A nationwide study finds that individuals diagnosed with colon cancer who resided in previously redlined neighborhoods are more likely to be diagnosed with advanced-stage disease and have worse survival rates. The research highlights the long-lasting impact of institutional racism on access to quality cancer care.
SourceUniversity of Alabama at Birmingham·JournalJCO Oncology Practice·TypeData/statistical analysis·DateMar 28, 2024
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
Researchers assessed the feasibility of dual PD-L1/CTLA-4 checkpoint inhibition in Stage II or III hormone receptor-positive, HER2-negative breast cancer. Eight patients received upfront durvalumab and tremelimumab prior to neoadjuvant chemotherapy, showing mixed responses and limited benefit.
SourceImpact Journals LLC·JournalOncotarget·TypeRandomized controlled/clinical trial·DateMar 27, 2024
Researchers have identified a protein, NPEPPS, that enables cisplatin-resistant cancer cells to become responsive to treatment. This discovery could increase patient eligibility and make platinum-based therapies more effective.
SourceUniversity of Colorado Anschutz Medical Campus·JournalCancer Research·DateMar 27, 2024
Researchers at the University of Toronto have found that two enzymes, APOBEC3C and APOBEC3D, promote resistance to chemotherapy drug gemcitabine in pancreatic cancer cells. Removing these enzymes can kill cancer cells by stymieing DNA repair.
SourceUniversity of Toronto·JournalNature Cancer·DateMar 27, 2024
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
The University of Cincinnati Cancer Center team has opened a Phase 2 clinical trial to test a new combination treatment for glioblastomas, a deadly form of brain tumors. The treatment uses letrozole, a drug that targets an enzyme present in breast cancer cells, and temozolomide, a chemotherapy drug already approved as a GBM treatment.
SourceUniversity of Cincinnati·JournalClinical Cancer Research·TypeRandomized controlled/clinical trial·DateMar 26, 2024
A team of scientists discovered new fusion sites in protein evolution that enable faster and more targeted drug development. By combining evolutionary processes with synthetic biology, they created customized biological drugs with improved therapeutic properties.
SourceMax-Planck-Gesellschaft·JournalScience·DateMar 21, 2024
A new study suggests that tailored treatment can predict the response of breast cancer patients to chemotherapy, allowing for safe omission of extensive lymph node removal. The MARI protocol showed a 95% overall survival rate and 89% disease-free survival rate in patients who achieved pathological complete response.
SourceEuropean Organisation for Research and Treatment of Cancer·TypeObservational study·DateMar 21, 2024
A study by IRB Barcelona and Sant Joan de Déu Hospital reveals three distinct patterns explaining the occurrence of second cancers in children, including a mutational footprint from chemotherapy. The research advances understanding of pediatric cancer and highlights the importance of clinical data sharing.
SourceInstitute for Research in Biomedicine (IRB Barcelona)·JournalCancer Discovery·DateMar 19, 2024
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
New data show that adding pembrolizumab to chemotherapy before and after surgery for breast cancer leads to better outcomes, with significant increases in pathological complete response rates across all age groups. The study also found similar rates of breast-conserving surgery and mastectomy, as well as lower residual cancer burdens.
SourceEuropean Organisation for Research and Treatment of Cancer·TypeRandomized controlled/clinical trial·DateMar 19, 2024
The ALEXANDRA/IMpassion030 phase 3 trial found that adding atezolizumab to chemotherapy after surgery did not improve survival for early-stage triple-negative breast cancer patients. Researchers also found no benefit in different sub-groups, such as those with lymph node spread and PD-L1 positive cancer.
SourceEuropean Organisation for Research and Treatment of Cancer·TypeRandomized controlled/clinical trial·DateMar 19, 2024
A new genetic test has identified patients with triple negative early-stage breast cancer who are unlikely to respond to immunotherapy drugs. The test, called ImPrintTN, can predict a patient's likelihood of responding to these treatments and help avoid severe side effects.
SourceEuropean Organisation for Research and Treatment of Cancer·TypeRandomized controlled/clinical trial·DateMar 19, 2024
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A research team at the University of Cologne has identified mechanisms governing drug response in small cell lung cancer. The study reveals that large populations of treatment-sensitive cells often hide numerous therapy-resistant cells that can multiply unchecked after successful treatment.
SourceUniversity of Cologne·JournalNature·TypeExperimental study·DateMar 13, 2024
Researchers have deciphered trabectedin's precise mechanism of action, revealing its ability to induce persistent DNA breaks in cancer cells. This disruption of the transcription-coupled nucleotide excision repair (TC-NER) pathway leads to long-lasting DNA breaks that ultimately kill cancer cells.
SourceInstitute for Basic Science·JournalNature Communications·TypeExperimental study·DateMar 12, 2024
A new study reveals that MAGE family proteins bind to RAD18 using a groove, preventing its degradation and contributing to cancer progression. The findings also suggest that blocking this interaction could lead to re-sensitization of cancer cells to chemotherapy and radiotherapy.
SourceEuropean Molecular Biology Laboratory·JournalThe EMBO Journal·DateMar 6, 2024
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers at MIT discovered that daily exposure to light and sound with a frequency of 40 hertz protects brain cells from chemotherapy-induced damage, preventing memory loss and improving cognitive functions. The treatment also helped prevent DNA damage, inflammation, and promoted the growth of oligodendrocytes, the cells responsible...
SourceMassachusetts Institute of Technology·JournalScience Translational Medicine·DateMar 6, 2024
Researchers investigated combining Sacituzumab govitecan with platinum-based chemotherapeutics for triple-negative breast cancer, urinary bladder carcinoma, and small-cell lung carcinoma. The study showed additive to synergistic antitumor effects in vitro and in vivo, with improved outcomes in tumor-bearing animals.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateMar 4, 2024
The European LeukemiaNet has published two-part guidelines for adult acute lymphoblastic leukemia treatment, covering diagnostics, prognostic factors, response assessments, and comprehensive management. These recommendations are based on a decade of systematic work by European experts, improving the prognosis of adult patients with ALL.
SourceGoethe University Frankfurt·JournalBlood·TypeMeta-analysis·DateMar 1, 2024
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers developed an oxidative stress-based prognostic model for bladder cancer, identifying distinct molecular subtypes and predicting patient outcomes. The model shows promise in tailoring personalized treatment approaches, particularly for patients with low-risk profiles.
SourceImpact Journals LLC·JournalAging-US·TypeComputational simulation/modeling·DateFeb 28, 2024
Head and neck cancer patients exposed to secondhand smoke during chemotherapy have reduced treatment effectiveness. Secondhand smoke alters protein expression, restricting chemotherapy's ability to kill cancer cells. This raises concerns about cancer prognosis and the importance of smoking cessation.
SourceUniversity of Oklahoma·JournalInternational Journal of Molecular Sciences·TypeNews article·DateFeb 27, 2024
Two new studies reveal that UK cancer patients face long waits for chemotherapy and radiotherapy, leading to poorer outcomes. The research highlights the need for a strategic approach to addressing treatment variation and improving cancer services in the UK.
SourceCancer Research UK·JournalThe Lancet Oncology·TypeData/statistical analysis·DateFeb 26, 2024
Researchers created Elenagen, a novel DNA immunotherapy for deadly ovarian cancer, which significantly enhances standard chemotherapy and provides clinical benefits. The study shows that Elenagen delays disease progression in patients with stage III and IV platinum-resistant ovarian cancer.
SourceCureLab Oncology Inc.·JournalFrontiers in Oncology·TypeRandomized controlled/clinical trial·DateFeb 22, 2024
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Researchers have discovered a new way to target chemotherapy-resistant ovarian cancer cells by depriving them of cholesterol, leading to significant tumor growth reduction. The nanoparticles starve the cells of cholesterol, triggering cell death through oxidation of lipids in the cell membrane.
SourceNorthwestern University·JournalAdvanced Science·TypeExperimental study·DateFeb 21, 2024
Research shows that lowering doses and adjusting chemotherapy schedules for older adults with advanced cancer can reduce toxic side effects and preserve daily functions. Over 30% of patients benefited from treatment regimen modifications, with a 15% reduced risk of serious clinician-rated toxic effects.
SourceUniversity of Rochester Medical Center·JournalJAMA Network Open·TypeData/statistical analysis·DateFeb 16, 2024
A large retrospective cohort analysis found that neoadjuvant chemotherapy improved overall and progression-free survival for locally advanced penile squamous cell carcinoma patients. The study also showed that platinum-based chemotherapy was well-tolerated, with low treatment-related mortality.
SourceH. Lee Moffitt Cancer Center & Research Institute·JournalJNCI Journal of the National Cancer Institute·TypeMeta-analysis·DateFeb 16, 2024
A new treatment combining a novel drug with traditional chemotherapy has been shown to increase the survival of patients with malignant mesothelioma, a rare and aggressive cancer. The ATOMIC-meso trial found that this treatment quadrupled the survival at 36 months compared to placebo-chemotherapy.
SourceQueen Mary University of London·JournalJAMA Oncology·TypeRandomized controlled/clinical trial·DateFeb 15, 2024
A four-drug chemotherapy regimen, NALIRIFOX, has been approved by the FDA for frontline treatment of metastatic pancreatic adenocarcinoma. The regimen, combining irinotecan liposome, oxaliplatin, leucovorin, and fluorouracil, resulted in longer overall survival compared to a two-drug protocol.
SourceUniversity of California - Los Angeles Health Sciences·JournalThe Lancet·DateFeb 15, 2024
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
Researchers discovered genes encoding growth regulators normally not present in myeloid cells are expressed by leukaemic stem cells, allowing them to grow. Repurposed drugs targeting these receptors show promise in blocking stem cell growth and preventing disease relapse in specific types of AML.
SourceUniversity of Birmingham·JournalNature Communications·TypeExperimental study·DateFeb 15, 2024
Researchers found that USP1 inhibits cdc42, increases EWS-FLI1 transcriptional output, and simulates Ewing sarcoma growth. A pharmacological inhibitor of USP1 activated cdc42 and inhibited Ewing sarcoma growth.
SourceImpact Journals LLC·JournalGenes & Cancer·DateFeb 14, 2024
A team of physicists and veterinary scientists at Purdue University has developed a method to detect chemoresistance in cancer patients using biodynamic imaging (BDI). This technique measures the motions inside cancer cells and how they respond to chemotherapy, identifying patients who will not respond to treatment. The study shows pro...
SourcePurdue University·JournalScientific Reports·DateFeb 13, 2024
Researchers propose a novel augmentation regimen, IPIAD, combining five generic non-oncology drugs with standard chemotherapy for pancreatic ductal adenocarcinoma. The IPIAD regimen uses repurposed drugs like irbesartan and azithromycin to potentially slow disease growth and improve outcomes.
SourceImpact Journals LLC·JournalOncoscience·TypeCommentary/editorial·DateFeb 9, 2024
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Researchers identified mechanisms that cause ponatinib to harm the heart and found a promising treatment that could reverse this process. The treatment protects heart cells without diminishing the tumor-fighting efficacy of the drug.
SourceUniversity of Illinois Chicago·JournalCirculation Research·DateFeb 8, 2024
Researchers discovered a link between single cancer cell mutations and clinical response to epigenetic therapy in myelodysplastic syndrome. Patients showing treatment benefits had decreased mutation counts in stem cells and immature granulocytes, suggesting early tumor elimination is key to therapy success.
SourceJosep Carreras Leukaemia Research Institute·JournalCancer Research Communications·TypeExperimental study·DateFeb 5, 2024
A team of researchers found that diffuse anaplasia (DA) subtype of Wilms tumor grows despite high DNA damage and TP53 mutation, leading to resistance to chemotherapy. The study suggests that DA histology emerges through accumulating DNA damage and CNAs, creating selection pressure for TP53 mutations.
SourceNagoya University·JournalModern Pathology·DateFeb 1, 2024
A team led by UCF College of Nursing Professor Victoria Loerzel developed an innovative educational game for older adults with cancer, simulating symptoms and self-management. The game was successful in increasing the use of preventative strategies among participants, reducing symptom severity and hospital admissions.
A study found that the 21-gene breast recurrence score test may underestimate chemotherapy benefits for young Black women with estrogen receptor-positive breast cancer. The researchers recommend lowering the test's cutoff point to ensure accurate treatment recommendations for all patients regardless of race or ethnicity.
SourceUniversity of Illinois Chicago·JournalJournal of the National Comprehensive Cancer Network·DateJan 29, 2024
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Researchers discovered that cisplatin chemotherapy enhances the immune system's ability to fight bladder cancer by modulating the immune response and damaging DNA in cancer cells. This approach may lead to durable disease control in a subset of patients with metastatic bladder cancer.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalCell Reports Medicine·DateJan 26, 2024
Senescent tumour cells generated by chemotherapy can create an environment that helps tumour cells escape treatment. Eliminating these cells with immunotherapy boosts the effectiveness of chemotherapy.
SourceInstitute for Research in Biomedicine (IRB Barcelona)·JournalNature Cancer·DateJan 24, 2024
Researchers found that high levels of FSP1 are associated with relapse after cisplatin treatment in head and neck squamous cell carcinoma. Targeting FSP1 can attenuate tumor stemness and downregulate invasion and metastatic rates, suggesting a potential new approach for treating drug-tolerant persister cancer cells.
SourceImpact Journals LLC·JournalAging-US·TypeExperimental study·DateJan 24, 2024
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
Researchers at Washington State University have discovered a key protein in prostate cancer cells' resistance to docetaxel. Blocking this protein, CHRM1, with dicyclomine restored the effectiveness of docetaxel and reduced tumor growth.
SourceWashington State University·JournalCell Reports Medicine·TypeExperimental study·DateJan 22, 2024
A groundbreaking study uses machine learning to predict treatment resistance in cervical cancer by analyzing genetic mutations. The algorithm identified molecular assemblies driving treatment resistance and pinpointed tumors most susceptible to therapy, resulting in improved patient outcomes.
SourceUniversity of California - San Diego·JournalCancer Discovery·DateJan 18, 2024
Researchers found a combination treatment involving high doses of radiation and chemotherapy to be safe and effective in treating locally advanced non-small cell lung cancer. The treatment, which includes an adaptive boost plan, showed promising results in improving progression-free survival and reducing toxic side effects.
SourceUniversity of California - Los Angeles Health Sciences·JournalJAMA Oncology·DateJan 11, 2024
Davis Instruments Vantage Pro2 Weather Station
Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
A systematic analysis of cancer cells identifies 370 candidate priority drug targets across 27 cancer types. Researchers used machine learning methods to find promising targets and linked them to specific biological markers and genetic features.
SourceWellcome Trust Sanger Institute·JournalCancer Cell·TypeData/statistical analysis·DateJan 11, 2024
A new trial found that combining anti-angiogenic drugs with chemotherapy led to more young people seeing their tumors shrink, from 18% in the control group to 26%. Patients who received Bevacizumab additionally had better one year progression-free survival rates.
SourceUniversity of Birmingham·JournalJournal of Clinical Oncology·TypeRandomized controlled/clinical trial·DateJan 9, 2024
Researchers created nanoparticles using ultraviolet light crosslinked amino acids, loaded with doxorubicin and coated with tannic acid complex. The nanoparticles exhibited superior stability and drug release under different pH conditions, showing excellent anticancer activity in tumor-bearing mice.
SourceJapan Advanced Institute of Science and Technology·JournalSmall·DateJan 8, 2024
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
Researchers have identified a gene that links deafness to cell death in the inner ear, creating new opportunities for preventing hearing loss. The discovery suggests that UPR-blocking drugs could prevent deafness caused by loud noise exposure or aging.
SourceUniversity of California - San Francisco·JournalJCI Insight·DateJan 8, 2024
A phase III study found that selpercatinib significantly improves cancer progression-free survival in patients with NSCLC and RET gene translocations. The therapy also demonstrated efficacy in treating intracranial lesions, a common challenge in advanced NSCLC.
SourceD'Or Institute for Research and Education·JournalNew England Journal of Medicine·DateJan 5, 2024
Researchers have developed a novel method to produce a selective anticancer precursor substance. The synthesis involves the reaction of metal-active oxygen species with nitrile, utilizing cost-effective metals at lower temperatures. This breakthrough opens up new possibilities in developing innovative drugs against cancer.
SourceUlsan National Institute of Science and Technology(UNIST)·JournalJACS Au·DateDec 28, 2023
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers from Brazil discuss the management of refractory or relapsed classic Hodgkin lymphoma in adults, highlighting novel agents such as brentuximab vedotin and immunotherapy. The Brazilian healthcare system's constraints are also considered when making treatment decisions.
SourceImpact Journals LLC·JournalOncotarget·TypeLiterature review·DateDec 20, 2023
Researchers have identified promising treatment candidates for morphine tolerance and cancer, as well as a biomarker for kidney injury. A monoclonal antibody targeting the mu-opioid receptor has been shown to alleviate morphine tolerance and physical dependence, while inducing excessive mitochondrial fission in tumor cells. Additionall...
SourceCactus Communications·JournalJournal of Pharmaceutical Analysis·TypeExperimental study·DateDec 14, 2023
The combination of atezolizumab and carboplatin improved overall survival by 3.9 months, and lengthened progression-free survival from 2.2 to 4.1 months. Patients with higher body mass indexes and uncontrolled blood glucose levels showed greater benefits.
SourceVanderbilt University Medical Center·JournalJAMA Oncology·DateDec 14, 2023
A phase III clinical trial found that neoadjuvant chemotherapy can downstage lymph node-positive breast cancer, allowing patients to safely omit adjuvant regional nodal irradiation. This treatment de-escalation strategy is an option for patients whose lymph nodes become cancer-free after neoadjuvant treatment.
SourceAmerican Association for Cancer Research·DateDec 6, 2023
Researchers at Salk Institute discovered how anti-cancer drugs can prevent fibroblast activation, a protective barrier around pancreatic tumors. The therapy reduces tumor growth and slows disease progression in mice and human patients, offering a promising treatment for pancreatic cancer.
SourceSalk Institute·JournalNature Communications·DateDec 6, 2023
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers from Japan have discovered a novel targeted molecular therapy using microRNA-451a to suppress the progression of gemcitabine-resistant biliary tract cancers. The study found that miR-451a significantly diminished cell proliferation, induced cell death, and reduced chemoresistance in cancer cells.
SourceOkayama University·JournalMolecular Therapy — Nucleic Acids·TypeExperimental study·DateNov 30, 2023
Scientists have developed a drug-eluting hydrogel that provides sustained, pH-dependent drug co-delivery and promotes anti-tumor immune responses, reducing tumor cell proliferation and growth. The treatment shows promise in treating hepatocellular carcinoma, with enhanced efficacy compared to traditional methods.
SourceTerasaki Institute for Biomedical Innovation·JournalAdvanced Functional Materials·TypeExperimental study·DateNov 29, 2023
A new AI tool combines cancerous and non-cancerous cell patterns to predict breast cancer outcomes, allowing for more precise treatment plans. This could lead to reduced chemotherapy duration and intensity for some patients.
SourceNorthwestern University·JournalNature Medicine·DateNov 27, 2023
Researchers developed novel small molecule inhibitors of CPSF3, a key regulator of transcription termination in ovarian cancer cells. These inhibitors exhibited potent antiproliferative effects and suppressed tumor growth in vivo.
SourceChinese Academy of Sciences Headquarters·JournalScience Advances·TypeExperimental study·DateNov 24, 2023
A study of 103,000 early-stage breast cancer patients reveals a significant racial disparity in chemosensitivity and survival rates. Black patients are more likely to experience residual disease after neoadjuvant chemotherapy, leading to a higher mortality risk.
SourceJAMA Network·JournalJAMA Network Open·DateNov 22, 2023
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers from ICMR-National Institute of Nutrition advocate for repurposing non-cancerous drugs to target Cancer Stem Cells (CSCs), which are resilient to conventional treatments. The study identified a range of non-cancer drugs with potential to target CSCs directly, and combining these with micronutrients amplifies their anticance...
SourceChongqing Medical University·JournalGenes & Diseases·DateNov 22, 2023
Researchers investigate nanoparticles for cancer treatment, hoping to reduce side effects and improve efficacy. La-Beck's lab aims to understand the body's interaction with nanoparticles and their impact on tumor growth and immune responses.
SourceTexas Tech University Health Sciences Center·DateNov 17, 2023
Two phase-3 clinical trials demonstrate a significant increase in overall survival and progression-free survival for bladder cancer patients treated with immunotherapy combinations. The studies show a 22% reduction in the risk of death compared to chemotherapy alone, providing a promising new approach for treating advanced bladder cancer.
SourceNetherlands Cancer Institute·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateNov 16, 2023