Researchers developed a new mathematical technique to analyze cell nucleus organization, revealing self-sustaining transcription clusters that play a key role in maintaining cell identity. This understanding may expose vulnerabilities for targeting cancer cells and reprogramming them to stop uncontrollable cell division.
Researchers analyzed over 6,700 patients treated for blood clots and irregular heart rhythms. Stopping aspirin significantly reduced bleeding complications by 32.3% and prevented one major bleeding event per every 1,000 patients who stopped taking aspirin.
A new study reveals that androgen receptor inhibitors can fundamentally rewire prostate tumors, making them more aggressive. The researchers found that most tumors remain fuel-dependent after treatment, but a small percentage convert to double-negative prostate cancer.
A study published in JAMA Cardiology found that the mortality rate for patients with a torn aorta has decreased significantly, from 37% in the 1950s to nearly 6% today. However, patients who did not receive surgery died at a rate five times higher than those who underwent treatment.
A new poll reveals that nearly half of people over 50 experience joint pain, and many turn to prescription-based treatments despite potential health risks. The poll's authors stress the need for healthcare providers to discuss medication interactions and non-drug options with patients.
A new study reveals that over half of hospital-based maternal deaths in the US occur during pregnancy or postpartum, rather than at delivery. Researchers are calling for a renewed focus on examining the causes of these deaths to inform clinical and policy interventions.
A new map of brain stem circuits controlling eating behavior could lead to better obesity treatments. The atlas, built from recent discoveries in mice and human studies, identifies two food intake-suppressing circuits in the brain stem, one causing nausea and another not.
A study published in PLOS ONE demonstrates that adding two 8-inch rubber bands to a surgical mask can improve its protective seal against particle exposure to N-95 levels. Thirty-one of 40 test subjects achieved modified masks that passed an N95 fit test, with improved results over time.
A substance produced by gut microorganisms, TMAO, can lead to scarring and vascular damage in scleroderma. The Western diet rich in meat contributes to TMAO formation, which reprograms cells to become scar-forming myofibroblasts.
Researchers developed a blood test that predicts poor outcomes in patients with traumatic brain injury (TBI), allowing clinicians to make decisions earlier on possible treatment. The test, which measures protein biomarkers GFAP and UCH-L1, showed high accuracy in predicting death and severe disability six months after injury.
Researchers at Michigan Medicine have discovered a molecular mechanism that drives the disease-causing effects of the most common genetic risk factor for lupus. The study suggests that targeting this new pathway could lead to the development of safe and effective treatments for SLE, an autoimmune disease that affects millions worldwide.
Researchers developed a new anti-cancer drug LP-182 that simultaneously targets two molecular signaling pathways responsible for cancer growth. The drug is absorbed through the gut's lymphatic system, maintaining optimal therapeutic levels over time.
A new poll shows that 61% of people over 50 who have already gotten at least one dose of COVID-19 vaccine are very likely to roll up their sleeves for an updated booster shot. Health providers' recommendations will play a crucial role in increasing vaccination rates among older adults.
A new study suggests that members of the public want to know if their health information or samples from their bodies will be used in research or to help develop new biomedical products. The study found that patients are more likely to want notification about research use of their health information than biospecimens.
Researchers found that higher suPAR levels were associated with increased risk of blood clot formation in COVID-19 patients. Combining suPAR and D-dimer may improve predicting who is at high or low risk of blood clots, enabling targeted therapies to prevent critical outcomes.
A Michigan Medicine study found that patients who received preoperative education on opioid risks and nonopioid pain management options consumed significantly less oxycodone, with only 16 doses used despite similar pain scores. The results suggest a multimodal approach to managing pain can reduce harm and prevent substance use disorders.
A new study reveals racial and gender disparities in access to life-saving heart-assisting implants, with Black patients and women facing lower rates of surgery. Despite similar survival rates, the findings suggest that unconscious bias may be influencing healthcare provider decisions.
A University of Michigan-led analysis found that training patients to voice their concerns and advocate for themselves can reduce the impact of physicians' racial biases on care. The study showed that 'patient activation' creates more equitable interactions between patients and physicians.
A new study shows that telehealth, particularly audio-only visits, helped keep VA patients on medication for opioid use disorder during the pandemic. Phone visits also played a key role in reducing dropouts from care.
A study of over 500 patients with multiple myeloma reveals a high prevalence of genetic alterations in oncogenic pathways, leading to treatment resistance. The research found a specific link between RASopathies and mutations in these pathways, offering new insights into the development of resistance mechanisms.
According to a new poll, nearly 40% of older adults (50-80) use at least one integrative medicine strategy to alleviate symptoms or relax. However, only 18% discuss these strategies with their healthcare providers. The poll highlights the importance of primary care clinicians discussing integrative approaches with patients.
A new study published in JAMA Internal Medicine found that an alert about a shortage of blood test tubes led to a significant reduction in unnecessary blood clotting tests. The study suggests that similar interventions could reduce low-value care and promote wise use of medical tests.
A new study led by researchers from the University of Michigan and Penn State College of Medicine compared two approaches for people with early form of memory loss: mnemonic strategy training and spaced retrieval training. Mnemonic strategy training showed increased brain activity in areas often affected by Alzheimer's disease, while s...
Researchers developed an AI-driven device that detects and predicts hemodynamic instability using a single ECG lead, outperforming traditional vital sign measurements with nearly 97% sensitivity. The technology has the potential to provide continuous dynamic monitoring capabilities in patients with intermittent static vital sign measur...
A new study published in JAMA Surgery found that surgeons who oversee multiple surgeries simultaneously have a higher risk of complications and death. For surgeries involving one anesthesiologist directing CRNA or resident care, those managing three to four overlapping cases saw complication rates rise by 14%.
The 2016 CDC guideline aimed to reduce opioid-related overdose deaths by encouraging clinicians to weigh the benefits and risks of prescribing opioids. Researchers found a significant increase in nonopioid pain medication prescribing rates, coinciding with a drop in opioid prescribing.
Researchers have created a noninvasive method to identify tumors causing hypertension by reducing radiation exposure. The new fluorine-based agent replaces an iodine-based agent and may allow for screening of patients with hypertension-linked aldosterone adenomas.
A new study found that while the availability of lower-priced epinephrine auto-injector competitors has improved affordability for many patients, a significant minority still pay significantly more for life-saving medication. High-deductible health plans are a major contributing factor to these high costs.
A Michigan Medicine study found that people with cerebral palsy and spina bifida are prescribed opioids at a rate up to five times higher than those without the conditions. Chronic pain is the most commonly reported symptom among these individuals, raising concerns over addiction and overdose issues.
A new study found that pulse oximeters missed low oxygen levels in over 75,000 Black veterans each year, compared to fewer instances in White veterans. The study highlights the need for better, more accurate pulse oximeters and increased clinician awareness to address this issue.
A new study reveals that up to 10% of pre-teen children are curious about using substances, with boys more likely than girls to be interested. Parents' rules and home access play a significant role in shaping their children's curiosity, with Black parents being more likely to set rules against substance use.
The global contrast media shortage has affected millions of diagnostic imaging examinations and requires immediate attention. Researchers propose several methods to conserve contrast media, including weight-based dosing and adjusting CT settings.
A new study found that hospitals can reduce excessive opioid prescribing by implementing an evidence-based default setting for opioid prescriptions written in electronic health records. The study showed that patients who received a standard prescription size with a lower default dose of opioids had similar pain control, but took home f...
A study by Michigan Medicine researchers has identified oncostreams, highly active cells connected to brain tumor growth and invasion. The team found that eliminating Collagen 1 production from tumor cells reduces tumor aggressive behavior. This discovery could lead to novel therapeutic targets for treating lethal brain tumors.
New research shows a decrease in antibiotic use, treatment within 48 hours, and broad-spectrum antibiotics among patients with signs of systemic inflammatory response syndrome (SIRS). The study found improvements in mortality rates and development of multi-drug resistant bacteria without increasing antibiotic overuse.
Researchers used CT and MRI perfusion techniques to analyze 19 patients with successful free flap reconstruction and five with wound failure. The study found that both methods showed significant differences between the two patient groups. Early postoperative scans could help surgeons intervene earlier, potentially reducing hospital stays.
A new study finds that four in five apps target preschool-aged children with manipulative designs, keeping them engaged longer and encouraging purchases or watching ads. Children from disadvantaged backgrounds are disproportionately affected, highlighting inequities in how young children's attention is exploited for monetization.
A new study found a close link between ageism and poor physical and mental health in older adults. Those with more health concerns experienced higher rates of everyday ageism, including internalized and interpersonal forms.
A new Michigan Medicine study found that elementary school-aged children in remote learning experienced greater behavioral and learning-related difficulties compared to those in in-person instruction. Children in virtual school also showed signs of hyperactivity, peer problems, and sleep issues.
A new study found that 82% of teens and young adults are open to COVID-19 vaccine incentives, but 21% question their ethics. Most youth believe incentives will promote vaccination and serve the greater good, while some express concerns about bribery or eroding trust in vaccines.
A new study by Michigan Medicine reveals that people in some states will be significantly affected by restrictions on interstate telehealth. Rural residents have taken advantage of this service, with 18% using it for in-person care or telehealth, compared to 13% of non-rural residents.
A study found that high fat diets and synthetic substances in unregulated athletic performance enhancers can activate a receptor accelerating the progression of pre-cancerous lesions to pancreatic cancer in mice. Limiting exposure to these substances may help prevent pancreatic cancer development.
A Michigan study reveals that hundreds of thousands of surgical and dental opioid prescriptions are filled long after writing, but a state law helped reduce this trend. The authors suggest tightening state laws to prevent or reduce misuse associated with delayed dispensing of opioids.
The US healthcare system faces a significant challenge in providing high-quality, personalized obesity care due to lack of insurance coverage for effective medications and societal stigma. Recent efforts aim to address this issue through framework development and policy changes, which may lead to improved patient outcomes and cost savi...
A new poll found that most Gen Z youth want their healthcare providers to screen for and provide support for social determinants of health. Nearly 81% of respondents believe providers should ask about factors such as housing, food, education, safety, and discrimination.
A decade-long effort to reduce medication risks for nursing home residents with dementia has shown some positive results, but also unintended consequences. Fewer people are receiving antipsychotic and anti-anxiety drugs, which can raise the risk of falling or dying, but more are receiving alternative behavior-changing medications with ...
A new study from Michigan Medicine reveals that dementia diagnoses are often accompanied by significant increases in healthcare costs. The research found that the average Medicare spending jumped by 150% after a formal diagnosis of Alzheimer's disease or another type of dementia.
Researchers at Michigan Medicine developed a nanoparticle-based inhibitor that successfully triggers the immune system to eliminate brain tumors in mouse models. The approach breaks the shield built by glioma cells around the immune system, allowing the immune cells to attack and delay tumor progression.
Research found that men taking abiraterone or enzalutamide plus hormone therapy had a higher risk of metabolic and cardiovascular issues than those undergoing hormone therapy alone. This increased risk was observed in patients with Medicare health insurance, who were significantly older than those in clinical trials.
Scientists found that lithium chloride can cause X-inactivation loss in female hESCs, leading to cell death. The study suggests a possible new model for regulating X-inactivation and warns against using GSK-3 inhibitors like lithium.