Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
A UC Riverside-led study found that COVID-19 variability may have underlying molecular sources in SARS-CoV-2 host gene expression. The researchers identified specific genes, such as ACE2 and CLEC4G, that are variably expressed and linked to infection susceptibility and symptom severity.
Researchers used a novel MRI-based approach to study the interaction between patients and clinicians, finding that mirroring in facial expressions and brain activity can affect the patient-clinician bond and treatment. This study suggests that the clinical encounter has a measurable impact on the brain, emotions, and clinical outcomes.
A pilot study found that cognitive behavioral therapy (CBT) significantly reduced insomnia severity among young adult binge drinkers, leading to improved sleep efficiency and decreased alcohol use outcomes. CBT participants showed greater improvements in insomnia symptoms compared to those who received a single session on sleep hygiene.
A study investigated whether early tocilizumab treatment reduced the risk of death among critically ill COVID-19 patients. The results showed that patients treated with tocilizumab in the first two days after admission had a lower risk of death compared to those not treated early.
Researchers compared two popular autism interventions and found that more intensive treatment did not lead to better results. The study, led by UC Davis Health, suggests that therapists can adapt their approaches to meet individual child needs.
A new study found that approximately 26% of Europeans with severe vision loss have unmet needs for eye care, with the UK figure at around 23%. Poor health, social isolation, smoking, and poverty are associated with higher levels of self-reported severe vision loss.
A study by Karolinska Institutet reveals that microglial autophagy plays a crucial role in MS progression. The researchers found that removing an autophagy gene, Atg7, disrupts the immune cells' ability to clean up damaged tissue residues, leading to disease worsening.
OnSight Medical's AI-based software provides real-time expert-level scans with high-quality 4D images, enhancing access to cardiac ultrasound in underserved populations. The company won the TCT Connect 2020 Shark Tank Innovation Competition and received a $200,000 award from the Jon DeHaan Foundation.
The DEFINE-FLOW study found that vessels with abnormal FFR (<0.8) but intact CFR (>=2.0) do not have non-inferior outcomes compared to those with normal FFR and CFR when treated medically. The study's results suggest that invasive CFR assessment may not be necessary for lesions with preserved coronary flow reserve.
The MITHRAS trial found that interventional closure of an iatrogenic atrial septal defect (iASD) driven by transcatheter mitral valve repair was not superior to conservative medical treatment. The study also revealed that the presence of a persistent iASD is associated with increased long-term mortality and morbidity following TMVR.
Researchers from the University of Minnesota developed a bimodal neuromodulation treatment using sound and electrical stimulation to reduce tinnitus symptoms. The study, published in Science Translational Medicine, showed significant improvements in symptom severity for 86% of participants after 12 weeks of treatment.
A new self-expanding bioprosthetic valve used in TAVR failed to demonstrate non-inferiority compared to an existing valve. The SCOPE II Trial found increased rates of cardiac death and moderate-severe aortic regurgitation with the new valve.
The PROSPECT ABSORB trial found PCI safe with favorable long-term outcomes for non-flow-limiting vulnerable plaques. Follow-up lumen areas were substantially enlarged in BVS-treated lesions compared to GDMT alone.
Researchers discovered a blood profile that predicts patients at greatest risk of life-threatening immune system overreaction in COVID-19. Combining this cytokine test with clinical assessment could help doctors identify and treat those most at risk.
Researchers found abnormalities in brain areas including caudate that normalized after four weeks of CBT, but not in those who didn't receive treatment. Pre-treatment HRF patterns can predict individual patient response to CBT with high accuracy.
A research team from Russia and Japan explored jet formation in an optical fiber immersed in liquid, revealing the reasons behind this phenomenon. The study found that the jet velocity depends on the relationship between the vapor bubble size and fiber radius, with potential applications for laser surgical techniques.
Researchers are collecting detailed health information from people with atypical forms of diabetes to understand their causes and differences from common types. The study aims to provide critical insight into the emerging spectrum of diabetes, potentially leading to new targets for prevention and treatment.
A study of over 24,000 trauma patients in four countries found that longer delays in treatment can increase the risk of disability or death. The authors suggest that rapid transportation may be associated with reduced risk of poor outcomes and urge emergency services staff to make the most of prehospital time.
A new study found that continuous positive airway pressure (CPAP) treatment can lower daytime resting heart rates in patients with prediabetes who have obstructive sleep apnea, reducing their risk of cardiovascular disease. Optimal CPAP treatment also lowers heart rates during the day, similar to regular exercise.
A deep learning model can quickly identify large vessel occlusions, which account for a significant proportion of ischemic strokes. The algorithm's sensitivity was found to be 100%, outperforming single-phase CTA in detecting these critical blockages.
A study published in JAMA Internal Medicine reveals that older persons are highly likely to be excluded from COVID-19 clinical trials, despite accounting for 30-40% of cases and 80% of deaths globally. The exclusion poses a risk to the effectiveness and safety of treatments for older adults.
Randomized clinical trials for COVID-19 treatments and vaccines often exclude older adults, according to a new study. The study found that the likelihood of excluding older persons is significant in these trials, raising concerns about equity and inclusivity.
A team of dentists from RUDN University presented a new classification system for root canal shape changes, which can vary depending on the tooth part and patient age. The study used CT scans of 300 patients and identified four groups of shape changes to help dentists choose proper tools and treatment methods.
A new neuroimaging study has found links between brain regions and dissociative symptoms in women with a history of childhood abuse, shedding light on the 'invisible wounds' of trauma. The study may help tailor treatments for affected patients and increase awareness around dissociative disorders.
A multi-state consortium will compile a large dataset to examine associations of improved outcomes with various treatments for COVID-19 patients. The project aims to answer fundamental questions about the virus's effects, including chronic complications and long-term impacts.
A clinical trial led by Imperial College London researchers found that early surgical treatment of leg ulcers reduces the risk of recurrence and improves healing times compared to current methods. The study suggests revising guidelines to include earlier assessment and surgery, potentially saving the NHS £100 million per year.
Researchers analyzed focus groups with individuals who experienced post-exertional malaise (PEM), a key feature of ME/CFS. PEM symptoms included exhaustion, cognitive difficulties, and neuromuscular complaints, affecting daily life and requiring complete rest to reduce symptoms.
The National Institutes of Health (NIH) is expanding two randomized, placebo-controlled clinical trials to evaluate the effectiveness and safety of convalescent plasma as a treatment for patients hospitalized with COVID-19. The trials aim to assess clinical improvement measures and resource needs, such as ventilators.
A study of over 1,600 obese women found no significant difference in infection rates between those treated with NPWT and standard wound dressing. Despite this, women in the negative pressure group experienced more skin irritations.
A new report highlights the need for top hospitals to prioritize tobacco treatment, citing a disconnect between rankings and smoking cessation care. The study's authors argue that addressing tobacco dependence should be a priority, especially given its impact on various health conditions, resulting in significant healthcare costs.
ALS Ventures has closed its first round of investments with a $59M commitment, targeting novel therapeutics in preclinical development. The firm aims to accelerate R&D from discovery stage to late preclinical development.
A machine learning classifier accurately detected the beginning stages of osteoarthritis progression in a study of 86 individuals. The classifier achieved 78% accuracy up to 3 years before symptom onset, suggesting early detection may enable treatment at a reversible stage.
A study of suspended fertility treatments during COVID-19 found that 86% of women reported negative mental health impacts and 52% experienced clinically significant depression. Protective factors like lower defensive pessimism, greater infertility acceptance, and better social support were associated with less decline in mental health.
Recent research on severe COVID-19 infections highlights the need for enhanced treatment strategies and management of acute respiratory distress syndrome (ARDS). The study provides valuable insights into patient outcomes and future directions for clinical practice.
The study highlights the low awareness of foreigners about Russian medical services, lack of language-skilled staff, and limited resources as major obstacles. Experts recommend improving personnel and equipment, informing potential patients, and promoting clinics through word-of-mouth and online platforms to boost medical tourism in Ru...
A novel study explores how Black patients with mental health concerns evaluate verbal and non-verbal communication during treatment, revealing significant fear of being negatively judged based on stereotypes. The research provides suggestions for creating environments that foster person-centered care and reducing provider burnout.
A new study from the University of Warwick reveals that individuals diagnosed with obstructive sleep apnoea may be at higher risk of severe COVID-19 outcomes. The review of eighteen studies highlights the need for better recording and management of the condition, which is estimated to affect up to 85% of people in the UK.
A new COVID-19 risk score, called the 4C Mortality Score, accurately predicts mortality in adult patients admitted to hospital with covid-19. The score categorises patients as low, intermediate, high, or very high risk of death, informing treatment decisions and resource allocation.
Researchers at New York University have discovered that flowing water carves ultra-sharp spikes in landforms, creating the pointed rock formations known as stone forests. The study sheds light on a mechanism that explains the prevalence of these structures in karst topography.
A study by Charité - Universitätsmedizin Berlin reveals that the immune system is less effective at fighting COVID-19 in older people and those with comorbidities. The researchers found a link between T-helper cell function and risk factors, suggesting a potential new treatment target.
A new ECU study found that early intervention and less-intensive therapy can lead to better communication outcomes. The researchers suggest tailoring the difficulty level of aphasia therapy to individual tolerance and spacing sessions to enhance learning consolidation.
Purdue University innovators developed a wearable solution to treat antibiotic-resistant infections, allowing patients to receive treatment from home. The low-cost patch and battery-powered device deliver ozone therapy to accelerate healing.
Scientists have created a model that replicates the progression of age-related macular degeneration (AMD), a disease with no current treatment. By understanding how RPE cells respond to stress and changes in gene expression, researchers can now test potential therapeutics for dry AMD.
A novel 'disease-in-a-dish' model has been developed to study the basic molecular factors leading to type 2 diabetes. The model, using reprogrammed induced pluripotent stem cells from patients with type 2 diabetes and healthy controls, reveals defects in proteins with unknown roles in metabolism or diabetes.
A randomized clinical trial in France evaluated the effect of low-dose hydrocortisone on ICU patients with COVID-19-related acute respiratory failure. The study found that hydrocortisone treatment reduced mortality and decreased the need for respiratory support among critically ill COVID-19 patients.
A Yale clinical trial is using an automated bilingual computerized approach to screen for and intervene with high-risk drinking behaviors among Latino patients in emergency departments. The study aims to explore unique differences within Latino subgroups and advance understanding of addressing health disparities in alcohol use disorders.
The PARALLAX trial found that sacubitril/valsartan reduces NT-proBNP levels by 16.4% compared to individualised medical therapy, indicating improved heart failure severity. However, functional capacity was not improved, with no significant difference in six-minute walk distance between groups at week 24.
A new generation of long-term brain monitoring technologies records neural activity to provide a reliable alternative to subjective seizure diaries. These devices, such as the Wyss Center's Epios system, offer flexible configurations and could enable optimized and personalized treatment for each patient.
A UMass Amherst health informatician has received a $2.4 million grant to develop a mobile health system using finger-worn sensors to monitor and encourage movement in stroke survivors' weak upper limbs. The goal is to provide individually tailored data and visualization tools to motivate patients and inform clinicians.
A new study found that more than 30% of hospital patients who have a heart attack complicated by low blood pressure undergo an aggressive treatment, despite the existence of a less aggressive approach called a 'culprit-only' strategy. This strategy places stents only in the blocked blood vessels that caused the heart attack.
A study found that yoga, tai chi, and meditation improve overall physical and mental health, reducing perceived stress. Veterans reported using 14 different CIH therapies, with yoga being the most popular.
A randomized trial compared remdesivir with standard care in patients with moderate pneumonia and SARS-CoV-2 infection. Remdesivir treatment resulted in improved clinical status, with no increased risk of adverse events.
Researchers emphasize the importance of implementing effective post-fracture care coordination programs to reduce secondary fractures, frailty, and mortality in older patients. A novel FLS benefits calculator has been introduced to support decision-making at national and local levels.
Researchers have discovered a series of misfolded alpha-synuclein protein structures that are thought to be highly relevant to the onset of Parkinson's disease. These unique structures were found in the presence of phospholipids, which play an essential role in living cells, and take on a striking variety of shapes.
Research suggests that providing a mitochondria-targeted antioxidant supplement to mothers with complicated pregnancies can prevent heart disease in their offspring. The study used sheep and found that MitoQ protects against fetal growth restriction and high blood pressure in adults.
Research published in the Journal of the American Heart Association found that PAD patients with depressive symptoms have a poorer recovery rate. Women are twice as likely to be depressed than men. The study highlights the importance of integrating mental health screening and treatment into chronic disease management for optimal outcomes.
A first-in-human study found that MRG-110 significantly reduced miR-92a levels in healthy humans after a single intravenous dose. This inhibition has shown beneficial effects in animal models, including improved vascularization after myocardial infarction and accelerated wound healing.
A University of Wisconsin Oshkosh study found that treating people like people makes life easier for both ends of the power dynamic in jail. Interpersonal communication skills are key to diffusing explosive situations and avoiding physical force, according to research by assistant criminal justice professor Matt Richie.
A large European cross-sectional study found that patients with axial spondyloarthritis experience a significant delay in diagnosis due to misdirected referrals and involvement of multiple medical professionals. The study recommends initiating measures to prevent such delays and facilitate timely referral to a rheumatologist.
A comprehensive assessment of genomic sequencing as a standalone newborn screening tool found it comes up short, missing about 160 cases and incorrectly identifying 8,000. However, sequencing can still be useful in suspicious cases not clearly identified by MS/MS.