Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
New guidelines aim to standardize interpretation of MRI scans in patients with pelvic floor disorders, promoting shared understanding among professionals. The consensus statement provides definitions and templates for diagnosing conditions such as incontinence, constipation, and prolapse.
The World Health Organization (WHO) recommends a treatment combining casirivimab and imdevimab for patients with non-severe COVID-19 who are at highest risk of hospitalization. For severely ill patients, the recommendation is based on data showing reduced deaths and need for mechanical ventilation in seronegative patients.
Researchers compared COVID-19 treatment outcomes among high-risk Native American patients who received versus did not receive monoclonal antibodies. The study found significant disparities in treatment response and mortality rates among this population.
Researchers at MD Anderson Cancer Center presented new findings on novel therapeutic approaches, including cell therapy for solid tumors and antibody drug conjugates targeting TROP2. The therapies achieved partial responses in six patients, with an overall response rate of 35.3% and disease control rate of 70.6%.
A new study found that psychological interventions can have a significant effect on the treatment of subthreshold depression in adolescents. The meta-analysis showed that approximately eight adolescents need to be treated to see one more positive outcome than no treatment, with moderate effects size.
A study found that only about 2-2.5% of individuals with alcohol dependence in Sweden receive alcohol medication, highlighting unequal provision of treatment across sociodemographic factors and co-morbid conditions. The research suggests low knowledge among physicians and patients, as well as preference for psychological treatment over...
A new study found that high-intensity rehabilitation significantly improves motor function in stroke patients compared to low-intensity therapy. Implementing high-intensity therapy sooner after a stroke can overcome the detrimental effects of starting late, according to researchers.
Researchers develop novel models to investigate the impact of drug-eluting stents on arterial tissue permeability and blood flow. The study identifies key factors contributing to restenosis near stent edges, highlighting potential avenues for design improvements.
A new study uses AI to predict the risk of stroke recurrence in individuals, identifying high blood pressure, raised cholesterol, and atrial fibrillation as key risk factors. This personalized approach aims to improve patient treatment adherence and reduce the likelihood of another stroke.
A team of scientists at McGill University has invented a smart device for personalized skin care inspired by the male diving beetle. The device collects and monitors body fluids while sticking to the skin's surface, paving the way for more accurate diagnostics and treatment for skin diseases like acne.
Researchers from Florida Atlantic University's Schmidt College of Medicine review recent randomized trials, concluding that hydroxychloroquine poses significant harm in treating COVID-19. The study suggests a halt on prescribing the medication, recommending vaccination and masking instead as effective public health strategies.
A pooled analysis of two trials found that empagliflozin reduced the risk of cardiovascular death or hospitalisation for heart failure patients, regardless of ejection fraction. The drug also showed benefits in reducing major renal outcomes, particularly at lower ejection fractions.
A study found that transcranial stimulation can increase the benefits of aerobic exercise and improve gait in Parkinson's patients. The treatment uses a weak current delivered by electrodes placed over specific brain regions, activating the pre-frontal cortex.
A novel CT scan-based approach detects changes in lung tissue indicating emphysema and airway constriction in patients with asthma. This finding may explain why conventional anti-inflammatory treatments are ineffective in some asthmatics, paving the way for personalized management of the disease.
A low-cost prototype breathing device designed for poorer-resourced healthcare settings has shown promising results in a pilot trial involving healthy volunteers. The device provides continuous positive airway pressure (CPAP) therapy and operates with oxygen concentrators, which are commonly used in low-pressure systems.
A Swedish study found that 43% of children with new-onset type 1 diabetes did not receive hospital treatment on the same day as primary care contact. Delayed care can lead to life-threatening conditions like diabetic ketoacidosis. Improved awareness and rapid treatment are crucial for preventing complications.
A NIH study published in The New England Journal of Medicine found that administering convalescent plasma to outpatients with early symptoms of COVID-19 did not prevent disease progression. The trial, which enrolled over 500 participants, showed a significant reduction of less than 2% in disease progression.
The researcher is investigating the inflammatory responses produced by exposure to chemical agents, comparing different chemical exposures at both whole-body and tissue levels. The study aims to develop a common treatment for chemical exposures and diagnose the responsible chemicals.
A US nationwide cohort study found that nearly 85% of hospitalized COVID-19 patients were not back to their pre-COVID lives one month later. The study also revealed significant factors driving people's inability to recover, including a lack of follow-up healthcare services and new disabilities preventing daily activities.
A new proposal aims to enable parents to participate in decision-making about life-saving treatment for premature infants. This balance is crucial as treatment can do great harm, while without it, the infant dies. Guidelines vary between countries, with some allowing treatment up to gestational week 23.
A study of 1,349 Malawian women aged 16-26 found that nearly 13% reported difficulty conceiving, with 85.5% seeking help. Traditional healers were the most common source of support, used by 44.4% of women.
Researchers developed subthreshold electrical stimulation to aid brain recovery after a stroke. The technique uses less energy and has fewer side effects than existing methods, showing promise for improving motor function and strengthening connections between brain regions.
Researchers at University of California San Diego School of Medicine modified remdesivir to create an oral version that can be taken earlier in COVID-19 diagnoses. The revised drug proved effective and safe in cell and animal studies.
A recent study reveals that many Latinx immigrants have concerns about COVID-19 testing, treatment, and contact tracing, affecting their willingness to engage with healthcare services. The findings highlight the need for culturally sensitive and accessible healthcare solutions to address these concerns.
Using accurate language to describe mental illness and substance use disorders can help reduce stigma, improving treatment outcomes. The NIH highlights the importance of changing language to mobilize resources toward mental health services and erase prejudices that prevent people from seeking care.
An observational study of 2,344 US veterans hospitalized with COVID-19 found remdesivir treatment associated with prolonged hospitalization but no improved survival rates. The study suggests that while remdesivir may help reduce the length of hospital stays, it does not significantly impact patient outcomes in terms of survival.
A study found that COVID-19 pandemic led to a decline in addiction treatment initiations in California, but the cause of this decline is still unclear. Researchers are investigating whether reduced demand for services or reduced supply were the main factors behind the decrease in admissions.
In a proof-of-concept study, researchers used DNA base editing in a prenatal mouse model to correct the single base mutation responsible for Hurler syndrome. The treatment demonstrated increased survival and improvement of metabolic, skeletal, and cardiac disease in prenatally treated mice.
Researchers are developing a stroke rehabilitation robot using brain-inspired intelligent technology to improve outcomes for patients. The robot will analyze movement intentions and respond with precision, aiming to recognize eight hand movements with an accuracy rate of 90% and response time of 300ms within five years.
Researchers found that a synthetic meniscus implant provided superior relief from post-meniscectomy knee pain compared to non-surgical care. Patients treated with the implant experienced higher Knee Injury and Osteoarthritis Outcome Scores, indicating improved function and quality of life.
A global systematic review and meta-analysis found that nearly 8% of men who have sex with men (MSM) are infected with syphilis worldwide, significantly higher than the general population. The study highlights the urgent need to address this high-risk group's unique challenges in accessing healthcare services.
A study by Newcastle University highlights the difficulties people with smell and taste disorders face in accessing treatment. The research found that only around 20% of patients reported an improvement in symptoms following treatment, while over 60% suffered from anxiety or depression.
Researchers at Cincinnati Children's Hospital Medical Center are exploring telehealth as a treatment option for adolescents with suicidal thoughts, following a $7.5 million PCORI award. The study aims to evaluate the safety and effectiveness of suicide prevention treatment delivered by telehealth during the pandemic.
Researchers at Wayne State University are developing new strategies to assess appropriate treatments of peripheral nerve diseases using MRI biomarkers. The study focuses on nerve MRI methods that can directly image pathology within nerves, offering valuable information on disease progression and improving treatment evaluation.
A team-based model assists primary care physicians in managing specific health conditions through a care manager with advanced expertise. This helps patients process information, review treatment options, and receive needed support between physician visits.
The Biological Engineering: Wastewater Innovation at Scale (BEWISe) facility, launched by Newcastle University and Northumbrian Water, will host researchers to explore new low-carbon alternatives for sewage treatment. This £1.2 million EPSRC-funded facility operates with a quadrillion microbes, enabling experimentation with different t...
Researchers at Tohoku University have identified a novel disease-modifying therapeutic candidate SAK3 that rescues neurons in most protein-misfolding neurodegenerative diseases. SAK3 administration significantly prevented progression of neurodegenerative behaviors, including cognitive impairment and motor dysfunction.
A new study by Pendulum Therapeutics presents proprietary probiotic formulations that may improve glucose control in patients with Type 2 Diabetes. The research shows that Pendulum Glucose Control increases circulating butyrate and ursodeoxycholic acid, supporting the mechanism for improvement in glucose control.
Researchers found that metabolic activators reduced recovery time for mild-to-moderate COVID-19 patients by 3.5 days. The treatment also improved liver health and decreased inflammatory markers. This study builds on phase two clinical data and demonstrates the potential benefits of metabolic activator therapy in COVID-19 patients.
A randomized clinical trial found that patients matched with therapists who have a strong track record of treating their primary concerns experienced greater reductions in general impairment. This 'match effect' was more pronounced for patients with severe problems and those from traditionally underserved populations.
Researchers created a hybrid neural network called NAIMS that accurately predicts premature baby mortality risk using demographics and vital signs. The technique has shown strong performance in predicting an infant's risk of mortality within 3, 7, or 14 days, with potential to analyze responsiveness to treatment.
Researchers at UTHealth are investigating pairing patients with PTSD undergoing treatment for peer support and exposure therapy to improve treatment completion rates. The study aims to reduce the high dropout rate of 25-50% by providing a supportive network for patients to overcome triggers and work towards recovery.
A new study by researchers at UC and Michigan State University found that electronic monitoring tethers failed to reduce reoffending among girls involved in the juvenile justice system. The study suggests that tethering may be harmful because it limits girls' access to treatment programs, leading to higher recidivism rates.
A decade-long study found that personalized medicine, considering patient needs and environment, is more effective than one-size-fits-all approaches. The research team recommended a tailored approach for distal radius fractures, taking into account the patient's social environment and risk tolerance.
Researchers estimated survival and outcomes of very preterm infants in China discharged from neonatal intensive care units compared to those receiving full treatment. Discharge against medical advice was associated with higher mortality rates among these vulnerable infants.
A study published in Cell identified specific nerve cells and proteins that trigger the sneeze reflex, which may lead to new treatments for infectious respiratory diseases. The researchers found that stimulating these cells with a molecule called neuromedin B could induce sneezing, even without exposure to allergens or viruses.
Researchers develop a novel aquaponics treatment system inspired by sewage plants that breaks down fish sludge and turns nutrients from fish waste into an effective fertilizer for plants. The system successfully delivers nutrients to plants in the form of a liquid fertilizer, improving plant growth and reducing waste.
A new study reveals regional disparities in dental care utilization in Japan, particularly among lower-income and less educated populations. The research found that these groups are more likely to neglect preventive treatments like calculus removal, leading to more severe tooth problems and increased healthcare costs.
Researchers summarize the mechanism of ultrasound neuromodulation, which uses focused ultrasound to regulate neural circuits. The treatment shows promise for treating various neurological disorders, including epilepsy and depression, with potential for future developments in genetic engineering or nanotechnology.
Researchers found that experiencing rudeness amplifies the anchoring bias, leading people to fixate on one piece of information despite inconsistent feedback. Perspective-taking and information elaboration can counteract this effect, suggesting a need to rethink workplace behavior.
A study by Inselspital and RetinAI uses AI to predict anti-VEGF treatment demand for patients with AMD, RVO, and DME. The model achieved high accuracy in predicting treatment need, even at the initial visit or before the first injection.
Researchers developed new clinical guidelines for Australian doctors to treat insomnia with Cognitive Behavioural Therapy for insomnia (CBTi), improving mental health and quality of life. CBTi can be more successful than sleeping pills in managing insomnia.
During the COVID-19 pandemic, many ECT centers reduced services, but most were able to react and return to care by mid-summer. The survey found that 70% of sites had patients return to inpatient psychiatric care due to unscheduled ECT cancellations.
The American Heart Association recommends increasing physical activity as the first treatment choice for mild to moderately elevated blood pressure and cholesterol. Regular exercise can lower blood pressure and cholesterol, with benefits extending to other health areas.
A new study estimates global economic burden of P. vivax malaria, finding that widespread access to radical cure could reduce costs substantially and achieve elimination of the disease.
Researchers found a significant reduction in galling on plant roots after incorporating beer bagasse and rapeseed cake into the soil with fresh cow manure. The treatment also boosted populations of beneficial microorganisms and increased crop yields by around 15% compared to control plots.
Researchers from Trinity College Dublin developed tools for designing vitamin D clinical trials that capture seasonal and population-wide differences. The study found many trials were underpowered, failing to detect a benefit of vitamin D supplementation due to individual differences and seasonal fluctuations.
Researchers have developed CareGum, a green and recyclable sensor material that can monitor motor impairment associated with neurological disorders. The material offers stretchability, self-healing capacities, and electrical conductivity, allowing for personalized bioelectronics and real-time monitoring of movements.
A new study found that couple cognitive-behavioural therapy (CBT) is more effective than lidocaine in reducing women's fear of pain and improving their sexual experience. The therapy helps break the vicious cycle of fear and avoidance, allowing couples to refocus on pleasurable experiences.
A randomized study found that guided yoga therapy was more effective in preventing fainting and improving quality of life compared to standard treatment. The study enrolled 100 patients with vasovagal syncope and found that the yoga group had fewer blackouts and better quality of life scores at 3, 6, and 12 months.