Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
A study in rats suggests that vitamin C supplementation can help preserve skeletal muscle after doxorubicin therapy, reducing oxidative stress and inflammation. The findings suggest vitamin C may represent a promising opportunity to reduce some of the drug's most debilitating side effects.
A study presented at the American College of Cardiology's Annual Scientific Session found that personalized nutrition education in grocery stores significantly improved DASH diet adherence. Participants who received six one-on-one sessions with a dietitian showed an average increase of 4.7 points on their DASH scores.
A new study suggests that cardamonin, a compound from the cardamom spice, can kill triple-negative breast cancer cells and reduce PD-L1 expression. The findings hold promise for improving cancer therapy without severe side effects.
Researchers developed an algorithm to classify 16 distinct adult sleep patterns based on arm acceleration data from 100,000 UK Biobank participants. These patterns can be used to diagnose insomnia and develop personalized treatment methods, offering new insights into human sleep behavior.
A new collaboration between UW Oshkosh and Fauna Bio aims to translate animal disease resistance into human treatments. The partnership will enable researchers to study emerging animal models, such as the 13-lined ground squirrel, to develop novel therapeutic programs.
H. Alex Choi receives NIH grant to develop protein biomarkers for delayed cerebral ischemia, a complication after subarachnoid hemorrhage that affects approximately 50,000 Americans annually. The goal is to predict which patients will worsen and identify biological processes causing worsening patients.
Researchers at Okayama University have created a new method to kill cancer cells using light-activated protein AR3, reducing the risk of adverse reactions. The approach uses green light to trigger apoptosis in targeted cells, offering a promising alternative to conventional treatments.
A new treatment approach has been proposed for children with congenital muscle disorders, using inhibitors to improve muscle function and movement in mice with mutations in the RYR1 gene. The therapy targets genetic material overload caused by excessive enzyme production, leading to reduced access of genes to cellular machinery.
Researchers at UVA Health System discovered a cluster of cells in the brainstem that controls the body's response to severe blood loss. The study found that re-activating these neurons can restore blood pressure and heart rate in lab rats, offering new hope for treating traumatic injuries.
Researchers at Boston University have developed optoacoustic neurostimulation with single neuron and subcellular level precision. Optoacoustic neuromodulation may offer advantages over ultrasonic neuromodulation, including higher spatial temporal resolution.
A report by the British Pharmacological Society and Royal College of Physicians recommends integrating pharmacogenomic testing to ensure medicines work safely and effectively for individual patients. The UK is a world leader in genomic medicine, and expanded testing would further demonstrate this leadership.
The Experimental Biology (EB) 2022 meeting features live presentations and a moderated Q&A session on groundbreaking studies. The virtual press conference reveals potential treatments for Parkinson's disease, COVID-19 vaccine-associated side effects, and alleviating food allergies.
In an animal study, researchers created an implantable biotechnology called MASTER that produces and releases CAR-T cells for attacking cancerous tumors. This technology reduces the manufacturing time from weeks to hours, increasing efficiency and effectiveness.
Research found that IVF clinics offering money-back guarantees have a higher live-birth success rate and lower multiple birth risks compared to those without MBGs. The study suggests that these programs serve as signals of high-quality care in the field of IVF and other healthcare services.
A study found that 42% of TikTok videos on high blood pressure focused on alternative medicine, while only 5% mentioned exercise. Most creators were not healthcare professionals, highlighting the need for more emphasis on credible sources.
Researchers have identified a new family of proteins in blood vessels that prevent fluid from entering the lungs, offering a potential new avenue for treating acute respiratory distress syndrome. Stimulating these bitter taste receptors has been shown to provide protection against fluid leak into the lung.
A study found that 25.3% of children with mild head injuries continue to suffer from persistent post-concussion syndrome for years, often misdiagnosed as ADHD or sleep disorders. The syndrome causes chronic symptoms like forgetfulness, memory problems, and sensitivity to light and noise.
A recent study found that approximately 1 in 3 heart attack survivors experience significant mental decline in the days and months following their heart attack. Cognitive deficits can impact quality of life and treatment adherence, emphasizing the need for cardiologists to monitor patients regularly.
The American College of Chest Physicians journal features cutting-edge original research on various chest medicine topics, including asthma, COPD, critical care, and sleep. The March issue includes a special series on nontuberculous mycobacterial pulmonary disease, offering insights into clinical epidemiology, risk factors, and diagnosis.
Researchers found that obstructive sleep apnea (OSA) accelerates the biological aging process and causes epigenetic age acceleration, leading to increased mortality risk. However, one year of CPAP treatment significantly slows down biological age acceleration in OSA patients, suggesting a potential reversal of age-related trends.
Researchers found that four-month treatment is as effective as six months in non-severe TB cases, allowing for savings on screening and training healthcare workers. The study's results led to a change in the World Health Organisation's global guidelines, recommending a shorter treatment course for children with non-severe TB.
A study of 1,164 patients with COVID-19 found that continuing dexamethasone treatment at hospital discharge was associated with lower readmission rates and mortality within 14 days. The treatment also showed significant benefits in reducing the risk of severe disease progression.
The World Congress on Osteoporosis, Osteoarthritis & Musculoskeletal Diseases (WCO-IOF-ESCEO) 2022 will discuss secondary fracture prevention. Global experts will provide clinical guidance and information on post-fracture care through various sessions.
A team of UTSA researchers has developed an innovative inhibitor that blocks the effects of cytochrome P450 8B1, a key enzyme linked to cholesterol absorption and obesity. The treatment shows promise in reducing glucose levels without affecting body weight, offering potential relief from obesity-associated metabolic disorders.
Researchers analyzed mortality rates and complications among 5,500 COVID-19 patients treated at dedicated vs non-dedicated hospitals in Minnesota. The study found no significant difference in outcomes between the two types of hospitals.
Researchers at University of Texas at Austin create first-ever biologically authentic computer model of HIV-1 virus liposome, shedding light on replication and infectivity. The study reveals key characteristics of the liposome's asymmetry and its role in shaping macroscopic properties.
Researchers found that it took nearly three years for these drugs and biologics to be incorporated into clinical guidelines, highlighting a significant delay in patient access. The study suggests that expedited approval processes are only the first step, and planning ahead is crucial to bring needed treatments to patients.
Researchers at MIT have performed a systematic study on how different-sized polymer nanoparticles circulate in the body and interact with platelets to stop bleeding. They found that intermediate-sized particles (150 nanometers) were the most effective, with less likelihood of accumulating in off-target sites.
Researchers have made a significant breakthrough in predicting heart attacks and strokes by developing a non-invasive method using super-resolution ultrasound imaging. The technology aims to detect high-risk atherosclerotic plaques that are prone to rupture, allowing doctors to prescribe life-saving interventions.
Researchers have solved atomic-level structures of the muscle-type nicotinic acetylcholine receptor, a crucial step in understanding its function. The new findings could lead to breakthroughs in treating neurological disorders such as congenital myasthenic syndrome and myasthenia gravis.
A new study by Carnegie Mellon University found that veterans who received emergency treatment at VA hospitals had a 20% lower mortality rate compared to those treated at non-VA hospitals. The survival advantage was consistent across different patient groups, including men, women, age, and pre-existing conditions.
A new poll of people aged 50 and older found that nearly 1 in 3 had a COVID-related delay for healthcare appointments in 2021. Many unvaccinated individuals still haven't rescheduled their appointments, posing concerns about preventive care, chronic condition management, and operations.
A combined analysis of 149 studies reveals that treatment rates for major depressive disorder remain low worldwide, particularly in low and lower-middle income countries. Treatment rates are estimated to be 33% in high-income countries and just 8% in low and lower-middle income countries.
Researchers found that infusing bone-marrow stem cells into mice with sepsis increased their survival by 50-60% and decreased inflammation. This treatment could offer an alternative to current granulocyte transfusions, which have limited benefits.
A recent study by researchers from Ritsumeikan University found that athletes with a history of sprained ankle showed reduced gut bacteria diversity compared to those without such a history. This suggests that musculoskeletal injury may have a negative impact on the gut microbiota, potentially leading to long-term health consequences.
Researchers at Tokyo University of Science have developed bionanoparticles derived from corn that selectively target and inhibit the growth of cancer cells, inducing tumor necrosis factor-α release. These findings suggest a novel, economical, and safe anti-cancer therapy approach.
A new machine learning process has been developed to identify and classify hip fractures from X-rays, achieving 92% accuracy and confidence. This approach aims to improve patient outcomes, reduce care costs, and alleviate the bottleneck of unreported radiographs in the UK.
The American Heart Association has outlined five core elements to optimize the treatment of in-hospital strokes. These include education, quality review, and oversight for in-patient stroke response teams. Developing targeted quality improvement plans is crucial to reducing delays and improving outcomes for hospitalized patients.
Researchers found no clinical improvements in very elderly patients with CPAP therapy for moderate-to-severe sleep apnea. The study suggests that CPAP treatment is less effective in patients older than 80 due to a more sedentary lifestyle and other underlying disorders, limiting its long-term adherence.
Scientists have engineered baker's yeast to produce D-lysergic acid, a medication used to treat neuro-cognitive diseases. This sustainable method could potentially produce up to five tons of DLA annually, reducing the environmental impact of industrial drug production.
Researchers have discovered a streamlined two-step synthesis strategy to produce neoechinulin B and its derivatives, exhibiting strong anti-HCV and anti-SARS-CoV-2 activities. The novel process utilizes a piperazine-2,5-dione derivative and tetra-n-butylammonium fluoride (TBAF) as key reagents.
Many pragmatic trials fail to collect patient-reported data on experience, burden of disease, and quality of life. Despite this, the authors suggest that including patient-reported outcomes can provide valuable insights into patient well-being. The study urges researchers to prioritize patient-centered approaches in clinical trials.
A new genomics study has helped guide the development of vaccines against Shigella, a leading cause of severe diarrhoea in children. The research revealed the extent of genomic diversity among Shigella species, highlighting challenges to current vaccine approaches.
A plant-based diet has been shown to lower the risk of COVID-19 infection and severe illness, with some studies suggesting a 9% lower risk and 73% lower risk among healthcare workers. The 'blue zone' diet, prevalent in Okinawa, Japan, may also provide benefits.
Samuel Galgano and Pankaj Gupta have been named the 2022 Melvin M. Figley Fellow in Radiology Journalism and the 2022 Lee F. Rogers International Fellow in Radiology Journalism, respectively. They will attend the 2022 ARRS Annual Meeting and participate in the Editor’s Forum.
Researchers developed a new 'Easy-BILAG' tool to measure lupus disease progression, enabling accurate and consistent assessments in 91.3% of cases. The single-page document uses color-coding to make assessment more user-friendly, reducing completion time from 80 minutes to under an hour.
Researchers at MU developed a new framework to identify people previously overlooked for AUD, focusing on 13 risk factors such as impulsive behavior and reward sensitivity. The framework aims to provide more accurate diagnoses and connect individuals with tailored treatment options.
The WV Clinical and Translational Science Institute is leading a national study on post-acute sequelae of COVID-19 (PASC) among adults. The study, funded by the National Institutes of Health, aims to better understand the long-term effects of COVID-19 and develop effective treatments for this disabling complication.
Researchers at National Jewish Health have discovered that mitochondria do not function properly in patients with post-COVID syndrome, leading to debilitating symptoms. The study's findings may lead to treatments for patients struggling with fluctuating heart rates, extreme fatigue and memory issues.
A pre-clinical study showed that the use of extracellular matrix supports improved nerve fibre regeneration across large nerve defects. The team's novel ECM-loaded medical device increased pro-repair inflammation, blood vessel density, and regenerating nerves, offering a promising alternative to current therapies.
A ketogenic diet has been shown to improve spatial memory and visual memory, lower brain inflammation indices, and cause less neuronal death in individuals with traumatic brain injuries. The diet may also slow down the rate of cellular aging, offering hope for those suffering from this condition.
Researchers at Waseda University discovered a new protein isoform called Senp5S, which helps regulate Drp1 and mitochondrial dynamics during brain development. The study suggests a novel and vital role for post-translational SUMOylation in neuronal differentiation.
A team of scientists at the University of Missouri used small wearable sensors to gather data on how people with a traumatic hand amputation use a prosthesis versus a transplanted hand. The study found that hand transplant recipients exhibit a more balanced pattern of limb use, while prosthesis users rely heavily on their prosthetic hand.
A study identified 17 military medical treatment facilities that can provide high-quality obstetric care, including emergency cesarean delivery. This collaboration could reduce preventable maternal mortality and improve care for pregnant patients in rural communities.
The January issues of American Psychiatric Association journals feature new research on the factors underlying alcohol and cannabis use, as well as their interactions with other psychiatric illnesses. The journals also address disparities in coercive treatment for psychosis and provide insights into mental health services delivery.
A recent University of Waterloo study shows that wearable biosensors can provide insight into patterns of health-related behaviour and disease symptoms, enabling remote monitoring of people with complex health conditions. The study found that participants were willing to wear multi-sensor devices for extended periods, highlighting the ...
Research found the female genital field's location varies among women and is thicker with more frequent sex. The somatosensory cortex devotes space to detecting touch, and the region's structure alters in relation to use.
A new study has made an Alzheimer's disease biomarker test available to all Canadians, enabling doctors to accurately diagnose the disease even when mild symptoms are present. The test aims to improve care and support for individuals living with Alzheimer's disease and their families.
Researchers discover novel compound AD732 with anti-inflammatory and analgesic properties, outperforming standard NSAIDs while causing minimal harm. The compound may be a safer alternative for treating pain and inflammation in difficult diseases like ulcerative colitis and Crohn's disease.
A survey of 121 fertility specialists in Australia, UK, and New Zealand found that endometrial scratching is still offered by 34% of clinics despite lack of evidence, primarily for psychological benefits. Many respondents considered the procedure's drawbacks, including pain and cost.