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Institute of Science and Technology Austria


Feed them or lose them

Researchers found that a group of amino acids influence brain development, leading to severe effects after birth if nerve cells are starved. The study showed that mice with low levels of essential amino acids developed microcephaly and exhibited long-term behavioral abnormalities similar to those in autism spectrum disorders.

SourceInstitute of Science and Technology Austria·JournalCell·TypeExperimental study·DateMar 29, 2023

Reducing their natural signals: How sneaky germs hide from ants

A study by Sylvia Cremer and her team reveals that pathogens reduce their chemical detection signals in response to ant's social care intervention. This adaptation allows the fungi to counteract spore removal and escape the ant's immune system, demonstrating the impact of collective hygiene measures on pathogens.

SourceInstitute of Science and Technology Austria·JournalNature Ecology & Evolution·TypeExperimental study·DateFeb 2, 2023

DREADDful mimicry

Researchers successfully developed artificial replicas of GPCRs, allowing for controlled activation and replication of original functionality. The method enables precise modulation of immune cells' responses, holding promise for treating diseases targeted by GPCRs.

SourceInstitute of Science and Technology Austria·JournalNature Communications·DateAug 15, 2022

Resisting the pressure

Researchers at IST Austria find that a specific gene, Fos, regulates macrophage infiltration into surrounding tissue by creating an actin shell, making it easier for immune cells to invade. This discovery raises hopes for new targets in treating cancer and understanding the immune system.

Spot the difference

A full-scale model of the mouse hippocampus uncovers a new mechanism for pattern separation, where inhibition separates patterns and reduces activity makes it easier to distinguish differences. The study challenges historical views on pattern separation and suggests focal inhibition as an essential factor.

SourceInstitute of Science and Technology Austria·JournalNature Computational Science·DateDec 16, 2021

Unfinding a split electron

Researchers from Austria, Copenhagen, and Madrid found that a valid signal for Majorana zero modes, crucial for topological qubits, can be a false flag. By varying the nanowire setup, they discovered that a specific architecture causes a mimicking signal, leading to a crucial step forward in understanding nanowires.

Frozen: Cutting-edge technology reveals structures within cells

Researchers have developed a new method to visualize protein complexes in their natural environment, revealing the structure of the Arp2/3 complex and its role in cell motility. The study provides insights into the regulation and activity of this important protein complex, which could lead to better understanding of disease mechanisms.

SourceInstitute of Science and Technology Austria·JournalNature Communications·DateDec 22, 2020

Plants on aspirin

A new study published in Cell Reports found that painkillers such as Aspirin and Ibuprofen interfere with the auxin flow in plants, leading to abnormal root growth. The drugs also suppress the movement and trafficking of substances within plant cells, impairing their ability to develop properly.

Sticking together

Researchers find that cell adhesion proteins and a gradient of signaling molecule Sonic Hedgehog work together to create precise sorting of cells into domains. By combining experiments from biophysics, genetics, and developmental biology, the team successfully solves the puzzle of how patterns are created in developing organisms.

Wound-healing waves

Cells utilize long-distance traveling waves in a self-organized manner to close wounds, guided by intricate interplay of cell movement, sensing, and protein activation. This coupled system enables robust communication of direction over large distances, promoting coordinated behavior for healing and growth.