Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
A meta-analysis found that adding revascularization to medical therapy reduces cardiovascular death by 21% in patients with stable ischemic heart disease. The benefit increases over time, with a greater impact on survival for those with extensive disease.
A meta-analysis of 106 RCTs found psychosocial interventions prolonging life by 20% compared to standard care. Interventions promoting health behaviors were associated with improved survival, while those focusing solely on emotional support yielded smaller gains.
A study found that two-fifths of Medicare beneficiaries with chronic obstructive pulmonary disease (COPD) have limited access to pulmonary rehabilitation services. The researchers identified significant disparities in access across urban, suburban, and rural areas.
Research from Brigham Young University found that providing social support to medical patients through group meetings and family sessions promotes healthy behaviors and increases survival rates. The study analyzed data from 106 trials involving over 40,000 patients, showing a significant impact on patient outcomes.
A new meta-analysis of 19,806 patients with chronic coronary syndromes found a statistically significant 21% relative risk reduction in cardiac death with revascularization plus medical therapy. The study also showed a parallel significant reduction in spontaneous myocardial infarction, but no difference in all-cause death.
The Cool AMI EU pivotal trial evaluated the safety and effectiveness of systemic mild hypothermia as an adjunctive therapy to primary PCI in patients with anterior STEMI. The trial showed significant differences between treatment groups, including longer randomization-to-balloon time and total ischemic time.
The American College of Cardiology's Global Heart Attack Treatment Initiative has shown measurable positive impacts on care delivery for heart attacks in low- and middle-income countries. The program tracked STEMI treatment metrics and outcomes for over 2,000 patients across 18 medical centers in 13 countries.
Research at ATS 2021 International Conference found a link between severe obstructive sleep apnea (OSA) and increased COVID-19 risk. Patients who adhered to positive airway pressure (PAP) therapy for longer periods had lower infection rates, suggesting PAP has a direct physiological benefit.
A new study by the ISARIC Coronavirus Clinical Characterisation Consortium found that in-hospital mortality declined from 32% to 16% as treatments like steroids and dexamethasone improved patient outcomes. Improvements in respiratory support and critical care also contributed to the better survival rates.
Researchers discovered that fair treatment alone is insufficient to foster a sense of value in groups; instead, recognizing individual talents and qualities provides a sense of inclusion while promoting mental health. This approach complements the idea of 'fitting in' by allowing individuals to stand out and feel valuable.
A study found that people in India blamed minorities and healthcare workers for the virus spread. However, when presented with accurate information, stigmatization decreased and people were more likely to get tested and seek medical help.
Researchers at Karolinska Institutet have developed an internet-delivered CBT programme that significantly reduces social anxiety and comorbid psychiatric symptoms in young people with SAD. The digital format increases accessibility and reduces therapist time, making it a cost-effective option.
A team of researchers has developed a machine-learning artificial intelligence tool that can assess strokes at smaller regional facilities. The technology uses CT angiography scans, which are more widely available than advanced imaging used in larger academic centers.
Researchers found that internet-delivered cognitive behavioral therapy can be as effective as conventional CBT in reducing OCD symptoms in children and adolescents. The study showed that stepped digital CBT reduced symptoms as much as conventional CBT and required fewer resources.
Researchers evaluated CO2 levels and ventilation rates in dental operatories, finding that CO2 levels can be measured with a simple consumer-grade CO2 sensor. They also demonstrated that ventilation rates can be assessed by observing CO2 levels after mixing baking soda and vinegar.
Researchers discovered that manganese-enhanced MRI scans provide more accurate details of heart function than traditional methods, potentially increasing survival chances. The study suggests that early detection within the first few hours of a heart attack can optimize treatment regimes and regulate cardiac muscle changes.
Researchers found that pediatricians are more likely to refer toddlers for evaluation if parents independently express concerns, leading to earlier diagnosis and treatment. The Get SET Early program, a simple screening tool, has been linked to improved outcomes for children with ASD.
Point-of-care ultrasonography significantly improves diagnostic accuracy in patients with acute dyspnea, allowing for quicker diagnosis and treatment initiation. The technology involves mobile ultrasound devices that enable rapid scanning of multiple organs, including lungs, hearts, and leg veins.
Researchers set four ambitious goals to accelerate mental health research, focusing on reducing persistent mental health problems in children, improving physical-mental health links, increasing new treatments, and enhancing access to care. The targets aim to improve mental health outcomes, reduce costs, and promote innovation.
Researchers discovered that a specific gene mutation, EPHB2, causes autism predominantly in females, while males are less affected. The study highlights the importance of considering sex-specific differences in ASD research to develop personalized treatments.
Experts argue that PTSD is often conflated with normal responses to stress, leading to increased pressure on services. However, another study suggests that PTSD may be underdiagnosed, with only a small proportion of those seeking help receiving a diagnosis.
Patients with segmental CTEPH treated surgically achieved excellent outcomes, with 80% long-term survival and good quality of life. Multidisciplinary post-operative care is crucial for optimal results.
A new, low-profile thoracic aortic endograft device has demonstrated safety and effectiveness in treating descending thoracic aorta aneurysms and PAU diseases. The RELAYPro endovascular device achieved 89.2% one-year treatment success rate with a reduced risk of complications.
A new study found that patients with severe mitral regurgitation who undergo transcatheter edge-to-edge mitral repair (TEER) may need surgical intervention if treatment fails. Up to 95% of these patients cannot have their valves repaired and require mitral valve replacement.
The USPSTF reaffirms its recommendation of screening for high blood pressure in adults 18 years or older, highlighting the condition's significant impact on cardiovascular health. Regular screenings are crucial for early detection and effective management of hypertension.
Researchers developed an eye-tracking app that can screen children at risk for autism spectrum disorder (ASD) by tracking their gaze patterns while watching social videos. The study found that children with ASD were less likely to focus on social cues and visually track conversations in the videos.
A new tool called PhenoBench standardizes data analysis for traumatic brain injury (TBI), enabling researchers to identify patient subgroups for personalized care. The study aims to provide tailored treatments that improve recovery and reduce long-term consequences of TBI.
A study by Virginia Commonwealth University researchers found that romantic relationships can help alleviate the negative impact of trauma on drinking behavior among college students. The study, which involved nearly 9,000 participants, discovered that students who experienced interpersonal trauma during college consumed more alcohol t...
A new study found a marker of PTSD in brain regions associated with emotional regulation, particularly in those with impaired executive function. The researchers suggest that this subgroup may respond best to specific treatments targeting cognitive and brain functioning.
A retrospective study suggests that MitraClip reduces death and heart failure hospitalizations by up to 50% for patients with secondary MR, even with slightly smaller mitral valve openings. The study also found improvements in quality of life measures in some patients with higher gradients.
A study published in JAMA Internal Medicine found that training physicians to use time-limited trials of ICU treatments improves the quality of family meetings. This approach engages families in decision-making, reducing unnecessary ICU treatments for critically ill patients with poor prognoses.
A large US study found that critically ill COVID-19 patients treated with extracorporeal membrane oxygenation (ECMO) have a significantly lower risk of death compared to initial studies. The study analyzed outcomes of over 11,000 patients and found that ECMO treatment resulted in an overall in-hospital mortality rate of 45.9%.
A comprehensive analysis of 80 scientific studies found a 'window of impairment' of 3-10 hours caused by moderate to high doses of THC. Impairment duration varies depending on dose, method of consumption, and user's regularity., The study suggests that laws should focus on safety on the roads rather than arbitrary punishment.
Researchers used AI to identify three new MS subtypes based on brain images, which can help predict disease progression and treatment response. The study found a clear difference in patients' response to different treatments by subtype, paving the way for individualized treatment planning.
A recent update from the American Academy of Sleep Medicine highlights the benefits of telemedicine in providing safe and effective sleep care. The use of telemedicine has improved adherence to CPAP therapy for obstructive sleep apnea patients, while cognitive behavioral therapy for insomnia shows similar results to in-person treatment.
A study published in Chinese Medical Journal identified factors that predict patients with STEMI refusing PCI, including age, history of myocardial infarction, and heart rate. The findings suggest that healthcare providers may use these predictors to improve treatment compliance and outcomes for patients with STEMI.
A study published in Frontiers in Psychiatry found that patients with Obsessive Compulsive Disorder (OCD) and other psychiatric comorbidities responded well to Deep Brain Stimulation (DBS) treatment, experiencing significant improvements in OCD and mood symptoms.
A new pilot study suggests that administering platelet-rich plasma and gonadotropins near the ovarian follicles can restore ovarian function in women during early menopause. The results show that 11 out of 12 participants resumed menstruation, with one achieving clinical pregnancy.
A novel skin-mounted sticker has been developed to diagnose cystic fibrosis within minutes by changing color in response to chloride levels in sweat. The device is softer and more comfortable than traditional diagnostic tools, allowing for easier collection of sweat samples and faster diagnosis.
Researchers highlight the importance of myocardial fibrosis in HCM diagnosis and treatment, citing gene mutation and abnormal energy metabolism as contributing factors. The use of magnetic resonance imaging is also discussed as a diagnostic tool for fibrosis.
The FDA has granted Breakthrough Device Designation to Tempus' ECG Analysis Platform, which aids clinicians in identifying patients at increased risk of developing atrial fibrillation. The platform uses artificial intelligence to analyze ECG results and provide insight into a patient's risk of future atrial fibrillation events.
Research suggests that postpartum women are at a higher risk of developing obsessive-compulsive disorder (OCD) than previously thought, with symptoms often going undetected. The study found that up to 17% of new mothers experience OCD symptoms related to infant-related harm, emphasizing the need for targeted screening and assessment me...
A new report by Harvard Medical School researchers found that TB diagnoses in the US are often delayed, leading to a higher likelihood of infection transmission and disease progression. The study suggests that increased clinician awareness and education can help minimize these delays.
A lifestyle intervention targeting women with obesity and infertility significantly improves pregnancy rates, especially spontaneous pregnancies. The Fit-For-Fertility program shows promise as a cost-effective alternative to fertility treatments, with a live-birth rate 14.2 percentage points higher than the control group.
Spirrow Therapeutics develops nanopolymer surfactant to restore lung function in patients with acute respiratory distress syndrome (ARDS), a condition that affects over 200,000 people annually. The startup aims to use its technology not only for ARDS but also to aid those infected with COVID-19.
A new study found that Transcendental Meditation significantly reduces PTSD symptom severity, depression, and anxiety in veterans. After three months, 50% of meditating veterans no longer met criteria for PTSD, compared to 10% of controls.
A new study finds that mobile stroke units (MSUs) improve patient outcomes and lessen the chance for disability by delivering care faster than standard stroke care. MSU patients received tPA treatment within 60 minutes, resulting in better outcomes and less disability.
Researchers from the University of Pennsylvania School of Medicine used machine learning to analyze online reviews of substance use treatment facilities, finding that staff dedication and professionalism were key qualities that drove patient satisfaction. The study identified 16 recurring themes in reviews, with 'dedicated staff' and '...
Recent studies suggest that postural orthostatic tachycardia syndrome (POTS) is an autoimmune disorder characterized by elevated inflammatory markers and autoantibodies. Researchers have documented significant elevations of five inflammatory markers in patients with POTS, similar to those seen in other autoimmune disorders.
MIS-C is a rare but life-threatening condition that can cause severe inflammation in organs like the heart, brain, lungs, kidneys, and gastrointestinal system. Diagnosing and treating MIS-C requires accurate differentiation from severe COVID-19 and Kawasaki disease.
Researchers propose using patient-specific digital twins to model viral infections, integrating human physiology, immunology, and real-time clinical data. Medical digital twins could aid in optimizing treatments for individual COVID-19 patients, combining mechanistic knowledge with observational data and artificial intelligence.
A survey of pregnant Japanese women and fertility patients found higher levels of anxiety related to health monitoring and social isolation. The study suggests improving communication to help pregnant women cope with anxiety during the COVID-19 pandemic.
The Penn Integrated Care program, developed by the University of Pennsylvania, provides a resource center and collaborative care services to increase access to mental health professionals. This model has shown promising results, achieving remission in symptoms for nearly 40% of patients with anxiety and 33% of those with depression.
A study found that family members of patients following the Mediterranean diet-based PREDIMED-Plus program experienced significant weight loss, averaging almost 4 kg over two years. Improved dietary habits were also observed, with family members showing increased commitment to the Mediterranean diet.
The Baylor prognostic scoring system has been externally validated in a separate group of patients presenting with gunshot wounds to the head, showing excellent discrimination of mortality and good functional outcome. Despite some limitations, the score remains a simple yet useful tool for predicting survival and long-term outcomes.
A mobile app designed to help women manage urinary incontinence was found to be equally effective as usual, in-person treatment. After four months, both groups experienced a decline in symptom severity, less frequent leakage, and improved quality of life.
Researchers defined parameters for white blood cell counts in children's urine to diagnose and treat urinary tract infections (UTIs) more effectively. The new guidelines could help speed treatment, prevent complications, and reduce the risk of lifelong consequences like kidney scarring and hypertension.
Clinical trial registrations for COVID-19 interventions with high publicized attention were compared to those without comparable promotion. The study found that highly publicized treatments had significantly lower registration rates and higher completion rates, leading to concerns about bias in research.
A randomized clinical trial found that ivermectin did not improve the time to resolution of symptoms in adults with mild COVID-19. The study suggests that ivermectin may have no effect on treating mild cases of the disease, highlighting the need for further research.
The study found that eating disorders in the US resulted in a total economic cost of $64.7 billion and a substantial reduction in wellbeing worth $326.5 billion. The authors aim to scale up effective prevention, early detection, and treatment interventions for eating disorders.