Scientists at ISTA used brain organoids to study the effects of CHD8 mutations on brain development. The study found that mutant organoids produced larger amounts of neurons, leading to brain overgrowth and macrocephaly similar to patient symptoms.
Researchers at ISTA discovered a novel protein, Atossa, that boosts energy production in immune cells, enabling them to invade tissues. This discovery has significant implications for understanding human physiology and potentially treating neurodegenerative diseases.
Researchers create a microscopic sandwich of an aluminium superconductor on top of an indium-arsenic semiconductor to probe quantum interactions in super-semi sandwiches. They developed a novel probing technique, paving the way for new applications like topological quantum bits based on Majorana zero modes.
Researchers at ISTA have identified a protein called MFSD1 that prevents tumor cells from migrating and spreading to other parts of the body. This discovery could lead to new therapeutic targets for certain types of cancer, such as breast, gastric, and lung cancer.
Tamás Hausel and Nigel Hitchin develop a new theory on Higgs bundles, connecting combinatorial, differential, and algebraic geometry to particle physics. The theory provides insight into the representation theory of Lie groups and could lead to new insights in mathematical physics.
Researchers at IST Austria find that a specific gene, Fos, regulates macrophage infiltration into surrounding tissue by creating an actin shell, making it easier for immune cells to invade. This discovery raises hopes for new targets in treating cancer and understanding the immune system.
A full-scale model of the mouse hippocampus uncovers a new mechanism for pattern separation, where inhibition separates patterns and reduces activity makes it easier to distinguish differences. The study challenges historical views on pattern separation and suggests focal inhibition as an essential factor.
Researchers provide explanation for superconductivity in trilayer graphene, reconciling two seemingly contradictory phenomena. The new theory suggests that an interaction between electrons provides the 'glue' that holds them together, leading to unconventional superconductivity.
Researchers found a mechanism that regulates cell behavior depending on environment's curvature change, using soft hydrogels to replicate folding patterns in living tissues. The study reveals how curvature governs cell distribution, shape, and density in complex environments.
Researchers have identified the structure of a protein complex, supercomplex CIII2CIV, that plays a crucial role in energy conversion in animal cells. The complex pumps charged particles through the mitochondrial membrane, facilitating energy production.
Researchers at IST Austria find that ketamine and 60-hertz light flickering can remove the perineuronal net, a structure responsible for stabilizing brain connections. This could lead to new therapeutic approaches for treating post-traumatic stress disorder and amblyopia.
Researchers from Austria, Copenhagen, and Madrid found that a valid signal for Majorana zero modes, crucial for topological qubits, can be a false flag. By varying the nanowire setup, they discovered that a specific architecture causes a mimicking signal, leading to a crucial step forward in understanding nanowires.
MADM technology has been expanded to enable the analysis of over 96% of mouse genes at the single-cell level. This breakthrough allows researchers to study disease progression, including cancer, and gain insights into gene function.
Researchers created a new qubit by manipulating hole spins in a germanium layer, enabling faster processing speeds and reduced magnetic field requirements. This breakthrough could lead to the development of more efficient quantum computers combining semiconductors and superconductors.
Researchers at IST Austria have uncovered the crucial role of IP6 in stabilizing virus shells, preventing premature genome release. The study provides insights into the variability of capsid shapes and potential differences in infectivity.
Researchers found that the defective Cullin 3 gene leads to increased levels of Plastin 3, causing neurons to migrate slower and accumulating in the cortex. This study provides new insights into the mechanisms underlying autism spectrum disorder and may pave the way for therapeutic treatments.
Researchers at IST Austria discovered that key synapses in the hippocampus can send information in both directions, influencing pre-synaptic plasticity. The mossy fiber synapse adapts to the post-synaptic neuron's activity status, improving information storage in downstream networks.
Researchers create unified model of direct and indirect reciprocity, demonstrating how cooperation can be a successful strategy. The study reveals that reputation and experience significantly influence willingness to cooperate, paving the way for new insights into human social norms.
Research reveals that testing limits make timing crucial for lockdown effectiveness, with marginal differences between success and failure, and super-exponential growth causing rapid increases in infections.
Scientists developed a new mathematical model to predict disease onset risk using patient genomic data, providing improved predictive quality and personalized health risks for patients. The model can analyze large datasets of genetic markers linked to high blood pressure, heart disease, and type 2 diabetes.
Scientists discover a crucial phase of embryonic development in zebrafish where the solid-like tissue becomes fluid-like, leading to morphogenesis. The study reveals that this change is caused by a critical point in cell connectivity, similar to phase transitions in non-living systems.
Researchers developed a statistical framework to test and quantify adaptation in complex biological systems, enabling prediction of evolutionary outcomes. The new framework allows for rigorous analysis of organism adaptation to their ecological niche, building bridges between mathematics and biology.
Researchers found that Arabidopsis seedlings adapted by increasing cell division and reducing cell elongation on ammonium, but reversed this balance on nitrate. The key hormone auxin regulated the balance between cell proliferation and cell expansion.
Researchers have developed a new method to visualize protein complexes in their natural environment, revealing the structure of the Arp2/3 complex and its role in cell motility. The study provides insights into the regulation and activity of this important protein complex, which could lead to better understanding of disease mechanisms.
A new tool allows architects to design curved glass façades using an interactive, data-driven approach. The software uses deep neural networks to predict glass panel shapes and fabricability, enabling efficient optimization of designs while balancing economic, aesthetic, and engineering criteria.
Researchers propose minimal extension to classic equilibrium model, capturing high specificity and noise in eukaryotic gene expression. The new model suggests a trade-off between specificity and noise, with high specificity leading to increased noise.
A new study published in Cell Reports found that painkillers such as Aspirin and Ibuprofen interfere with the auxin flow in plants, leading to abnormal root growth. The drugs also suppress the movement and trafficking of substances within plant cells, impairing their ability to develop properly.
Cell division becomes softer and deformable in response to mechanical forces from neighboring cells, altering its orientation. This study reveals a new mechanism influencing tissue dynamics and may have implications for clinical studies.
Scientists at IST Austria identified a molecular compass that perceives auxin concentration and allows cells to synchronize their behavior for coordinated vein formation and regeneration. This phenomenon also applies to wound healing, enabling the growth of more mechanically resistant plants.
Researchers have identified a new key player in long-term memory formation, the connection between mossy cells and granule cells in the hippocampus. This discovery sheds light on how new environments are processed and stored in the brain.
A new deep learning model inspired by tiny animals has shown decisive advantages over previous models in tasks such as autonomous driving. The model achieves better performance with fewer neurons and is more interpretable than complex 'black box' systems.
Researchers find that cell adhesion proteins and a gradient of signaling molecule Sonic Hedgehog work together to create precise sorting of cells into domains. By combining experiments from biophysics, genetics, and developmental biology, the team successfully solves the puzzle of how patterns are created in developing organisms.
Cells utilize long-distance traveling waves in a self-organized manner to close wounds, guided by intricate interplay of cell movement, sensing, and protein activation. This coupled system enables robust communication of direction over large distances, promoting coordinated behavior for healing and growth.
Researchers Leonid Sazanov and his team at IST Austria have solved the mystery of how complex I transports protons across the mitochondrial membrane. They discovered a water wire plays a crucial role in proton transfer, with conformational changes and electrostatic waves facilitating the movement of four protons per cycle.
Researchers have solved the structure of F1Fo ATP synthase, shedding light on its rotation mechanism and permeability transition pore formation. The fully resolved structure reveals the c-ring is plugged by two lipids, one from each side of the membrane.
Researchers identify granule cells as gatekeepers of the hippocampus, filtering out irrelevant information. These cells also appear to be involved in processing spatial information, converting grid cell activity into place cell activity.
Researchers used the MADM technique to investigate how cells respond to changes in genomic imprinting. They found that cells activate certain gene groups involved in cell death, growth, and synapse development, particularly in astrocytes.
Researchers found that random movements allow cells to overcome pushing forces and return to the stem cell niche. The team's findings suggest that the dynamics and geometry of tissues play a crucial role in defining stem cell number and dynamics, potentially opening new insights into organ renewal.
Researchers at IST Austria found that hormone Auxin and pressure play a crucial role in plant wound healing. By manipulating Auxin levels and cellular pressure, the team identified these governing processes as key to understanding how plants regenerate and survive in challenging environments.
Researchers have discovered a possible physical trace of short-term memory, known as an engram, in the brain's synapses. The study found that vesicles containing neurotransmitters are stored at the pre-synaptic terminal after a granule cell fires, inducing plasticity and strengthening communication between neurons.
Researchers at IST Austria found that actin flows from front to tail, driving cell movement, and can couple with environment without integrins, enabling flexible crawling through tissues. This 'off-road' mode of locomotion allows cells to migrate efficiently in various environments.
Researchers at IST Austria have demonstrated a new detection technology called microwave quantum illumination that utilizes entangled microwave photons to detect objects in noisy thermal environments. The technology has potential applications for ultra-low power biomedical imaging and security scanners.
Researchers found that turbulent blood flows react strongly to vessel geometry, leading to higher velocity fluctuations and increased risk of arteriosclerosis. The study suggests a new mechanism for turbulence in cardiovascular flow at lower speeds than previously thought.
Researchers at IST Austria find that bacteria can copy genes as an adaptive strategy, creating genetic diversity and tuning gene expression levels. This mechanism allows for quick adaptation on ecological timescales, potentially impacting antibiotic resistance.
Ants' social interactions and sanitary care significantly impact the competitive outcome of coinfecting pathogens within the insect body. By modulating pathogen competition, ants' grooming helps prevent infections, altering the disease outcome.
Researchers discovered that Cdkn1c loss leads to cell death and smaller brains when targeted at the single-cell level. In contrast, whole animal studies revealed no effect on brain size, suggesting a new growth-promoting role of Cdkn1c.
Researchers develop 'flash and freeze' method to study structure and function of synapses in intact neural circuits. The method allows for simultaneous observation of structural changes during signaling, revealing a near-identity between structurally and functionally defined vesicle pools.
Researchers have visualized the atomic structure of the metabolic enzyme transhydrogenase (NNT) using cryo-electron microscopy. The study reveals the enzyme's channel gating mechanism and has implications for understanding metabolic regulation and developing novel therapies.
Researchers have determined the first atomic structure of the V/A-ATPase family, a key energy machine in cells. The enzyme's structure reveals a turbine-like structure with two or three peripheral stalks and additional connecting protein subunits, enabling greater plasticity and flexibility in its rotation mechanism.
Research found that high inequality reduces willingness to cooperate in groups, but some inequality can help ensure everyone contributes to the public good. The study suggests policy-makers should consider the optimal level of inequality when funding public goods and services.