The study found that drug-resistant Leishmania parasites have distinct protein production profiles compared to sensitive parasites, suggesting a global reprogramming of protein synthesis. This pre-emptive adaptation enables the parasite to quickly respond to the presence of the drug and survive when it is absent.
SourceTexas Tech University Health Sciences Center·JournalNature Communications·TypeExperimental study·DateJun 22, 2023
Recent studies in the New Journal of Pharmaceutical Analysis feature novel diagnostic tools, RNA sequencing-based workflows, and mechanical property evaluations to enhance cancer and cardiovascular disease treatment outcomes. These innovations aim to improve the therapeutic effect of drugs and promote personalized medicine.
SourceCactus Communications·JournalJournal of Pharmaceutical Analysis·TypeExperimental study·DateJun 21, 2023
Researchers found that combining radiation with a genetically engineered oncolytic vaccinia virus improved treatment outcomes for glioblastoma brain tumors in mice. The combination showed a 15% cure rate and 62% rejection of new cancer cells, outperforming radiation alone.
SourceUniversity of Alberta·JournalCancer Letters·TypeExperimental study·DateJun 20, 2023
A study by Martin-Luther-University Halle-Wittenberg found a link between high levels of IGF2BP2 and faster-growing bowel cancer tumours with chemotherapy resistance. The protein's role in cell growth and metabolism may lead to the development of new diagnostic procedures and therapeutic strategies.
SourceMartin-Luther-Universität Halle-Wittenberg·JournalMolecular Cancer·TypeExperimental study·DateJun 15, 2023
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers from Medical College of Wisconsin found that older breast cancer survivors, particularly those exposed to chemotherapy, showed greater epigenetic aging than their same-aged peers without cancer. This acceleration in biological aging may be associated with worse functional outcomes and quality of life for these patients.
SourceMedical College of Wisconsin·JournalCancer·TypeObservational study·DateJun 14, 2023
A retrospective study found a 24% response rate to Docetaxel among patients with stage IV non-small cell lung cancer who experienced progression on immunotherapy. The median progression-free survival was 3 months, suggesting chemotherapy may still play an important role in treatment after immunotherapy failure.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateJun 7, 2023
Researchers created a new type of wound dressing material using advanced polymers, enabling customized dressings with fine-tuned surface adhesion. The material has potential applications in burn treatment and drug delivery for cancer patients, providing constant medication release outside the clinic setting.
SourceUniversity of Waterloo·JournalJournal of Colloid and Interface Science·DateJun 6, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Erdafitinib achieves tumor-agnostic benefits across 16 cancer types, including urothelial, lung, and other cancers. The trial demonstrated a disease control rate of 73.7% and clinical benefit rate of 45.6%, with notable improvements in pancreatic and cholangiocarcinoma patients.
SourceUniversity of Texas M. D. Anderson Cancer Center·DateJun 5, 2023
A phase 3 clinical trial by Dana-Farber Cancer Institute has shown vorasidenib significantly prolongs progression-free survival and delays radiation and chemotherapy for patients with Grade 2 IDH-mutant glioma. Treatment with vorasidenib can delay cognitive dysfunction in patients and preserve their quality of life.
SourceDana-Farber Cancer Institute·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateJun 4, 2023
The Phase 3 S1826 trial demonstrates one-year progression-free survival in 94% of patients with Stage 3 or 4 classic Hodgkin lymphoma treated with nivolumab and chemotherapy. The therapy was well-tolerated, with few serious immune-related side effects.
SourceSWOG Cancer Research Network·TypeRandomized controlled/clinical trial·DateJun 4, 2023
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
The nucleus is metabolically active and uses antioxidant enzymes to repair DNA damage. Cells relocate mitochondrial machinery to the nucleus in response to DNA damage, highlighting a paradigm shift in cellular biology.
SourceCenter for Genomic Regulation·JournalMolecular Systems Biology·TypeExperimental study·DateJun 1, 2023
A large study tracked CIPN in over 1,100 breast cancer patients treated with taxanes, showing persistent sensory and motor symptoms with more severe symptoms with paclitaxel than docetaxel. The study defines a risk prediction model to help doctors individualize patient care.
SourceSWOG Cancer Research Network·TypeObservational study·DateMay 31, 2023
Researchers discuss chemotherapeutic resistance in recurring ovarian cancer, focusing on the unfolded protein response and its effect on polyploid giant cancer cells. Understanding this mechanism could lead to investigating cancer cell molecular mechanisms and potential therapeutic strategies.
SourceImpact Journals LLC·JournalOncoscience·TypeCommentary/editorial·DateMay 26, 2023
UMC Utrecht researchers are conducting two new projects to treat cancer using image-guided interventions. One project uses MRI-guided radiotherapy for locally advanced pancreatic cancer, while the other employs ultrasound techniques for head and neck cancers.
Researchers found that distant cancers alter liver function by inducing fat accumulation and inflammation in liver cells. The process involves secretion of extracellular vesicles containing fatty acids, which reprogram the liver to resemble fatty liver disease.
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Researchers have developed new methods to analyze dry-coated drug particles using 3D Raman mapping, which can effectively slow down dissolution rates. Another study introduces a novel technique for detecting complex traditional Chinese medicines, preventing adulteration and counterfeiting.
SourceCactus Communications·JournalJournal of Pharmaceutical Analysis·TypeExperimental study·DateMay 24, 2023
A new Northwestern Medicine study found young adult cancer survivors (18-39 years old) are 2.6 times more likely to develop heart failure when treated with anthracyclines. The incidence is highest among leukemia and other specific cancer types.
SourceNorthwestern University·JournalJournal of the American College of Cardiology·DateMay 16, 2023
Researchers at USC Norris Comprehensive Cancer Center have identified a biomarker, CX3CR1, that can predict which patients with non-small cell lung cancer will respond well to chemoimmunotherapy. Elevated levels of the biomarker in T-cells after six to nine weeks of treatment indicate long-term benefits from the combination therapy.
SourceKeck School of Medicine of USC·JournalCancer Research Communications·TypeObservational study·DateMay 11, 2023
Researchers from Amsterdam UMC and Copenhagen University have found that a chemofree drug-combination therapy is more effective than traditional chemotherapy in treating CLL, resulting in reduced side effects and improved patient outcomes. The study, the largest ever conducted on CLL, involved 920 fit patients and showed that treatment...
SourceAmsterdam University Medical Center·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateMay 10, 2023
A recent clinical trial showed that cemiplimab plus platinum chemotherapy can prolong survival in patients with advanced lung cancer, improving their quality of life. The treatment also reduced symptoms such as pain and cough, and delayed clinically meaningful deterioration.
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
A multi-institutional phase 3 clinical trial found that a cancer stem cell test can accurately decide more effective treatments and lead to increased survival for patients with recurrent glioblastoma. ChemoID, a CLIA-accredited diagnostic test, was used to select chemotherapy treatments, resulting in significantly lower risk of death a...
SourceUniversity of Cincinnati·JournalCell Reports Medicine·TypeRandomized controlled/clinical trial·DateMay 5, 2023
A phase 2 clinical trial testing a treatment combining standard chemotherapy with azacitidine showed nearly 90% of patients with aggressive T-cell lymphoma achieved complete remission. The treatment, which targets gene-silencing marks on DNA, has an estimated two-year progression-free survival rate of 69.2%.
SourceWeill Cornell Medicine·JournalBlood·DateMay 4, 2023
Scientists successfully opened the blood-brain barrier using a novel ultrasound device, delivering chemotherapy to treat glioblastoma patients. The treatment increased drug concentrations by 4-6 times and was safe and well-tolerated.
SourceNorthwestern University·JournalThe Lancet Oncology·DateMay 2, 2023
Researchers have identified 11 somatic mutations in the RAS/MAPK pathway that contribute to treatment-resistant adult epilepsy, suggesting the potential for repurposed anti-cancer agents as new treatments. This study provides insight into the genetic mechanisms underlying this form of epilepsy and opens up new avenues for targeted ther...
SourceMass General Brigham·JournalJournal of the American Medical Association·TypeCase study·DateMay 1, 2023
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
A new study found that cannabis use by cancer patients leads to reduced pain levels, improved sleep quality, and enhanced cognitive function. After two weeks of sustained use, patients reported better thinking clarity and objective measures of cognition also showed improvements.
SourceUniversity of Colorado at Boulder·JournalExploration of Medicine·TypeObservational study·DateMay 1, 2023
Researchers found that spinal cord stimulation reduced pain response in rats with human lung cancer tissue without compromising paclitaxel effectiveness. The study also showed SCS improved antitumor efficacy of paclitaxel, providing evidence for its potential as a companion treatment.
SourceJohns Hopkins Medicine·JournalNeuromodulation Technology at the Neural Interface·DateApr 27, 2023
An international study of 1,044 patients with head and neck squamous cell carcinoma found that combining radiotherapy with chemotherapy significantly improves survival rates compared to radiotherapy alone. The benefit was particularly notable in patients between 65-79 years old with good general health.
SourceUniversität Leipzig·JournalJAMA Network Open·TypeRandomized controlled/clinical trial·DateApr 26, 2023
Research suggests that patients with advanced melanoma who receive immunotherapy medications may benefit from maintaining normal vitamin D levels. The study found a favorable response rate in 56% of patients with normal baseline vitamin D levels, compared to 36% with low levels.
Researchers developed a gene signature called CisSig to predict cancer patients' response to cisplatin. The approach aims to overcome the obstacle of interpreting gene signatures in the human body and has been validated in muscle-invasive bladder cancer patients.
SourceCleveland Clinic·JournalNature·TypeExperimental study·DateApr 20, 2023
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers discuss rapamycin's potential to delay cancer onset by slowing cell proliferation and tumor progression. The mTOR pathway is involved in both cancer and aging, making rapamycin a promising chemopreventive agent.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateApr 17, 2023
A new meta-analysis finds that Black patients are 71% more likely to experience heart damage following chemotherapy treatment. The study highlights the need for further research into underlying factors contributing to these disparities to reduce cardiovascular risk associated with chemotherapy.
The new American Heart Association scientific statement emphasizes the importance of including non-biological factors and social determinants in CVD risk assessment for women. These factors include economic stability, neighborhood safety, education level, and access to quality healthcare, which disproportionately affect women from dive...
SourceAmerican Heart Association·JournalCirculation·DateApr 10, 2023
Researchers developed a chelator-free-radiolabeled polymersome capable of long-term multiday PET imaging in vivo. The nanovesicle meets key requirements for targeted cancer therapy, including precision targeting, stable radiotracer binding, and biocompatibility.
SourceUniversity of Alabama at Birmingham·JournalBiomacromolecules·TypeExperimental study·DateApr 10, 2023
Researchers at Mayo Clinic Arizona have developed a new intravesical chemotherapy delivery system called TAR-200, which is safe and shows initial evidence of effectiveness in treating muscle-invasive bladder cancer (MIBC) in frail patients. The treatment has been shown to limit cancer growth while minimizing toxic effects.
SourceWolters Kluwer Health·JournalThe Journal of Urology·DateApr 7, 2023
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
A team of scientists from City University of Hong Kong and HKUST discovered novel, tridimensional compounds with high anticancer activity and low toxicity. These compounds can overcome drug resistance in cancer cells by inducing a different cell death pathway.
SourceCity University of Hong Kong·JournalNature Synthesis·TypeExperimental study·DateApr 6, 2023
Researchers developed a complex that accumulates in tumour tissue and is activated by ultrasound waves, triggering the release of a toxic compound and eradicating tumours. This method could make cancer treatment less invasive and more effective for large and deep-seated tumours.
SourceRuhr-University Bochum·JournalAngewandte Chemie International Edition·TypeExperimental study·DateApr 5, 2023
Cancer-associated fibroblasts (CAFs) are a type of cell that plays a crucial role in the tumor microenvironment. The authors suggest that understanding CAFs is essential for developing effective cancer therapies. Research targeting CAFs has shown promise, but challenges remain due to their complex nature.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateApr 5, 2023
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
A UNIGE team created customizable treatments by testing drugs on artificial tumors derived from patients' cancer tissue. The approach opens the way for optimized and tailored therapies against various cancers and diseases.
SourceUniversité de Genève·JournalJournal of Experimental & Clinical Cancer Research·TypeNews article·DateApr 4, 2023
Researchers at Rice University have created a new technology called PULSED that can deliver time-released drugs and vaccines for extended periods. The technology uses high-resolution 3D printing and soft lithography to produce microcylinders made of biodegradable polymers, which can be loaded with drugs and release them over time.
SourceRice University·JournalAdvanced Materials·TypeExperimental study·DateApr 3, 2023
Researchers have shown lorlatinib to be safe and effective in treating high-risk neuroblastoma with ALK gene mutations. The targeted therapy has led to a major amendment in a phase 3 clinical trial, offering new hope for patients with this often lethal cancer.
SourceChildren's Hospital of Philadelphia·JournalNature Medicine·DateApr 3, 2023
Researchers from Tokyo University of Science reveal the crystal structure of centromere-associated protein E (CENP-E), a promising target for inhibitor therapy. The discovery is expected to facilitate the development of anticancer drugs with fewer adverse effects on patients.
SourceTokyo University of Science·JournalFEBS Letters·TypeExperimental study·DateApr 3, 2023
Researchers propose conjugating a cell-penetrating peptide to oxaliplatin to overcome chemotherapy resistance in colorectal cancer. The new approach reduces platinum accumulation in tumour microenvironment and healthy tissues.
SourceIMIM (Hospital del Mar Medical Research Institute)·JournalJournal of Medicinal Chemistry·DateMar 30, 2023
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
This study of 690 patients with early-stage breast cancer found racial disparities in pathological complete response to neoadjuvant chemotherapy, affecting survival outcomes. Racial disparities varied across different breast cancer subtypes and highlight the importance of understanding tumor biology.
SourceJAMA Network·JournalJAMA Network Open·DateMar 30, 2023
Researchers at the University of Texas M. D. Anderson Cancer Center have developed a novel approach to administer intrathecal and intravenous immunotherapy to treat leptomeningeal disease (LMD) in melanoma patients, showing promising results in improving survival rates and quality of life for some patients.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalNature Medicine·DateMar 30, 2023
A literature review published by the Society of Nuclear Medicine and Molecular Imaging reveals how nuclear medicine brain imaging can help evaluate biological changes causing chemotherapy-related cognitive impairment. The findings confirmed the impact of chemotherapy drugs on cognitive function and highlighted the utility of various SP...
SourceSociety of Nuclear Medicine and Molecular Imaging·JournalJournal of Nuclear Medicine·DateMar 28, 2023
ENZAMET, a new drug combination, has shown significant improvement in survival rates for men with advanced prostate cancer. After five years, the treatment led to a 67% survival rate, compared to 57% for standard therapy.
SourceUniversity of Adelaide·JournalThe Lancet Oncology·TypeRandomized controlled/clinical trial·DateMar 27, 2023
Researchers developed a hybrid micro-robot that can navigate in physiological environments and capture targeted damaged cells. The micro-robot uses electric and magnetic mechanisms to identify and transport single cells for further study.
SourceTel-Aviv University·JournalAdvanced Science·DateMar 26, 2023
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
The new medicine has shown promising results in a Phase 1 clinical trial, with 70% of patients stable after six weeks and one patient remaining stable for over two years. Developed by NTNU researcher Marit Otterlei, ATX-101 targets cancer cells' stress regulation system, leaving healthy cells unaffected.
SourceNorwegian University of Science and Technology·JournalOncogene·TypeRandomized controlled/clinical trial·DateMar 22, 2023
A pilot study found that patients who listened to their favorite music experienced reduced nausea severity and distress. Music was believed to affect serotonin levels, a neurotransmitter associated with chemotherapy-induced nausea, in a way that could complement medication.
SourceMichigan State University·JournalClinical Nursing Research·DateMar 21, 2023
A Phase II trial led by researchers from the University of Texas MD Anderson Cancer Center demonstrated that adding ipilimumab to a neoadjuvant combination of nivolumab plus platinum-based chemotherapy resulted in a major pathologic response in half of all treated patients with early-stage non-small cell lung cancer. The treatment also...
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalNature Medicine·DateMar 16, 2023
A new review paper suggests that selective protection of normal cells from chemotherapy could increase the therapeutic window and improve outcomes for cancer patients. The authors propose using antagonistic drug combinations to kill drug-resistant cancer cells, reducing side effects and improving quality of life.
SourceImpact Journals LLC·JournalOncotarget·TypeLiterature review·DateMar 13, 2023
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
A new drug called CADD522 blocks a gene associated with driving bone cancer's spread, increasing survival rates by 50% in mice implanted with human bone cancer. The breakthrough treatment shows promise in all main bone cancer subtypes and has the potential to save lives and reduce disability.
SourceUniversity of East Anglia·JournalJournal of Bone Oncology·TypeExperimental study·DateMar 7, 2023
Two compounds, A5 and C1, have shown promising results in inhibiting the growth of glioblastoma cells, a type of aggressive brain cancer. Further research is needed to confirm their effectiveness on normal nerve cells and to move towards clinical trials.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalScientific Reports·DateMar 6, 2023
Tumour cells exhibit an innate randomness in their ability to respond to chemotherapy, which can lead to resistance. Researchers identified a marker for resistance and propose combining chemotherapy with drugs targeting this 'noise' to improve treatment outcomes.
SourceGarvan Institute of Medical Research·JournalScience Advances·TypeExperimental study·DateMar 3, 2023
Researchers discovered that quiescent ovarian cancer cells secrete follistatin, which induces resistance in neighboring cells and worsens survival rates. Targeting this protein may improve chemotherapy response and boost survival in patients with aggressive ovarian cancer.
SourceUniversity of Pittsburgh·JournalClinical Cancer Research·TypeExperimental study·DateMar 3, 2023
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A new study found that chemotherapy alters the immune cell landscape in pancreatic cancer, reducing checkpoint molecules and increasing tumor growth. The research suggests that this may lead to resistance to subsequent immunotherapy, highlighting the need for further study on combining chemotherapy with immunotherapy.
SourceNYU Langone Health / NYU Grossman School of Medicine·JournalNature Communications·TypeExperimental study·DateMar 1, 2023
A new study finds that a combination of chemotherapy drugs performs better than BCG in preventing high-grade cancer recurrence in patients with non-muscle invasive bladder cancer. This alternative treatment has shown excellent safety and efficacy outcomes, providing a viable option for patients facing a shortage of standard care treatm...
SourceUniversity of Iowa Health Care·JournalJAMA Network Open·TypeData/statistical analysis·DateFeb 28, 2023
A new study found that polypharmacy, the concurrent use of multiple medications, increases the risk of adverse treatment outcomes in older adults with advanced cancer. Patients taking multiple medications had a 59% higher chance of stopping cancer treatment earlier than recommended.
SourceUniversity of Rochester Medical Center·JournalCancer·TypeRandomized controlled/clinical trial·DateFeb 28, 2023
Researchers identified microglia as key players in chemo brain inflammation, suggesting a potential target for treatment. In a mouse study, deleting microglia restored memory and lowered brain inflammation after paclitaxel treatment.
SourceOhio State University·JournalBrain Behavior and Immunity·TypeExperimental study·DateFeb 28, 2023
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers re-examine molecular characteristics of WNT-subgroup patients to identify optimal treatment strategies for low-risk medulloblastoma. Key findings suggest that therapy-related late toxicity remains a concern, despite comparable survival rates between children and adolescents with this disease subtype.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateFeb 27, 2023