Researchers found epigenetic alterations in normal breast tissue adjacent to cancer, marking susceptible precursor cells. These changes were associated with poorer prognosis and decreased survivorship from the disease. The study aims to decode how breast cancer develops and understand risk factors.
A team of scientists at UCL has discovered a way to fast-track the screening of induced pluripotent stem cells (iPSCs) using DNA methylation as a biomarker. This new approach can help identify 'good' and 'bad' cell lines, which is crucial for laboratory research and potential cell replacement therapies.
Researchers found that estrogens selectively calm hyperactive behavior in zebrafish with a genetic mutation linked to autism. The study suggests estrogens may target specific brain pathways affected in ASD, which could lead to new treatments for the condition.
A large study found tenofovir-resistant strains in 60% of HIV patients in sub-Saharan Africa, highlighting a significant concern for global HIV control strategies. The study suggests that up to 15% of HIV patients will develop resistance in the first year of treatment alone.
Research funded by the Medical Research Council found that bereavement by suicide increases the risk of suicide attempt by 65%, with 8% of those affected dropping out of education or work. Support and guidance are available to help those affected navigate their grief.
Researchers have found an epilepsy drug that can protect nerve damage in MS patients, according to a study published in the Lancet Neurology. The anti-convulsant drug phenytoin protected neural tissue in patients with optic neuritis, a symptom of MS.
Scientists have developed a new strategy for constructing highly specific synthetic pores using DNA, which can control the release of therapeutics. The pores are designed to act like doors, opening only when provided with the right key, allowing for precise targeting of drugs to specific tissues.
A new study has identified the factors contributing to the transmission of zoonotic diseases from bats to humans, highlighting areas at high risk in West Africa, sub-Saharan Africa, and South East Asia. The research used data spanning over 110 years to create a global map showing hotspots for bat-human virus transmission risk.
A new model developed by UCL scientists predicts the 'shelf life' of library and archival collections, taking into account factors such as temperature, humidity, and handling. The model suggests that a hotter and more humid climate will accelerate degradation, but also provides strategies for mitigating damage and optimizing preservation.
The study analyzed the fossil record and found a burst of evolution into new forms, followed by specialization that resulted in modern mammal groups. The team built an updated tree of life containing over 177 species, revealing a significant increase in mammal diversity after the extinction event.
A UCL-led study reveals that oxygen levels in oceans and atmosphere rose to support animal life 100 million years earlier than previously thought. This finding suggests that increased oxygen may have kick-started early animal evolution, rather than a change in animal behavior.
A UCL-led team used sophisticated imaging to track the degradation of disposable Lithium batteries in real-time, revealing internal structural damage that affects performance. The study provides valuable insights for manufacturers to predict battery performance and optimize material design.
A new study published in The Lancet found that annual blood tests for ovarian cancer screening may reduce mortality rates by up to 20%. The UK Collaborative Trial of Ovarian Cancer Screening showed a delayed effect on mortality between the screening and control arms, becoming significant after seven years.
A new study found that tropical groundwater is replenished disproportionately from heavy rainfalls, making it a climate-resilient source of freshwater. The long-term viability of these resources relies on the replenishment of groundwater supplies.
A new sensor developed by UCL scientists can detect and identify five commonly used explosives in solution within 10 seconds. The sensor uses fluorescent technology to create unique 'fingerprints' for each compound, allowing for multiple explosives to be detected with a single test.
A mathematical problem in particle and quantum physics is provably unsolvable, showing that even a complete microscopic description cannot predict macroscopic behavior. This finding limits the extent to which we can predict the behavior of quantum materials.
A new UCL study found that concentrating attention on a visual task significantly reduces brain response to sound and increases failures to detect audible sounds. This phenomenon, known as inattentional deafness, has serious implications for everyday life and tasks requiring focus, such as operating theatres or driving.
Scientists have discovered a potential solution to chronic pain by identifying the key ingredient responsible for painlessness in people born with a rare genetic mutation. By combining low-dose opioids with Nav1.7 blockers, researchers hope to replicate the effect and develop new treatments for millions of patients worldwide.
A new UCL study of 77,045 dementia patients across the UK found that those from more affluent areas are 27% more likely to be prescribed anti-dementia drugs. This inequality was not seen in Scotland, Northern Ireland, or Wales.
Researchers have identified a new way for molecules to move across graphene surfaces, allowing for faster and more controlled motion than previously observed. This discovery opens up possibilities for industrial applications in improved sensors and filters.
A new study by University College London finds that positive images are highly distracting, even when the task is difficult, while negative images can be ignored. The researchers suggest using positive images in marketing campaigns to capture attention, as people are more focused on pleasure seeking than potential harm.
A new UCL study has highlighted genes involved in schizophrenia and obesity, which could aid in developing improved prevention and treatment strategies. Variants in CRHR1 and SNORD115 were found to be more common in obese subjects, suggesting that disruptions in these genes may increase the risk of obesity.
A pair of neurons found in the brains of male nematode worms, called 'mystery cells of the male' or 'MCMs', are responsible for sex-based differences in learning and behavior. These MCMs create behavioral differences between males and females by changing a brain circuit common to both sexes.
A new study published in the Journal of Neuroscience found that the anterior cingulate cortex (ACC) responds differently to others' good fortune depending on an individual's level of empathy. Participants with high empathy scores showed a specialized ACC response only when another person was likely to win, while those with low empathy ...
New research shows Islamist insurgency has a strong impact on where polio cases occur, particularly in the past few years, likely due to counterinsurgency strategies. The study suggests that improving vaccines and administration is not enough to eradicate polio; political and social barriers must be addressed.
A study of 1,298 NFL coaches found that junior coaches with connections to highly reputable head coaches are more likely to receive promotions. However, these connections do not lead to superior career outcomes in the long term, and instead favor those who missed out on initial advantages but excelled through merit.
A study from UCL and Oxford University found that US NFL fans and sports reporters have unrealistic expectations about their team's performance. The average number of wins predicted by fans was 9.59, while expert predictions were no better than a naive forecasting model.
A new UCL study found that over one-quarter of people with intellectual disabilities in the UK are being inappropriately prescribed antipsychotic drugs. Behaviour problems not due to mental illness were often treated with these medications.
A study by University College London found that warm, stagnant water from the deep Arctic Ocean and Nordic Seas contributed to the end of the last Ice Age. The researchers used proxy data to reconstruct past ocean circulation changes, which showed a warmer deep Arctic Mediterranean during glacial times.
Researchers at University College London developed a novel AI approach to predict fine wine prices more accurately, outperforming traditional methods by 15% on average. The new method uses machine learning to learn relevant information from data and improve predictive accuracy.
Researchers found that Arctic sea ice experienced a significant increase in volume after a cool summer in 2013, contrary to expected long-term decline trends. This suggests the ice pack is more sensitive to summer melting than winter cooling, enabling better predictions of future changes.
Researchers at University College London have investigated positronium's behavior in collisions with hydrogen, argon, helium, and carbon dioxide gases. They found a strong preference for positronium to be emitted in the forward direction, particularly when positrons hit the gas at high speed.
Researchers at University College London have discovered that when we try to remember a single aspect of an event, our brain reconstructs the entire episode, including details we weren't consciously aware of. This process is made possible by the hippocampus, which associates different aspects of the event and enables pattern completion.
Healthy people given citalopram were willing to pay more to prevent harm to themselves or others than those on placebo drugs, highlighting the serotonin-enhancing antidepressant's effect on moral decision-making. In contrast, levodopa made healthy people more selfish and less altruistic.
Researchers monitored brain activity in rats and found that during rest, the hippocampus simulates walking to and from food that was previously inaccessible. This suggests that the hippocampus plans routes for the future as well as recording past experiences with motivational cues like food. The study could help explain why people with...
Scientists at University College London have designed a chemical compound called MM41 that targets quadruplexes, faulty genes found in pancreatic cancers. The compound reduced tumor growth by 80% and prevented regrowth in mice, showing promise for treating pancreatic cancer.
A UCL-led study has found that a small molecule drug, trametinib, can delay the ageing process in animals, including fruit flies. The treated fruit flies lived 12% longer than average, staying healthier for longer.
Researchers found that Titan's atmosphere loses hydrocarbons and nitriles due to a polar wind powered by sunlight and the Saturnian magnetic field. This phenomenon has been observed on Earth in polar regions, suggesting Titan may have a similarly widespread 'polar wind' beyond its poles.
A new calculation method developed by a UCL-led team of scientists can accurately predict how much radiation carbon dioxide absorbs, reducing uncertainties in climate change modeling and enabling more accurate predictions about Earth's warming over the next few decades. The improved accuracy will enable missions to achieve their goals.
Researchers discovered a genetic fault preventing SEMA3E from working correctly in two brothers with Kallman Syndrome, leading to the loss of nerve cells regulating sexual reproduction. The study demonstrates a powerful method for identifying genetic causes without relying on large statistical samples.
Research published in JAMA Oncology finds that smoking induces epigenetic changes in cheek cells, which can also be seen in non-smoking related cancers. This discovery provides a potential tool for early detection of breast and gynaecological cancers.
A new UCL study reveals that sex equality in residential decision-making explains the unique social structure of hunter-gatherers. The research found that when both men and women have influence over camp assortment, group relatedness is much lower due to individuals seeking to live with as many kin as possible.
A new test developed by a UCL-led team can identify drug-resistant tuberculosis strains in days, reducing the time needed for genetic sequencing from weeks to days. This could lead to better treatment outcomes and control of transmission.
Researchers at University College London have found that hepatitis B virus can persist in the liver by exploiting starved T cells. The study suggests that boosting the immune system and counteracting the liver's suppressive effect could potentially clear the infection.
A new screening method can detect twice as many women with ovarian cancer as conventional strategies, according to the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). The method uses a statistical calculation to interpret changing CA125 levels in women's blood, providing a more accurate prediction of individual risk.
A UCL-led team used high-energy synchrotron X-rays and thermal imaging to track lithium-ion battery damage in real-time. The study found that internal structural damage can spread to neighboring batteries, causing severe failure.
Hot vents on the seabed may have spontaneously produced organic molecules essential for life, according to a new study. The surfaces of mineral particles inside hydrothermal vents exhibit chemical properties similar to enzymes, allowing them to create simple carbon-based molecules like methanol and formic acid.
A UCL study finds that realising how places connect geographically causes local maps in the brain to join, forming one big map. This merged map helps with planning future journeys by understanding absolute location and distances between places.
Research reveals that men donate more when seeing other men have donated large amounts, especially if the fundraiser is attractive. Men compete to show generosity, while women don't react in a similar way.
Researchers found that the human immune system can control re-awakened HIV with a vaccine-based approach, reducing virus levels to 50 copies per ml within six weeks. This study demonstrates the potential of a 'kick and kill' strategy, which could lead to an effective cure for HIV.