Id genes have been linked to heart development for the first time, revealing a new tool to create large numbers of cardiac cells to regenerate damaged heart tissue. The study uses CRISPR-Cas9 gene editing and high-throughput microRNA screening to identify the role Id genes play in heart development.
Researchers at Sanford Burnham Prebys and Mayo Clinic have been awarded a three-year NIH grant to identify molecules that could become new medicines to inhibit myocardial fibrosis, a major cause of heart failure. The collaboration aims to accelerate the development of novel approaches to fight disease.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have published a study on K-80003, an anti-cancer agent that prevents activation of the PI3K pathway, resulting in inhibition of cancer cell growth.
Scientists at Sanford Burnham Prebys Medical Discovery Institute propose a therapeutic strategy to suppress formation of bony tumors in multiple hereditary exostoses, a rare disease affecting 1 in 50,000 people. Researchers identify BMP signaling as the culprit and demonstrate success with an inhibitor compound.
A team of scientists compared 20 subgene resolution algorithms to analyze cancer genome data, reproducing known cancer genes and discovering new drivers. This study informs potential users about algorithm assumptions and results, shedding light on the complexities of cancer.
A study by Sanford Burnham Prebys Medical Discovery Institute researchers found that autophagy declines with age, leading to incomplete recycling of cellular waste. The team discovered this decline occurs after autophagosomes are formed, potentially blocking the conversion process and contributing to age-related diseases.
A new compound has been discovered that can inhibit the spread of the Zika virus, a significant step towards developing a treatment for its neurological complications. The compound blocks viral propagation in human cells and mice, offering promise as a starting point for an even more potent drug.
A recent study has identified the molecular mechanism behind lithium's effectiveness in treating bipolar disorder, providing a clear path to developing new diagnostic tests and therapies. The research, led by Sanford Burnham Prebys Medical Discovery Institute, utilized human induced pluripotent stem cells to map lithium's response path...
A new study from Sanford Burnham Prebys Medical Discovery Institute uncovers the role of non-coding RNA SPRIGHTLY in tumor growth and metastasis, suggesting it as a potential therapeutic target or diagnostic marker for skin cancer. The molecule binds to over 115 RNA partners, including genes implicated in various cancers.
Researchers have identified a previously unrecognized step in muscle regeneration, highlighting the molecular mechanisms that impair muscle stem cells with age. The study also provides insight into the connection between accelerated muscle stem cell aging and muscular dystrophies.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified K-homology splicing regulatory protein (KHSRP) as a regulator of the innate immune response. Depleting KHSRP improves immune signaling and reduces viral replication, suggesting that drugs inhibiting the protein may have therapeutic value.
Scientists at Sanford Burnham Prebys Medical Discovery Institute identified autophagy as a key process linking mild stress to improved survival and reduced protein aggregation. The study provides new avenues for treatments of neurological disorders such as Huntington's disease.
Scientists have discovered that GSK3 plays a crucial role in controlling B cell metabolism, adapting to varying energy needs. The study found that GSK3 limits metabolic activity in circulating B cells while slowing glycolysis and production of mitochondria in proliferating B cells in germinal centers.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have discovered that sorting nexin 27 (SNX27) is required for the formation of cells that maintain normal flow of fluid out of the brain. The study found that deleting SNX27 causes hydrocephalus, and gave hope for potential non-surgical treatments.
A new study reveals that diabetes drugs' weight loss effects are controlled by multiple brain regions, excluding the hypothalamus. Researchers hope to develop more effective treatments for obesity by understanding how these drugs work in the brain.
A new study from Sanford Burnham Prebys Medical Discovery Institute reveals that a key group of transcription factors are 'druggable,' including those involved in cancer, metabolism, and immunity. The research identifies seven bHLH-PAS proteins with pockets where drugs could fit and remain tightly bound.
Researchers at Sanford Burnham Prebys Medical Discovery Institute found that a key signaling protein helps suppress inflammation and scarring in the liver. The study suggests that p62, which is usually absent from cells that initiate inflammatory signals, plays a crucial role in preventing liver cancer progression.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have discovered a previously unknown protein, SETDB2, that helps the liver adapt to fasting states. This protein is increased during times of fasting and alters the genome to turn on genes needed for energy storage.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a potential target for preventing type 2 diabetes by blocking the cellular glucose sensor MondoA in muscle, improving insulin responsiveness. This study suggests that MondoA regulates genes involved in fat synthesis and inhibits insulin signaling.
Scientists at Sanford Burnham Prebys Medical Discovery Institute made a major advance in understanding how stem cells become specialized. The study shows that the stem cell-specific protein OCT4 primes certain genes that cause differentiation, customizing stem cells' responses to signals.
Researchers discovered 122 genetic regions linked to immune cell infiltration in tumors, which could inform the development of future immunotherapies. The study analyzed a large public genomic database and identified new leads for cancer immunology research.
Research from Sanford Burnham Prebys Medical Discovery Institute shows that cell recycling in the intestine is crucial for healthy aging, leading to longer lifespans.
Researchers have identified RBPJ as a key control point for controlling blood vessel growth in the adult heart, which may lead to new treatments for heart disease. The discovery suggests that blocking RBPJ could promote new blood supplies and improve heart attack outcomes.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have discovered a peptide sequence that can carry molecules and nanoparticles to acutely damaged areas of the brain, providing a new means of delivering therapeutics for traumatic brain injuries. This technology has the potential to minimize the effects of secondary injur...
Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a new regulator of immune responses, PSGL-1, which acts as a negative regulator of T cell function. The study found that PSGL-1 is required to increase levels of immune checkpoints, allowing T cells to remain active longer than normal.
A study by Sanford Burnham Prebys Medical Discovery Institute identified a super-oncogenic protein, activating transcription factor 2 (ATF2), that drives the formation of melanoma in mice with BRAF mutations. Inactive ATF2 was found to cause tumors to develop slower than expected, making it a potential indicator of tumor aggressiveness.
Scientists at UNC School of Medicine and Sanford Burnham Prebys discovered a human protein, NLRX1, that represses the innate immune response to HIV. This finding provides critical insight into improving HIV antiviral therapies and has implications for cancer treatment.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a protein complex that converts
Researchers have identified a new combination therapy for the most aggressive form of medulloblastoma, a fast-growing type of pediatric brain cancer. The study found that combining two drugs, histone deacetylase inhibitors and phosphatidylinositol 3-kinase inhibitors, potently kills cancer cells with minimal toxicity.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified ARGK-1 as a protein that can extend the natural lifespan of C. elegans by increasing energy regulation within cells. This finding may lead to new avenues for delaying human age-related diseases such as cancer and neurodegenerative disorders.
Scientists at Sanford Burnham Prebys have found that fetal muscle stem cells can remodel their microenvironment to encourage adult muscle regeneration. This discovery provides rationale for developing drugs to trigger this transition, offering new hope for treating muscular dystrophies and muscle-wasting disorders.
A new study found an important relationship between proteins secreted by the heart and obesity, glucose intolerance and insulin resistance. Higher levels of cardiac natriuretic peptides and lower clearance receptor in adipose tissue suggest a potential new approach to treating metabolic disorders.
Researchers at Sanford Burnham Prebys Medical Research Institute have identified the protein complex controlling muscle gene expression, resolving a longstanding issue in muscle regeneration. The discovery sheds light on molecular targets for regenerative medicine-based interventions to treat muscle degenerative disorders.
Researchers from Sanford Burnham Prebys Medical Discovery Institute found that failing hearts switch to ketone metabolism as an alternative fuel source. This discovery may lead to new therapeutic targets to prevent or slow progression of heart failure.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have solved the atomic structure of a unique ubiquitin ligase complex, which plays a key role in modulating the immune system. The study reveals significant therapeutic potential for developing novel drug targets for cancer and inflammatory diseases.
A team of researchers combined large genomic and proteomic datasets to identify new factors that can be targeted to prevent viruses from spreading. They found 20 previously unrecognized host proteins required for IAV replication, including the pivotal protein UBR4.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a promising new melanoma drug, SBI-756. The compound targets the translation initiation complex and has been shown to inhibit melanoma cell growth. SBI-756 may offer a significant advantage in overcoming tumor resistance.
Scientists at Sanford Burnham Prebys Medical Discovery Institute used publicly available cancer databases to identify novel cancer driver genes associated with cancer progression. The study found 71 previously unrecognized interfaces in proteins that may serve as new predictive markers or drug targets.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have identified a mechanism by which secreted proteins age and turnover, shedding light on health and disease. The discovery highlights the importance of N-glycan remodeling and lectin recognition in regulating protein abundance.
Researchers have found a new strategy to eliminate HIV by reactivating latent infected cells using a class of drugs called Smac mimetics. The approach, which has shown promising results in clinical trials for cancer, may lead to a safe and effective treatment to cure the virus.
A recent study published in Neuron highlights a novel role for the appoptosin protein in initiating tau aggregation, a key component of brain lesions. Elevated levels of appoptosin increase caspase-mediated tau cleavage, leading to synaptic dysfunction and progressive deterioration of the central nervous system.
Researchers at Sanford Burnham Prebys Medical Discovery Institute solved the structure of hypoxia-inducible factors (HIFs), important regulators of tumor response to low oxygen. The findings identify potential targets for new cancer drugs, which could inhibit HIF functions and reduce tumor growth.
Researchers at Sanford Burnham Prebys Medical Discovery Institute have discovered a new way to improve liver cancer treatment by blocking the activity of the lymphotoxin-beta receptor. The approach, which combines drugs currently in clinical trials with those targeting oncogene signals, may lead to improved patient outcomes.
Researchers at Sanford-Burnham Medical Research Institute have discovered a protein called polyglutamine-binding protein 1 (PQBP1) that recognizes HIV and initiates an immune response. The study suggests that designing a drug mimicking the PQBP1-HIV interface could create an effective vaccine environment, potentially preventing infection.
Sanford-Burnham researchers have identified a new molecular pathway, JAK1, that drives resistance to BRAF inhibitor treatment in melanoma tumors. Targeting JAK1 may improve the effectiveness of current therapy for patients with drug-resistant melanoma.
Researchers have identified a novel approach to treating pancreatic cancer by introducing the protein E47, which can reprogram cancer cells back to their original state. This breakthrough offers new therapeutic possibilities and may lead to improved patient outcomes.
A study by Sanford-Burnham Medical Research Institute identifies a protein called RNF5 that determines breast cancer response to paclitaxel, a chemotherapy drug. The researchers found that RNF5 causes degradation of glutamine carrier proteins, leading to sensitization of breast cancer tumors to death.
A new study by Sanford-Burnham Medical Research Institute has identified a specific stem cell signaling process that regulates intestinal tumors. The findings suggest that protein kinase C-zeta inhibits stem cell activity through downregulation of two signaling pathways: beta-catenin and Yap.
Scientists developed a method to induce human hair growth using pluripotent stem cells, providing an unlimited source of cells for transplantation and improving upon existing methods. The research team successfully coaxed human pluripotent stem cells to become dermal papilla cells, which regulate hair-follicle formation and growth cycle.
Researchers found that exercise after bariatric surgery improves insulin sensitivity and glucose metabolism in patients who participate in an exercise program. Cardiovascular fitness also improves, providing additional health benefits beyond weight loss.