Researchers found that bypass surgery resulted in a 32% lower risk of major medical events related to CLTI, as well as significant reductions in repeat surgeries and amputations. Adults without optimal veins for the bypass had no significant differences in outcomes between open bypass and endovascular procedures.
Adults with hypertension experienced a small rise in blood pressure levels during the first eight months of the COVID-19 pandemic, while the number of measured readings decreased significantly. The study found that telemedicine and home monitoring may have contributed to better blood pressure control.
Two NIH-funded studies show long-term e-cigarette use can impair blood vessel function, increasing the risk for cardiovascular disease. The findings also suggest combining e-cigs with tobacco may increase health risks compared to using them individually.
A recent NIH-supported study found that Black adults treated at advanced heart failure centers received potentially life-changing therapies, such as transplants and heart pumps, about half as often as white adults due to racial bias. The researchers also suggest that unconscious bias and overt racism may be driving these disparities.
Researchers found that getting enough sleep influences the environment where monocytes form, develop, and get primed to support immune function. This process, hematopoiesis, occurs in the bone marrow and can accelerate clonal hematopoiesis, an age-related condition linked to cardiovascular disease.
Research finds dual bronchodilators offer little relief to adults with smoking-related respiratory issues, but no COPD diagnosis. The study highlights the importance of spirometry testing for accurate diagnoses and calls for new therapies for patients without COPD.
Researchers developed a novel blood test that measures cell-free DNA to evaluate PAH severity and predict survivability. The test showed significant improvement over conventional tests and may allow doctors to intervene faster to prevent disease progression.
Researchers found enteric viruses like noroviruses replicate in the salivary glands of mice and can be transmitted through their saliva, potentially explaining high infection rates worldwide. This discovery could lead to new prevention and treatment strategies for diseases caused by these viruses.
Researchers found that people living with SCD have more medical appointments and urgent care visits, leading to higher out-of-pocket costs of $1,300 annually. The study suggests that curative therapies could reduce these costs, but accessing them will depend on conversations among policymakers, insurers, and patients.
A study funded by NIH found that women who had high blood pressure during pregnancy had a 63% increased risk for developing cardiovascular disease later in life. Early screening and monitoring in targeted areas can help delay or prevent future cardiovascular events among these women.
A study published in European Heart Journal found that serum sodium levels can help identify adults with a greater chance of experiencing heart disease. The research suggests that staying well-hydrated and consuming sufficient amounts of fluids throughout life may also reduce the risk of severe heart problems in the future.
Researchers found circulating antiphospholipid antibodies and autoantibodies in COVID-19 patients, which may explain mechanisms associated with severe blood clotting. IgG levels were also linked to disease severity, and removing it from samples led to reduced 'blood vessel stickiness',
Researchers found a rare genetic mutation in Black Americans is associated with an earlier onset of heart failure and a higher risk of hospitalization. The study suggests that early screening for the mutation could lead to faster treatment and improved outcomes for this vulnerable group.
A small clinical trial found that eating during the nighttime increased glucose levels, while restricting meals to the daytime prevented this effect. The study suggests that better alignment between internal and external circadian rhythms may drive these benefits.
A NIH-funded study found that patients with a two-step surgical approach for 'leaky heart valves' had better short-term outcomes, but were more likely to need a pacemaker. The procedure involved repairing the tricuspid valve at the time of mitral valve surgery, and results showed reduced risk of death, reoperation, or severe regurgitat...
A NIH study published in The New England Journal of Medicine found that administering convalescent plasma to outpatients with early symptoms of COVID-19 did not prevent disease progression. The trial, which enrolled over 500 participants, showed a significant reduction of less than 2% in disease progression.
A clinical trial shows that full-dose blood thinner treatment reduced the need for organ support and improved hospital outcomes in moderately ill COVID-19 patients. However, this benefit was not seen in critically ill patients requiring intensive care.
A new study found that children with obstructive sleep apnea are nearly three times more likely to develop high blood pressure when they become teenagers than those without the disorder. Early treatment is crucial to prevent future cardiovascular disease, researchers say.
Researchers discovered a link between small airways and increased COPD risk in non-smokers. People with smaller airways relative to their lungs may have lower breathing capacity, making them more susceptible to COPD.
Two NIH-funded studies find that invasive procedures like stenting and surgery provide better symptom relief but not reduced risk for heart attack and death compared to medication and lifestyle changes. The trials followed over 5,000 patients with stable ischemic heart disease for three years.
A new study finds that irregular sleep patterns, such as no regular bedtime and wake-up schedule or varying amounts of sleep each night, may represent a novel and independent heart disease risk factor. Older adults with these patterns are nearly twice as likely to develop cardiovascular disease.
A large clinical trial has found that fresh red blood cell transfusions do not reduce the risk of organ failure or death in critically ill children. The study included 1,461 patients and showed similar outcomes between fresh and older red cells.
A study published in the American Journal of Human Genetics has identified 57 genetic variations associated with declines in blood oxygen levels during sleep. These findings provide insight into the hereditary basis of this trait and its relationship to sleep disorders and lung diseases.
Researchers at the National Institutes of Health have developed a new and improved viral vector that can deliver therapeutic genes more efficiently than conventional vectors. The new vector shows promising results in animal models, with up to 10 times higher efficiency and six times higher carrying capacity.
Researchers at NIH and Siemens developed a low-magnetic-field MRI system that improves image quality of lungs and other internal structures, making medical imaging more affordable and accessible. The new system also reduces the risk of heating and allows for safer procedures for patients with pacemakers or defibrillators.
Researchers found that women who experience complications such as preterm births and preeclampsia during their first pregnancy are nearly twice more likely than women without complications to develop high blood pressure later in life. The study emphasizes the need for doctors to focus on knowing the health histories of women.
A new study found that almost half of young African American children responded better to increasing inhaled corticosteroid doses than adding long-acting bronchodilators. For adolescents and adults, most showed improved responses with adding a long-lasting bronchodilator, but some had no difference.
A new NIH-funded study found that hospital emergency room closures can adversely affect health outcomes for heart attack patients at neighboring hospitals. Conversely, when a new emergency department opens, health outcomes for those patients improve.
Researchers found that anti-inflammatory biologic therapies can significantly reduce coronary inflammation in psoriasis patients, using a novel imaging biomarker. The study has implications for other chronic inflammatory diseases, such as lupus and rheumatoid arthritis.
A new NIH-funded study supports a 70% ratio of forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) as an accurate threshold for diagnosing clinically significant airflow obstruction in COPD. This simple approach may lead to earlier detection and treatment, improving patient care and public health.
A large study of over 1 million patients found no association between red blood cell donation from previously pregnant women and increased risk of death among recipients. The research adds to the growing body of literature on blood donor characteristics and transfusion outcomes.
A new study found that irregular sleep patterns are associated with a higher risk of metabolic disorders, including obesity and high cholesterol. The research suggests that maintaining a regular sleep schedule has beneficial effects on metabolism.
A new study found that a mobile phone app designed for physically inactive women increased their daily physical activity and helped them sustain it over nine months. The app, combined with an activity tracker and personal counseling, provided motivational messages and interactive feedback, leading to short- and long-term fitness benefits.
Researchers developed a novel technique called LAMPOON to prevent left ventricular outflow tract obstruction, a common complication of transcatheter mitral valve replacement. The study found that the new method increased treatment options for high-risk patients and achieved better survival rates compared to other methods.
A recent study of nearly 300 patients with mild persistent asthma found that inhaled steroids were no more effective than placebo in nearly three-fourths of the study patients. However, for those with high levels of eosinophils, inhaled steroids were better than placebo, suggesting a potential new approach to targeting specific therapies.
New studies show that catheter ablation is not more effective than drug therapy in preventing strokes and deaths from atrial fibrillation. However, patients who undergo the procedure experience significant improvements in quality of life and symptoms, including reduced hospitalizations and recurrences of the condition.
A new study found that light physical activity can significantly lower the risk of cardiovascular disease among women 63 and older. The study, which involved over 5,800 women, showed a 42% reduction in heart attack or coronary death rates.
Researchers found that the medication amphotericin helps lung cells function, making it easier for patients to fight chronic bacterial infections. The finding holds special promise for a subset of patients who do not respond to current treatments.
Researchers discovered a previously unknown mechanism between the brain, bone marrow, and blood vessels that appears to protect against hardening of arteries when sleep is healthy. Disrupted sleep leads to increased inflammation and atherosclerosis in mice, highlighting the importance of quality sleep for cardiovascular health.
Treating psoriasis with biologic drugs has been shown to reduce early plaque buildup in arteries, restricting blood flow and leading to heart attacks and stroke. The study highlights the potential of immunotherapies in reducing cardiovascular disease risks.
Researchers discovered that specific gut cells, intraepithelial T lymphocytes, limit the availability of hormones that speed up metabolism, leading to slowed metabolic rates and increased risk of obesity and cardiovascular disease. The study's findings could pave the way for new therapeutic avenues to treat related conditions.
Researchers developed a blood test that detects severe lung transplant rejection early, even when no signs are present. The test uses DNA sequencing and has shown promising results in improving transplant outcomes.
Researchers found that people who eat a diet rich in red meat have triple the TMAO levels of those who eat a diet rich in either white meat or mostly plant-based proteins. However, discontinuation of red meat eventually lowers these TMAO levels, suggesting a promising new strategy for individualizing diets and preventing heart disease.
Researchers identified a gene mutation linked to lower risk of diabetes, obesity, heart failure, and death. Selectively blocking the SGLT-1 receptor could slow down glucose uptake to prevent or treat cardiometabolic disease.
A new study found that a change in breathing tube use can significantly improve survival rates for patients with sudden cardiac arrest. The new technique, which uses laryngeal tubes, resulted in higher survival rates compared to traditional endotracheal intubation.
Researchers found that viruses like norovirus and rotavirus are transmitted through membrane-cloaked 'virus clusters' that increase disease severity. These clusters, previously unknown to cause human-to-human transmission, may lead to more effective treatments targeting these clusters.
Researchers found that short-term increases in inhaled steroid doses do not effectively prevent severe asthma flare-ups in children. Instead, they may be associated with a small decrease in growth rate, echoing previous studies on the topic.
Researchers identified dozens of genetic variations affecting blood pressure by analyzing cigarette smoking behavior in a large cohort. The study confirms the role of known genes and identifies novel ones associated with blood pressure regulation, offering potential for individually targeted treatments.
Recent advances in gene therapy have led to successful treatments for patients with serious medical conditions. Emerging genome editing technologies, such as CRISPR/Cas9, hold promise for broader and more effective gene therapy approaches.
Scientists tagged bone marrow cells with a genetic label to track their family tree as they form naturally. The study reveals differences in how stem cells behave in their native environment versus laboratory settings, with implications for blood cell transplantation and gene therapy.