Articles tagged with Positron Emission Tomography
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Researchers used total-body PET imaging to track the distribution of 89Zr-labeled antibodies in preclinical trials, achieving excellent image quality up to 30 days after injection. The study demonstrates the potential of this technique for extended imaging windows and low-dose radioactivity.
Researchers used PET myocardial perfusion imaging to quantify myocardial blood flow and flow reserve, successfully detecting cardiac allograft vasculopathy and predicting prognosis. The study found MFR had higher accuracy in predicting overall prognosis for cardiac transplant patients.
A new radiopharmaceutical, [55Co]Co-DOTATATE, has been developed to aid in the diagnosis of neuroendocrine tumor metastases. It resulted in superior image contrast and enhanced detection compared to commonly used imaging agents.
A team of researchers at Wake Forest School of Medicine will use a novel brain-imaging technique to image microtubules in the brain, which could potentially predict the onset of Alzheimer's disease. The study aims to identify a biomarker for neural degeneration and cognitive impairment.
A new drug called Myeliviz has been approved for its first human trials to aid multiple sclerosis (MS) diagnoses. The drug targets and binds to myelin, allowing for its imaging by a PET scanner, potentially providing earlier and more accurate diagnoses.
Scientists have developed a method to reduce noise and reconstruct images from raw data, capturing ultrafast whole-body dynamic tracer imaging with improved image quality at a timescale of 100 milliseconds.
Researchers developed a total-body PET/CT scanner with advanced reconstruction techniques to capture radiotracer transport in humans at 100 ms timescales. This approach offers clear images of cardiac blood pool changes throughout the cardiac cycle, enabling real-time motion tracking and neural activity analysis.
A new radiotracer, 68Ga-FAPI-04 PET, can effectively image fibroblast activation after myocardial infarction, identifying a time window during which cardiac fibrosis can be prevented. This technology may aid in the clinical management of patients after a heart attack.
A new study finds that tau protein is a more reliable predictor of brain atrophy in Alzheimer's patients than amyloid plaques. Tau PET imaging technology has the potential to accelerate clinical trials and improve individualized patient care.
Researchers Marcos Barp and Felipe Arretche developed a model predicting rotational energy loss when positrons collide with molecules like CF4 and methane. The model agreed well with experimental results and could improve PET scanning techniques, providing new insights into matter-antimatter interactions.
A study published in Journal of Nuclear Cardiology found that combining Transcendental Meditation with cardiac rehabilitation increases myocardial blood flow by 20.7%. This increase is significantly higher than the 5.8% improvement seen with cardiac rehabilitation alone.
A multi-centre registry trial is testing the use of a new PSMA tracer to detect early recurrence of prostate cancer. The trial provides valuable insights and has already shown promising results for patients like Wayne Smith, who was able to have a shorter round of hormone therapy.
Researchers at UCLA Jonsson Comprehensive Cancer Center identified a new biomarker tracking mitochondrial activity in lung tumors using noninvasive imaging. This level of activity may predict favorable response to complex I inhibitor and inform treatment decisions for individuals with lung cancer.
A team of researchers at the University of Pennsylvania is developing a critical tool for imaging the brains of patients with Parkinson's disease. They plan to use a special type of PET scan to detect the disease early on and provide detailed information about its progression.
A new study finds that 68Ga-DOTATATE PET/CT is a more accurate method for selecting patients with neuroendocrine tumors who may benefit from peptide receptor radionuclide therapy. The imaging modality yields significantly higher Krenning scores and detects eligible patients with smaller lesions.
The study used the 18F-labelled PSMA-1007 radiotracer to detect recurrent and metastatic prostate cancer, which was not identified by conventional diagnostic imaging. The hospital aims to spread nuclear medicine that uses drugs labeled with α-emitting radionuclides for higher therapeutic effects.
Researchers studied tau protein accumulation after a single traumatic brain injury (TBI) in 32 individuals and found increased deposition of tau associated with poorer memory and cognitive performance. Higher tau levels were also linked to more severe neurodegeneration and damage to the brain's white matter.
Researchers have developed a blood test that can detect Alzheimer's disease with 94% accuracy when combined with age and genetic risk factor. The test measures levels of amyloid beta in the blood to predict brain changes, potentially allowing for earlier intervention.
A $47 million grant will incorporate advanced brain imaging into the Alzheimer's Association's U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER) clinical trial. The study aims to determine whether lifestyle changes can protect memory in people at risk of developing dementia.
A new imaging diagnosis device called a Compton camera enables simultaneous PET and SPECT scans, reducing time and radiation exposure. Researchers detected and imaged radioactive tracers with improved accuracy, paving the way for new forms of medical analysis.
A Louisiana State University biologist conducted a groundbreaking study using PET scans on wild songbirds to understand the role of dopamine in stress resilience. The research found that dopamine receptors decrease over time during captivity, leading to anxiety-related behaviors.
A new study uses amyloid positron emission tomography to track β-amyloid cerebrospinal fluid and monitor Alzheimer's disease progression over six years. The researchers found a significant correlation between β-amyloid levels and cognitive decline, providing valuable insights into the disease's progression.
A new study by UC Berkeley psychologists links disrupted sleep in 50s and 60s to increased protein tangles in the aging brain, raising the risk of developing Alzheimer's disease. The research highlights the importance of sleep for maintaining a healthy brain into old age.
Researchers have developed ultrasmall nanoclusters with antioxidative properties that can pass through the kidneys' filtration barrier to alleviate clinical symptoms of AKI. Selenium-doped carbon quantum dots also demonstrated effective treatment and prevention of AKI in mice by localizing in the kidneys and eliminating ROS.
A new class of radiopharmaceuticals, named radiohybrids (rh), has been developed for cancer imaging and radioligand therapy (theranostics). These rhPSMA-ligands have a unique feature that both fluorine and the metal are always present, but only one of them is present as a radioactive isotope.
Research shows that adding an interim scan during therapy can help guide patient treatment, predicting survival and tumor response. Interim scans using PSMA PET imaging have shown significant predictive value for overall survival in patients undergoing 177Lu-PSMA radioligand therapy.
A study using PET imaging reveals that women with the ApoE 4 allele are more susceptible than men to tau accumulation in the brain. The study also found that sex modulates the effect of ApoE ε4 on brain tau depositing in individuals with mild cognitive impairment.
Researchers at UNC Lineberger Comprehensive Cancer Center discovered a new way to attach Fluorine-18, a widely used PET imaging isotope, to existing compounds. This breakthrough enables the creation of novel PET agents from existing drugs, opening up possibilities for tracking pharmaceuticals and diagnosing diseases like cancer.
A new study from McGill University and the University of Antwerp has developed a PET imaging platform that allows simultaneous scanning of multiple awake animals. This breakthrough enables unprecedented experimental designs and opens up new avenues for research into brain function, neurochemistry, and behavior.
A team of researchers developed a macrocyclic peptide, HiP-8, that selectively inhibits active Hepatocyte Growth Factor (HGF), a protein promoting cancer cell invasion and survival. HiP-8 shows high affinity for HGF and has potential as a PET imaging probe and anti-cancer drug.
Cardiovascular PET has grown into a staple of contemporary cardiovascular care, with emerging techniques expanding its applications to CAD, CMD, and vascular plaques. The development of new tracers and absolute flow assessment are poised to further improve diagnostic information and treatment outcomes.
Researchers at the University of Zurich have developed a simple and fast method for radiolabelling antibodies against breast cancer using UV light. The new procedure allows for the production of radioactive drugs and diagnostic agents in under 20 minutes, making it a game-changer for PET imaging and targeted radioimmunotherapy.
Researchers found elevated tau protein levels in brain regions affected by CTE in living former NFL players with cognitive and mood symptoms. The study also discovered a correlation between years of tackle football played and tau protein levels.
Researchers have discovered a new PET imaging biomarker that can better predict the progression of Alzheimer's disease. Microglial activation levels, as measured by TSPO-PET imaging, showed a significant correlation with cognitive outcomes in an amyloid mouse model.
A study of 11,400 patients with dementia or mild cognitive impairment found that amyloid PET imaging was associated with changes in clinical management within 90 days. The use of this imaging technique was reported in 55% of MCI patients and 70% of those with dementia.
A nationwide study found that amyloid PET imaging significantly influenced clinical management of patients with mild cognitive impairment and dementia. The technique altered diagnoses and treatment plans in nearly two-thirds of cases, more than double predictions.
The first total-body PET/CT scanner has shown promising results in enhancing image quality, reducing scan time, and lowering dose. Clinical trials have demonstrated improved diagnostic capabilities with minimal impact on patient exposure.
Researchers at Washington University have developed a new method for precise drug delivery using cavitation dose painting, which combines focused ultrasound with ultrasound therapy to target specific locations in the body. This technique uses passive cavitation imaging to predict where a drug goes and how much is delivered.
Researchers have developed a novel PET/CT tracer that detects and characterizes blood clots in the legs, where conventional imaging has limitations. The new imaging agent may provide more accurate diagnoses and information on clot growth or embolization, leading to changes in clinical intervention.
Researchers use new PET scan technique to show that people with PTLDS have elevated levels of a chemical marker of brain inflammation, compared to healthy controls. The study suggests new avenues for treating the long-term fatigue and cognitive symptoms associated with PTLDS.
A 58-year-old female patient with advanced Alzheimer's disease showed significant improvement in brain metabolism and symptoms after undergoing hyperbaric oxygen therapy. The patient reported increased energy, mood, and cognitive function, and experienced reduced anxiety and disorientation.
A study using PET technology found that dopamine release in the brain happens twice during a meal: first when eating and second when food reaches the stomach. This release is linked to brain regions involved in reward, sensory perception, and higher cognitive functions.
Recent advancements in prostate imaging modalities have significantly enhanced the diagnosis of prostate cancer. Androgen receptor-based imaging is emerging as a promising approach for non-invasive detection using non-steroidal antiandrogen agents.
A study using a PET scan tracer has identified epigenetic differences between the brains of individuals with schizophrenia and those of unaffected participants. Reduced histone deacetylase (HDAC) levels were observed in the dorsolateral prefrontal cortex, which is important for executive functions affected by schizophrenia.
Researchers used PET scans to track TB drug levels in a rabbit model and human patients, revealing that current treatments may not be effective due to poor penetration of the drug into infected brain lesions. The study aims to optimize treatment by tailoring doses for individual patients based on imaging results.
A new second-generation positron emission tomography (PET) tracer has been identified for imaging tau pathology in Alzheimer's disease patients. The tracer, 18F-RO-948, showed promising results in a human evaluation study, outperforming other novel tau-specific radiopharmaceuticals.
A new study found that repetitive subconcussive head impacts in youth football can alter the corpus callosum, a critical band of nerve fibers connecting the two halves of the brain. This change may lead to greater risk of cognitive and motor problems in these young athletes.
The EXPLORER scanner captures a 3-D picture of the whole human body at once, producing images in as little as one second. It can track specially tagged drugs and has countless applications in diagnostics, disease progression, and new drug therapies.
Researchers developed a precision-medicine platform that uses genomic data, biospecimen measurements, and other inputs to create personalized treatment plans for mild Alzheimer's disease and at-risk individuals. The study showed significant improvements in memory function scores for 80% of participants.
A new method for treating and preventing acute kidney injury (AKI) has been developed using tiny, self-assembling forms of DNA origami nanostructures. These nanostructures were shown to protect the kidneys from harm as effectively as the leading drug therapy and alleviate symptoms of AKI.
Researchers used PSMA PET/CT to detect prostate cancer outside the prostate gland with higher sensitivity and specificity than standard imaging techniques. This improved accuracy enables more precisely targeted treatment, potentially increasing the chances of successful outcomes.
A new study published in Radiology uses deep learning to predict Alzheimer's disease from brain imaging, achieving 100% sensitivity in detecting the disease an average of more than six years prior to final diagnosis. The algorithm has the potential to complement existing tests and provide opportunities for early intervention.
A new preclinical study shows that PET imaging with the 18F-FAC radiotracer can image T cells in the liver, potentially reducing biopsies and improving treatment. The approach could lead to personalized treatment of patients with immune-related liver disease.
A new PET imaging radiotracer, <sup> 18 </sup> F-XTRA, was tested on adults to study the distribution of the α4β2 nicotinic acetylcholine receptor in the brain. The research found that the radiotracer rapidly entered the brain and distributed quickly, with lower binding in the hippocampus with healthy aging.
The study evaluated [18F]SRF101, a PET radiotracer for astrocytosis detection. The results showed no systemic signs of toxicity in mice and estimated the human radiation dosimetry to be comparable to other 18F radiopharmaceuticals.
A new Ontario clinical study shows adding PET imaging to CT scans can change treatment plans for women with locally advanced cervix cancer. The study found that patients who received PET scans were twice as likely to have a change in their treatment, leading to more extensive radiation therapy.
A recent study highlights the potential for misinterpretation of Prostate-Specific Membrane Antigen (PSMA) PET results, which can affect diagnostic accuracy and guide therapy. Researchers urge nuclear medicine physicians to analyze PSMA-ligand uptake in conjunction with lesion localization to avoid misdiagnosis.
Researchers have developed a novel PET imaging method that can measure beta-cell mass, enhancing the ability to monitor and guide diabetes therapies. The new imaging method uses a radioligand to identify beta cells and has shown promising results in differentiating between healthy individuals and those with type 1 diabetes.
Researchers have developed a new method to directly measure synaptic loss in individuals with Alzheimer's disease, using PET imaging technology. The study found that participants with Alzheimer's disease had a 41% reduction in synaptic density compared to those with normal cognition.
A new PET imaging method evaluates the extent of rheumatoid arthritis inflammation by targeting translocator protein (TSPO) expression in joint lining tissue. The study demonstrates that TSPO PET can image not only synovial macrophages but also activated synovial fibroblasts, a critical process in RA pathogenesis.