Articles tagged with Atherosclerosis
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A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that diabetic men with low testosterone levels are more likely to develop severe atherosclerotic plaques and other cardiovascular markers. The research suggests a strong association between low testosterone concentration and the severi...
Researchers at The Scripps Research Institute have created a synthetic molecule that mimics 'good' cholesterol, reducing plaque buildup in animal models. After two weeks, the molecule improved cholesterol levels, pointing toward a new method for treating atherosclerosis.
Researchers at Brigham and Women's Hospital identified a link between BET bromodomain-containing proteins and atherosclerosis. By inhibiting these proteins, they found significant decreases in inflammation and atherosclerosis in pre-clinical models.
A long-term study found that statin therapy initiated in childhood showed benefits on atherosclerosis progression and reduced carotid intima-media thickness. However, low-density lipoprotein levels remained high, suggesting stronger or earlier treatment may be needed.
A new study found that moderate wine consumption is protective against cardiovascular disease in people who exercise regularly. However, the study did not find any benefits for people with no exercise habits.
A new study finds that calcium buildup in coronary arteries is a strong indicator of heart disease risk in individuals with chronic kidney disease. This measure outperforms other commonly used tests in predicting cardiovascular disease among CKD patients, who are at high risk for heart disease.
A new study published in Menopause finds that lifelong soy consumption helps prevent atherosclerosis and improves cholesterol levels in premenopausal monkeys. After menopause, switching to a soy diet can also improve cholesterol levels, but has limited effect on plaque progression.
A study of mummies from various regions reveals evidence of atherosclerosis in ancient populations, contradicting the assumption that the disease is modern. Non-traditional risk factors like cooking fire smoke and chronic infection may have contributed to the condition.
A new study comparing ancient and modern Egyptian whole-body CT scans found no significant differences in atherosclerotic disease incidence or severity. Despite higher age ranges in modern Egyptians, researchers detected vascular calcifications strongly correlated to age in both groups.
A study published in Global Heart explores the prevalence of atherosclerosis across ancient populations, revealing that genetic susceptibility is present in all cultures. Environmental factors such as diet, lifestyle, and physical activity play a crucial role in determining when and how quickly atherosclerosis develops.
The study investigates progerin's potential causative factor for atherosclerosis in both modern and ancient populations. Progerin is found to be expressed in vascular cells, leading to vessel wall cell loss and replacement by fibrous tissue.
A study found that early initiation of menopausal hormone therapy has a neutral effect on atherosclerosis progression in women. Meanwhile, the effectiveness of decision aids for advanced care planning is unclear due to limited research. Additionally, recent safety lapses at government labs pose a bioterror risk, highlighting the need f...
Researchers at UT Southwestern Medical Center have discovered a new driver of atherosclerosis, a molecule called 27-hydroxycholesterol (27HC), which exacerbates the condition and may be a promising therapeutic target. Blocking 27HC or inhibiting its actions could provide a complementary approach to preventing vascular disease.
Researchers have found that disturbed blood flow leads to epigenetic changes in genes lining blood vessels, contributing to atherosclerosis. The study suggests that good blood flow patterns can persist over time due to these lasting changes.
Researchers at Georgia Institute of Technology and Emory University discovered that altered blood flow induces epigenetic alterations in endothelial cells, leading to atherosclerosis. Additionally, they found that reduced expression of the aldehyde dehydrogenase 1 enzyme makes dopaminergic neurons more susceptible to degeneration in Pa...
Researchers develop protocol combining hard X-ray tomography and histology to visualize constricted vessels, enabling simulation of blood flow and targeted drug delivery. The method also characterizes soft tissues in the vicinity of calcified arteries with high precision.
A study by Changcheng Zhou and colleagues found that IKKβ deficiency in smooth muscle cells decreases vascular inflammation and atherosclerosis, while also blocking fat cell differentiation. This suggests a novel therapeutic target for treating obesity, atherosclerosis, and metabolic disorders.
Researchers investigated the neural circuitry behind stress and heart disease, finding that negative emotions increase pro-inflammatory chemicals in the body. Individuals who struggled to regulate their emotions showed elevated blood levels of inflammatory cytokines and atherosclerosis markers.
Scientists at Johns Hopkins Medicine have found a way to block abnormal cholesterol production, transport and breakdown, preventing the development of atherosclerosis in mice and rabbits. The treatment, using an existing compound called D-PDMP, successfully prevented the formation of fatty plaque and calcium deposits inside blood vessels.
Researchers found that early but not advanced forms of atherosclerotic plaques in mice regress when 'bad' cholesterol is lowered. The study suggests that preventative cholesterol-lowering treatment could prevent more advanced plaque development and reduce the risk of stroke or heart attack.
A team of scientists designed a microchip coated with blood vessel cells to study nanoparticle accumulation in atherosclerotic arteries. The device demonstrated the ability to screen and optimize nanoparticles' design, correlating well with animal model results.
Researchers at Wayne State University have discovered a potential way to improve lipid profiles in hemodialysis patients, which may prevent cardiovascular disease. Vitamin E supplements improved patients' triglycerides and HDL cholesterol levels compared to placebo groups.
Researchers discover a molecule that causes atherosclerosis also activates white blood cells called T cells in mice, worsening autoimmune disease symptoms. This finding sheds light on the link between autoimmunity and atherosclerosis, potentially leading to improved treatments.
Scientists at Emory and Georgia Tech have developed a potential treatment for atherosclerosis by targeting a micro RNA molecule that regulates inflammation in blood vessels. In animal models, a drug blocking the micro RNA can halt artery blockages despite high-fat diets.
Researchers found no evidence of an association between iron levels and the risk of atherosclerosis, contradicting a long-held hypothesis. The study's findings carry important implications for patients with chronic kidney disease or anemia related to inflammatory disorders.
Research suggests nicotine drives cell invasion contributing to atherosclerosis and plaque formation in coronary arteries. E-cigarettes may not significantly reduce smokers' risk for heart disease, according to Brown University study findings.
A prospective study found that improved periodontal health slows atherosclerosis progression, while worsening infections parallel increased risk for coronary events. The study suggests a clear relationship between mouth bacteria and thickening of the carotid artery.
Researchers found a significant association between longer duration of HIV infection and increased risk for atherosclerosis, regardless of antiretroviral therapy. The study suggests that inflammatory imbalance may play a key role in the development of atherosclerosis in HIV patients.
A Finnish study found that binge drinking accelerates atherosclerosis and increases the risk of stroke in middle-aged men, particularly those who experience hangovers. The study also highlights the importance of moderate alcohol consumption and managing other risk factors such as hypertension and overweight.
Researchers from CNIC and CSIC discover that inhibiting protein Rcan1 reduces burden of atherosclerosis in mice. Genetic inactivation of the protein represses disease development by favoring anti-inflammatory characteristics in macrophages.
Research reveals that high 'bad' cholesterol levels stimulate production of hematopoietic stem/progenitor cells, which promote inflammation and atherosclerosis. The study opens up a potential new approach to preventing heart attack and stroke by focusing on interactions between cholesterol and these cells.
A Binghamton University researcher has received funding to develop a more accurate way of determining a patient's risk of heart attack or stroke. The goal is to identify which plaques are stable and which ones are dangerous, allowing doctors to make informed decisions.
Researchers found that atorvastatin treatment decreased levels of inflammatory markers, thrombogenesis, and hyperlipidemia, suggesting its anti-inflammatory and anti-thrombotic effects. This study expanded the use of atorvastatin for acute ischemic stroke treatment by measuring multiple biomarkers.
A study published in JAMA Network found that aliskiren, a renin inhibitor, did not slow the progression of coronary artery disease in patients with prehypertension. The treatment had no significant impact on atheroma burden or regression of fatty deposits.
A new study from the University of Toronto and Massachusetts General Hospital found that macrophage growth inside arterial plaques is not reliant on external cells. This discovery may lead to alternative approaches to treating atherosclerosis, a leading cause of cardiovascular disease.
A genetic study published in Neural Regeneration Research identified the G4A polymorphism of the scavenger receptor class B type I gene as a possible predisposing risk factor for atherosclerotic cerebral infarction. The study found that individuals with the G4A GA + AA genotype had higher serum levels of high-density lipoprotein choles...
Researchers found that excessive PKC beta in endothelial cells exacerbates atherosclerosis, a condition where blood vessel walls thicken due to fatty deposits. This inhibition leads to decreased nitric oxide production, increasing cardiovascular disease risk.
Researchers discovered a common biochemical thread to multiple diseases and found that CD36 draws soluble particles inside cells, triggering an inflammatory response. Blocking the CD36 receptor reduces inflammation and improves symptoms in mice with atherosclerosis.
A study of over 2,000 adults found that increased abdominal aortic wall thickness and plaque buildup are associated with future cardiovascular events. MRI measurements can help identify individuals at risk of these events.
Researchers at UT Southwestern Medical Center used MRI to measure aortic atherosclerosis and found that thicker walls were associated with a higher risk of cardiovascular events, including heart attacks. A smaller plaque buildup was linked to increased risk of peripheral vascular occlusion, stroke, and abdominal aortic aneurysms.
Fine-particle air pollution and nighttime traffic noise pollution independently associated with subclinical atherosclerosis. Researchers found strong associations among younger participants, those with coronary artery disease, and statin users.
A nationwide study reveals that heredity plays a significant role in common forms of atherosclerotic disease, with risk highest for individuals with family history. The study found a strong correlation between early-onset aortic atherosclerosis and increased risk of developing the same type of disease.
Researchers at the Montreal Heart Institute have discovered a blood protein that contributes to the early development of atherosclerosis. Angiopoietin-like protein 2 (angptl2) is found six times higher in subjects with coronary heart disease than healthy individuals, making it a potential early biomarker for the condition.
A new study links type 1 diabetes to an increased risk of heart disease through the production of the inflammatory protein calprotectin, which fuels the buildup of artery-clogging plaque.
Long-term exposure to air pollution may be linked to heart attacks and strokes by speeding up atherosclerosis, or hardening of the arteries. Higher concentrations of fine particulate air pollution were found to be linked to faster thickening of the inner two layers of the common carotid artery.
Long-term exposure to air pollution may accelerate atherosclerosis, increasing the risk of heart attacks and strokes. Fine particulate air pollution was found to be associated with faster thickening of the inner two layers of the common carotid artery.
A large cohort study found that long-term exposure to fine particle matter and road traffic noise are associated with atherosclerosis. Exposure to PM2.5 and proximity to major roads increased aortic calcification, while night time noise also showed a borderline increase in thoracic aorta calcification.
Researchers have discovered a cell-permeable peptide that reduces nuclear NF-ĸB activity in vascular smooth muscle cells and macrophages of aortic plaques. The peptide also inhibits lesion development in mice with a high-fat diet.
A new study by Cleveland Clinic researchers reveals a connection between red meat consumption and an increased risk of heart disease. The research found that a diet high in carnitine promotes the growth of bacteria that metabolize the compound, leading to the production of TMAO, which is associated with atherosclerosis.
A team of medical researchers has identified a specific microRNA, miR-342-5p, that plays a key role in promoting inflammation in atherosclerosis. Inhibiting this microRNA has been shown to retard the progression of the disease in animal models.
A study of ancient mummies from diverse cultures reveals that hardening of the arteries was a widespread problem globally, contradicting previous assumptions about its occurrence in ancient Egypt and diet-related factors. The research found that nearly half of the examined mummies showed signs of probable or definite atherosclerosis.
A study of 137 mummies from around the world reveals that preindustrial hunter-gatherers suffered from clogged arteries, challenging the assumption that modern lifestyles are the primary cause. The researchers found artery plaque in every single population studied, indicating a more basic connection to inflammation and aging.
Researchers identify critical role of CCR1 and CCR5 receptors in monocyte recruitment to atherosclerotic lesions. The findings suggest that inhibiting these receptors may provide novel therapeutic strategies for treating atherosclerosis.
An autopsy-based study among US service members (2001-2011) reveals high prevalence of atherosclerosis, associated with older age, lower education level, and higher BMI. The study's findings highlight the need for continued efforts to reduce cardiovascular risk factors.
Researchers at Case Western Reserve University School of Medicine identified a genetic factor KLF4 that prevents blockages from forming in blood vessels. The study found that a shortage of KLF4 makes the lining more prone to plaque buildup and clot formation, while sufficient levels protect against toxins and disease.
Daniel J. Rader, MD, has been awarded the American Heart Association's (AHA) Clinical Research Prize for developing new methods to identify factors regulating fat particle metabolism and testing their impact on atherosclerosis. His research focuses on genetic and pharmacologic regulation of lipoprotein metabolism and atherosclerosis.
A study by researchers at the University of Pennsylvania School of Medicine found that apolipoprotein E (apoE) plays a key role in maintaining arterial softness. The protein is associated with the production of collagen and other extracellular matrix proteins, which contribute to cardiovascular disease risk.
Researchers found that high-saturated fat diets increase endothelial lipase levels, associated with atherosclerosis, while omega-3 polyunsaturated fats lower these levels. This discovery may help explain why certain diabetes drugs raise heart risks and provides a new link between diet and cardiovascular disease.
Research reveals that activated macrophages accumulate triglycerides to support their function, leading to increased pathogen destruction. This finding provides new insights into the development of atherosclerosis and potential approaches to slowing its progression.
Researchers will analyze data from a unique NIH-funded repository to identify genetic variants associated with premature cardiovascular disease. The goal is to create new screening strategies and therapeutic targets to reduce the human and financial costs of cardiovascular disease.