A recent study found that immunotherapy costs accounted for 84% of the net increase in Medicare spending on outpatient cancer care at the end of life. Payments for radiation oncology decreased by 2%, while palliative care spending rose, reflecting a shift towards hypofractionated radiation treatments.
SourceAmerican Society for Radiation Oncology·JournalInternational Journal of Radiation Oncology*Biology*Physics·DateFeb 27, 2023
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
The ESMO Targeted Anticancer Therapies Congress 2023 features presentations on drug discovery and development for various targets, precision medicine, and early clinical trial methodology. Keynote lectures highlight novel insights in mutational signatures and epigenetic therapies.
SourceEuropean Society for Medical Oncology·DateFeb 23, 2023
A study published in Nature Communications reveals that platinum accumulates in healthy cells surrounding cancer cells, particularly fibroblasts, and induces gene activation associated with poor response to chemotherapy. Periostin levels serve as a marker of TGF-β activity in fibroblasts and predict treatment benefit.
SourceInstitute for Research in Biomedicine (IRB Barcelona)·JournalNature Communications·DateFeb 23, 2023
Researchers have developed a novel prognostic index to predict survival outcomes in gastric cancer patients. The inflammation-combined prognostic index (ICPI) combines three biomarkers - lymphocyte-to-monocyte ratio, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio - to provide a personalized prognosis for each patient.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateFeb 14, 2023
Engineers at the University of Waterloo developed AI technology to predict breast cancer treatment effectiveness, allowing doctors to prescribe personalized treatments and reduce unnecessary side effects. The new algorithm uses synthetic correlated diffusion imaging images to forecast patient responses to chemotherapy.
Etoposide's impact on DNA structure has been untangled by Cornell researchers using optical tweezers and magnetic tweezers. The study found that etoposide promotes DNA loop trapping and barrier formation by topoisomerase II, enabling the creation of sensitive screening tools for improving patient treatment.
SourceCornell University·JournalNature Chemical Biology·DateJan 30, 2023
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A study found that immune checkpoint inhibitors enhance chemotherapy-induced neuropathic pain by blocking interaction between macrophages and neurons via PD1-PDL1 synergy. This discovery could lead to the development of therapeutic alternatives to prevent pain while maintaining anti-neoplastic effects.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalCancer Immunology Research·DateJan 30, 2023
The world's first international clinical guidelines have been created to prevent and treat heart complications in children undergoing cancer treatment. The guidelines cover cardiovascular disease assessment, screening, and follow-up for pediatric patients receiving various cancer treatments.
SourceMurdoch Childrens Research Institute·JournalJACC Advances·TypeContent analysis·DateJan 29, 2023
Researchers found that female lymphoma patients who received afternoon chemotherapy had a 12.5 times reduced mortality rate and a 2.8 times decreased cancer recurrence rate compared to morning treatment. This is due to the body's natural circadian rhythm, which affects white blood cell counts and bone marrow proliferation.
SourceThe Korea Advanced Institute of Science and Technology (KAIST)·JournalJCI Insight·TypeMeta-analysis·DateJan 27, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers have discovered a way to produce limonoids, a family of valuable chemicals with potential as bee-friendly insecticides and anti-cancer drugs. By identifying the enzymes required for production, they can now use host organisms to create these compounds in a more sustainable way.
SourceJohn Innes Centre·JournalScience·TypeExperimental study·DateJan 26, 2023
Researchers developed a cancer-selective therapeutic agent that targets cancer cells' unique acidic pH microenvironment, inducing mitochondrial dysfunction and killing only cancer cells. The agent, Mito-SA, forms charge-shielded nano-assemblies that selectively disassemble in the tumoral environment.
SourceUlsan National Institute of Science and Technology(UNIST)·JournalAdvanced Functional Materials·DateJan 26, 2023
A new study finds that andiroba oil accelerates wound healing, increases contraction rates, and promotes local re-epithelialization. The oil also presents a similar potential to low-level laser therapy (LLLT) in treating oral mucositis, a common side effect of chemotherapy.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateJan 24, 2023
Researchers found that female patients with diffuse large B-cell lymphoma treated in the afternoon had reduced mortality rates and cancer recurrence compared to those treated in the morning. The study suggests that timing chemotherapy delivery according to an individual's circadian clock may improve treatment outcomes.
SourceInstitute for Basic Science·JournalJCI Insight·TypeRandomized controlled/clinical trial·DateJan 24, 2023
A Phase 3 clinical trial has shown that a four-drug chemotherapy regimen significantly increases overall survival and progression-free survival in patients with stage 4 pancreatic ductal adenocarcinoma. The study's results suggest that this more aggressive treatment approach may be considered for eligible patients.
SourceUniversity of California - Los Angeles Health Sciences·TypeRandomized controlled/clinical trial·DateJan 20, 2023
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
A Cancer Research UK-funded clinical trial found that chemotherapy before surgery reduces the chance of colon cancer returning within 2 years by 28%. The study involved 1,053 patients and showed significant benefits in terms of preventing cancer recurrence.
SourceCancer Research UK·JournalJournal of Clinical Oncology·TypeRandomized controlled/clinical trial·DateJan 19, 2023
A new personalized treatment for bile duct cancer has shown remarkable results, with patients surviving for up to two years when treated with the drug futibatinib. The Phase II clinical trial found that the drug was more effective at reducing tumor size and producing modest side effects compared to chemotherapy.
SourceUniversity College London·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateJan 18, 2023
A team of researchers from Korea and USA identified the importance of lipid homeostasis in overcoming brain cancer radioresistance. They found that regulating diacylglycerol kinase B and diacylglycerol acyltransferase 1 could potentially sensitize brain cancer cells to radiotherapy, offering a new treatment strategy.
SourcePusan National University·JournalCell Reports Medicine·TypeExperimental study·DateJan 18, 2023
Researchers discovered a molecular pathway critical to the initiation of pancreatic tumors, which can contribute to disease resistance and metastasis. Targeting this pathway could limit tumor progression, relapse, and spread by disrupting the interaction between cancer cells and their microenvironment.
SourceUniversity of California - San Diego·JournalNature Cell Biology·DateJan 16, 2023
Kestrel 3000 Pocket Weather Meter
Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Researchers found that a pro-oxidant mixture of resveratrol and copper can inactivate cell-free chromatin particles, reducing chemotherapy toxicity. The treatment also showed promise in preventing aging and sepsis.
SourceCactus Communications·JournalMedical Oncology·TypeRandomized controlled/clinical trial·DateJan 16, 2023
Researchers found that EWS::FLI1 induces Slit2 expression, which activates Robo receptors and enhances Ewing sarcoma growth. Silencing Slit2 strongly inhibited Ewing sarcoma cell growth, providing an opportunity for targeted therapy.
SourceImpact Journals LLC·JournalGenes & Cancer·TypeObservational study·DateJan 13, 2023
A new study found that COVID-19 primarily affected patients with a moderate to critical course, often with comorbidities, whereas many had mild courses despite metastatic melanoma and systemic therapy, recommending continued treatment whenever possible.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateJan 11, 2023
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers found that dendritic cells in meninges produce mediators causing pain hypersensitivity after nerve injury. The kynurenine pathway, primarily driven by IDO1, is involved in pain production.
SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalJournal of Clinical Investigation·DateJan 10, 2023
Researchers at the University of Bergen have developed a method to predict cancer patient survival within hours of chemotherapy. By analyzing protein ERK1/2 levels in blood samples, they can identify patients who are responding or not responding to treatment, enabling early intervention.
SourceThe University of Bergen·JournalNature Communications·TypeExperimental study·DateJan 10, 2023
Researchers have discovered a new biomarker that predicts the response to CAR-T cell therapy in patients with diffuse large B cell lymphoma. The biomarker identifies differentiated T cells, which can be removed from leukemia products to improve therapy success rates.
SourceMedical University of Vienna·JournalFrontiers in Immunology·DateJan 9, 2023
The EMBRACE-I study demonstrated the superiority of personalized brachytherapy in treating locally advanced cervical cancer. A targeted approach using magnetic resonance imaging-defined tumor volume resulted in a high tumor control rate and low risk of recurrence.
SourceMedical University of Vienna·JournalJournal of Clinical Oncology·DateJan 5, 2023
Researchers at Salk Institute discover thousands of previously unknown microproteins in brown and white fat tissue, finding that one, Gm8773, increases feeding activity in mice. This discovery could lead to the development of a therapeutic to promote weight gain in certain disease situations.
SourceSalk Institute·JournalCell Metabolism·DateJan 3, 2023
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers have made a breakthrough in precision oncology for patients with metastatic urothelial carcinoma, identifying that certain cell surface molecules decrease or are absent in these patients, making them resistant to the new drug enfortumab vedotin.
SourceUniversitatsklinikum Bonn·JournalClinical Cancer Research·DateDec 30, 2022
Researchers developed predictive models using serum microRNAs to identify patients at risk of requiring early palliative care. The study used serum samples from 178 patients with various types of cancer and found that miRNA-based models had higher accuracy than clinical models in predicting referral to a palliative care unit.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateDec 29, 2022
A team of researchers has identified a protein called hemopexin that may help protect the heart from damage caused by anthracycline chemotherapy. Levels of hemopexin in the blood were associated with increased cardiac toxicity, but administering hemopexin prevented the development of cardiac dysfunction in mice.
SourceBeth Israel Deaconess Medical Center·JournalScience Advances·DateDec 27, 2022
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Researchers developed a cell-based method to predict breast cancer treatment responses, showing promising results and potential for personalized medicine. The method uses tumour cells and supporting cells from patients, allowing for efficient drug profiling and accurate treatment prediction.
SourceKarolinska Institutet·JournalProceedings of the National Academy of Sciences·DateDec 26, 2022
The Endocrine Society's Clinical Practice Guideline provides suggestions for the treatment of hypercalcemia of malignancy, a common and life-threatening metabolic complication of cancer. Treatment options include intravenous bisphosphonates or denosumab medications, with denosumab recommended as the preferred choice.
SourceThe Endocrine Society·JournalThe Journal of Clinical Endocrinology & Metabolism·DateDec 21, 2022
Researchers from the University of Cambridge have identified a method to track and kill resistant cancer cells in mice. By tagging different types of breast cancer cells with unique genetic barcodes, they were able to identify which cells are evading chemotherapy and target them specifically with a new treatment approach.
SourceUniversity of Cambridge·JournaleLife·TypeExperimental study·DateDec 20, 2022
Researchers at Tulane University discovered that breast cancer cells use complex immune-modulatory programs to evade immune clearance, leading to treatment resistance. They identified 16 immune checkpoint genes and found that chemotherapy triggers a program of immune checkpoints that shield cancer cells from different lines of attack.
SourceTulane University·JournalNature Cancer·DateDec 15, 2022
Researchers identify CDK4 and filamin proteins as predictors of response to paclitaxel in HER2-negative breast cancer patients. High levels of these proteins are associated with a positive response rate in 90% of cases.
SourceCentro Nacional de Investigaciones Oncológicas (CNIO)·JournalNature Communications·TypeObservational study·DateDec 14, 2022
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers describe results using cladribine-based combination epigenetic and immunotherapy in MCL, achieving an increased overall survival greater than 40 months with durable remissions without relapse for longer than 5 years. The approach is promising in the treatment of MCL and potentially other previously treatment-refractory canc...
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateDec 13, 2022
A new clinical trial has found that chemotherapy before surgery significantly improves 1-year survival rates for patients with borderline resectable pancreatic cancer. The study, led by the University of Liverpool, compared immediate surgery with short-course neoadjuvant therapy and found a significant survival benefit.
SourceUniversity of Liverpool·TypeRandomized controlled/clinical trial·DateDec 12, 2022
A new treatment protocol has been shown to significantly reduce the risk of aggressive childhood leukemia returning after chemotherapy. The ALL-11 protocol, which includes an extra year of maintenance chemotherapy for children with specific genetic mutations, has improved five-year survival rates and quality of life for these patients....
SourcePrincess Máxima Center for Pediatric Oncology·TypeRandomized controlled/clinical trial·DateDec 10, 2022
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
A nationwide retrospective study showed that adjuvant chemotherapy after neo-adjuvant chemotherapy and surgery significantly improved overall survival in patients with pancreatic adenocarcinoma, regardless of lymph node status or resection margins. The study included nearly 900 patients and was published in JAMA Oncology.
SourceUniversity of Colorado Anschutz Medical Campus·JournalJAMA Oncology·DateDec 8, 2022
Research found that male rats exposed to ifosfamide during adolescence had offspring and grand-offspring with increased incidence of diseases, including kidney and testis problems. The study's epigenetic analysis revealed changes passed down through sperm and ova, indicating a potential risk for future generations.
SourceWashington State University·JournaliScience·DateNov 28, 2022
Researchers at CU Anschutz Medical Campus have identified a less invasive way to treat HPV-unrelated head and neck squamous cell carcinomas by combining radiation with immunotherapy. The approach resulted in remarkable success rates, including 75% of patients experiencing major pathological responses or complete responses.
SourceUniversity of Colorado Anschutz Medical Campus·JournalNature Cancer·DateNov 28, 2022
Researchers at University of Pittsburgh have designed novel nanoparticles that co-deliver a chemotherapy drug and a novel immunotherapy, shrinking tumors in mouse models of colon and pancreatic cancer. The therapy silences a gene involved in immunosuppression by blocking Xkr8 protein distribution on the cell membrane.
SourceUniversity of Pittsburgh·JournalNature Nanotechnology·TypeExperimental study·DateNov 24, 2022
Sky & Telescope Pocket Sky Atlas, 2nd Edition
Sky & Telescope Pocket Sky Atlas, 2nd Edition is a durable star atlas for planning sessions, identifying targets, and teaching celestial navigation.
Researchers have identified a protein that can predict how well breast cancer patients will respond to chemotherapy. Increasing levels of this variant p53 makes breast cancer cells unresponsive to existing therapies, highlighting its potential as a target for enhanced treatments.
SourceHunter Medical Research Institute·JournalCell Death and Disease·TypeExperimental study·DateNov 22, 2022
A team of researchers discovered that the gut microbiome plays a critical role in driving granulopoiesis, a process formation of granulocytes, in mice models. The study found that alterations in the gut microbiome composition induced by neutropenia stimulate reactive granulopoiesis via interleukin 17A secreted by T cells, promoting neu...
SourceHokkaido University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateNov 21, 2022
Researchers found that HER2-positive breast cancer patients with high levels of tumour infiltrating lymphocytes in residual disease have significantly shorter overall survival. High levels of TILs are associated with poorer outcomes, while lower levels are linked to improved survival rates.
SourceEuropean Organisation for Research and Treatment of Cancer·TypeObservational study·DateNov 17, 2022
A new study analyzed tumor biopsies from patients with newly-diagnosed germinal center B cell lymphoma and found that CREBBP mutations were associated with lower disease-free survival rates. The researchers identified CLMA as a practical tool to translate experimental findings into clinical applications.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateNov 17, 2022
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers at Goethe University Frankfurt found that dying colon cancer cells release ATP to neighboring tumor cells, activating a survival signaling pathway. Interrupting this communication can significantly increase the effectiveness of chemotherapy against resistant tumors.
SourceGoethe University Frankfurt·JournalNature·TypeExperimental study·DateNov 17, 2022
A 30-year follow-up study of patients with early breast cancer found that radiotherapy does not improve overall survival rates after 10 years but reduces the risk of recurrence in the same breast. The study's findings challenge traditional concepts of long-term anti-cancer benefits of radiotherapy.
SourceEuropean Organisation for Research and Treatment of Cancer·TypeRandomized controlled/clinical trial·DateNov 17, 2022
Scientists have identified a potential therapy to reduce the side effects of cisplatin chemotherapy, which can cause kidney toxicity and neuropathic pain. Istradefylline, an approved Parkinson's disease drug, has been found to mitigate these harmful effects while preserving cisplatin's anti-tumor properties.
SourceINSERM (Institut national de la santé et de la recherche médicale)·JournalJournal of Clinical Investigation·DateNov 15, 2022
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Neuroblastoma tumour cells adapt to mimic embryonic cells, making them resistant to chemotherapy. This understanding can lead to targeted treatments that better reach the entire tumour and avoid resistance development.
SourceLund University·JournalScience Advances·DateNov 11, 2022
Researchers from the University of Zurich have discovered why a stem cell transplant is effective in treating multiple sclerosis. The study found that memory T cells reappear immediately after the transplant and do not trigger an autoimmune reaction due to pre-damage caused by chemotherapy. This knowledge enables the body to gradually ...
SourceUniversity of Zurich·JournalScience Translational Medicine·TypeExperimental study·DateNov 10, 2022
A new study published in JNCCN found significant disparities in ovarian cancer treatment based on patient race, ability to pay, and healthcare access. Non-Hispanic Black patients were less likely to receive guideline-appropriate treatment compared to White patients.
SourceNational Comprehensive Cancer Network·JournalJournal of the National Comprehensive Cancer Network·DateNov 9, 2022
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
The West Texas Pharmacology Core laboratory at TTUHSC will focus on two primary areas: drug development and pediatric cancer. The core aims to address obstacles in drug development, including limited pharmacology expertise for small biotech companies and low profitability for pediatric cancer drugs.
SourceTexas Tech University Health Sciences Center·DateNov 9, 2022
Research suggests that antibiotics used in ovarian cancer treatment can accelerate cancer progression and lower survival rates. Reintroducing healthy gut bacteria may slow down cancer growth and restore sensitivity to chemotherapy.
SourceCleveland Clinic·JournalCancer Research·DateNov 8, 2022
A study using mRNA and miRNA expression profiles identified molecular signatures that can differentiate muscle invasive bladder cancer patients who respond to neoadjuvant chemotherapy from those who do not. The research found distinct gene pathways and subtypes associated with response, which may lead to more effective treatment delivery.
SourceImpact Journals LLC·JournalOncotarget·TypeData/statistical analysis·DateNov 8, 2022
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
A combination of pembrolizumab and nanoparticle-bound paclitaxel has shown a high response rate of 50% in patients with platinum-refractory or ineligible urothelial cancers. The treatment has also been associated with improved median duration of response and overall survival time, providing an urgently needed new treatment option.
SourceWolters Kluwer Health·JournalThe Journal of Urology·DateNov 3, 2022
Researchers have designed DNA-based transporters that can deliver precise concentrations of drugs, potentially improving cancer treatment. These nanotransporters can also be programmed to prolong the effect of a drug and minimize its dosage, reducing side effects.
SourceUniversity of Montreal·JournalNature Communications·TypeExperimental study·DateNov 2, 2022
A small clinical trial showed 40% of patients experienced progression-free survival when treated with a CD105 inhibitor, which prevented cancer cells from making splice variant proteins. This approach may resensitize select patients to androgen suppression therapy.
SourceCedars-Sinai Medical Center·JournalMolecular Therapy·DateNov 2, 2022
A comparison of two cancer drugs reveals that life cycle management strategy is crucial for a drug's commercial success. The research found that product sales are closely linked to the number of approved indications and inter-organizational alliances.
SourceRitsumeikan University·JournalDrug Discovery Today·TypeCase study·DateNov 1, 2022
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Researchers mapped the detailed neural pathway of defensive responses from the gut to the brain in mice after detecting germs. The study could lead to better anti-nausea medications for cancer patients undergoing chemotherapy.
SourceCell Press·JournalCell·TypeExperimental study·DateNov 1, 2022
Two new discoveries led by Cedars-Sinai Cancer investigators improve understanding of ovarian cancer's development and suggest personalized therapeutic approaches. They identified four new genetic regions linked to increased ovarian cancer risk and found that some tumors may develop resistance to chemotherapy from an early stage.
SourceCedars-Sinai Medical Center·JournalJNCI Journal of the National Cancer Institute·DateNov 1, 2022