A team of researchers developed a vaccine that stimulates regulatory T cells to suppress harmful immune cells, prolonging allograft survival in mice. This discovery identifies an analogous pathway in humans, suggesting potential treatment for autoimmune disorders and organ transplant patients.
SourceBrigham and Women's Hospital·JournalJournal of Clinical Investigation·TypeExperimental study·DateNov 15, 2023
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Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Maintenance immunosuppressive drugs linked to increased COVID-19 hospitalization risk in solid organ transplant patients. Clinicians treating transplant recipients should consider these findings for epidemic-related decisions.
SourceJAMA Network·JournalJAMA Network Open·DateNov 7, 2023
Researchers at Children's Hospital Los Angeles have developed a novel app called the CHALF score to predict if a child with acute liver failure needs a transplant. The tool assesses liver failure risk on a scale of 5-60 and has been shown to accurately predict patient outcomes.
SourceChildren's Hospital Los Angeles·JournalTransplantation·TypeComputational simulation/modeling·DateOct 24, 2023
Engineers use module assembly to develop vascularized organotypic tissues with high cell density and well-organized vasculature. This approach enables the rapid generation of functional tissue substitutes with improved efficacy in treating diseases.
SourceInternational Journal of Extreme Manufacturing·JournalInternational Journal of Extreme Manufacturing·DateOct 24, 2023
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A new study published in JAMA Network Open found live vaccinations safe and effective for children who have received liver or kidney transplants, offering protection against life-threatening conditions. The study showed high antibody levels and minimal adverse events following vaccination.
SourceCincinnati Children's Hospital Medical Center·JournalJAMA Network Open·TypeRandomized controlled/clinical trial·DateOct 16, 2023
A new clinical trial has shown that infusing immune cells from living donors into recipients before transplantation may reduce the need for lifelong immunosuppressant medication. The treatment involves infusing donor-derived regulatory dendritic cells, which help the recipient's immune system distinguish between foreign and self-cells.
SourceUniversity of Pittsburgh·JournalScience Translational Medicine·TypeRandomized controlled/clinical trial·DateOct 11, 2023
A new model developed by Cleveland Clinic researchers can more accurately prioritize patients waiting for a lung transplant, taking into account their disease severity and time on the waiting list. This approach may help reduce waitlist mortality for patients with end-stage lung disease.
SourceCleveland Clinic·JournalAmerican Journal of Respiratory and Critical Care Medicine·DateSep 29, 2023
A new study found that living donor liver transplant access optimizes the timing of transplant for older, frail cirrhosis patients. Patients with moderate to severe frailty, short stature, and low MELD scores benefited from LDLT, reducing waitlist mortality and improving post-transplant outcomes.
SourceImpact Journals LLC·JournalAging-US·TypeObservational study·DateSep 26, 2023
A novel study shows that Senolytics can prevent the transfer of senescence, a key mechanism of ageing, and associated physical and cognitive impairments in recipients of older donor organs. This breakthrough could lead to improved outcomes and increase organ availability for transplantation.
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Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
A new study found that islet transplantation significantly reduces the risk of kidney transplant failure and mortality in patients with type 1 diabetes. The study compared the long-term outcomes of patients who received an islet transplantation with those who underwent kidney transplantation and managed their diabetes with insulin alone.
Researchers analyzed data from 2005-2020 and found that 10-year conditional survival was similar between biventricular and most single-ventricle CHD patients. Biventricular CHD patients also showed better 10-year survival compared to non-CHD heart transplant recipients.
SourceUniversity of California - Los Angeles Health Sciences·JournalJournal of the American College of Cardiology·TypeData/statistical analysis·DateSep 11, 2023
Research reveals that heart transplant recipients from economically disadvantaged areas are at a greater risk of graft failure and mortality, with a 10% increased relative risk compared to those from non-distressed communities. The disparity in outcomes has widened since the implementation of the 2018 UNOS Heart Allocation policy.
SourceUniversity of California - Los Angeles Health Sciences·JournalAnnals of Surgery·TypeData/statistical analysis·DateAug 31, 2023
The Texas Heart Institute has received a five-year, $2 million grant from the National Institutes of Health to advance organ bioengineering. The project aims to develop transplantable bioartificial hearts to combat end-stage heart failure.
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Researchers investigating early liver transplantation for alcohol-associated liver disease aim to understand who benefits most and develop best practices. They will collect data on patient outcomes, biological samples, and audio recordings to identify factors influencing selection decisions.
A long-term study of nearly 2,400 solid organ transplant recipients found that COVID-19 vaccination significantly reduced hospitalization rates, with a 75% decrease in later omicron waves. Despite this, post-vaccination SARS-CoV-2 viral infections remain common, highlighting the importance of vaccination in high-risk populations.
SourceJohns Hopkins Medicine·JournalJAMA Network Open·DateAug 18, 2023
Researchers have found that mouse stem cells mimic their parent animals' cold resistance, generating energy differently at low temperatures. This discovery opens up new avenues for studying organ preservation and human hibernation using in vitro models.
A new study found that around one in five people with compromised immune systems have no COVID-19 antibodies after three or more vaccinations. The MELODY study identified specific groups at higher risk of not producing antibodies, highlighting the need for targeted interventions and booster vaccines.
SourceUniversity of Southampton·JournalThe Lancet Rheumatology·DateAug 15, 2023
A third COVID-19 vaccination dose significantly improved antibody responses in transplant recipients, offering better protection against variants. However, cross-protection was only partial, highlighting the need for multiple vaccine doses to maintain immunity in this vulnerable population.
SourceMassachusetts General Hospital·JournalOpen Forum Infectious Diseases·TypeExperimental study·DateAug 10, 2023
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Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
Researchers identify key protein interactions that control the body's immune response during liver transplantation, leading to improved transplant survival rates. The study found that a specific communication pathway between CEACAM1 and TIM-3 proteins plays a crucial role in controlling the immune response.
SourceUniversity of California - Los Angeles Health Sciences·JournalGastroenterology·TypeExperimental study·DateJul 19, 2023
In a groundbreaking procedure, Adriana Rodriguez received a dual-organ transplant, with her healthy liver transplanted into another patient to mitigate rejection risk. This innovative approach, known as HALT-D, demonstrates the potential for immunoprotection and has implications for highly sensitized patients requiring multiple organs.
SourceUniversity of Washington School of Medicine/UW Medicine·JournalThe Journal of Heart and Lung Transplantation·TypeCase study·DateJul 13, 2023
The study found that the presence of microbiota increases tacrolimus levels in the blood, reducing the risk of rejection but also increasing side effects. Clinical tests revealed two specific types of bacteria associated with reduced tacrolimus dosages, and a link between Anaerostipes bacteria and diabetes prevention.
SourceUniversité catholique de Louvain·JournalMicrobiome·TypeExperimental study·DateJul 6, 2023
Researchers analyzed data from the first genetically-modified pig heart transplant into a human patient and found that several overlapping factors contributed to heart failure, including poor pre-transplant health, immunocompromised state, and use of intravenous immunoglobulin. The study provides crucial insight into how these factors ...
SourceUniversity of Maryland School of Medicine·JournalThe Lancet·TypeCase study·DateJun 29, 2023
Researchers have identified specific cellular signatures for kidney transplant rejection, which could lead to the development of more effective anti-rejection therapies. The study's findings suggest that treatments often do not thoroughly eliminate T cells responsible for rejection, and new drug targets may be able to address this issue.
SourceCincinnati Children's Hospital Medical Center·JournalJournal of Clinical Investigation·TypeExperimental study·DateJun 28, 2023
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Researchers aim to prevent transplant rejection by targeting trained immunity, a newly explored part of the immune system. The five-year program will investigate how trained immunity drives rejection and develop tools for diagnosing and regulating it.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·DateJun 28, 2023
A study published in Annals of the American Thoracic Society found that race-neutral lung function interpretation could lead to more equitable access to lung transplants for Black patients. The researchers analyzed data from over 8,900 patients and discovered that a race-specific approach resulted in lower Lung Allocation Scores (LAS) ...
SourceAmerican Thoracic Society·JournalAnnals of the American Thoracic Society·TypeData/statistical analysis·DateJun 23, 2023
Researchers have developed a new manufacturing pipeline to simplify and advance high-value manufacturing of tissue-compatible organs, reducing costs and increasing efficiency. This breakthrough aims to address the dire need for artificially engineered organs and tissue grafts, potentially saving thousands of lives in the UK.
SourceUniversity of Huddersfield·JournalAdvanced Healthcare Materials·TypeImaging analysis·DateJun 12, 2023
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SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A study found that most kidneys offered to transplant centers were given to lower-priority candidates, citing concerns about organ quality. This practice, known as 'list diving,' harms some patients and contributes to disparities in organ transplantation.
SourceColumbia University Irving Medical Center·JournalJAMA Network Open·TypeData/statistical analysis·DateJun 8, 2023
Researchers at Weill Cornell Medicine have successfully converted human stomach stem cells into insulin-secreting cells, offering a promising approach to treating type 1 and severe type 2 diabetes. The transplants reversed disease signs in mouse models, suggesting good durability.
SourceWeill Cornell Medicine·JournalNature Cell Biology·DateMay 25, 2023
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
SourceXi'an Jiaotong-Liverpool University·JournalNano Letters·TypeExperimental study·DateMay 8, 2023
A new study suggests that the US liver allocation policy remains biased towards certain regions, with a customized approach to equalize supply-to-demand ratios being recommended. The researchers developed a model that accurately predicts the change in a patient's organ-offer acceptance probability due to changes in policy.
SourceCarnegie Mellon University·JournalManufacturing and Service Operations Management·DateMay 1, 2023
Researchers at University of Pittsburgh have discovered a type of immune cell that drives chronic organ transplant failure and uncovered pathways to improve patient outcomes. Blocking IL-15 signaling has been shown to prolong graft survival in mouse kidney recipients, offering a promising therapeutic target.
SourceUniversity of Pittsburgh·JournalScience Immunology·TypeExperimental study·DateApr 21, 2023
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GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
The funding will support preclinical research using genetically modified pigs, aiming to improve compatibility and reduce immune rejection in xenotransplantation. The goal is to enable human clinical trials and address the organ shortage crisis.
Researchers found that restoring function to donor hearts through taNRP can significantly increase the donor pool, leading to more transplantations. The study showed comparable survival rates between DCD and DBD heart transplants, with 97% of patients surviving for over 30 days.
SourceUniversity of Cambridge·JournalEClinicalMedicine·TypeObservational study·DateMar 15, 2023
Researchers at UC San Diego develop new bioink with iodixanol, reducing light scattering and enabling high cell density printing. The technique creates functional human-like tissues with improved resolution and perfusion systems for long-term culture.
SourceUniversity of California - San Diego·JournalScience Advances·TypeExperimental study·DateFeb 22, 2023
Researchers found better survival rates at all points in time for pediatric patients with more serious heart disease, thanks to improved immunosuppression therapies, techniques, and postoperative care. A multidisciplinary team approach also contributed to the better outcomes.
SourceAmerican College of Surgeons·JournalJournal of the American College of Surgeons·DateFeb 22, 2023
A new study found that a medication previously used to treat seizures can reprogram donor hearts to boost the production of beneficial enzymes, increasing storage time and improving post-transplant function. This technology could lead to a paradigm shift in extending heart storage and reducing primary graft dysfunction.
SourceMichigan Medicine - University of Michigan·JournalScience Translational Medicine·TypeExperimental study·DateFeb 8, 2023
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Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
A recent study published in JAMA Surgery found that underperforming organ procurement organizations significantly impact the nation's organ supply. The research analyzed data from 13 hospitals and identified large gaps between potential and actual donors, highlighting the need for improved oversight and performance standards.
SourceVanderbilt University Medical Center·JournalJAMA Surgery·DateFeb 8, 2023
A study found that standardizing evaluation processes and expanding telehealth use can significantly improve access to kidney transplants for African Americans. The interventions also led to increased organ acceptance rates, but post-transplant survival outcomes were not statistically significant.
SourceAmerican College of Surgeons·JournalJournal of the American College of Surgeons·DateJan 26, 2023
Researchers compared two methods of corneal transplant tissue preparation, finding the new DMEK EndoGlide technique to be safe and effective while providing a faster process. The study suggests this method may lead to better long-term outcomes for patients with Fuchs' dystrophy.
SourceUniversity of Colorado Anschutz Medical Campus·JournalCornea·TypeExperimental study·DateJan 18, 2023
A recent UK trial found that treating patients with transplant-rejecting antibodies did not reduce transplant failure rates. The OuTSMART trial tested two groups of over 2000 transplant patients and found no significant difference in failure rates between those who received oral drugs and those who followed standard care.
SourceKing's College London·JournalEClinicalMedicine·DateJan 18, 2023
A recent study found that patients treated at centers that don't perform transplants have a 79% higher odds of being denied bridge-to-transplant designation. This change could exacerbate existing disparities in access to heart transplantation, according to the research team.
SourceMichigan Medicine - University of Michigan·JournalJAMA Network Open·TypeData/statistical analysis·DateJan 11, 2023
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
A new analysis by Cedars-Sinai investigators shows that similar levels of COVID-19 antibodies are reached over an extended period of time in different population groups. Individuals with autoimmune diseases and solid organ transplant patients experience lower long-term antibody levels.
SourceCedars-Sinai Medical Center·JournalJournal of Internal Medicine·DateJan 10, 2023
Researchers have created a humanized mouse model that can predict the best match for a living organ donor and detect early signs of transplant rejection. The model uses a combination of HLA-G and B regulatory cells to identify patients who may need less immunosuppressive therapy.
SourceMedical College of Georgia at Augusta University·DateJan 10, 2023
A new system will prioritize medical needs over geographical location for lung transplant candidates. The change is expected to reduce waitlist mortality and improve post-transplant survival.
SourceCleveland Clinic·JournalAmerican Journal of Transplantation·DateJan 5, 2023
Researchers at UCSF have developed a novel approach to prevent antibodies from triggering immune rejection of engineered therapeutic and transplant cells. By using a decoy receptor, they can capture the antibodies and take them out of circulation before they can kill the therapeutic cells.
SourceUniversity of California - San Francisco·JournalNature Biotechnology·DateJan 2, 2023
Apple Watch Series 11 (GPS, 46mm)
Apple Watch Series 11 (GPS, 46mm) tracks health metrics and safety alerts during long observing sessions, fieldwork, and remote expeditions.
A University of Michigan-led study found most heart transplant center websites are written at a college junior's reading level, making them difficult for patients to understand. Only 56% offered resources for non-English speakers, with the mid-Atlantic region performing poorly.
SourceMichigan Medicine - University of Michigan·JournalJournal of Cardiac Failure·DateNov 29, 2022
A study by Harvard Medical School researchers found that organ donations and transplants increase by 21% during the week of large motorcycle rallies, with 26% more transplant recipients per day. The surge in donations does not alleviate the critical shortage of donor organs, highlighting the need for improved safety protocols.
SourceHarvard Medical School·JournalJAMA Internal Medicine·TypeObservational study·DateNov 28, 2022
A recent study found that American transplant centers and organ procurement organizations were 5% less likely to choose organs from 70-year-old donors compared to those who were 69. This bias, known as left digit bias, has significant implications for the availability of deceased donor organs
SourceMichigan Medicine - University of Michigan·JournalThe American Journal of Surgery·DateNov 16, 2022
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GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
Researchers have discovered how a new class of drugs can inhibit the complement system, which causes damage to the body in some cases. These findings pave the way for further optimization of such inhibitors, potentially leading to novel therapeutic strategies for treating autoimmune diseases.
SourceUniversity of Basel·JournalNature Communications·DateNov 16, 2022
A team of researchers is developing a new method to evaluate the viability of donor kidneys using optical coherence tomography (OCT) scanning technology. OCT scans provide a more complete view of the organ's overall functional capacity, allowing for better matching with transplant patients. The goal is to increase kidney availability a...
A multistate study found that mRNA COVID vaccines were less effective in immunocompromised adults, with protection rates ranging from 34% to 71% after multiple doses. The study emphasizes the importance of non-pharmaceutical interventions, such as masks and antibody treatment, for additional protection against severe COVID-19.
Researchers found a significant association between NTM infection and increased mortality in patients with end-stage renal disease. Early diagnosis and treatment may improve survival. NTM can cause nonspecific symptoms like fever and weight loss, and patients with compromised immune systems are at higher risk.
SourceMedical College of Georgia at Augusta University·JournalJournal of Investigative Medicine·DateOct 25, 2022
The University of Missouri has earned an $8 million grant from the National Institutes of Health to expand its National Swine Resource and Research Center. The center will support research using genetically modified pigs to study human diseases, with a focus on therapies that can be translated from pig models to humans.
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Researchers found a drastic decrease in bacterial abundance on the skin of patients with graft-versus-host disease, while an increased occurrence of staphylococci was observed. This discovery may lead to improved treatment measures for GVHD, which affects approximately 30-70% of stem cell transplant recipients.
SourceMedical University of Vienna·JournalLeukemia·DateOct 12, 2022
A national US kidney disease registry found that 60% of participants were unaware of their kidney function level, hindering clinical trial recruitment. The National Kidney Foundation Patient Network aims to address this issue through real-world data collection and patient-centered research.
SourceNational Kidney Foundation·JournalAmerican Journal of Kidney Diseases·DateSep 30, 2022
In a new study, researchers found that immune T cells lacking the key transcription factor Satb1 are more susceptible to suppression by regulatory T cells, leading to transplant tolerance. The study provides insight into the mechanism behind transplantation tolerance and may lead to the development of new immunosuppression regimens.
SourceUniversity of Chicago·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateSep 26, 2022
A new study identified a remdesivir-resistant version of COVID-19 in two kidney transplant patients treated with immunosuppressive drugs. The virus developed the V7921 gene mutation, which allows it to resist antiviral therapy, highlighting the need for continued monitoring and potential development of additional treatments.
SourceNYU Langone Health / NYU Grossman School of Medicine·JournalClinical Infectious Diseases·TypeCase study·DateSep 26, 2022
A new study published in the Journal of Hepatology found that living donor liver transplants can reduce waitlist time and deaths in Western countries. Long-term outcomes were excellent despite relatively low use of this procedure, with high patient survival rates and similar mortality risk among three countries.
SourceElsevier·JournalJournal of Hepatology·TypeData/statistical analysis·DateSep 25, 2022
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Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
In the UK, both eligible organ donors and actual organ donations decreased by around 30% during the first two years of the COVID-19 pandemic. The proportion of eligible donors who proceeded to donation remained relatively constant.
Researchers have developed a model mouse embryo that has beating hearts, foundations for a brain, and all the organs in a mouse body. This breakthrough could help understand why some embryos fail and provide insights into repairing synthetic human organs.
SourceCalifornia Institute of Technology·JournalNature·DateAug 25, 2022