Researchers identify DNA-PK as a master regulator of gene networks promoting aggressive prostate cancer behaviors. A clinical trial combining standard-of-care with a first-in-man DNA-PK inhibitor shows promising early results.
Chlamydia trachomatis produces a protein called IncA that facilitates the fusion of bacterial compartments, leading to increased disease pathogenicity. The discovery provides a new tool for researchers to study key disease processes caused by bacteria.
Researchers have identified patients more likely to have treatable underlying lesions from brain-bleeds, allowing for faster treatment. The study found that patients over 85 were unlikely to have a treatable lesion, while those under 50 had a 37% chance of finding a structural lesion.
Researchers analyzed data from 234 patients undergoing minimally invasive laser surgery for epilepsy, finding that targeting specific brain regions such as the amygdala and hippocampal head improved seizure-free outcomes with minimal side effects. The study's results provide insights into the most effective approach for this type of su...
A mindfulness-based parenting intervention has been shown to decrease depression symptoms in mothers with opioid use disorder, particularly those with moderate to severe depression symptoms. The study, published in Issues in Mental Health Nursing, found that the intervention was a practical alternative to pharmaceutical treatment.
Researchers discovered a type of bone cell that can subdue cancer cells, slowing their growth in breast cancer patients. Osteoblasts release factors that halt cancer cell growth, restoring production of the cell-cycle checkpoint protein p21 and putting cancer cells to sleep.
Researchers at Thomas Jefferson University have discovered a way to target both of a bacteria's defenses with one hit, weakening its ability to develop antibiotic resistance. By interfering with a specific type of tRNA molecule, the team was able to make bacteria more susceptible to antibiotics.
A novel colorectal cancer vaccine has demonstrated positive phase I results, with patients showing no signs of serious adverse events and activation of immune cells. The vaccine was found to be safe and effective in a small sample of human subjects, paving the way for further testing to determine its potential as a treatment.
Researchers discovered that gasdermin E forms holes in cell membranes, leading to cell death and suppressing tumor growth. The protein's expression is lower in many types of cancer, suggesting it may be a useful target for improving cancer therapy.
A new study found that transfer RNA-derived fragments play a significant role in gene expression, differing by cancer type and sex of the patient. The mitochondrion is involved in these interactions, particularly with repetitive elements.
Researchers developed a novel recombinant vaccine called NIPRAB that shows strong immunization against Nipah virus in animal models. The live vaccine is safe in mice, eliciting a strong antibodies response and reacting to similar viruses like Hendra and Rabies.
A new study from Thomas Jefferson University reveals that decreased oxygen supply to tendons leads to a loss of flexibility and an increase in fibrocartilage-like cells. This knowledge could help develop better treatments for tendinosis and regrow damaged tissue, which is common in older individuals.
A new experimental glioblastoma vaccine developed by Jefferson and Imvax has shown promising results in a phase Ib clinical trial. The treatment was found to slow tumor recurrence and prolong patient survival in patients with newly diagnosed glioblastoma multiforme.
Researchers found that a mother's diet during pregnancy can affect the expression of genes regulating lung health in her offspring. Epigenetic changes may contribute to increased rates of lung disease, such as asthma, in children born to undernourished mothers.
Researchers have discovered a potential treatment for cancer in patients with epidermolysis bullosa, a severe skin disease also known as butterfly disease. The new drug, rigosertib, was shown to be highly effective at killing cancer cells in preclinical studies and may target the cancer without harming healthy cells.
A team of researchers has found a novel function for the signaling molecule TRADD, which was previously considered dispensable. Without RIPK1 protein, having two copies of the TRADD gene or no copies results in cell death, while one copy promotes survival. This discovery sheds light on regulating cell death and survival pathways.
Fibrosis, a major complication of butterfly syndrome, is driven by the protein TSP1 and its activation of TGF-beta signaling. Researchers have identified a potential treatment by inhibiting TSP1, reducing fibrosis in tissue-engineered models.
A new recovery pathway has been implemented to reduce hospital stays after the Whipple operation by 15 days, allowing patients with pancreatic cancer to transition more quickly to the next phase of treatment. The study found that this accelerated care did not increase complication rates and improved patient outcomes.
Researchers have identified a key trigger for toxic protein production in ALS and frontotemporal dementia. Targeting the integrated stress response with an approved antidepressant drug shows promise in reducing toxic protein production in laboratory tests.
A new retrospective study shows that thyroid surgery readmissions are highest within a week of the procedure, with patients experiencing severe symptoms such as tremors and muscle spasms being most at risk. The study identifies risk factors that can be addressed to prevent these readmissions, including timely follow-up using telehealth.
Researchers at Thomas Jefferson University discovered a compound from Christmas berry primrose plants can inhibit uveal melanoma growth, offering potential new treatments for patients. The compound, FR900359, works by blocking mutated G proteins that promote cancer growth.
Researchers discovered that melanomas produce BRAF proteins that become active complexes with MEK, making them resistant to RAF-inhibiting drugs. Blocking this complex can restore the potency of the therapy.
Researchers at Thomas Jefferson University found that hot-brewed coffee contains higher levels of antioxidants than cold-brew coffee. This contradicts the popular perception that cold brew is less acidic and thus less likely to cause gastrointestinal problems.
Researchers developed a diagnostic test that rapidly parses out infections of the brain from other diseases by analyzing cytokine profiles in cerebral spinal fluid. The test shows promise for quickly identifying central nervous system disorders and guiding immediate intervention.
Researchers at Jefferson University have identified a molecular lock and key that controls calcium's entry into mitochondria, revealing a new target for drug discovery. The finding suggests that compounds like ruthenium red/360 can block calcium entry into cells, potentially treating neurodegenerative diseases.
Researchers found that patients with a non-functional IDO2 gene had more favorable outcomes when receiving radiotherapy, living cancer-free for almost twice as long. The discovery could lead to personalized treatment recommendations and improve patient survival rates.
A new Lassa fever and rabies vaccine has demonstrated effective protection in animal models of disease, suggesting a new way to test for protection against the virus. Researchers have also identified a new surrogate measure of protection that could aid in vaccine development.
Contrary to conventional wisdom, some seizures begin after a brief burst from neurons that normally inhibit brain activity. Researchers found this unexpected mechanism in their study.
A recent study published in the journal Cancer found that patients with locally advanced prostate cancer who received a combination of prostate removal and radiation therapy had a higher rate of survival compared to those treated with radiation alone. The study analyzed data from over 13,000 men diagnosed with high-risk prostate cancer...
Mitochondria use one-way doors called mitochondrial calcium uniporter channel complexes (MCUCs) to control access, but the exit door proteins are abundant only in areas far from the entrances. This separation allows mitochondria to operate at maximum efficiency even when stressed.
A randomized controlled trial shows that a behavioral treatment, Behavioral Activation, can reduce the risk of future memory loss by increasing social, cognitive, and/or physical activity. The study found an 88% reduction in cognitive decline compared to the control group.
Patients with end-stage ankle arthritis experience significant improvements in range of motion, pain levels, and functionality after total ankle arthroplasty. On average, surgery boosts ankle range of motion by over 60% and reduces pain scores by 59 points.
Researchers identified APOBEC enzymes as major contributors to the development of aggressive skin cancer in patients with Butterfly Syndrome. The discovery reveals a mechanism that instigates tissue damage-driven cancers and provides new therapeutic strategies.
Blocking POM121 transport inhibits tumor aggressiveness and restores chemotherapy efficacy in preclinical models. This study identifies nuclear pore proteins as effective anti-cancer targets for advanced prostate cancers, offering a new approach to target undruggable molecular drivers.
A team of researchers has identified a complex interaction between three cell types that work together to recruit protective NK cells in the lymph node after a viral infection. This collaboration enables the body to mount an effective response against certain viruses, such as mousepox.
ER patients often want more than just a diagnosis; they seek reassurance, symptom management guidance, and navigation of the healthcare system. Research reveals that addressing these concrete needs can improve patient care outcomes.
Researchers discovered a molecular inhibitor that could help fight prostate cancer when resistance develops to CDK4/6 inhibitors. The study found that tumors become more aggressive and dependent on the MAPK-6 pathway when resistance occurs, making MEK inhibitors a potential therapeutic option.
Researchers at Thomas Jefferson University have discovered a single molecule, EphB2, that makes the yes-or-no decision to form stable connections between brain cells. The molecule repels unproductive contacts and connects where appropriate based on signal strength.
Researchers at Thomas Jefferson University successfully killed tumors and prevented metastatic growth in mouse models of colorectal cancer using CAR-T cell therapy, targeting the GUCY2C antigen. The therapy achieved high survival rates without side effects, paving the way for potential human clinical trials.
Researchers developed a composite score to identify census tracts with high prostate cancer burden, considering incidence and mortality rates. The tool helps pinpoint clusters of high-risk areas that don't always align with demographics, highlighting the need for further study on underlying factors contributing to poor outcomes.
Using advanced imaging technology, researchers found structural changes in the connections between neurons that strengthen to enable learning. The molecules involved in sending and receiving signals appeared to be organized in clumps or 'nanomodules' that both dance and multiply when stimulated by learning-like signals.
Researchers developed nanoparticles that deliver microRNA-29b to lung tumors, potentially improving treatment outcomes. The technology overcomes limitations of traditional delivery methods and demonstrates promising results in mouse models.
Researchers found that changing the scheduling of drug administration can improve outcomes in mouse models of melanoma, leading to more complete responses. A combination of MEK inhibitor given continuously with intermittent CDK4/6 inhibitor was the most effective schedule in mice.
Researchers discovered that a common Parkinson's gene mutation alters immune cells' reaction to generic infections like colds, triggering an inflammatory reaction in the brain. This 'second hit' initiates the destruction of brain areas responsible for movement.
Researchers have discovered that increasing lipid production in the lungs can reduce lung scarring by 70-80 percent. The study's findings suggest that failing to produce lipids due to injury or age-related metabolic changes may contribute to lung fibrosis development.
A recent study published in Scientific Reports suggests that the eye is not as immune as previously thought, with some components being accessible to immune cells. This discovery has implications for wound healing and changes in vision such as cataracts, and may change the way we think about eye disorders.
Researchers developed a method using next-generation genomic sequencing to isolate infecting organisms after joint replacement surgery. The technique identified pathogens in over 80% of cases that previously went undetected, revolutionizing treatment for patients with joint-replacement infections.
An international panel of experts has developed a comprehensive set of recommendations for genetic counseling and testing in men with high-risk prostate cancer. The guidelines aim to inform screening, treatment planning, and personalized care, taking into account the rapidly evolving field of practice.
Researchers at Thomas Jefferson University discovered how losing a gene leads to large-scale genetic changes that make cancer more aggressive and resistant to treatment. The study shows promise for personalized therapy using liquid biopsies to track RB status in prostate cancer patients.
The phase III clinical trial showed that fremanezumab reduced the number of headache days by an average of 4.3 days with quarterly treatment and 4.6 days with monthly treatment. The therapy also demonstrated a favorable safety profile, with most common adverse event being irritation at injection site.