A new ultra-sensitive test can detect mutant huntingtin protein in the cerebrospinal fluid of HD patients, predicting disease severity. The test has the potential to guide clinical decisions and monitor treatment efficacy.
A new model for HIV progression finds that it spreads in a similar way to some computer worms, predicting early treatment is key to preventing AIDS. The model shows that cell-to-cell transfer is an important part of HIV spread and that completely blocking this mechanism could prevent progression to AIDS.
Research from University College London found that young adolescents (aged 12-14) were most influenced by their peers' opinions on risk, while older age groups adjusted their ratings more towards adults. The study suggests that targeting adolescent social norms may be key to public health interventions.
Researchers at University College London used the thermal grill illusion to study pain perception. They found that crossing fingers can change what you feel on a single finger by manipulating the spatial arrangement of nerve pathways.
A study by University College London researchers discovered that male birds with physical ornaments tend to have genomes with mildly negative mutations. This leads to reduced fitness in their descendants. The study focused on the Galloanserae bird group, analyzing genetic material from various species.
Researchers have discovered that the three-dimensional structures of mRNAs determine their stability and efficiency inside cells. This knowledge could help explain minor mutations causing neurodegenerative diseases.
Researchers at UCL develop technology to suspend and cool glass particles to absolute zero, enabling the creation of quantum states in objects far larger than atoms. This could lead to breakthroughs in motion sensors and quantum computer networks.
Researchers used remote eye-trackers to monitor participants' gaze while thinking about complex moral questions. The results showed that participants' moral decisions were systematically biased towards the target alternative, with a 58% success rate for choosing the randomly selected option.
Scientists at UCL conclude humans became a geological power with global environmental changes starting around 1610. A golden spike marker, the 'Orbis Spike', was found in Antarctic ice-core records, indicating an irreversible exchange of species between the Old and New Worlds.
New research from University College London suggests that people with differing competence give each other's views equal weight, preventing optimal group decisions. This 'equality bias' affects decision-making processes in various contexts, including everyday situations and high-level policy decisions.
A new paint developed by researchers at UCL creates self-cleaning surfaces that resist everyday wear and tear. The paint's unique properties allow it to withstand damage and maintain its self-cleaning abilities, making it suitable for a wide range of applications.
Research from UCL's ESRC International Centre for Lifecourse Studies found direct biological effects of stress during unemployment contribute to higher levels of inflammatory markers, predicting atherosclerosis and heart disease. Unemployed men and women had higher levels than employed counterparts, with stronger effects in Scotland.
A new review finds that people with mild cognitive impairment are 65% more likely to develop dementia if they have diabetes and over twice as likely if they have psychiatric symptoms. Lifestyle changes such as a healthy diet and regular exercise may help prevent dementia.
Research at University College London reveals that grid cells in the brain modify their patterns based on the environment's geometry. The study found that grid patterns align with the local environment and distort in trapezoid-shaped spaces, challenging previous theories about the brain's navigation system.
Researchers have discovered a family of 'second laws' that govern the behavior of systems at very small scales, leading to counterintuitive phenomena and constraints on disorder. These new laws complement the traditional second law of thermodynamics, which describes the universe's growing state of disorder.
Researchers at UCL have developed a new method to process fibre optic signals, which can correct corrupted data and increase the useful capacity of fibres. This technique has the potential to double the distance data can travel error-free through sub-marine cables.
A new study published in Proceedings of the National Academy of Sciences has found microscopic spheres of calcium phosphate in eyes with age-related macular degeneration (AMD), a leading cause of blindness. The discovery opens up new avenues for diagnosis and treatment, potentially allowing early detection and prevention of the disease.
A third of oil reserves, half of gas reserves, and over 80% of current coal reserves globally should remain in the ground if global warming is to stay below the 2°C target. The study identifies regions that stand to lose most from achieving this goal, including China, Russia, and the United States.
Scientists at UCL have discovered the root of the problem in making blue LEDs by examining gallium nitride's unusual behavior using sophisticated computer simulations. The study reveals that doping with magnesium is necessary to achieve the desired properties, but the complexity of the process was previously unknown.
Researchers at UCL have developed a technique that combines two cutting-edge technologies to read and write electrical activity in the brain. By using flashes of light, they can both observe and control brain activity in mice, opening up new possibilities for understanding neurological conditions such as autism and dementia.
Adults who lose all their teeth show significant declines in memory and walking speeds compared to those with some teeth. The association between tooth loss and decline remains after adjusting for various factors.
Researchers have identified a key brain region responsible for navigational skills and found that its signal strength predicts performance. The study's findings provide new insights into the neural mechanisms underlying spatial navigation, which may help explain why some individuals are better at navigating than others.
A new study published in the Maternal and Child Health Journal found that households with obese mothers and stunted children often rely on high-energy, low-nutrient foods like chocolate and biscuits. In contrast, diets rich in fruits and vegetables are associated with lower rates of double-burden households.
Researchers developed a 'virtual lab' to study nanocomposites, allowing for prediction of material properties based on chemical composition and processing conditions. The simulations revealed how polymers and clay particles interact, enabling the development of improved composite materials.
UCL scientists have discovered a new pathway to deliver therapies to the nervous system, offering a potential treatment for tetanus and neurological disorders such as motor neuron disease. By blocking the entry of tetanus neurotoxin into nerve cells, researchers hope to develop targeted treatments with fewer side effects.
A UCL-led team of scientists has uncovered the structure of pores found in cell nuclei, revealing how they selectively block certain molecules from entering to protect genetic material and normal cell functions. The discovery could lead to the development of new antiviral drugs and better delivery mechanisms for gene therapy.
A UCL-led experiment found that people are willing to inflict an average of 20p per shock on themselves and 40p per shock on strangers in exchange for money, highlighting a surprisingly optimistic view of human nature. This contradicts previous studies claiming humans prioritize their own interests over others.
Researchers have developed a new method using virtual reality to improve self-compassion in individuals, particularly those with high levels of self-criticism. The study found that women who experienced a first-person perspective through the eyes of a virtual child showed increased feelings of contentment and reduced self-criticism.
A UCL-led study found that individuals with the greatest sense of wellbeing were 30% less likely to die over an eight and a half year period than those with the least wellbeing. People with higher wellbeing lived on average two years longer than those in lower wellbeing groups.
A study of 517 mothers found that nearly 15% had taken recreational drugs during pregnancy, and mothers of babies with brain birth defects were more likely to have used drugs. The study suggests a link between brain birth defects and recreational drug use in expectant mothers.
Researchers have found that emerging viruses are causing severe disease and mass deaths in many amphibian species, including frogs and salamanders. The viruses, part of the Ranavirus group, are being spread through human activities and are having a devastating impact on entire host communities.
Researchers at UCL discovered that new myelin must be made each time a skill is learned later in life, and its structure changes during practice. The team found that once a new skill has been learnt, it is retained even after myelin production stops.
Research published in JAMA Psychiatry found that leisure time physical activity reduces depressive symptoms and risk of depression, with a protective effect across the entire population.
Researchers found stenting as effective as endarterectomy for preventing fatal and disabling strokes, with slightly higher risk of minor strokes in the stented group. The study suggests stenting should be offered to more patients under 70 due to its lower risks.
Poor oral health in elite athletes shows no signs of improvement and must be remedied. Experts recommend simple measures like better brushing and flossing can provide marginal performance gains similar to expensive physical therapies.
A new web privacy system, COWL, protects users' data by confining malicious code, allowing flexible web development while improving surfing safety. The system will be freely available for download on October 15th.
A randomized controlled trial found that using StopAdvisor increased the likelihood of quitting among lower-income smokers by 36%. The website was designed to mimic the support provided by NHS stop-smoking advisors and improved quit rates among those with lower socioeconomic status.
A large-scale analysis found statin use associated with a 12% increased risk of type 2 diabetes over four years, as well as an average weight gain of 240g. Genetic variants linked to statin efficacy also showed smaller effects on weight and diabetes risk.
Research from University College London suggests reducing sugar consumption to 3% of total energy intake can significantly reduce tooth decay. Experts recommend policy changes to address the issue, including taxing sugar-rich foods and drinks.
A study of 2,944 UK adults found that those who experienced weight discrimination gained more weight than those who did not, on average gaining 0.95kg while those without discrimination lost 0.71kg over four years. This contradicts the common perception that fat shaming might encourage weight loss.
A new study led by University College London found that 40% of women with severe mental illness have suffered rape or attempted rape in adulthood, compared to 7% of the general population. Women with severe mental illness are also more likely to suffer domestic violence, with 69% reporting childhood abuse and 49% reporting adult abuse.
Researchers from UCL and collaborators aim to determine whether numerous small galaxies or rare quasars produce more ultraviolet light. A forthcoming survey will analyze detailed measurements of a million distant quasars to map the neutral hydrogen gas in the universe, revealing its history.
Researchers at UCL used mathematical modeling to find that life's Last Universal Common Ancestor (LUCA) had a 'leaky' membrane, enabling it to harness energy from its surroundings. This discovery answers two big questions in biology: how cells harvest energy and why bacteria and archaea have different cell membranes.
Researchers have discovered a way to efficiently generate and control currents using the magnetic nature of electrons in semi-conducting materials, which could lead to the development of new electronic devices. This approach, known as spintronics, has the potential to outperform traditional technologies with lower power consumption.
New research finds that weight loss significantly improves physical health markers but is less effective in improving mood and overall wellbeing. Participants who lost at least 5% of their initial body weight were more likely to report depressed mood, even after adjusting for serious health issues.
Researchers at UCL developed an equation to predict happiness based on recent rewards, expectations, and neural activity. The study involved 18,420 participants and found that moment-to-moment happiness reflects not just how well things are going but whether they're better than expected.
A study found that goalkeepers dive in the opposite direction of consecutive penalties aimed in the same direction, exploiting the 'gambler's fallacy'. However, kickers failed to capitalize on this pattern, suggesting they focus on their individual kicks rather than the goalkeeper's previous moves.
A recent UCL study discovered that the human habenula, a tiny part of the brain, tracks expectations about negative events like painful electric shocks. This tiny region suppresses dopamine, driving motivation, and its activation can signal how bad outcomes are expected.
The study found that invertebrate numbers decreased by 45% over a 35-year period, with habitat loss and climate disruption being major contributors. This decline compromises nature's ability to provide essential services such as pollination, pest control, nutrient cycling, and water filtration.
A rare gene variant associated with a threefold risk of bipolar disorder, a two-to-three-fold increased risk of schizophrenia or alcohol dependence, and a threefold risk of developing the condition. The variant is found in approximately one in every 200 people.