Researchers from the University of Sheffield have discovered spherical structures in zebrafish brains containing nitric oxide, potentially linked to genetic forms of stroke. The study provides new insights into neurological and cardiovascular research.
Researchers developed a new class of drugs to treat autosomal dominant polycystic kidney disease (ADPKD), a hereditary progressive disease causing cysts and kidney failure. The compound reduces levels of cyclic AMP, suppressing cyst growth and potentially controlling the disease.
Scientists at the University of Sheffield have discovered a new compound that kills antibiotic-resistant gram-negative bacteria, including E. coli. The compound's unique properties make it difficult for resistance to emerge in the bacteria, paving the way for new treatment options.
New research at the University of Sheffield reveals that dead cells can disrupt the normal function of immune cells, called macrophages, which are crucial for responding to wounds and patrolling for infection. The study's findings could lead to new therapies to manipulate white blood cells and accelerate healing processes.
Researchers discovered that bedbugs have been parasitic companions with other species aside from humans for more than 100 million years. The team found that bedbugs are 50 million years older than bats and were already specialized on a single host type, even though the host was unknown at the time of T. rex.
Scientists at the University of Sheffield discovered how genes create proteins based on mRNA instructions, helping understanding of cancers and conditions like motor neuron disease. The process, similar across many living organisms, could aid development of treatments for human diseases.
Researchers at the University of Sheffield have discovered a mechanism used by bacteria E. faecalis to hide from the immune system, paving the way for new treatments. The study found that the bacteria modifies its cell surface to evade recognition by host immune cells.
Scientists at the University of Sheffield used a high-speed camera to measure the mass and radius of an ancient star for the first time. This breakthrough verifies stellar structure theory and provides detailed predictions about the star's brightness, color, and future evolution.
Researchers discovered how specific fungal prostaglandins deactivate immune cells, allowing fungi to grow and increase infection. This finding provides insight into the interaction between fungal pathogens and the human immune system.
Researchers found that females who had assistance from other female helpers benefitted from a longer, healthier lifespan. Older dominant females really benefit from having female helpers, losing less of their telomeres and aging slower.
Researchers discovered that graphene-like materials stack together in a way that changes their properties, creating novel hybrid materials. The twist angle controls the hybridization, enabling precise control over composite materials and nano-devices.
Scientists have discovered a new gene variation that causes motor neurone disease (MND) in a novel biological pathway. MND is a devastating neurodegenerative disorder affecting the nerves, causing muscle weakness and eventually wasting.
Researchers from the University of Sheffield discovered a compound that kills cancer cells without triggering apoptosis, making it resistant to treatment. The new drug lead is highly active against treatment-resistant cancers and may be particularly effective against ovarian cancer.
Researchers at the University of Sheffield have developed a new method to protect concrete from fire damage using recycled tire fibers. The fibers reduce spalling and strengthen steel reinforcements, preventing collapse and structural failure.
Scientists discovered grasses are genetically modifying themselves by taking genes from neighbors, gaining a competitive advantage and breaking the rules of evolution. This process, called lateral gene transfer, allows them to adapt to their environment without millions of years of natural selection.
Scientists have discovered new messenger molecules, miR-494-3p, that regulate genes involved in maintaining neuron health. The study found that introducing this micro-RNA into astrocyte-motor neuron cultures significantly improved neuron survival rates, potentially leading to new therapies for ALS and other neurodegenerative diseases.
A large-scale genetic study has uncovered 52 new genetic changes linked to osteoarthritis, which may help identify new treatment targets and repurpose existing medications. The study analyzed the genomes of over 77,000 people with osteoarthritis and found potential avenues for drug exploration.
Researchers have developed a new approach to creating engineering components using additive manufacturing by mimicking polycrystalline microstructures in lattice structures. These meta-crystals exhibit high energy absorption and can withstand up to seven times the energy before failure compared to single-crystal materials.
Researchers developed a new concept called Ancient Ancestry Informative Markers (aAIMs) that can accurately identify and classify ancient populations. The tool enables testing of an individual's similarity to ancient people from various regions, providing insights into their primeval origins.
Engineers at the University of Sheffield are developing more effective bomb protection systems by studying explosions in detail. The project aims to provide a better understanding of blast loading and its effects on structures, enabling the design of safer buildings and materials.
Scientists from the University of Sheffield have created zebrafish that carry the genetic change known to cause motor neurone disease. This breakthrough will accelerate pioneering research and experimental drug trials, which could lead to new treatments for the devastating neurogenerative disorder.
Researchers have discovered a binary star system containing massive Wolf-Rayet stars that are spinning extremely fast, producing incredibly fast winds. The system's wind speeds are 100,000 times quicker than a hurricane on Earth, while the surrounding dust cloud moves at a much slower pace, suggesting unequal gas distribution.
Scientists have discovered a new OGG1 inhibitor that decreases lung inflammation in mice, which could lead to better treatments for diseases like sepsis and autoimmune disorders. The inhibitor blocks the onset of inflammation associated with oxidative stress, offering a new mechanism for preventing inflammatory conditions.
A study by the University of Sheffield reveals that high levels of nitrogen dioxide pollution damage plant defenses, leading to poor growth in herbivorous insects. The research suggests that urban green spaces play a modest role in removing pollutants from the air.
Researchers found that shark scales follow the same patterning method as mouse hair and chicken feathers, reducing drag for efficient swimming. Studying this process can help design new materials with similar properties.
A study found a concerning decrease in antibiotic prescribing for high-risk dental patients, despite an increase in infective endocarditis cases. The research supports the American Heart Association's recommendation to continue prophylaxis for those at high-risk of IE.
A joint study by University of Sheffield and National University of Singapore found that combined impacts of deforestation and wildlife trade on Sundaland bird species are underestimated, with 50-90 species at risk of extinction by 2100.
Researchers have identified optimal bridge concepts that require minimal material volume, potentially making longer spans feasible. The proposed designs contain regions resembling a bicycle wheel and would be significantly lighter than traditional suspension bridge designs.
A study by the University of Sheffield found that online abuse of UK politicians on Twitter increased substantially between 2015 and 2017, with more abuse sent in 2017. The most common topics for abusive replies were national security and terror attacks.
A new study reveals that two-thirds of alcohol industry revenue in England comes from consumers drinking at risky levels. If all drinkers complied with the Chief Medical Officer's recommended guideline levels, alcohol sales would decline by £13 billion.
A new study from the University of Sheffield found that areas with a high density of alcohol outlets have higher drink-related hospital admission rates. The places in England with the most pubs, bars, and nightclubs had a 13% higher admission rate for acute conditions caused by alcohol.
The study, conducted by the University of Sheffield, found that 2.2% of participants were infected with high-risk human papillomavirus (HR-HPV) oral infection, lower than previous US studies. Smoking and sexual behavior were identified as significant risk factors for oral HPV infection.
Researchers found that periwinkles have developed a genetic toolkit with specific genes clustered on three chromosomes to help them adapt to environments threatened by crabs and waves. This rapid adaptation is thought to have occurred within 5,000 generations, enabling the snails to survive in rapidly changing coastal habitats.
Rice plants engineered to have fewer stomata are more tolerant of drought and resilient to future climate change, conserving water and surviving longer under drought and high temperatures. This discovery has significant implications for food security as much of the global rice crop relies on rain-fed agricultural systems.
The research identifies 22 key questions to address the most pressing knowledge gaps in chemical regulation, including identifying hotspots of contaminants and developing methods to protect biodiversity. Scientists emphasize the need for a holistic approach to assessing the effects of combinations of chemicals on ecological communities.
A new study by the University of Sheffield has discovered that antimicrobial resistant pathogens use benign bacteria present in the skin to initiate infection. The study reveals how Staphylococcus aureus can survive immune system mechanisms, providing new avenues for approaches to prevent and treat infection.
The team has generated rapid single-photon light pulses, which cannot be intercepted without disturbing them. This enables secure data transfer using light passed along fibre optic cables, making it ideal for environments where security is paramount.
Scientists have developed a biodegradable patch that sticks to the inside of the mouth, administering steroids directly to oral ulcers while creating a protective barrier. The novel plaster, called Rivelin, is effective in treating conditions such as oral lichen planus and recurrent aphthous stomatitis.
Researchers found that ASMR users had significantly reduced heart rates while watching ASMR videos compared to non-users. They also experienced increased positive emotions, relaxation, and social connection.
A new study reveals children's immune systems can control infections and prevent sepsis, a disease responsible for more UK deaths than cancer combined. The research identifies key responses in children's cells that help them ward off severe infections.
Scientists at the University of Sheffield have discovered an enzyme called UCHL3 that regulates DNA repair and may hold promise in improving treatment for chemotherapy-resistant cancers. The findings also suggest a link between UCHL3 activity and brain ageing, which could impact memory, cognitive function, and learning.
A new study reveals widespread labor exploitation in the global tea and cocoa industries, with workers facing severe poverty, abuse, and lack of basic services. The research found that even certified companies are failing to prevent labor abuses, highlighting a need for structural changes to address the root causes.
Researchers from the University of Sheffield have developed an algorithm that pairs wearable sensors with real-life data to monitor MS patients' walking patterns. This innovation helps clinicians assess treatment effectiveness and disease progression, leading to better patient outcomes.
Researchers have determined the structure of a photosynthetic LH1-RC complex from the bacterium Blastochloris viridis, which can harness and use light at wavelengths over 1,000 nm. This breakthrough reveals how the protein converts near-infrared light into an electrical charge to power cell metabolism.
A study by University of Sheffield researchers found that honeybee colonies follow the same laws as the human brain when making collective decisions, including Pieron's Law, Hick's Law, and Weber's Law. This discovery could lead to a better understanding of the basic mechanisms of human behavior and cognition.
A study from the University of Sheffield found that a rapid switch from coal to natural gas in Britain resulted in a 6% decrease in emissions. The key factor behind this reduction was effective carbon pricing, which incentivized the fuel switch.
Researchers have discovered nine new genes associated with osteoarthritis, a degenerative disease causing joint damage and pain. The findings could lead to the development of targeted therapies for this debilitating condition, affecting 10 million people in the UK.
A new study suggests that adding fast-reacting silicate rocks to croplands can capture CO2, reduce pests and diseases, and restore soil fertility. This approach doesn't compete for land or increase freshwater demand, offering benefits such as reduced fertilizers and pesticides use.
Researchers from the University of Sheffield have identified key drivers of herbicide resistance in crops, including higher volumes of herbicide use. The study found that farms using more herbicides had greater resistance, highlighting the need for diversifying management techniques to reduce evolution of resistance.
A new study from the University of Sheffield has found that patients with a longer clot lysis time are at higher risk of recurrent myocardial infarction or death due to cardiovascular disease. The research may lead to new treatments targeting fibrin clot lysis time, aiming to reduce this risk.