIN) for assessing health outcomes in U.S. cities. The OIN identified poor and favorable health metrics, with some cities showing high variability over time.

SourceHokkaido University·JournalScience Advances·DateFeb 2, 2018

Letting molecular robots swarm like birds

Researchers developed DNA-assisted molecular robots that autonomously swarm in response to chemical and physical signals. The swarm behavior resembles that of fish, ants, and birds, featuring complex structures, distinct divisions of labor, robustness, and flexibility.

SourceHokkaido University·JournalNature Communications·DateJan 31, 2018

Is punishment as effective as we think?

A social dilemma experiment found that punishment is ineffective in promoting cooperation among players, with players instead replacing defection with punishment. The study suggests that punishment has a demoralizing effect and reduces the incentive to choose cooperation over competition.

SourceHokkaido University·JournalProceedings of the National Academy of Sciences·DateDec 27, 2017

Understanding the molecular mechanisms of ALS

Researchers at Hokkaido University have shed light on the molecular mechanisms behind ALS by studying the depletion of protein TDP-43. The study found that TDP-43 binds to U6 snRNA, stabilizing it, which leads to its degradation and eventual cell death. This discovery may lead to ways to slow or stop neuronal cell death in ALS patients.

SourceHokkaido University·JournalPLOS ONE·DateDec 26, 2017

A kiss of death for prostate cancer

Researchers at Hokkaido University have identified a cellular protein called STAP-2 that stabilizes the EGFR signaling pathway, leading to increased cell proliferation and tumor formation in prostate cancer. Suppressing STAP-2 with inhibitors could potentially treat Gefitinib-resistant prostate cancers.

SourceHokkaido University·JournalJournal of Biological Chemistry·DateDec 21, 2017

A risk factor for drug-induced skin disease identified

A type of human leukocyte antigen (HLA) gene, HLA-DQB1*03:01, is associated with an increased risk of developing bullous pemphigoid (BP) in diabetic patients taking DPP-4 inhibitory drugs. The gene was found to be present in 86% of non-inflammatory BP patients administered with DPP-4i, compared to 18% in the general population.

SourceHokkaido University·JournalJournal of Investigative Dermatology·DateDec 6, 2017