Hybrid hepatocytes, discovered by researchers at University of California - San Diego School of Medicine, have been found to proliferate and replenish liver mass after chronic liver injuries, showing promise as a therapeutic option for liver diseases. Unlike induced pluripotent stem cells, hybrid hepatocytes do not contribute to cancer.
Researchers at University of California, San Diego School of Medicine reveal a more accurate structure of Protein Kinase C (PKC), providing new targets to fine-tune the enzyme's activity. The corrected structure suggests ways to turn PKC 'on' for cancer treatment and 'off' for neurodegenerative disease treatment.
A study by University of California, San Diego researchers found that Medicare reimbursement for radiation therapy varies widely among patients with breast, lung, and prostate cancer. Factors such as provider type, location, and clinic type accounted for most of the variation in costs.
Researchers define the core set of genes and functions that a bacterial cell needs to sustain life, providing a foundation for new cell engineering approaches. The study identifies 356 essential genes across various microorganisms, enabling the rapid construction of genome-scale cellular growth models.
Researchers found that nearly 25% of female sex workers entered the sex trade before age 18, and six percent tested positive for HIV. Adolescents were more likely to experience violence, have multiple clients per day, and not use condoms, increasing their risk of infection.
Researchers found that mice with lower levels of EDNRB protein are more tolerant to hypoxia and better able to maintain cardiac function and oxygen delivery. This study suggests that EDNRB could be targeted to treat sea level diseases related to low oxygen, such as heart attack and stroke.
Researchers have demonstrated a direct connection between two signaling proteins (NOX1 and NOX4) and liver fibrosis, a scarring process underlying chronic liver disease. The study adds credence to a pharmaceutical effort to create new treatments for diabetic nephropathy, liver fibrosis, and other progressive fibrotic diseases.
Engineers at the University of California, San Diego, have found inspiration in the boxfish's armor, which includes hexagon-shaped scales and sutures. The structure provides a balance between flexibility and strength, making it an ideal design for body armor and flexible electronics.
Researchers will evaluate existing Cathepsin S inhibitor as new potential Chagas disease therapeutic, addressing a neglected tropical disease with no FDA-approved therapies. The grant aims to confirm the antiparasitic activity and test safety and effectiveness in humans.
Researchers have established the safety and dosing of a new drug for treating blood cancers, targeting dormant cancer stem cells. The drug coaxes these cells to differentiate and exit the bone marrow, where they can be destroyed by chemotherapy agents.
Researchers from Scripps Institution of Oceanography accurately mapped the 7.8-magnitude Nepal earthquake's movement, revealing a three-stage rupture process that poses significant seismic risks to the region. The study will serve as an important benchmark for understanding future seismic risks in the Himalayan region.
Researchers at University of California, San Diego School of Medicine discovered a protein's critical role in developing and progressing acute myeloid leukemia. Blocking this molecule leads to a profound inhibition of leukemia growth, offering a novel target for better treating AML.
A new study by University of California, San Diego researchers has identified a pivotal player in diabetic kidney disease and a potential biomarker for diagnosing and monitoring chronic kidney disease. The study uses metabolomics analysis to clarify a central mechanism of action involving the NADPH oxidase proteins NOX1 and NOX4.
In bacterial communities, resolving social conflict is key to survival. The discovery reveals that biofilms develop an 'emergent phenomenon' where individuals balance opposing needs through metabolic codependence. This strategy allows bacteria to coordinate activities, resolve internal conflicts and ensure the survival of the community.
Researchers at University of California, San Diego School of Medicine have developed a novel treatment regimen that effectively treats hepatitis C virus (HCV) in patients co-infected with human immunodeficiency virus type 1 (HIV), with a 97% success rate
Scientists have discovered that light can be stored and trap particles of light called phonon polaritons behave in unique ways. The light's movement isn't random but follows fixed angles with respect to the atomic structure, leading to interesting resonances.
Researchers at Harvard University and UC San Diego have developed a new software that predicts the most active guide RNAs for specific gene targets, facilitating faster and more efficient genome engineering experiments. This breakthrough has the potential to accelerate discoveries in gene therapies and basic genetics research.
Scientists designed nanoparticles that release chemotherapy drugs paclitaxel in the presence of matrix metalloproteinases (MMPs), which enable cancer metastasis. The system effectively delivers high doses of the drug, halting tumor growth and reducing toxicity.
Researchers found that learning enhances top-down control in the brain's visual cortex, allowing it to better predict and fill in missing information. This cognitive process has implications for understanding psychiatric diseases such as schizophrenia.
The study identifies the retrosplenial cortex as a critical brain region for navigating complex environments, combining mapping interior and exterior spaces. The findings support computational modeling research and clinical observations of Alzheimer's disease, with potential applications in robotics and early disease detection.
Researchers found a strong correlation between the three-dimensional shape of the cerebral cortex and ancestral background. The study used data from over 1,200 children and adolescents to analyze genetic and neuroimaging information.
Researchers at the University of California - San Diego have created a 3D-printed robot with a soft exterior and rigid core, enabling over 30 untethered jumps. The robot's design combines nature-inspired materials to achieve improved agility and robustness for safe human interaction.
Scientists at the University of California - San Diego have designed a new type of cloak that is both thin and does not alter the brightness of light around a hidden object. The technology behind this cloak has more applications than invisibility, such as concentrating solar energy.
Researchers found an enzyme called LSD1 turns off genes required to maintain cancer stem cell properties in glioblastoma. Drugs modifying LSD1 levels could provide a new approach to treating the disease.
A team of researchers found that a seahorse's square, overlapping tail segments provide better armor and gripping abilities compared to traditional cylindrical tails. The squared shape absorbs more energy before permanent failure begins and creates more contact points with surfaces.
A recent study found that statins can decrease aggression in men, while increasing it in postmenopausal women. The effects on testosterone and sleep levels also played a role in the observed changes.
Researchers found improved median survival of patients with low-grade gliomas increasing from 44 months to 57 months between 1999 and 2010. The study suggests more effective chemotherapies contribute to the increased survival, despite a decrease in radiation therapy use.
A new study using high-resolution simulations suggests that there are far fewer faint galaxies than previously thought. The Renaissance Simulations, conducted on the Blue Waters supercomputer, show hundreds of well-resolved galaxies and provide novel predictions for the James Webb Space Telescope.
A recent study discovered that Daple protein is a tumor suppressor in the early stages of colorectal cancer, but may actually facilitate disease spread at later stages. Researchers found that higher levels of Daple were associated with better patient survival rates and lower tumor growth.
Scientists at UC San Diego discovered that freshwater planarians are comparably sensitive to tested chemicals as zebrafish larvae and nematodes, but offer unique advantages such as studying genetically identical adult and developing animals. This could reduce the use of laboratory mammals in toxicology tests.
Scientists discover that mass extinction event triggered by asteroid strike led to the rise of ray-finned fishes as the ocean's most diverse and dominant vertebrates. The abundance of ray-finned fish teeth began to explode after the extinction event, becoming eight times more abundant in 24 million years.
Researchers at UC San Diego School of Medicine have discovered a self-regulating loop in the Hippo pathway that maintains cellular balance by controlling cell growth and promoting cell death. This finding has significant implications for understanding cancer development and potential therapeutic targets.
Researchers at University of California, San Diego School of Medicine found that early indicators of Alzheimer's disease are not fixed in a specific sequence, complicating diagnosis efforts. The study suggests that different neurobiological pathways lead to the expression of the disease.
A new study provides the first detailed view of calling blue and fin whale distribution in Southern California, revealing a steady population trend for blue whales and an upward trend for fin whales. The research uses acoustic data collected from 2006-2012, indicating that fin whales are more likely to be detected further offshore.
Electrical engineers have developed a method to increase the distance information can travel in fiber optic cables without distorting the signal. By using wideband frequency combs, they can predict and reversible crosstalk between communication channels, enabling longer transmission distances and cheaper networks.
Researchers have successfully controlled the length and strength of waves of atomic motion, promising applications in fine-scale imaging and information transmission. Hybrid polaritons propagate throughout many layers of a crystalline material and can be tuned with an electronic gate.
Researchers at UC San Diego have developed a new method to control electrical transport through high-temperature superconductors, enabling the creation of sophisticated electronic devices capable of measuring tiny magnetic fields in the brain or heart. This breakthrough paves the way for improved satellite communications and novel tech...
Researchers at UC San Diego have designed and synthesized artificial cell membranes capable of sustained growth. The membranes mimic features of complex living organisms, adapting to environmental cues and supporting persistent phospholipid formation.
Researchers at University of California, San Diego School of Medicine have identified a biological marker for mental illness in female patients. The study found that specific genes, including XIST, are over-produced in women with mental illnesses like bipolar disorder, major depression, and schizophrenia.
The study found that Fam20C phosphorylates more than 100 different secreted proteins, directing numerous cellular processes. This discovery has significant implications for understanding cancer cell metastasis and developing new therapeutic targets.
Researchers used X-ray imaging and data analysis to study the mechanical properties of a cathode material called LNMO spinel. The study found that defects within the material move around when charged, causing changes in strain fields. This unique behavior may be used to design new battery materials with improved performance.
Researchers identified two genes, ERCC1 and TS, that can predict positive response to chemotherapy and longer survival times in metastatic colorectal cancer patients. Low levels of these genes are associated with improved survival rates when treated with oxaliplatin, while high levels may require irinotecan as the first treatment choice.
A team of researchers found that the contractile function of fruit flies' hearts is improved when overexpressing vinculin, a protein that accumulates at higher levels in aging rats and humans. This improvement leads to longer lifespans in genetically modified flies.
A study published in PLOS ONE found that men under 45 who consume more trans fats have poorer memory function, with an average drop of 86 words recalled compared to those consuming no trans fats. The researchers linked this association to the adverse effects of trans fats on brain function.
Researchers found that growing bacteria in mammalian tissue culture media instead of standard bacteriologic media makes them more sensitive to azithromycin. The drug is also effective when paired with colistin or antimicrobial peptides produced by the human body during infection, reducing bacterial counts by up to 99% in mouse models.
Boosting a naturally occurring molecule in the body can help protect against obesity-related diseases by reducing inflammation in fat tissues. The study found significant disease improvement, primarily affecting fat tissue, and demonstrated the potential of fundamental research to reduce inflammation.
A team of scientists has developed a new method to visualize the growth of complex self-assembled nanostructures in liquids, enabling detailed understanding of their formation. This breakthrough will facilitate future advances in nanotechnology.
Researchers at the University of California, San Diego developed a novel facial pattern recognition software to assess pediatric pain levels. The software achieved good-to-excellent accuracy in assessing pain conditions and performed equivalent to parents but better than nurses.
A team of engineers at the University of California, San Diego, has developed a smart fabric that can regulate body temperature using adaptive thermoelectric technology. The smart fabric aims to cut energy use in buildings and homes by at least 15%, reducing heating and air conditioning bills.
A study identified a previously unknown gene mutation underlying achromatopsia, an inherited eye disorder that causes severe color blindness and visual impairment. The ATF6 gene mutation damages proteins necessary for proper function of the cone photoreceptors, leading to significant vision loss.