Researchers discovered that an algorithm called additive increase, multiplicative decrease (AIMD) is used both in engineered systems like the Internet and biological networks like the human brain. This finding sheds light on how the brain manages information and potentially helps understand learning disabilities.
Research from the Salk Institute shows that certain bacteria, such as Salmonella Typhimurium, can block the host's appetite loss response to make themselves healthier while also promoting transmission. This discovery could have implications in treating infectious diseases and may lead to new therapies for metabolic disease.
Researchers at Salk Institute successfully integrated stem cells from one species into the early-stage development of another, growing a rat pancreas, heart, and eyes in a mouse. They also generated human cells and tissues in pig embryos, marking a step toward generating transplantable human organs.
Researchers at Salk Institute found that pancreatic cancer cells alter their metabolism in response to signals from surrounding stromal cells. Blocking these signals with a drug called JQ1 can slow tumor growth in mice, paving the way for potential new treatments.
Researchers found that inhibiting PLSCR1 controls the infected cell's antiviral response, providing long-term protection from immune attack and excessive inflammation. This discovery holds promise for virally delivered treatments, inflammatory conditions, autoimmune disorders, and neurodegenerative diseases.
A study by Salk Institute scientists reveals that adolescent roundworms exhibit erratic behavior when seeking food, unlike adult worms which show efficient behavior. This discovery provides insight into the drivers of neurological development and may shed light on human brain function and diseases.
Researchers have solved the atomic structure of HIV's intasome, a key piece of machinery that integrates virus into human DNA. The discovery provides structural clues informing the development of new HIV drugs and sheds light on mechanisms of viral resistance.
Scientists at the Salk Institute have developed a 3D mini-brain model grown from human stem cells, which is structurally and functionally more similar to real brains than existing 2D models. This breakthrough model may help understand brain development and neurological diseases like Alzheimer's or schizophrenia.
Researchers at the Salk Institute have discovered that intermittent expression of genes normally associated with an embryonic state can reverse the hallmarks of old age. This approach resulted in the rejuvenation of mice with a premature aging disease, countering signs of aging and increasing their lifespan by 30%. The early-stage work...
Researchers at the Salk Institute identified a microprotein involved in clearing out genetic material that's no longer needed, shedding light on gene regulation and mRNA recycling. The discovery highlights the importance of overlooked microproteins and their potential role in disease.
Scientists found that a balance of telomere elongation and trimming in stem cells is necessary for optimal telomere length. Over-elongated telomeres accumulate DNA damage and can lead to cancer. The study deepens understanding of stem cell biology and has implications for regenerative medicine and aging research.
Scientists used cutting-edge imaging and computational tools to decipher the assembly process of ribosomes, revealing multiple routes for assembly and parallel pathways. This discovery has significant implications for understanding diseases and developing safer medicines.
Researchers at Salk Institute have discovered that T cell receptors amplify 'invader' signals by producing and releasing ZAP70 protein, enabling rapid signal transmission throughout the cell. This finding could lead to the development of more effective treatments for cancer and autoimmune diseases.
Researchers at Salk Institute discover a holy grail of gene editing, allowing precise DNA insertion into adult organs and tissues. This breakthrough enables partial restoration of visual responses in blind rodents and holds promise for treating retinal, heart, and neurological diseases.
Sleeping brain waves form associations between memory components, enabling long-term memory consolidation. Researchers discovered 'Princess Leia' oscillations in the neocortex, peaking in one area and then adjacent areas, facilitating neuronal communication and memory linking.
Scientists at the Salk Institute have discovered key molecular conductors in plant stress responses, enabling a better understanding of how plants cope with environmental hardships. By controlling these conductors, researchers can potentially develop new technologies to optimize water use in plants and help agriculture adapt to drought.
A new study reveals that the nuclear membrane acts as an active regulatory structure, influencing gene expression and contributing to diseases like leukemia, heart disease, and aging disorders. The discovery provides insight into the critical role of nucleoporins in regulating genomic sites.
Researchers have adapted a facial analysis software to quantify how often patients' eyes closed when instructed to keep them open, finding a correlation with clinician ratings. The new program has the potential to help study facial tics and twitches in other contexts, including Tourette Syndrome, schizophrenia, and Parkinson's disease.
Izpisua Belmonte's lab aims to generate functional primate organs and tissues in vivo using novel stem cell technologies. His work could lead to new methods for growing transplantable human tissues and overcoming organ rejection issues.
Sreekanth Chalasani's sonogenetics technique uses ultrasonic waves to selectively activate cells in mammals, opening doors to deep brain stimulation, pacemaker technology and more. The $1 million grant from the BRAIN Initiative could lead to breakthroughs in treating neurological disorders.
A team of researchers at the Salk Institute has found a way to obstruct the creation of fat molecules in cancer cells, stalling their growth. This approach involves inhibiting an enzyme called Acetyl-CoA Carboxylase, which is crucial for lipid synthesis activity.
Salk Institute scientists have discovered a method to create unlimited numbers of precursor kidney cells using a three-dimensional culture and new supporting molecules. These early-stage kidney cells could be used to grow replacement kidney tissue for studying and treating diseases.
Researchers at Salk Institute created a comprehensive map of the striatum, a lesser-known brain structure that controls movement. The study reveals how patch and matrix neurons coordinate diverse functions, shedding light on long-standing questions about neurodegenerative diseases like Parkinson's.
New research boosts levels of neuregulin-1 to alleviate hallmark features of Alzheimer's disease in a mouse model, promoting metabolism of brain plaques. The study suggests that neuregulin-1 may improve performance on spatial memory tests and lower cellular markers of disease.
Researchers at Salk Institute identify a connection between ApoE4 and protein build-up associated with Alzheimer's, providing a possible biochemical explanation for extra ApoE4 causing the disease. They also found that ApoE4 keeps the enzyme HtrA1 from breaking down tau protein, responsible for tau tangles associated with Alzheimer's.
Research by Salk Institute scientists reveals phaseic acid's unexpected role as a plant hormone crucial for drought resistance and survival traits. The study suggests that phaseic acid may inform the development of new, hardier crops to weather climate change-induced natural disasters.
Researchers at Salk Institute discover that the timing of brain activity, not just the number of spikes, is crucial for recognizing shapes and perceiving the world. The study's findings have potential applications in developing more accurate visual prosthetics for people with blindness.
Scientists developed guidelines to evaluate laboratory-generated stem cells, finding that no current methods produce truly naïve embryonic cells. The new criteria may aid researchers in achieving this goal, which could benefit both basic research and medical applications of stem cells.
A new study co-led by Salk Institute scientists found that some people with autism spectrum disorder have brains that grow faster than usual, often before diagnosis. The researchers used stem cell reprogramming technologies to model the earliest stages of complex disorders and evaluate potential therapeutic drugs.
Scientists at Salk Institute discovered that microRNA miR-19 regulates new neuron placement in adult brains and is disrupted in schizophrenia patients. The study paves the way for understanding how adult brains control new neuron growth and its potential link to neuropsychiatric disorders like schizophrenia.
Researchers found that THC and other cannabinoids reduce amyloid beta protein levels and eliminate inflammatory responses in brain cells. This study may provide insights into developing novel therapeutics for Alzheimer's disease.
Salk Institute researchers have visualized the natural arrangements of vital receptors on T cell surfaces in lymph nodes, revealing pre-organized 'territories'. This study could help scientists better understand how to modulate the immune system's activity for autoimmune diseases or cancer treatments.
Researchers at the Salk Institute found that REV-ERBα acts as a molecular conductor to regulate thousands of genes, with disruptions to its amplitude affecting metabolism and hormone levels. Studying mice with altered REV-ERBα levels revealed a link between circadian rhythms and glucose and lipid metabolism.
Scientists at Salk Institute create system to rapidly map regions of DNA targeted by regulatory proteins, revealing how plants control gene expression and uncovering potential role of epigenomic marks in regulation. The technique, DAP-seq, identifies thousands of binding sites across the genome of Arabidopsis thaliana.
A molecular pathway in brain helps halt spread of intestinal bacteria into bloodstream, strengthening gut barrier to prevent immune system activation. Researchers discover genetic switch Crtc plays key role in maintaining this barrier.
A recent study tracked developing cells in an adult mouse brain, finding that the brain prunes back excess dendrite branches to achieve optimal design. This pruning process may hold implications for understanding neurological disorders such as autism, intellectual disabilities, and schizophrenia.
A new miniaturized microscope reveals that astrocytes, traditionally thought to be passive support cells, respond to intense stimuli by generating their own chemical signals. This discovery offers unprecedented insight into nervous system function and could lead to novel pain treatments.
Researchers at the Salk Institute found that a protein complex called AMPK plays a critical role in monitoring and managing cells' energy processes during development. The discovery sheds new light on cancer and diabetes pathways, offering potential insights into stem cell therapies and cancer treatments.
Salk Institute scientists have developed a new reagent to map the brain's complex network of connections, 20 times more efficient than the previous version. The improved tool allows researchers to visualize neural circuitry and learn more about conditions like motor diseases and neurodevelopmental disorders.
Salk researchers have found a hidden energy switch that powers up pancreatic cells to respond to glucose, enabling the production of functional human beta cells. The breakthrough could lead to a viable treatment for type 1 and 2 diabetes.
Salk scientists discovered that specific immune receptors in the brain play a crucial role in clearing both healthy and dying neurons. In their absence, new neurons increased dramatically in certain regions, suggesting that these receptors may also target living but dysfunctional cells.
Researchers have determined the structure of a protein complex that lets viruses like HIV establish permanent infections in human cells. The new findings reveal a novel paradigm for retroviral DNA integration and provide insights into how viruses interact with host DNA.
Researchers at Salk Institute and Cambridge University found that grafted plants can share epigenetic traits, enabling them to communicate with each other. This discovery may allow growers to exploit epigenetic information to improve crops and yields.
When cells are exposed to mitochondrial damage, AMPK sends an emergency alert instructing them to break apart into tiny fragments. This process helps recycle damaged pieces and promotes mitochondrial health.
A gene linked to mental disorders helps lay the foundation for a crucial brain structure during prenatal development. Mutations in this gene can lead to severe depletion of neurons in the cortex, compromising its ability to communicate with other brain areas.
Researchers at Salk Institute identify nuclear factor kB as a key player in glioblastoma multiforme proliferation. Targeting this protein with NBD peptide or Timp1 gene slows tumor growth and increases mouse survival time, offering potential new treatment avenues.
Scientists at the Salk Institute discovered a way plants assess shade to outgrow menacing neighbors, triggering accelerated growth through molecular sensors. This finding could improve crop productivity and help farmers grow crops closer together.
Research reveals tiny genetic molecules called microRNAs play crucial role in controlling muscles, with dysfunction linked to devastating neurodegenerative diseases such as ALS and SMA. The findings open new avenues for treating these disorders by correcting dysfunctional microRNAs.
Researchers at the Salk Institute used genetic techniques to visualize three brain cell types in the visual cortex, shedding light on how the brain processes visual information. The study provides new insights into neural circuits and their potential implications for neurological disorders like schizophrenia and autism.
The Salk Institute has identified a drug called JQ1 that prevents and reverses liver fibrosis in animals, a condition that replaces normal liver cells with scar tissue until the organ no longer works. This discovery may also treat fibrosis in other organs such as the lung, pancreas, and kidney.