Researchers developed a novel strategy to produce aromatic polyesters from Escherichia coli strains using microbial fermentation and synthetic biology. The engineered E. coli strain can produce various high-valued aromatic polyesters from renewable biomass, offering a sustainable alternative for the bio-plastic industry.
A KAIST research team developed technology to identify the optimal drug target for cancer cells based on molecular network dynamics. This approach uses systems biology to analyze genetic mutations and predict drug response, which could lead to more effective treatment strategies.
A KAIST research team developed a new technology to detect RNase H activity using catalytic hairpin assembly, overcoming limitations of existing methods. The technology amplifies detection signals, enabling more sensitive assays and potential screening for inhibitors.
A KAIST research team has identified a mutant gene network in colon cancer, which could lead to the development of effective anti-cancer drugs. The study used large-scale genomic data to construct a mathematical model on the cooperative effects of multiple genetic mutations found in gene interaction networks.
Researchers at KAIST developed ultra-flexible organic flash memory that can be applied to non-conventional substrates like plastics and papers. The memory technology exhibits a significantly-long projected retention rate with programming voltages on par with industrial standards.
A Korean research team created a comprehensive computational model of human metabolism, enabling accurate prediction of personal metabolic features. The model incorporates alternative splicing information and was validated with over 11,000 Gene-Transcript-Protein-Reaction Associations.
A KAIST-UC Irvine team developed an ultra-fast hydrogen gas sensor using a palladium nanowire array with a metal-organic framework, detecting hydrogen levels under 1% in under 7 seconds. The sensor also detects hundreds of parts per million levels within 60 seconds at room temperature.
A KAIST research team has identified a new mechanism that causes the hallmark symptoms of Parkinson's disease, including tremors. The discovery presents a new perspective on three decades of conventional wisdom and opens up new avenues for alleviating motor problems.
Researchers developed combined photoacoustic imaging and photothermal therapy using Bilirubin (BR) nanoparticles, showing high biocompatibility and outstanding therapeutic effects. The technology has the potential to improve cancer diagnosis and treatment outcomes.
Researchers at KAIST have developed a novel fabrication technology to produce superomniphobic surfaces that can repel liquids, including water and oil. The new approach uses localized photofluidization of azobenzene molecule-containing polymers, resulting in a superior superomniphobic property.
Researchers at KAIST have developed a novel method to improve medication treatment for liver cancer, identifying the resistance mechanism of Sorafenib and discovering a new approach to block it. The study suggests the possibility of developing a new method to overcome drug resistance using network analysis.
Researchers at KAIST have created highly flexible wearable displays by integrating OLED into fabrics, enabling commercialization of clothing-shaped displays. The team's breakthrough technology reduces mechanical stress on OLEDs, resulting in high luminance and efficiency.
A research team led by Professor Hyoungsoo Kim quantified the Marangoni effect in miscible liquids, revealing a new mechanism for driving transport without surface contamination. The findings have potential applications in removing impurities from surfaces and developing alternative materials to surfactants.
A new nanocoating technique developed by KAIST researchers uses plant-derived polyphenol to extend the shelf life of produce. The sprayable nanocoating process has been shown to significantly prolong postharvest shelf life, preserving freshness beyond 28 days and 58 hours for certain fruits.
A KAIST research team developed molecular pulley binders for high-capacity silicon anodes in lithium ion batteries, improving charge-discharge cycles. The innovative binding system, inspired by the 'mechanical bond' concept, enhances electrode stability and capacity retention.
A research team at KAIST developed diagnostic sensors using protein-encapsulated nanocatalysts to analyze human exhaled breath and diagnose diseases. The sensors achieved high sensitivity and selectivity, detecting biomarker gases related to diseases with improved performance compared to conventional platinum-based catalysts.
Researchers studied the structure of MDGA1/Neuroligin-2 complex, revealing how it negatively modulates synapse development. The study provides key findings on the mechanism of action of MDGAs in regulating excitatory/inhibitory synapses.
A KAIST research team identified a software glitch in smartphones' screen rotation-tracking algorithms as the cause of frequent document photo orientation errors. Their novel technique can correct phone orientation in document-capturing tasks at 93% accuracy and seamlessly work with existing methods.
Researchers have discovered that mutations in the RB1 and TP53 genes play a key role in treatment-resistant cancer cell-type transformation in lung cancers. Lung adenocarcinomas with complete inactivation of both genes tend to have a higher risk of transforming into small cell lung cancer during EGFR inhibitor therapy.
Researchers developed a biocatalytic system to produce terephthalic acid from p-xylene using metabolically engineered E. coli, offering a greener alternative to traditional chemical methods. The resulting yield of 97 mol% demonstrates the feasibility of this bio-based technology for large-scale production.
KAIST researchers directly observed the phase transition of topological defects formed by liquid crystal materials for the first time. The defect structures have radial, circular, or spiral shapes centering on a singularity and can be easily observed with an optical microscope.
Professor Sang Yup Lee was elected as a foreign associate to the US National Academy of Sciences (NAS) and previously to the US National Academy of Engineering (NAE). He is the first Korean to be elected to both prestigious academies, recognized for his leadership in microbial biotechnology and metabolic engineering.
Researchers develop a new optical manipulation technique that can control the 3D motion of complex-shaped objects, including living cells. The technique uses 3D holographic microscopy to measure object shapes and calculates light shapes for stable trapping.
Researchers at KAIST successfully synthesized the natural product (-)-flueggenine C via an accelerated intermolecular Rauhut-Currier reaction. The conventional RC reaction is non-selective and high-temperature, but the team modified it to use a base at ambient temperature.
A KAIST research team developed a hybrid animal-robot interaction system that attaches to a turtle and induces its object-tracking behavior through training sessions. The parasitic robot successfully controls the direction of movement in a water tank, offering an alternative solution to conventional mobile robot limitations.
The KAIST team discovered a new molecular signal triggered by IPMK enzyme in mediating innate immune response to sepsis. This finding suggests a potential therapeutic target for treating serious medical conditions like neuroinflammation and polymicrobial sepsis.
Scientists successfully produce stable Pickering emulsions by inducing depletion force between solid particles and liquid droplets. This technology has significant implications for industries such as separation film, systems engineering, drug delivery, and sensors.
Researchers at KAIST have synthesized DNA-copper nanoflowers using eco-friendly conditions, exhibiting high DNA loading capacities and low cytotoxicity. The hybrid nanoflowers show exceptional peroxidase activity, enabling sensitive detection of molecules.
A crowdsourced traffic violation reporting app, Mobile Roadwatch, has been developed to improve traffic safety. Drivers can capture and report traffic violations using their smartphones, providing valuable evidence for police to issue tickets.
A Korean research team develops high-performance silver nanowires with strong adhesion using flash light-material interactions. The Ag NWs demonstrate six times higher conductivity than pristine NWs, and their adhesion to substrates is enhanced by 310%.
Researchers at KAIST create a 3D holographic display that significantly enhances the performance of existing displays, allowing for larger images and wider viewing angles. By controlling volume speckle fields, they achieve an image size increase of up to 2 cm in length, width, and height.
A Korean research team has published two papers detailing the crystal structure of PHA synthase from Ralstonia eutropha and its reaction mechanisms. The study reveals that PHA synthase exists as a dimer with two distinct domains, enabling independent polymerization reactions at each site.
KAIST researchers create ultramicroporous benzothiazole polymers with exceptional stability and affinity for CO2, offering a sustainable solution to natural gas sweetening. The novel materials can be recycled back into an efficient process.
Researchers from KAIST and KIMM developed a technology to transfer and package flexible large-scale integrated circuits (LSI) on plastics using continuous roll-processing. The technology successfully demonstrated stable memory operations under severe bending conditions.
Researchers at KAIST have developed ultrathin, transparent oxide thin-film transistors that overcome previous challenges in flexible display technology. The new technology uses an inorganic-based laser lift-off method to create high-performance devices with excellent optical transparency and mobility.
At the Summer Davos Forum 2016, three KAIST professors discussed the Fourth Industrial Revolution's impact on biotechnology, artificial intelligence, and robotics. They explored opportunities and challenges in machine learning and autonomous robotics. The event highlighted KAIST's research excellence and global participation.
KAIST researchers deciphered the genome and proteome profiles of C. tyrobutyricum, revealing its unique metabolic features and energy conservation mechanisms. The bacterium shows higher tolerance to toxic compounds like 1-butanol, enabling efficient production of chemicals including butyric acid.
A Korean research team developed a graphene-based transparent electrode structure, achieving high efficiency and flexibility in flexible OLEDs. The new device architecture maximizes the efficiency of graphene-based OLEDs by inducing a synergistic collaboration between high- and low-index layers.
A Korean research team has developed metabolically engineered Escherichia coli strains to synthesize non-natural, biomedically important polymers including poly(lactate-co-glycolate) (PLGA). The team successfully produced PLGA and various novel copolymers through microbial fermentation directly from carbohydrates.
Researchers at KAIST developed K-Glass 3, a smart glasses device with a low-power multicore processor enabling convenient typing and screen pointing. The device features stereo vision and deep-learning algorithms, allowing users to enjoy enhanced AR experiences.
Researchers at KAIST and UCLA developed a method to manipulate membrane protein folding in a natural environment, revealing cooperative folding behavior. The study used magnetic tweezers to induce unfolding and refolding, allowing for the mapping of folding energy landscapes and kinetic rates.
Researchers at KAIST have developed ten general strategies of systems metabolic engineering to successfully develop industrial microbial strains. The strategies cover economic, state-of-the-art biological techniques and traditional bioprocess aspects.
Two Korean research teams have discovered the redox-switch of thiolase, a key enzyme involved in n-butanol biosynthesis. This finding enables increased n-butanol production using metabolic engineering approaches.
Daejeon-based researcher Jeong Ho Lee of KAIST has been awarded the 2015 Pediatric Epilepsies Research Award for his groundbreaking study on brain somatic mutations as a novel cause of childhood intractable epilepsy. The award grants $250,000 in funding to support his research efforts.
Jae Kyoung Kim's research uses mathematical modeling and synthetic biology to understand how biological circuits generate and sustain stable rhythms. The study found that a novel bacterial circuit generates robust rhythms under various conditions, providing insights into the fundamental mechanism of rhythm generation in biological syst...
Researchers at KAIST engineered an E. coli strain to produce 1,3-diaminopropane via fermentation, offering a sustainable alternative to petroleum-based processes. The production titer increased about 21-fold, with 13 grams per liter of 1,3-diaminopropane obtained through Fed-batch fermentation.
Researchers at KAIST have developed a wireless-power transfer (WPT) technology that allows mobile devices to be charged in any direction, even when away from the power source. The system can charge multiple devices simultaneously and wirelessly, with an efficiency of up to 34%, making it ideal for emergency situations.
The KAIST research team has developed the first flexible phase-change random access memory (PRAM) on plastic substrates, achieving significant power reduction. This innovation is made possible by self-assembled block copolymer silica nanostructures, which lower the contact area and reduce power consumption.
KAIST researchers create a novel technique for precisely tracking the 3D positions of optically trapped particles with complicated geometry. The Optical Diffraction Tomography (ODT) method measures 3D images in high speed, enabling the visualization and analysis of particles in various fields.
A KAIST research team has developed a hyper-stretchable elastic-composite energy harvester called a nanogenerator. The device can harvest mechanical energy to produce high power output with large elasticity and excellent durability.