A KAIST research team visualized pulmonary microcirculation in vivo using a custom-built 3D intravital microscope imaging system. They found that neutrophils aggregate inside capillaries during sepsis-induced acute lung injury, leading to tissue hypoxia and damage.
A KAIST research team synthesized a peroxidase-mimicking nanozyme with superior catalytic activity and selectivity, overcoming the limitations of natural enzymes. The nanozymes can accurately detect target materials like hydrogen peroxide and acetylcholine, paving the way for early diagnosis of Alzheimer's disease.
The study identifies a distinct control architecture in brain networks, characterized by a distributed and overlapping control system that enables robustness against targeted attacks and high efficiency in switching between network states. This finding has broad implications for cognitive neuroscience and clinical applications.
A KAIST research team created a microfluidic-based drug screening chip that identifies synergistic interactions between two antibiotics in just eight hours. This technology can aid in exploring critical pharmacological patterns of antibiotic interactions and guide clinical therapies.
Researchers at KAIST have designed an ultrathin display that can project dynamic, multi-colored 3D holographic images using tiny pinholes in a thin film. The system is small and scalable, paving the way for widespread applications of 3D holographic displays.
Researchers at KAIST created a textile-based wearable display module that is washable and does not require an external power source. The device integrates polymer solar cells with organic light emitting diodes and features a new encapsulation barrier for reliability.
A KAIST research team found that blue-enriched white light exposure improves melatonin levels and subjective perception of alertness, mood, and visual comfort compared to warm white light. This study proposes a new approach to indoor lighting strategies, benefiting residential areas, learning environments, and working spaces.
A KAIST team has developed a noninvasive light-sensitive photoactivatable recombinase suitable for genetic manipulation in vivo. The new tool enables spatiotemporal control of gene expression in the mouse brain with high precision and minimal side effects.
A KAIST team presents a detailed analysis of metabolic engineering routes and optimal synthetic pathways for producing various industrial bio-based chemicals. The comprehensive metabolic map charts all available strategies and pathways, serving as a blueprint for the production of interest from renewable resources.
Researchers from KAIST have identified novel pathways involving T immune cell exhaustion in liver cancer patients. The study provides evidence for designing optimal strategies for immune checkpoint blockades and offers a new path for customized medicine.
KAIST chemists have synthesized seven different iboga and post-iboga natural products from catharanthine, mirroring nature's biosynthetic post-modification of the iboga skeleton. The novel strategy involves selective oxidation and rearrangement reactions, offering a stepping stone for developing therapeutic medications against cancer a...
Researchers developed a novel thermoplastic anchoring polymer layer structure to suppress movement of conductive particles, achieving 90% capture rate. The new anisotropic conductive film shows excellent electrical conductivity, high reliability, and low cost.
A KAIST research team developed a molecular sensor that selectively concentrates charged small molecules, amplifying Raman signals and allowing for direct detection without pretreatment. This technology can be used to detect residual drugs or biomarkers in blood or urine, saving time and cost.
Researchers applied polydopamine as an infiltrate binder to achieve high mechanical and electrical properties in graphene-based liquid crystalline fibers. The bio-inspired defect engineering overcomes the limitations of conventional graphene fibers, making it suitable for flexible electronics, textiles, and wearable sensors.
Researchers at KAIST have developed a high-performance flexible transparent force touch sensor that overcomes traditional limitations in sensing performance. The sensor features high sensitivity, transparency, bending insensitivity, and manufacturability, making it suitable for industrial-grade applications.
Researchers developed a simple and robust malonyl-CoA biosensor to monitor intracellular malonyl-CoA abundance in bacteria. The biosensor enabled rapid screening for gene targets increasing malonyl-CoA accumulation, leading to high-level production of four natural products.
Researchers developed flexible piezoelectric acoustic sensors for improved speaker recognition, achieving sensitivity over two times higher than conventional sensors. These sensors enable 97.5% accurate speaker recognition and diverse voice detection in various environments.
A KAIST research team has reported a stretchable pressure insensitive strain sensor by using an all solution-based process. The new electronic skin can distinguish mechanical stimuli analogous to human skin and can be uniformly coated on 3-dimensional surfaces.
Researchers developed an engineered E. coli strain that converts formic acid and CO2 to pyruvate, producing cellular energy from formic acid through reconstructed one-carbon pathways. The strain efficiently utilizes formic acid as a carbon source while reducing glucose consumption.
Researchers identified a neuronal BRAF somatic mutation causing intrinsic epileptogenicity in pediatric brain tumors, leading to a potential new therapeutic target. The mutation arose from neural stem cells and was found to alleviate seizures in animal models treated with the BRAF inhibitor Vemurafenib.
Researchers created a new algorithm to safely herd flocks of birds away from airports, reducing bird strikes and potential damages. The drone-based system successfully diverted entire flocks without fragmenting their formation.
Engineered E. coli strains have successfully produced extracellular free haem using a novel strategy, overcoming previous limitations in production efficiency and yield. The optimized metabolic pathway enables high titer production of haem, paving the way for its use as a bioavailable iron-supplying agent in medical applications.
K-FLEX, a flexible endoscopic surgical robot, demonstrates precise control of 3.7 mm diameter robotic arms for minimally invasive procedures. The device successfully manipulated tissue during an in-vivo test on a porcine gallbladder, showcasing its potential for surgery on incipient cancer cells.
A KAIST research team has developed a flexible drug delivery device with controlled release, blurring the path toward theragnosis. The device boasts fewer side effects and uniform therapeutic results compared to oral ingestion, making it suitable for smart contact lenses and brain disease treatments.
KAIST neuroscientists discover the anterior cingulate cortex plays a role in inhibiting innate fear responses to predators' odors, shedding light on instinctive fear behavior. The study paves the way for therapeutic treatments of fear-related mental disorders such as panic and PTSD.
A KAIST research team identified where glioblastoma mutation drivers originate, revealing that normal SVZ tissue away from the tumor contains low-level mutations. The study suggests novel ways to treat glioblastoma and implies a new paradigm for therapeutic strategies.
A KAIST team introduced Agile 3D Sketching with Air Scaffolding, combining hand motions and pen-based sketching to create 3D shapes. The technique allows designers to reduce time while enhancing accuracy in defining proportion and scale of products.
A KAIST team identified that the formation of metal-oxide interfaces has a synergistic catalytic effect on bimetal catalysts. This is achieved through in situ imaging, revealing that interfacial platinum-nickel oxide nanostructures increase catalytic activity while providing thermodynamically efficient reaction pathways.
The KAIST research group created photonic capsules that can be injected into any target volume, exhibiting omnidirectional laser emissions. The capsules contain cholesteric liquid crystals (CLCs) with helical nanostructures, which reflect circularly-polarized light and enable wavelength-tunable lasing.
Research identifies brain-only MTOR mutations as a key factor in causing cortical malformations, intellectual disability, and developmental delay in children. The study found that disrupted ciliary formation leads to cortical dyslamination, providing new insights into the molecular mechanisms of FMCDs.
A KAIST research team developed a low-cost production technology for thin-film blue flexible vertical micro LEDs, achieving three times higher optical power density and longer device lifetime than lateral micro LEDs. This innovation enables the widespread adoption of micro LEDs in mobile and TV displays.
Professor Lee recognized for his work on metabolic engineering to develop sustainable chemical materials, with notable research in drug-drug and food interactions using AI and novel enzymes. He is the second Asian recipient of the prestigious award, honoring Professor Peter V. Danckwerts.
A KAIST research team has developed a novel perovskite material, Cs2Au2I6, which exhibits high efficiency and stability compared to conventional organic-inorganic hybrid perovskites. The new material is expected to overcome the limitations of previous perovskite materials, including toxicity issues.
A recombinant E. coli strain has been developed to biosynthesize 60 different nanomaterials covering 35 elements on the periodic table. The team successfully synthesized 33 novel nanomaterials for the first time, advancing the design of nanomaterials through biosynthesis.
A new study reveals that similar-status F1 drivers are more prone to collide, especially when they are age-similar, performing well, and feeling safe. The research team found structural equivalence triggers antagonism among interactants, leading to increased conflict.
Researchers at KAIST have identified a neural circuit in the hypothalamus governing obsessive behavior towards non-food objects in mice. The MPA-PAG circuit modulates object craving and facilitates hunting behavior, allowing for controlled mammalian behavior with optogenetics.
A Korean research team developed a deep learning-based framework, DeepDDI, to predict 86 types of drug-drug and drug-food interactions. The model accurately predicts interactions for drug-pair constituent pairs with a mean accuracy of 92.4%.
A KAIST research team developed a new anode material using copper sulfide, exhibiting 1.5 times better cyclability and 40% reduced cost compared to existing materials. The discovery may contribute to the commercialization of sodium ion batteries and reduce battery costs in consumer electronics.
Researchers at KAIST have developed a technology to increase the stability of amine-containing adsorbents by fifty times. This advancement brings solid carbon dioxide adsorbents closer to commercialization and paves the way for efficient capture of greenhouse gases.
Researchers at KAIST have identified flammable ice formed in oceans through clay minerals in sedimentary deposits. They proposed a new principle for gas hydrate formation and found that electric fields can promote hydrate nucleation.
A KAIST team created a technology to print heat patterns on a micron scale for controlling biological activities remotely. They achieved this by integrating precision inkjet printing with bio-functional thermo-plasmonic nanoparticles.
Researchers at KAIST identified the basic principle of electric wind in plasma, a phenomenon that can create air movement without mechanical movement. The team found that space charge drift following streamer propagation is the main cause of electric wind, with electrons playing a key role in certain plasmas.
Researchers at KAIST developed a hybrid energy storage device that can be charged in less than half a minute using aqueous electrolytes and graphene. The device facilitates rapid charging and high energy density, making it suitable for portable electronic devices.
Researchers at KAIST have identified a novel molecular mechanism for polyethylene terephthalate (PET) degradation, revealing superior degradability of PET. A new variant with enhanced PET-degrading activity was also developed using structural-based protein engineering.
The KAIST research team has developed flexible vertical micro LEDs (f-VLEDs) with high optical power density, improving thermal reliability and lifetime. These f-VLEDs can be used for optogenetics to control animal behavior and are suitable for biomedical applications.
KAIST researchers designed metallic nanostructure substrates to enhance Quantum Dot LED efficiency and reduce production costs. The technology uses silver and aluminum nanoparticles to increase fluorescent properties of QDs, resulting in brighter displays and lower unit prices.
A recent study by KAIST medical scientists reveals that regulatory T cells undergo inflammatory changes in patients with viral hepatitis, leading to the secretion of inflammatory cytokines called TNF. This discovery could pave the way for the development of new clinical treatments for severe viral hepatitis.
KAIST researchers have developed a new technique to improve the chemical stability of electrode materials in solid oxide fuel cells. By employing a small amount of metals, they can extend the lifespan of these energy technology devices. This innovation has the potential to improve the long-term performance and durability of fuel cells.
Researchers at KAIST developed fiber OLEDs that surpass existing plansar substrates in terms of luminance and current efficiency values. The new technology also allows for the fabrication of OLEDs on ultra-thin fibers, with diameters as low as 90?, enabling the creation of wearable displays.
A KAIST research team used electron microscopy and scanning tunneling microscope to study the connection between magnetism and superconductivity. They found that low-energy spin fluctuations cannot mediate pairing between electrons, a critical step for superconductivity. This breakthrough enables the development of novel antiferromagne...