A team of scientists and students from the University of Sheffield has published blueprints for a cheaper single-molecule microscope, making the technique more accessible to labs worldwide. The smfBox microscope is capable of single-molecule measurements and works as well as commercially available instruments.
Researchers from University of Sheffield and Manchester investigate link between heart disease and vascular dementia, testing a drug used to treat arthritis as a potential therapy. The study aims to identify a new treatment for vascular dementia, which affects 15% of all dementia cases.
Researchers found that male and female birds have different gene expressions due to alternative splicing, enabling the evolution of sex-specific traits. This process is crucial for generating biodiversity across the animal kingdom.
A national survey found that many cancer patients lack nutritional advice and face difficulties such as diarrhoea, appetite loss, and changes in taste and smell. Researchers emphasize the importance of individualized guidance for improved quality of life and overall survival.
A new drug developed by University of Sheffield researchers could block signals from a hormone that helps cancer cells grow and spread, potentially improving life expectancy and quality of life for pancreatic cancer patients. The compound targets a specific receptor in cancer cells without affecting vital bodily processes.
Researchers at University of Sheffield and UCL identified a key stage in forming the enteric nervous system using pluripotent stem cells. This breakthrough could pave the way for new treatments for neurodegenerative diseases such as Parkinson's, which is initiated in the enteric nervous system before reaching the brain.
Researchers developed new international radiocarbon calibration curves, improving accuracy for dating artefacts and predicting future climate patterns. The updated curves provide previously impossible precision and detail, enabling scientists to study the demise of the Neanderthals and understand historic climate patterns.
Scientists used mathematical modeling to track long-tailed tits in Sheffield's Rivelin Valley, finding patterns that help explain flock segregation. The study reveals birds avoid larger flocks and prefer woodland centers, contradicting previous assumptions about their behavior.
A new study published in PNAS explores the impact of poverty alleviation efforts on environmental targets, finding that successful programs can increase food production and reduce poverty but may also lead to trade-offs with environmental protection. The research highlights the importance of considering social and environmental outcome...
A new study from the University of Sheffield reveals that artificial intelligence (AI) can detect neurodegenerative disorders like Alzheimer's before progressive symptoms worsen. AI-powered technologies can help predict disease progression and suggest the best treatments for individual patients.
Scientists at the University of Sheffield have discovered genetic mutations in MRSA that allow it to become highly resistant to antibiotics like penicillin. This finding reveals important details on how MRSA evolves resistance and provides insight into developing new treatments and drugs.
A novel genetic measure called gSOS has been developed to assess fracture risk in osteoporosis, which could reduce the need for bone mineral density tests by 37-41%. This cost-effective approach may improve healthcare efficiency and identify individuals at higher risk of diseases like cancer and cardiovascular disease.
A new COVID-19 strain with the D614G mutation has become the globally dominant form, according to a recent study published in Cell. The variant is more infectious in cell cultures under laboratory conditions, leading to higher viral loads in patients with Covid-19.
Researchers found that long-tailed tits use distinctive calls to recognize close relatives and avoid inbreeding. The study reveals a potential mechanism for these birds to minimize the risk of reducing reproductive success.
Research by the University of Sheffield reveals people with diabetes are at a greater risk of bone fractures, especially hip fractures. Severity and length of time living with the condition also increase this risk.
The study, published in The Astrophysical Journal, found that there are more stars like the Sun than expected in these groups, increasing the chances of finding Earth-like planets. These 'magma ocean planets' are easier to detect near stars like the Sun and emit heat that can be observed with next-generation infrared telescopes.
A new study from the University of Sheffield reveals that bird species' development time is influenced by their lifestyle, environment, and evolutionary history. The research found that 'live fast die young' strategies allow birds to maximize offspring production in short periods.
Researchers at the University of Sheffield have discovered ways to reduce DNA damage and mutations in pluripotent stem cells, a crucial step for regenerative medicine. The findings may allow for safer use of these cells in patients and significantly reduce the risk of genetic mutations.
A study found 28 out of 55 UK rice samples contained high levels of arsenic, exceeding European Commission regulations. Brown and wild rice were found to contain higher levels of the carcinogen than white or organic rice.
Scientists have produced the first high-resolution images of the cell wall of Staphylococcus aureus, a deadly bacterium with antibiotic-resistant form MRSA. The findings overturn previous theories about bacterial structure and provide insight into how antibiotics work.
Researchers at the University of Sheffield have discovered a link between defective immune cells and rare childhood brain disorders, such as leukodystrophies. These diseases cause severe physical and mental disabilities in children, with limited treatment options available.
Research by University of Sheffield physicists indicates a difference in neutrino and antineutrino behavior, which could help explain the universe's matter-matter asymmetry. The T2K experiment strengthens previous observations and paves the way for future discoveries.
Researchers from the University of Sheffield found that plants in Peak District grasslands share key nutrients to co-exist, leading to high levels of plant diversity. This sharing is known as resource partitioning, allowing different types of phosphorus compounds to be used by each plant.
Research suggests that urban horticulture can provide a significant portion of the local population's 'five a day' by growing fruit and vegetables in domestic gardens, allotments, and public green spaces. This could feed approximately 709,000 people per year if all space is utilized.
Researchers at the University of Sheffield have discovered a pulsating ancient star in a double star system, allowing them to study the internal structure of a white dwarf in detail for the first time. The discovery provides key insights into the structure, evolution, and death of white dwarf stars, including their composition.
Researchers have discovered a novel 'toolkit' of proteins that can repair breaks in DNA, which can lead to cellular ageing, cancer, and neurological diseases. The discovery of the protein TEX264 holds promise for treating cancer and preventing age-related diseases.
Researchers at the University of Sheffield have developed a new compound that can kill cancer cells deep within tumors, addressing two major drawbacks of current photodynamic therapy. The compound uses infrared light to damage DNA directly, bypassing oxygen requirements.
Researchers found that switching to a rich diet after eating a restricted diet can decrease life expectancy and have negative effects on health. The study challenged the existing evolutionary theory, suggesting that dietary restriction triggers a survival strategy in humans and animals.
Researchers at the University of Sheffield have identified a class of cancer drugs that accelerate neutrophil cell death and promote healing in the lungs. This breakthrough could lead to the development of effective treatments for chronic obstructive pulmonary disease (COPD), which affects millions worldwide.
Researchers identified families with high carbon footprints as consuming more sweets, alcohol, and restaurant food. These food choices contribute significantly to their higher carbon footprint, with meat consumption explaining less than 10% of the difference.
A new gene therapy aims to 'switch off' genes that promote cardiovascular disease by reducing fatty material buildup in arteries. The treatment, developed at the University of Sheffield, has the potential to slow or stop the progression of heart disease.
Researchers at the University of Sheffield have identified an antibody that can potentially become a new treatment for pulmonary arterial hypertension. Treatment with this specific antibody was found to reverse the process behind PAH development, showing promise for clinical development.
Researchers have solved the structure of cytochrome b6f, a protein complex that powers plant growth via photosynthesis. The discovery reveals new insights into how the complex regulates photosynthetic efficiency in response to environmental conditions.
Researchers at the University of Sheffield have discovered that a bacterial toxin, lysostaphin, targets and breaks down MRSA cell walls, making it effective against antibiotic-resistant superbugs. This finding could lead to the development of new treatments targeting the same mechanism.
A new guide published by University of Sheffield researchers suggests that end-of-life carers should be entitled to up to six months paid time off work and job safeguards. The study highlights the economic benefits of supporting working carers, who can provide valuable services to society while reducing the burden on the NHS.
Researchers have identified a new therapeutic target for treating cardiovascular disease by studying the role of the TRIB1 protein in immune cells. The study found that higher levels of TRIB1 increased cholesterol uptake in foam cells, promoting arterial disease.
A recent University of Sheffield study found that taking vitamin D by oral spray is just as effective as taking a tablet in improving levels. The six-week trial compared the efficacy of vitamin D3 delivered through both capsule and sublingual methods, with results showing an equal rate of improvement in participants.
Research from the University of Sheffield's School of Health and Related Research found nearly 2000 more alcohol-related deaths in England since 2012 due to government cuts. The study modeled the impact of changes to alcohol duty policy, resulting in a one percent rise in alcohol consumption leading to additional deaths.
Researchers from the University of Sheffield found that few NHS mental health trusts collect and use patient feedback effectively. The study recommends that trusts engage with patients, staff, and relatives to provide meaningful change and ensure patient voices are heard.
A dietary compound found in tomatoes has been shown to improve sperm quality, increasing fast swimming sperm and improving size and shape. Researchers hope the discovery could transform the outlook for men with fertility problems.
A recent international trial showed that patients requiring emergency heart attack treatment also benefit from further intervention to reduce the risk of future heart attacks. The study found that additional stenting for significant narrowings in other untreated arteries significantly reduces the risk of future heart attacks and death.
New research by University of Sheffield scientists reveals a direct link between surface melting and short bursts of glacier acceleration in Antarctica, with some glaciers moving up to 400m per year. As temperatures continue to rise, this phenomenon is expected to become more common, affecting sea level rise predictions.
Researchers found that methotrexate significantly reduces symptoms associated with polycythemia vera and essential thrombocythemia, two types of blood cancer. The study suggests MTX could provide low-cost, safe, and effective treatment for patients suffering from these conditions.
Scientists have discovered how the typhoid toxin hijacks DNA repair machines and accelerates cellular aging, making cells more susceptible to infection. This breakthrough could lead to earlier diagnosis and faster treatment for typhoid sufferers, a major killer in low- and middle-income countries.
A new interactive board game has been developed to enhance training for healthcare professionals supporting victims of domestic violence and abuse. The game takes the form of an interactive board game which helps trainees understand the complexities of DVA and explore ways to support those in their care.
A new treatment could protect brain cells affected by Parkinson's disease, potentially slowing or stopping its progression. Dr Heather Mortiboys and her team will modify drug compounds that boost cell function in people living with Parkinson's.
Researchers at the University of Sheffield have discovered UK-size photospheric plasma swirls generating short-lived Alfvén pulses in the solar atmosphere. These pulses are estimated to carry more than 10 times higher energy flux than needed for heating the local upper solar chromosphere.
Scientists at the University of Sheffield discovered how climate change and deforestation interact to disconnection natural habitats, leaving wildlife with limited escape routes from rising temperatures. The study highlights the urgent need to fund reforestation efforts and stop tropical forest loss.
Research found that female bedbugs can cleverly manage their immune systems in anticipation of mating-related infection, allowing them to resist traumatic insemination and improve reproductive success. This ability may also be shared by other insects and could help control bedbug populations.
Researchers at the University of Sheffield have discovered how plants create networks of air channels to transport carbon dioxide, revealing a major step forward in understanding leaf structure and function. The study also shows that humans have bred wheat plants with fewer pores on their leaves, making them more water-efficient.