Researchers found bevacizumab significantly improved blood oxygen levels, body temperature, and inflammatory markers in severe COVID-19 patients. The treatment also reduced the need for oxygen support and shortened hospital stays.
A new DNA-based vaccine platform has been shown to induce potent immune responses in mice, generating high levels of antibodies and strong T cell responses. The vaccine was found to be immunogenic, efficiently neutralizing the SARS-CoV-2 virus after a single immunization.
A nationwide study found that nearly 11% of ICU patients in Sweden received opioid prescriptions for at least 6 months and up to 2 years after discharge. Chronic opioid use was linked to a 70% higher risk of death, with pre-admission history and certain medical conditions being major risk factors.
Researchers discovered that patients with severe COVID-19 have significantly elevated levels of M-MDSCs in their blood compared to milder cases and healthy individuals. These findings suggest a potential connection between early immune responses and disease severity.
Researchers at Karolinska Institutet have discovered a key role of monocytes in sarcoidosis, revealing they can be potent TNF producers and predict disease outcome. This breakthrough opens possibilities for identifying biomarkers and more effective treatment strategies, potentially reducing cases of chronic sarcoidosis.
A new study reveals that people with a genetically weakened skin barrier are more susceptible to faster uptake of common chemicals, increasing the risk of skin diseases and cancer. Researchers screened 500 participants in Sweden, finding twice as high doses of pesticides in those with the mutation.
A new study at Karolinska Institutet in Sweden has developed a urine test to identify and verify the type of asthma. The test uses lipid biomarkers to measure urinary metabolite levels of certain prostaglandins and leukotrienes, which are known mediators of asthmatic airway inflammation.
New small antibodies, called nanobodies, have been developed to prevent the SARS-CoV-2 coronavirus from entering human cells. The research found that a combined nanobody had exceptional effectiveness in blocking the virus' ability to spread between human cells.
A study published in JAMA Network Open found that associate clinicians performed inguinal hernia operations safely and effectively, with fewer cases of recurrence compared to medical doctors. The research suggests task sharing as an attractive option to expand surgical services in low-income countries.
A Swedish registry study found that only 0.77 intensive care patients per 100,000 children aged 1-16 were treated for COVID-19 or multi-inflammatory syndrome (MIS-C). Despite schools being open during the pandemic, none of the children died within two months after their intensive care period.
New research from Karolinska Institutet reveals the development of lung macrophages, immune cells that can protect or harm lungs. Classical monocytes migrate into airways and lung tissue, becoming protective macrophages, while non-classical monocytes develop into pro-inflammatory macrophages.
Researchers found that stopping RAS inhibitors reduced the risk of requiring dialysis but increased the risk of cardiovascular events and death. The study suggests that doctors must carefully weigh the benefits and harms of these medications in patients with advanced CKD.
Researchers found that the thymus produces Tregs specialized in dealing with physiological changes during pregnancy, preventing miscarriages. The study also shows that a deficiency of these cells leads to gestational diabetes and long-lasting effects on offspring.
Researchers developed inhibitors targeting mitochondrial DNA, affecting only rapidly dividing cells like cancer cells. Treatment stopped cell proliferation and reduced tumour growth without harming healthy cells.
Researchers at Karolinska Institutet have discovered a connection between metabolic disturbance in retinal ganglion cells and high intraocular pressure. Rapamycin and pyruvate treatments showed protective effects in animal and cell models.
Researchers at Karolinska Institutet identified two alternative pathways for amyloid pathology in Alzheimer's disease, revealing genetic explanations for method discrepancies. The study provides unique biological information for earlier and more individualized diagnosis and treatment.
Depressed children and teenagers have a significantly higher risk of premature death, self-harm, and suffering from other diseases later in life. The study found that depression was associated with 66 out of 69 examined medical conditions, including sleep disorders, type 2 diabetes, and kidney disease.
Researchers at Karolinska Institutet discovered a link between non-coding RNA mutations in the Neisseria meningitidis bacterium and severe invasive meningococcal disease. They also developed a PCR test to detect these mutations, which may aid in speedy identification and treatment.
The study describes how the different neurons form during fetal development, a process that follows different principles to brain neurons. The researchers identified twelve different kinds of ENS neuron, including subgroups of sensory neurons activated by substances in the intestines and affecting the immune system.
A large Swedish registry study found that DOAC use did not reduce the rate of hospitalisation, intensive care or fatality due to COVID-19. The study included over 100,000 patients with atrial fibrillation and over 350,000 individuals with cardiovascular disease.
Researchers found tau accumulation years before dementia symptoms appear in people with Down's syndrome, suggesting an early change. The study suggests potential for early prophylactic measures against tau accumulation to prevent Alzheimer pathology in childhood.
Women with frozen eggs and ovarian tissue had more children after breast cancer diagnosis compared to those without fertility preservation. The study highlights the importance of reproductive counseling for young breast cancer patients.
A combination of remdesivir and hrsACE2 reduced SARS-CoV-2 viral load and inhibited replication in cell cultures. The therapy achieved a dual effect with low doses and lower toxicity, paving the way for clinical trials. HrsACE2 is currently being evaluated in a phase II trial involving 200 people with severe COVID-19.
A recent study published in Science Advances found that baricitinib treatment significantly reduces mortality in COVID-19 patients with moderate to severe symptoms. The drug, commonly used for rheumatoid arthritis, was shown to block viral entry and reduce inflammation, leading to a 71% reduction in mortality rates.
Researchers found that early-life air pollution and smoking increase risk of chronic bronchitis and irreversible airflow limitation. Early life events are key to maintaining lung health in adulthood, highlighting the importance of early prevention.
A machine learning-based approach mapped key areas of COVID-19 research, revealing prioritized topics such as health care response, clinical manifestations, and psychosocial impact. The study also shows growing trends in protective measures and immunology research.
Researchers found that a commonly prescribed anti-depressant can halt the growth of childhood sarcoma by targeting a specific receptor, offering hope for novel treatment strategies. The study provides a new paradigm for controlling tumour-driving receptors and could lead to the development of specific therapeutics.
Researchers at Karolinska Institutet have developed a new DNA-based analytical method called NanoDeep, which enables the analysis of entire populations of cells. This breakthrough could lead to better drugs for breast and other cancers by providing a more detailed understanding of membrane protein organisation.
A nationwide cohort study found that severely obese individuals who underwent gastric bypass or sleeve procedure had a lower risk of additional myocardial infarctions and improved survival rates. The study suggests that metabolic surgery may have a positive impact on cardiometabolic risk factors beyond weight loss.
A study by Karolinska Institutet reveals that microglial autophagy plays a crucial role in MS progression. The researchers found that removing an autophagy gene, Atg7, disrupts the immune cells' ability to clean up damaged tissue residues, leading to disease worsening.
A nationwide cohort study has confirmed that non-alcoholic fatty liver disease (NAFLD) is associated with increased mortality risk, even in mild stages. The study found that patients with NAFLD had a 93% increased risk of all-cause mortality, driven primarily by deaths from extra-hepatic cancer and cirrhosis.
Researchers at Karolinska Institutet have identified a key protein called p11 that affects the brain's response to stress, potentially increasing the risk of depression. The study found that mice with low p11 levels react more strongly to stress and exhibit anxiety-like behavior.
Researchers at Karolinska Institutet discovered that stem cells in the mouse spinal cord can form new oligodendrocytes, essential for neuronal signal transmission, to help repair damaged tissue. This finding indicates a conceptually new strategy for stimulating repair after nervous system damage.
A large study by Karolinska Institutet found that HPV vaccination significantly reduces the risk of cervical cancer. Women vaccinated at a young age show a 88% reduced risk, while those vaccinated between ages 17 and 30 experience a halved risk.
A recent study published in Nature reveals that a Neandertal gene variant significantly increases the risk of developing severe COVID-19. The research found that this genetic variant is inherited from Neandertals and affects around three times more people than expected, with varying prevalence across different regions.
A study by Karolinska Institutet researchers found that MAIT cell activation is strongly linked to severe COVID-19 disease. The number of MAIT cells in the blood declines sharply in patients with moderate or severe COVID-19, while pro-inflammatory MAIT cells accumulate in the airways.
A study from Karolinska Institutet in Sweden found that women receiving fertility-sparing surgery for treatment of borderline ovarian tumours were able to have children, with most preserving natural fertility. The study also showed similar survival rates as those who underwent radical surgical cancer treatment.
Researchers at Karolinska Institutet have developed a method for fast, cheap, yet accurate testing for COVID-19 infection. The new test simplifies the diagnostic process by eliminating expensive reaction steps, enabling upscaling of diagnostics in limited resource settings.
A new study has investigated the association between a positive SARS-CoV-2 test during pregnancy and complications in mothers and their newborn babies. The researchers found no higher prevalence of complications during delivery or of ill-health in the neonates, but did note a higher prevalence of preeclampsia in infected women.
Researchers at Karolinska Institutet have identified all cell populations in mouse teeth and young human teeth, deciphering differentiation pathways of odontoblasts and ameloblasts. The study sheds light on tooth sensitivity and the formation of enamel.
Researchers have mapped the immune response in children with a rare and life-threatening inflammatory syndrome associated with COVID-19. The study found that the condition differs from Kawasaki disease and severe acute COVID-19, with distinct patterns of immune cell populations, inflammatory cytokines, and autoantibodies.
Scientists at Karolinska Institutet have identified a nanobody that can block SARS-CoV-2 from entering human cells, offering potential as an antiviral treatment for COVID-19. The nanobody, Ty1, neutralizes the virus by binding to its spike protein, preventing infection.
A systematic review of over 100 studies found that a more vegetable-rich diet, higher potassium intake, and reduced salt consumption can lower the risk of chronic kidney disease. Adhering to these recommendations could reduce the risk by 14-22%.
A blood test detecting SARS-CoV-2 presence in patients with confirmed COVID-19 can predict severe cases, highlighting the importance of early treatment and monitoring. Admitted patients without detectable virus have a low risk of severe symptoms.
A large Swedish-Norwegian study involving over two million pregnancies found no association between modafinil use and an increased risk of fetal malformations. The study, published in JAMA, compared exposure to modafinil during early pregnancy with non-exposure, finding a relative risk of 1.06, which was not statistically significant.
A large Swedish study found no association between H1N1 influenza vaccination during pregnancy and an increased risk of autism spectrum disorder in the offspring. Researchers adjusted for potential confounders to minimize influence from other factors.
Researchers at Karolinska Institutet have found that one AI algorithm is as accurate as the average radiologist in identifying breast cancer from mammograms. The study compared three AI algorithms and showed significant differences between them, with one outperforming others and rivaling human detection accuracy.
Researchers found that NK cell activation differed in patients with moderate and severe COVID-19. Adaptive NK cells, which have a greater ability to kill target cells, were observed in severely ill patients.
A large study found that antibiotic use, especially broad-spectrum antibiotics, is associated with an increased risk of new-onset inflammatory bowel disease (IBD) and its subtypes. The study suggests that perturbing the gut microbiome may impact the risk of gastrointestinal disease.
Researchers developed a new method to estimate the health risks of PFAS in drinking water. The study found that women are particularly at risk of decreased thyroid hormone T3 levels due to exposure. Around 4% of local women in Ronneby, Sweden, may experience a 10% drop in T3 levels.