Researchers have developed a new strategy to enhance catalytic activity using tungsten suboxide as a single-atom catalyst, significantly improving hydrogen evolution reaction performance. The study found that the support effect of tungsten suboxide enhances platinum's mass activity for hydrogen evolution by up to 16.3 times.
Researchers identified a single glucose-sensing neuron that controls insulin and glucagon hormone balance in flies, maintaining ideal glucose homeostasis. Silencing this neuron led to hyperglycemia, similar to diabetes in humans, supporting its critical role in regulating sugar levels.
A KAIST research team developed an advanced system to automatically analyze visual information in films and quantify gender bias. The study found that female characters are often depicted in passive emotions and surrounded by specific objects, promoting public awareness of the importance of prudence when creating characters.
A mathematical model developed by researchers at KAIST reveals how cells can communicate over long distances to spur collective action, even with short distance signaling. The team identified a cell communication mechanism that quickly forms a network of local interactions to facilitate synchronization.
The new technology uses machine learning to analyze sound and vibration responses from a smartphone's built-in sensors. It achieved high accuracy in identifying everyday objects in various environments, paving the way for innovative object interaction applications.
A new mechanism was discovered that induces programmed cell death in cancer cells by disrupting ion homeostasis, leading to increased reactive oxygen species and endoplasmic reticulum stress. This approach has been shown to strongly inhibit tumor growth in animal models.
Researchers developed a DNA vaccine for Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) that completely protects against lethal infection in ferrets. The vaccine induces both neutralizing antibody response and multifunctional T cell immunity.
Researchers from KAIST have created an ultrathin artificial muscle that expands, contracts, and rotates using electricity, opening doors for applications in wearable electronics and advanced prosthetics. The actuator is flexible, durable, and highly responsive, with a durability of over five hours.
Researchers at KAIST designed a flexible piezoresistive pressure sensor with high uniformity and low hysteresis, offering improved measurement reliability. The sensor's uniformity was found to be directly related to pore size and shape variability.
Researchers developed an advanced method to detect low-level somatic mutations in intractable epilepsy with 100% accuracy, surpassing conventional sequencing analysis which stands at 30%. The study used deep sequencing replicates of major focal epilepsy genes and identified mutations in approximately 5% of patients.
Researchers have designed plastic-based materials that can store natural gas more effectively, achieving a high deliverable gravimetric methane working capacity. The developed material, COP-150, has a total cost of only $1 USD per kilogram and can be produced using freely available plastic materials.
A team of researchers has developed a soft neural implant that can be wirelessly controlled using a smartphone, enabling chronic chemical and optical neuromodulation. The device uses replaceable drug cartridges and powerful low-energy Bluetooth for prolonged periods.
Researchers at KAIST have developed a novel synthesis method for single-crystalline hexagonal graphene quantum dots, which emit stable blue light. The team successfully created homogeneous nucleation of graphene quantum dots through a single-phase reaction.
KAIST researchers developed FLUID platform for dynamic UI distribution on multiple smart devices, accelerating the shift from single-device to multi-device paradigms. The technology supports diverse applications, including live video streaming and navigation apps, enabling users to engage with multiple screens simultaneously.
Researchers have identified non-inherited somatic mutations in the brain that could contribute to Alzheimer's disease progression. These mutations were found to be associated with hyperphosphorylation of tau proteins, a hallmark of AD.
Researchers have discovered a new strategy to extend sodium ion battery cyclability using copper sulfide as the electrode material. This leads to high-performance conversion reactions and is expected to improve the commercialization of sodium ion batteries.
A deep learning-powered computational framework called DeepEC has been developed to predict enzyme commission numbers with high accuracy and efficiency. It uses convolutional neural networks and homology analysis to identify EC numbers, which is essential for understanding enzyme functions.
A mathematical modeling study reveals that photosensitivity and PER2 level affect the efficacy of a clock-modulating drug, enabling precision medicine for circadian disruption. The researchers identified adaptive chronotherapeutics to identify precise dosing regimens that can restore normal circadian phase under different conditions.
Researchers developed a technology to transform game design according to latency levels, predicting player success rates and maintaining gaming performance. The team modified the Flappy Bird game's pillar heights to achieve similar success rates with added latency.
Researchers developed a practical gas phase modulator synthesis of hydrogen-natural gas blend (HNGB) without chemical waste, minimizing environmental impact. The new approach allows for efficient storage and transportation of hydrogen using clathrate hydrates.
Researchers have developed a new strain of microorganisms that can efficiently produce fatty acids and biodiesels from glucose. The resulting strains produced the highest concentrations ever reported by microbial fermentations, making them a potential game-changer for sustainable energy production.
The research team developed a system that allows for the real-time observation of MOF adsorption behavior, enabling accurate measurements and assessments of gas adsorption isotherms. By analyzing individual pore molecules, they identified a stepwise adsorption process and quantified the effects of pore structure and adsorption molecule...
Researchers found that catastrophic genome rearrangements can occur as early as childhood and lead to lung cancer decades later. Gene fusions in non-smokers mostly occur early on, sometimes as early as childhood or adolescence, and are often dormant for several decades before progressing into cancer.
Researchers found that autophagy in dendritic cells supports T-cell anticancer activity by regulating receptor CD36. This process enhances the phagocytosis of apoptotic tumor cells while restricting T-cell activation.
A KAIST research team visualized pulmonary microcirculation in vivo using a custom-built 3D intravital microscope imaging system. They found that neutrophils aggregate inside capillaries during sepsis-induced acute lung injury, leading to tissue hypoxia and damage.
A KAIST research team synthesized a peroxidase-mimicking nanozyme with superior catalytic activity and selectivity, overcoming the limitations of natural enzymes. The nanozymes can accurately detect target materials like hydrogen peroxide and acetylcholine, paving the way for early diagnosis of Alzheimer's disease.
The study identifies a distinct control architecture in brain networks, characterized by a distributed and overlapping control system that enables robustness against targeted attacks and high efficiency in switching between network states. This finding has broad implications for cognitive neuroscience and clinical applications.
A KAIST research team created a microfluidic-based drug screening chip that identifies synergistic interactions between two antibiotics in just eight hours. This technology can aid in exploring critical pharmacological patterns of antibiotic interactions and guide clinical therapies.
Researchers at KAIST have designed an ultrathin display that can project dynamic, multi-colored 3D holographic images using tiny pinholes in a thin film. The system is small and scalable, paving the way for widespread applications of 3D holographic displays.
Researchers at KAIST created a textile-based wearable display module that is washable and does not require an external power source. The device integrates polymer solar cells with organic light emitting diodes and features a new encapsulation barrier for reliability.
A KAIST research team found that blue-enriched white light exposure improves melatonin levels and subjective perception of alertness, mood, and visual comfort compared to warm white light. This study proposes a new approach to indoor lighting strategies, benefiting residential areas, learning environments, and working spaces.
A KAIST team has developed a noninvasive light-sensitive photoactivatable recombinase suitable for genetic manipulation in vivo. The new tool enables spatiotemporal control of gene expression in the mouse brain with high precision and minimal side effects.
A KAIST team presents a detailed analysis of metabolic engineering routes and optimal synthetic pathways for producing various industrial bio-based chemicals. The comprehensive metabolic map charts all available strategies and pathways, serving as a blueprint for the production of interest from renewable resources.
Researchers from KAIST have identified novel pathways involving T immune cell exhaustion in liver cancer patients. The study provides evidence for designing optimal strategies for immune checkpoint blockades and offers a new path for customized medicine.
KAIST chemists have synthesized seven different iboga and post-iboga natural products from catharanthine, mirroring nature's biosynthetic post-modification of the iboga skeleton. The novel strategy involves selective oxidation and rearrangement reactions, offering a stepping stone for developing therapeutic medications against cancer a...
Researchers developed a novel thermoplastic anchoring polymer layer structure to suppress movement of conductive particles, achieving 90% capture rate. The new anisotropic conductive film shows excellent electrical conductivity, high reliability, and low cost.
A KAIST research team developed a molecular sensor that selectively concentrates charged small molecules, amplifying Raman signals and allowing for direct detection without pretreatment. This technology can be used to detect residual drugs or biomarkers in blood or urine, saving time and cost.
Researchers applied polydopamine as an infiltrate binder to achieve high mechanical and electrical properties in graphene-based liquid crystalline fibers. The bio-inspired defect engineering overcomes the limitations of conventional graphene fibers, making it suitable for flexible electronics, textiles, and wearable sensors.
Researchers at KAIST have developed a high-performance flexible transparent force touch sensor that overcomes traditional limitations in sensing performance. The sensor features high sensitivity, transparency, bending insensitivity, and manufacturability, making it suitable for industrial-grade applications.
Researchers developed a simple and robust malonyl-CoA biosensor to monitor intracellular malonyl-CoA abundance in bacteria. The biosensor enabled rapid screening for gene targets increasing malonyl-CoA accumulation, leading to high-level production of four natural products.
Researchers developed flexible piezoelectric acoustic sensors for improved speaker recognition, achieving sensitivity over two times higher than conventional sensors. These sensors enable 97.5% accurate speaker recognition and diverse voice detection in various environments.
A KAIST research team has reported a stretchable pressure insensitive strain sensor by using an all solution-based process. The new electronic skin can distinguish mechanical stimuli analogous to human skin and can be uniformly coated on 3-dimensional surfaces.
Researchers developed an engineered E. coli strain that converts formic acid and CO2 to pyruvate, producing cellular energy from formic acid through reconstructed one-carbon pathways. The strain efficiently utilizes formic acid as a carbon source while reducing glucose consumption.
Researchers identified a neuronal BRAF somatic mutation causing intrinsic epileptogenicity in pediatric brain tumors, leading to a potential new therapeutic target. The mutation arose from neural stem cells and was found to alleviate seizures in animal models treated with the BRAF inhibitor Vemurafenib.
Researchers created a new algorithm to safely herd flocks of birds away from airports, reducing bird strikes and potential damages. The drone-based system successfully diverted entire flocks without fragmenting their formation.
Engineered E. coli strains have successfully produced extracellular free haem using a novel strategy, overcoming previous limitations in production efficiency and yield. The optimized metabolic pathway enables high titer production of haem, paving the way for its use as a bioavailable iron-supplying agent in medical applications.
K-FLEX, a flexible endoscopic surgical robot, demonstrates precise control of 3.7 mm diameter robotic arms for minimally invasive procedures. The device successfully manipulated tissue during an in-vivo test on a porcine gallbladder, showcasing its potential for surgery on incipient cancer cells.
A KAIST research team has developed a flexible drug delivery device with controlled release, blurring the path toward theragnosis. The device boasts fewer side effects and uniform therapeutic results compared to oral ingestion, making it suitable for smart contact lenses and brain disease treatments.
KAIST neuroscientists discover the anterior cingulate cortex plays a role in inhibiting innate fear responses to predators' odors, shedding light on instinctive fear behavior. The study paves the way for therapeutic treatments of fear-related mental disorders such as panic and PTSD.
A KAIST research team identified where glioblastoma mutation drivers originate, revealing that normal SVZ tissue away from the tumor contains low-level mutations. The study suggests novel ways to treat glioblastoma and implies a new paradigm for therapeutic strategies.