A new study found that anaphylaxis rates among Canadian children have doubled over four years, highlighting the need for increased awareness and proper use of epinephrine auto-injectors. The majority of cases were triggered by food, particularly peanut and tree nut allergies.
A new study by McGill University Health Centre researchers found that oral provocation tests are a more efficient and safer method for diagnosing non-life-threatening reactions to antibiotics in children. The study also showed that up to 10% of children may develop mild skin eruptions upon subsequent exposure.
A new approach to determining statin eligibility could improve prevention of heart disease, especially in younger individuals. The research team found that targeting statin treatment to this group would prevent an additional 266,000 heart attacks and strokes over 10 years.
Montreal scientists have discovered a mechanism that enables brain cells to adjust their support for neurons, potentially improving brain function or restoring lost potential in disease. The discovery sheds light on the complex functioning of astrocytes, star-shaped cells that protect and support brain neurons.
A new study suggests that gender role and personality traits, rather than biological sex, are associated with the risk of recurrence of cardiovascular events in adults. Adults with traditionally feminine characteristics had a higher risk of recurrence, regardless of their biological sex.
A new study by Avinash Vaidya and Dr. Lesley Fellows at the Montreal Neurological Institute and Hospital found that the dorsomedial prefrontal cortex (PFC) is crucial in decision-making, recalling the value of objects not directly in view to keep options open.
Researchers at The Neuro compiled a detailed map of the hippocampus, improving tools for diagnosing and treating epilepsy. The new atlas provides non-invasive ways to assess therapy impact and improve patient quality of life.
A study published in BMJ Open found that Canadians living in densely-populated areas with close services report more utilitarian walking but have lower total physical activity. The researchers suggest that walkability can be an opportunity to integrate activity into daily life.
A new diagnostic criteria for Parkinson's disease has been developed, aiming to improve diagnosis and treatment, especially in early stages. The criteria incorporate motor and non-motor symptoms, genetic factors, and propose a stage classification to focus on early detection.
Researchers at McGill University Health Centre uncover mechanism behind Leishmania parasite's infectious life cycle, revealing exosomes play key role in boosting infection. The study provides potential vaccine targets and diagnostic tools for Leishmania and other parasitic diseases.
A recent study by McGill University researchers has made significant progress in understanding the mechanisms responsible for multiple sclerosis and identifying potential new treatments. By targeting a subset of B cells known as GM-CSF-producing B cells, the therapy shows promise in reducing disease activity.
Researchers at McGill University Health Centre discover the structure of a key protein involved in body hydration and temperature regulation. This breakthrough could lead to new treatments and diagnostic tests for conditions such as hyponatremia, a disorder that affects sodium levels in the blood.
Researchers have identified a key mechanism linking chronic pain to abnormal activity in the anterior cingular cortex, a region of the brain involved in cognitive functions. The study provides insights into the role of HCN channels in controlling pain signals, suggesting new therapeutic strategies for relieving chronic pain.
A recent study published in the American Journal of Men's Health found that 13.3% of expectant fathers experience elevated levels of depressive symptoms during their partner's pregnancy. The research highlights the importance of depression screening and early prevention efforts for men who are about to become parents.
A Canadian research team found that daily cannabis users did not experience serious adverse events, while showing improvement in pain and quality of life. However, non-serious adverse events like headaches and respiratory problems were reported.
A new study identifies USP19 as a potential drug target for muscle wasting diseases in cancer patients, improving quality of life and longevity. The research team discovered that inhibiting the USP19 gene could protect against muscle wasting in mice models.
A recent study from McGill University Health Centre reveals that gestational diabetes in mothers can be a predictor for type 2 diabetes in their fathers. The research analyzed data from Quebec between 1990 and 2007, finding that men whose partners have gestational diabetes are 33% more likely to develop the disease.
A Canadian study found that 10% of children with cerebral palsy have copy number variations affecting genes deemed clinically relevant. This discovery could lead to the integration of genomic analyses into diagnostic assessments for cerebral palsy, providing new insights and treatment options.
A new crucial gene, POLR1C, has been identified as the cause of nearly 10% of cases with 4H leukodystrophy, a common form of the disease. This discovery sheds light on the molecular mechanism behind the disease and may lead to new diagnostic tools and therapeutic options.
A study by Montreal researchers found that the plasticizer DINCH's metabolite MINCH can act as a metabolic disrupter, affecting adipose tissue differentiation. The study suggests that DINCH exposure may pose a risk to human health and warrants further research.
Two RI-MUHC research leaders, Dr. Morag Park and Dr. Alain Ptito, have been awarded significant grants to advance their work in cancer therapy and brain injuries. The grants will support the development of new diagnostic tools and treatments for thousands of Canadians affected by head injuries.
A new research team at RI-MUHC has developed a glutamate biosensor platform using revolutionary protein engineering technology Cyto-iGluSnFR. This platform allows for the detection of glutamate levels in brain cells, enabling the screening of millions of chemical compounds to develop new drugs targeting EAATs.
A research team at McGill University Health Centre has developed a potential vaccine that nudges the immune response away from developing allergies, offering hope for Canadians with seasonal allergies. The study uses a molecule called STAT6-IP to redirect the immune system's response, teaching it to tolerate allergens.
The Quebec Cannabis Registry allows physicians to better manage medical cannabis use and monitor patient safety. The database will compile clinical data from patients using medical marijuana, providing valuable insights into its efficacy and risks.
A recent study suggests that genetic testing for BRCA1 and BRCA2 mutations in women with ovarian cancer can help identify carriers and reduce their risk. The study found that 19% of women with the most common form of ovarian cancer carry these mutations, which is higher than previous estimates.
Researchers from North America and the UK explore the emerging science behind medical cannabis, citing studies that suggest THCV produces anti-schizophrenic effects. The symposium aims to advance understanding of cannabinoids' role in health and disease through research and education.
An international research team identified a critical gene linked to childhood blindness and vision loss. The study reveals that mutations in this gene affect phospholipid metabolism, leading to photoreceptor death and vision impairment.
A new study published in The Lancet Diabetes and Endocrinology found that obesity can decrease life expectancy by up to 8 years. Researchers used data from the National Health and Nutrition Examination Survey to develop a model estimating annual risk of diabetes and cardiovascular disease in adults with different body weights.
A McGill University Health Centre study found that adopting structured antibiotic time-outs led to decreased antibiotic costs and a small decline in Clostridium difficile infections. The time-out program, which involved regular re-evaluation of treatment strategies, resulted in improved prescribing practices among physicians.
A new international study led by the Research Institute of McGill University Health Centre has identified a molecule that puts a brake on brain processing and when removed, brain function and memory recall are improved. The study found that suppressing the production of molecules required for building new memories leads to stronger con...
A study of 35,000 participants found that genetic predisposition to elevated LDL-C was associated with aortic valve calcium and narrowing, supporting a causal association. Lowering cholesterol early in the disease process may provide protection from developing aortic valve disease.
A study published in the Journal of the National Cancer Institute finds that osteoporosis treatment may also benefit breast cancer patients by slowing skeletal metastasis. Women who took oral bisphosphonates had a reduced risk of bone metastases, with longer medication use resulting in greater reduction.
A new oral medication has improved visual function in blind patients with Leber congenital amaurosis, a devastating retinal degeneration. The study found that the drug awakened dormant retinal cells, allowing patients to see and improving their visual fields and acuity.
A recent study published in BMC Medicine has found that living in a household with a spouse who has type 2 diabetes can increase the risk of developing the condition. The research team analyzed data from six studies and found that spousal diabetes was associated with a 26% increased risk of developing type 2 diabetes.
Researchers at McGill University Health Centre propose a new model for the development of ETMR/ETANTR, a deadly type of brain tumour found only in children under four. They identify DNMT3B as a potential target for therapies to combat the disease.
A study published in Cerebral Cortex found that mice raised without a father exhibited impaired social behavior, increased aggression, and altered brain anatomy. The findings suggest that paternal presence during critical growth periods is essential for healthy child development.
Researchers at McGill University Health Centre have identified a target molecule that can block Cryptosporidium parvum's ability to evade the immune system, providing a potential treatment for this deadly parasite. The discovery could lead to an effective treatment for cryptosporidiosis, which affects millions of people worldwide.
The Research Institute of the MUHC presented more than $3 million in awards to clinician-researchers recognized for their exceptional promise in various fields. The recipients demonstrated potential to advance knowledge and improve patient care through laboratory research and innovative surgical techniques.
Researchers at the McGill University Health Centre have identified genetic changes in the colon lining that could be used as biomarkers for early diagnosis of colorectal cancer. The study, published online in Cancer Prevention Research, has implications for the nearly one million people diagnosed annually worldwide.
The McGill/MUHC research team developed an innovative oral self-test screening strategy and interactive website/app called HIVSmart to address the stigma associated with HIV testing. The award-winning strategy aims to improve access to care by allowing individuals to be tested in the privacy of their own homes.
A study by McGill University Health Centre found that one in five young women (under 55) experiencing a heart attack do not exhibit chest pain as a symptom. The absence of this common indicator did not correlate with reduced disease severity, highlighting the need for more nuanced assessments and training for healthcare professionals.
A novel approach has been developed to scan the entire genome, allowing researchers to better understand the effect of genetic variants on protein translation. This method could lead to the development of biomarkers for personalized medicine and new therapies for complex diseases such as diabetes and schizophrenia.
A new study by RI-MUHC researchers identifies a previously unknown mode of cancer progression, where infection-fighting white blood cells activate cancer cells and facilitate their spread to secondary tumours. Medications already used for other non-cancer diseases may prevent this mechanism of cancer spread or metastasis.
A new study published in JAMA finds that the risk of death for children on dialysis has dramatically decreased over time, with a 20% reduction in mortality risk every five years. This improvement is attributed to better pre-dialysis care, advances in dialysis technology, and reduced waiting times for transplants.
The guidelines provide evidence-based tools for primary care physicians to diagnose and manage fibromyalgia, recommending exercise, relaxation techniques, and cognitive behavioral therapy. The main goal is to alleviate pain and improve quality of life, with medications tailored to individual patients.
A research team led by Dr. Robert Hess used Tetris to train both eyes to work together, alleviating suppression of the weaker eye and increasing brain plasticity. The treatment showed dramatic improvements in vision and 3-D depth perception in adults with amblyopia.
A systematic review confirms HIV self-testing is effective in removing fear and stigma associated with testing, leading to higher acceptability rates. Self-tests are non-invasive, convenient, and can provide results within 20 minutes, paving the way for early detection and treatment.
A new study published in PLOS ONE finds rapid and point-of-care tests for syphilis are as accurate as conventional laboratory tests, making them a viable solution for resource-limited settings. The findings have major worldwide implications for populations living in rural areas with limited access to healthcare.
Researchers have found a gene associated with an unusual type of cholesterol that increases the risk of developing aortic stenosis, the most common form of heart valve disease. High levels of Lipoprotein (a) cholesterol are predicted primarily by an individual's genetic make-up.
A landmark study published in Annals of the Rheumatic Diseases found that lupus patients taking immunosuppressive medications do not have a significantly increased risk of developing lymphoma. The study involved nearly 5,000 cancer-free lupus patients and found no clear association between disease activity and lymphoma risk.