Research on treating disease with medication. Covers psychedelics, combination cancer therapy, opioid treatment in pregnancy, and personalized guidelines.
Electrochemotherapy (ECT) combines electro-poration with chemotherapy to increase drug uptake in tumor cells, enhancing the radiosensitizing effect. The treatment has been shown to be effective in treating progressive skin tumors in the head and neck area, preserving cosmetic appearance and function of surrounding tissues.
Researchers at the University of York and Leeds have made a major discovery in Hepatitis B Virus assembly, paving the way for new drug treatments. The team identified an 'assembly code' in the genetic material that allows the virus to create a protective casing.
A team of international scientists has identified a critical gene-regulating protein, Bdf1, essential for the survival of Candida albicans. Compounds that bind to this target can disrupt fungal growth, opening the way for novel drug treatments. The discovery offers a promising alternative to existing antifungal therapies.
Researchers have developed a new sequential multiple assignment randomized (SMART) trial method to test two hypotheses at once. This approach allows for the simultaneous evaluation of different treatments, potentially leading to more accurate results and increased efficiency in clinical trials.
A clinical trial comparing traditional ferrous sulfate with a new iron polysaccharide complex preparation found that traditional treatment is more effective in treating iron-deficiency anemia in young children. The study, published in JAMA, showed that a low-dose daily treatment can be effective in restoring normal hemoglobin levels wi...
This study evaluated the effects of fluoride bleaching agents on human enamel. It found that fluorine bleaching agents increased the concentration of fluorine, calcium, and phosphorus ions in the enamel without altering its microhardness.
A new study suggests that dronabinol, an old pharmaceutical product, could be a potential treatment for obstructive sleep apnea. Researchers found that the drug reduced the frequency of apneas and hypopneas during sleep, decreased subjective sleepiness, and improved overall treatment satisfaction.
A new study has found that patients undergoing electroconvulsive therapy (ECT) for psychiatric disorders have a positive experience, with 80% viewing the treatment as useful and 70% finding it more efficacious than drug therapy. The study aims to validate ECT as a less frightening option by improving its administration standards.
A new cancer medicine, larotrectinib, has demonstrated compelling evidence for treating a range of advanced cancers. The therapy, which targets TRK fusion proteins, resulted in responses in 76% of patients across 17 different types of cancer. After 12 months of treatment, 79% of responding patients remained progression-free.
Researchers from Novartis and collaborators have discovered a novel drug candidate, KDU731, to combat the protozoan parasite Cryptosporidium, which causes cryptosporidiosis. This breakthrough offers hope for new treatment options against this disease, which currently has no effective treatments or vaccines.
The chartbook highlights the prevalence of multiple chronic conditions among older adults and women, emphasizing treatment challenges for patients with co-occurring health issues. The data also underscores the significant burden of chronic illness on the healthcare system.
Researchers identified a risk locus for urinary incontinence near the endothelin gene, which is involved in bladder contraction. The study suggests that drugs targeting this pathway may help alleviate symptoms, offering new hope for women suffering from stress and isolated urgency incontinence.
Researchers have identified a protein causing liver fibrosis, paving the way for new treatments. The discovery, led by Professor Jacob George and Doctor Mohammed Eslam, reveals that variations in the interferon lambda 3 (INLF3) protein are responsible for tissue damage in the liver.
Researchers analyzed thousands of social media posts to find that IBD patients are more concerned with the risks of biologic medications than their benefits or financial costs. The study suggests that physicians need to do a better job explaining the pros and cons of treatments.
A Phase 3 clinical trial found that adding mepolizumab to standard treatment for eosinophilic granulomatosis with polyangiitis (EGPA) significantly improved remission rates, with 28% of participants achieving remission after one year. The disease was in remission at weeks 36 and 48 in 32% of participants who received mepolizumab.
The Journal of Ocular Pharmacology and Therapeutics presents novel therapeutic approaches for treating uveitis, including cyclosporine, topical ganciclovir, and regulatory T cell therapy. These advances aim to improve treatment outcomes and quality of life for patients with autoimmune uveitis.
The American College of Physicians recommends treating women with osteoporosis with bisphosphonates or denosumab, while men may also benefit from treatment to reduce vertebral fracture risk. The guideline emphasizes the importance of medication adherence and avoids estrogen therapy due to its associated risks.
A comprehensive review of clinical and basic research studies found that antipsychotics improve outcomes for patients with schizophrenia and related disorders. The benefits of these medications outweigh potential side effects, and delaying treatment can lead to poorer long-term outcomes.
The USPSTF concludes that screening for preeclampsia has a substantial net benefit, allowing for early identification and effective treatment to prevent serious complications. Moderate-certainty evidence supports the effectiveness of well-established treatments in reducing maternal and perinatal morbidity and mortality.
Researchers have identified a new approach to protect patients from graft-versus-host disease by activating signal paths in the gut. The key to preventing GVHD is protecting the epithelial cells, which can be achieved by using RIG-I and STING proteins.
The American Telemedicine Association has published new guidelines to improve remote stroke care using telemedicine communication technologies. The guidelines describe the network of audio-visual communication systems and computer systems needed to link an expert stroke team with a remote patient, aiming to rapidly diagnose and treat i...
Researchers found UM-Palmitoylethanolamide to slow down Parkinson's disease progression and disability, improving non-motor and motor aspects of daily living. The study used ultra-micronized palmitoylethanolamide as an add-on therapy in advanced PD patients, with significant reductions in symptoms.
A new study published in Nature reveals that matching tumor size to the strength of the immune response can enhance treatment outcomes for melanoma patients. The research found that larger tumors require a stronger immune response to shrink, providing insights into why some patients don't respond to immunotherapy.
Omalizumab, an asthma drug, demonstrates significant symptom improvements and prevention in patients with cold urticaria and symptomatic dermographism. The treatment was found to be effective in nearly half of patients with symptoms after exposure to stimuli.
Researchers used patient's own muscle stem cells to create patches that were surgically glued onto the surface of patients' hearts. One year after treatment, patients showed improvements in exercise capacity and heart function, suggesting this cell patch may be a viable therapy for treating heart failure.
A new study by researchers at the University of Gothenburg found that many treatments for urinary and fecal incontinence are ineffective, with surgery being the most successful treatment option. The study analyzed thousands of research articles and found that only 37% of people treated with bulking agents achieved long-term success.
A new study found that continuing checkpoint inhibitor treatment after tumor growth can significantly extend survival for some head and neck cancer patients. The research, based on a phase 3 clinical trial, showed that 57 of 139 patients who continued treatment had a median survival period of 12.7 months.
The US Preventive Services Task Force found inadequate evidence on celiac disease screening accuracy, benefits and harms of screening, and treatment effects. Current evidence is insufficient to assess balance of benefits and harms of screening for asymptomatic individuals.
Researchers have discovered small molecule drugs that activate signaling pathways leading to specific adult brain cell types from stem cells. These findings provide new insights into neural development and repair, identifying several new approved drugs with potential therapeutic value for brain injury repair.
Researchers developed minitablets with synthetic flavourings and coatings to enhance palatability, making it easier for cats to take medication. The study found that amino acids and vitamin B-based flavours were promising options, but further research is needed.
Research reveals that expression levels of ABCB1 and ABCG2 transporters significantly affect cell resistance to Dasatinib. Lower transporter expression levels mediate lower resistance, implying a potential breakthrough for targeted cancer treatment.
Smokers in recovery from illicit drug use disorders face a higher risk of relapsing three years later compared to non-smokers. Quitting cigarettes may help adults stay sober and improve substance treatment outcomes.
A University of Liverpool-led trial has successfully used nanotechnology to improve drug therapies for HIV patients, achieving a 50% dose reduction while maintaining therapeutic exposure. The trial's results have the potential to revolutionize HIV treatment, making it safer, more affordable and accessible to resource-limited countries.
A study found that minority groups, women, and residents of the 'Stroke Belt' are less likely to receive tissue plasminogen activator (tPA) treatment for ischemic stroke. Despite efforts to increase access, disparities persist in healthcare delivery.
A new clinical practice guideline provides comprehensive analysis of individual agents used in treating chronic insomnia disorder. The guideline recommends specific medications for sleep onset and maintenance insomnia, emphasizing the importance of sound clinical judgment in patient care.
Sandra Horning, a cancer survivor and renowned oncologist, will receive the Duane Roth Memorial Award for her pioneering work in developing new treatments for lymphoma. Her commitment to personalized therapies and holistic approaches to patient care has improved cancer treatment outcomes.
Researchers identify factors determining when containment or aggressive treatment is best, providing new guidance for physicians and patients. Containment strategies can prolong treatment life and improve outcomes in certain situations.
A new mathematical analysis provides guidance for treating infections and tumors with drug resistance, suggesting that containment may extend effective life and improve patient outcomes in some cases. The study identifies two main factors influencing the choice between containment and aggressive treatment.
Older adults with newly diagnosed epilepsy are often prescribed older anti-epileptic drugs, with only half starting treatment within the first 30 days. Despite this, minority groups do not appear to receive different AED treatment compared to whites.
Researchers at the University of Cincinnati are developing a cell therapy that utilizes modified facial muscle cells to regenerate heart tissue. This innovative approach aims to address the limitations of existing treatments, which often rely on drug therapies or surgery, and may reduce rejection risks.
Researchers at Washington State University found that offering prizes can be an effective, low-cost treatment for alcohol abuse among individuals with serious mental illness, reducing tobacco and drug use. The study's findings could expand treatment options for millions of Americans, particularly those from native populations.
Dr. Stanley T. Crooke presents a detailed look at the mechanisms underlying antisense drug activity, including prehybridization, hybridization, and post-hybridization phases. He highlights his group's contributions to characterizing ASO therapeutics' design, targeting, and mechanism of action.
Researchers are studying the effectiveness of two treatment options for children with Kawasaki disease who resist initial therapy. The study aims to compare the impact of IVIG and infliximab on preventing heart damage in these patients.
The IOF-ECTS Position Paper proposes measuring specific bone turnover markers to detect low adherence to oral bisphosphonates, a common issue in chronic diseases. This early identification enables discussion and intervention with patients, potentially improving treatment efficacy.
Researchers demonstrate that massaging hair can increase the delivery of nanoparticles to hair follicles by creating channels for particle transport. The ratchet mechanism enhances particle speed and diffusion when massaged parallel to the resting surface.
Terrie E. Taylor, a Michigan State University professor, is working on developing new treatments for cerebral malaria, the deadliest form of the disease. Her research aims to identify interventions that can reduce brain swelling and save children's lives.
The US Preventive Services Task Force concludes that screening for obstructive sleep apnea (OSA) in asymptomatic adults lacks sufficient evidence to assess benefits and harms. Current evidence supports treatment with CPAP, but its applicability to screen-detected populations is unknown.
Researchers have made significant progress treating anti-NMDA receptor encephalitis with a new regimen, including patients who previously did not respond. The treatment, which includes bortezomib, has shown to quickly improve clinical symptoms and reduce antibodies responsible for the disease.
Hemodialysis patients have altered blood clots that increase cardiovascular and other cause mortality risks. Dense blood clots found in kidney failure patients also affect fibrinogen protein modifications.
A German multicenter study confirms the efficacy and safety of Lu-177-PSMA-617 radioligand therapy for metastatic castration-resistant prostate cancer, demonstrating a positive response rate of 45% and manageable side effects. The treatment offers an additional option for end-stage patients with high response rates and low toxicity.
Researchers at the University of Rochester Medical Center have identified a potential new treatment approach for lysosomal storage disorders, which cause disruptions in cellular functioning. The study found that repurposed drugs can overcome toxic build-up in affected cells, improving survival rates and quality of life.
A study of over 5,500 women found that younger patients and those who had taken hormone replacement therapy were less likely to adhere to their medicine. The researchers identified several factors that contributed to non-adherence, including socioeconomic status and marital status, highlighting the need for targeted strategies to impro...
A University of Liverpool study found that reducing the dose of leukemia drug tyrosine kinase inhibitors (TKI) can safely reduce side effects in patients with chronic myeloid leukemia. Patients who achieved stable molecular remission levels showed no evidence of leukaemia rebound after cutting their TKI dose, with some reporting signif...
Research shows that ibrutinib can benefit patients with GVHD who don't respond to corticosteroid treatment, with 71% experiencing sustained improvements. Ibrutinib targets specific immune cells involved in GVHD, offering a new therapeutic option for those with limited treatment options.
A recent randomized controlled trial found that high-dose baclofen added little to the effect of psychosocial treatment in patients with alcohol dependence. The study, involving 151 patients, showed no significant differences in relapse rates between groups receiving different doses of baclofen or placebo.
A panel of concussion experts recommends a more active approach to treatment, matching treatments to specific symptoms and impairments. The 'TEAM' approach aims to enhance recovery by targeting individual clinical profiles and using multidisciplinary rehabilitation teams.
A study published in BMJ Open found that many fertility clinics make unsubstantiated claims about treatments beyond standard IVF procedures. The researchers identified a lack of supporting evidence cited by websites and clinics, with only a few interventions having moderate quality evidence to support their benefits.
Research at RIT aims to understand vitreous humor properties that result in vision impairment. The study may unlock new treatments for vision disorders and improve drug delivery and eye surgery.
A randomized clinical trial led by Duke University School of Medicine researcher found that individual cognitive therapy relieved PTSD symptoms better and quicker than group therapy. Nearly half of participants who received one-on-one therapy improved so much they no longer carried a PTSD diagnosis, whereas almost 40 percent of those i...
The University of Utah Health has received a five-year contract renewal from the NIH to test drugs for treating refractory epilepsy, with the goal of identifying novel compounds. The program aims to address unmet medical needs in epilepsy patients and develop new therapies for different types of epilepsy.