Articles tagged with Atherosclerosis
Researchers identified MAARS, a lncRNA expressed specifically in macrophages of atherosclerotic plaques, contributing to disease progression. Targeted interruption of MAARS's function reduced atherosclerotic lesion formation by 52%.
Researchers at CNIC have identified mitochondrial protein ALDH4A1 as a potential marker for cardiovascular disease diagnosis and a possible therapeutic target. The study found that ALDH4A1 accumulates in plaques and its plasma concentration is elevated in patients with carotid atherosclerosis, suggesting it as a biomarker.
Researchers found that pre-treating early outgrowth cells with a chemical activator slows the development of atherosclerosis in mice. The study showed that this treatment reduced inflammation and plaque buildup in arteries, providing potential hope for treating cardiovascular diseases.
Individuals with rheumatoid arthritis are more likely to develop atherosclerosis when exposed to certain bacteria causing periodontal disease. Studies suggest that immune responses to these bacteria may play a role in the increased cardiovascular disease risk associated with rheumatoid arthritis.
A new screening questionnaire can predict individuals at high risk of coronary artery disease, according to a Swedish study. The questionnaire uses data easily measured at home and is successfully imaged using CCTA images to examine patients' arteries for the presence of plaque.
Macrophages, such as M1 and M2 cells, play a crucial role in the immune response. Researchers have developed a method using gold nanorod scattering to identify these cells from tissue fluids or blood samples. This technique has the potential to predict disease stages, including cancer, atherosclerosis, and fibrosis.
A new study confirms hormone therapy reduces biomarkers of inflammation in postmenopausal women, with greatest benefits seen in those nearing menopause. The study suggests hormone therapy may slow progression of atherosclerosis by targeting inflammatory processes.
Scientists at CNIC designed an algorithm that estimates cardiovascular risk in healthy middle-aged individuals based on variables like age, blood pressure, diet, and biomarkers. The EN-PESA algorithm provides a personalized risk profile for those with subclinical atherosclerosis or high short-term disease progression risk.
A University of Kentucky College of Medicine study reveals how the angiotensinogen (AGT) protein contributes to blood pressure regulation and atherosclerosis. Replacing amino acids in AGT did not affect blood pressure or atherosclerosis in mice, suggesting these proteins may not be critical regulators.
A new study reveals that certain T lymphocytes can increase inflammation and worsen atherosclerosis cases, contrary to their usual role as immune system defenders. Researchers at La Jolla Institute for Immunology are working to design a safe anti-atherosclerosis vaccine by harnessing the power of T cells.
Researchers have identified a new biomarker, asymmetric dimethylarginine (ADMA), associated with cognitive decline in old age. The study found that ADMA levels were linked to decline in cognitive performance assessments after four years.
Scientists have developed peptides that can remodel the gut microbiome, reducing cholesterol levels and inhibiting atherosclerosis in mice. The treatment significantly slowed the growth of undesirable gut bacteria and reduced atherosclerotic plaques by 40%.
A recent study from University of California, Berkeley reveals that disrupted nightly sleep leads to chronic inflammation, which is linked to atherosclerosis and cardiovascular disease. The findings suggest that poor sleep quality can be an important risk factor for heart health, highlighting the need for improved sleep hygiene.
A new study finds that disrupted sleep increases the risk of atherosclerosis and stroke by promoting inflammatory pathways. Sleep fragmentation was associated with higher neutrophil counts and coronary artery calcium, two markers of atherosclerosis pathology.
Researchers discovered a microRNA named miR-126-5p that protects endothelial cells from damage and reduces atherosclerosis risk. By inhibiting caspase-3 activity, miR-126-5p maintains vascular integrity and prevents the development of atherosclerotic lesions.
Researchers found that patients with type 2 diabetes have blood vessels resistant to insulin, leading to elevated oxidative stress and vessel dysfunction. A new therapy combining insulin treatment with DPP4 inhibitors shows promise in reversing damaging vascular effects.
Researchers at CNIC discovered a biomarker, complement component 5 (C5), that detects atherosclerosis in its preclinical phase. Plasma levels of C5 can identify individuals with subclinical atherosclerosis, helping to select those who would benefit from more costly imaging analysis.
Researchers found that 40% of asymptomatic people between 40-50 years old accumulated fatty plaques in their arteries at a rapid rate. The study shows a direct link between classical cardiovascular risk factors and disease progression.
Preliminary research suggests that taking estradiol within 6 years of menopause onset can prevent or slow atherosclerosis progression by reducing cholesterol deposits in artery walls. In contrast, starting therapy 10 years after menopause did not yield similar benefits.
A team of researchers has identified a long noncoding RNA molecule that may control aging in blood vessel walls. The discovery could lead to new treatments for cardiovascular disease states and may provide insights into why heart disease risk increases with age.
Researchers at Columbia University Irving Medical Center found putrescine, a compound responsible for the foul smell of decomposing flesh, may help treat atherosclerosis. The study suggests putrescine's role in removing dead cells through efferocytosis could improve plaques and prevent chronic inflammation.
The British Heart Foundation has announced four research projects competing for a £30 million award to tackle cardiovascular diseases. The projects include a soft robotic heart, a genetic cure for inherited heart conditions, a 'google map' of atherosclerosis, and next-generation health tech.
A protein found in the bran of foxtail millet has been shown to reduce plaque buildup and inflammation in mice with genetic predispositions to atherosclerosis. The study suggests that this natural compound may have great potential in preventing and treating heart disease.
A new study published in International Journal of Epidemiology found a strong association between air pollution and carotid intima-media thickness (CIMT) in peri-urban South India. People exposed to higher levels of fine particles had a higher CIMT index, indicating a higher risk of cardiovascular diseases.
A new study finds that increasing levels of 'good' cholesterol reversed disease in the blood vessels of mice with diabetes, reversing atherosclerosis. The study also shows that raising functional HDL levels stopped inflammation and improved cardiovascular disease processes.
A new study based on ELITE data found that hormone therapy affects estradiol levels in different ways for various determinants, such as BMI, smoking status, and medication use. Higher estradiol levels were associated with lower atherosclerosis risk among postmenopausal women.
Researchers have developed a nanotherapeutic called S-HDL that reduces inflammation in blood vessels, halting plaque accumulation and vessel wall inflammation in animal models. The new production method boosts therapeutic yields by up to 80-fold, paving the way for human application.
Researchers suggest a genetic mutation two to three million years ago led to a heightened risk of cardiovascular disease in all humans, while also setting up a further risk for red meat-eating humans. Human-like mice modified to lack the CMAH gene showed a significant increase in atherogenesis compared to control mice.
A new study from the University at Buffalo found a significant association between long-term exposure to air pollution and the severity of coronary artery calcium, or plaque buildup in artery walls. The study suggests that China may need to revise its standard for nitrogen dioxide limits to reduce the risk of cardiovascular disease.
A University at Buffalo study found a strong association between chronic ozone exposure and progression of carotid artery thickening, as well as an increased risk of carotid plaque. The research suggests that air pollution may contribute to cardiovascular disease and stroke by accelerating arterial conditions.
A study of over 8,000 participants found that elevated troponin I levels are associated with cardiac outcomes like heart attacks and fatal coronary disease. Adding troponin I to a risk prediction model improves accuracy in predicting heart failure risk, highlighting the potential for improved treatment strategies.
Researchers found that injections of a novel protein called VEGF-C 152S reduced artery blockage by about 30% and made plaque more stable, potentially reducing strokes. The protein targets the lymphatic system, which is understudied in atherosclerosis.
Researchers discovered that neutrophils can induce a previously unrecognized type of cell death in tissues, leading to the destabilization of atherosclerotic plaques. This process causes inflammation, which increases the likelihood of plaque rupture and subsequent cardiovascular events.
Researchers found that childhood oral infections, such as caries and periodontitis, are associated with increased risk of atherosclerosis and cardiovascular disease. A 27-year follow-up study showed that the more signs of oral infections present in childhood, the higher the risk for adulthood atherosclerosis.
Researchers at UT Southwestern have found that SR-B1 and DOCK4 proteins ferry LDL particles into and across endothelial cells, driving the development of atherosclerosis. Deleting these proteins from endothelial cells reduces LDL entry and atherosclerotic plaque formation.
Researchers used advanced PET/MRI technology to analyze inflammatory processes in arteries of individuals with atherosclerotic plaques. The study found that inflammation is present at early stages of atherosclerosis, particularly in regions without developed plaques.
Researchers have discovered a new molecular mechanism involved in premature atherosclerosis in mice with Hutchinson-Gilford progeria syndrome. The study identifies tauroursodeoxycholic acid as a potential therapeutic target that slows the progression of atherosclerosis and extends lifespan in progeroid mice.
A Massachusetts General Hospital study found that hypocretin, a hormone regulating wakefulness, also controls the production of inflammatory white blood cells. This discovery suggests that insufficient sleep increases the risk of cardiovascular disease by disrupting this process.
Researchers discovered a previously unknown mechanism between the brain, bone marrow, and blood vessels that appears to protect against hardening of arteries when sleep is healthy. Disrupted sleep leads to increased inflammation and atherosclerosis in mice, highlighting the importance of quality sleep for cardiovascular health.
A new study published in the Journal of the American College of Cardiology suggests that sleeping less than six hours a night may increase cardiovascular disease risk. Participants who slept poorly were 34% more likely to have atherosclerosis compared to those with good quality sleep.
The study found that participants who slept less than six hours were 27% more likely to have atherosclerosis compared to those who slept seven to eight hours. Poor quality sleep also increased the risk of atherosclerosis, with participants waking during the night or experiencing frequent movements during sleep being at higher risk.
Researchers have found that CD69 expression level inversely predicts subclinical atherosclerosis development. The study suggests that the molecule may play a role in controlling inflammation and preventing atherosclerosis.
Researchers at the University of Wisconsin-Madison identified a fatty acid called butyrate as the mechanism behind certain protective effects of a high-fiber diet. Mice with Roseburia bacteria and a high-fiber diet had reduced inflammation and atherosclerosis.
Scientists have discovered a way to detect the early signs of atherosclerosis, leading to blocked arteries, by analyzing changes in blood vessel cells. The study used single-cell RNA-sequencing and lineage labelling to identify unusual cells that express stem cell genes, which could help diagnose and treat cardiovascular diseases.
Researchers found that immune cells in lung tissue accumulate triglycerides, a type of fat, rather than cholesterol, and form through distinct mechanisms depending on the disease. This discovery may lead to new biomarkers and therapeutic strategies against tuberculosis.
A large study found that sleeping less than six hours or waking up several times in the night increases the risk of asymptomatic atherosclerosis. Participants with short and fragmented sleep had significantly more atherosclerosis, according to Dr. Fernando Dominguez.
Research suggests that people with deep forehead wrinkles, more than typical for their age, may have a higher risk of dying from cardiovascular disease. The study found that individuals with fewer wrinkles had lower risk compared to those with deeper wrinkles.
A study of 1,138 postmenopausal women found that higher HDL cholesterol did not lower cardiovascular disease risk, but rather masked a significant heart disease risk. Small HDL particles were beneficial for these women, while large particles increased risk.
The CNIC is leading a five-year Leducq Network project investigating genetic and environmental factors that promote clonal hematopoiesis and its link to cardiovascular disease. The project aims to understand the impact of clones on cardiovascular health and explore ways to modify their effects.
Researchers have identified a new cellular pathway that may help explain how arterial inflammation develops into atherosclerosis, leading to heart attacks and stroke. The findings suggest that blocking interleukin-1 beta production could enhance niacin therapy and improve therapies for atherosclerosis.
Dr. Daniel J. Rader, a renowned expert in heart disease prevention and treatment, has received the 2018 Gotto Prize for his pioneering work on lipoprotein metabolism. His research has significantly impacted current strategies to prevent and treat cardiovascular disease.
Researcher Phillip Owens aims to find better treatments for heart disease by studying PAR2 receptor's role in atherosclerosis. High cholesterol significantly increases risk of arterial thrombosis through modification of coagulation proteins.
Researchers at CeMM Research Center discovered a protective mechanism against atherosclerosis when targeting the molecule BAFF. The study found that blocking BAFF receptors actually increased plaque size, revealing an unexpected role for BAFF in reducing atherosclerosis risk.
Researchers discovered a naturally occurring antibody that binds to oxidized phospholipids, blocking inflammation and preventing arterial plaque formation. The antibody protected mice from atherosclerosis, aortic stenosis, hepatic steatosis, and prolonged their lives.
A study has found that circadian rhythms influence atherosclerosis, a condition leading to heart attacks and strokes. The researchers identified the molecular mechanism controlling rhythmic arterial leukocyte migration and developed a targeted therapy to stop its recruitment in atherosclerotic areas.
A new scientific statement from the American Heart Association highlights the unique health risks faced by South Asian Americans, including higher rates of atherosclerosis and heart attacks. The statement emphasizes the importance of lifestyle changes, such as dietary modifications and increased physical activity, to reduce this risk.
South Asian-Americans are at a higher risk for heart disease and stroke due to increased risks of severe atherosclerosis, diabetes, and poor diet habits. Behavioral factors such as physical inactivity and unhealthy dietary choices contribute to this risk.
Researchers developed peptide-based nanofibers that target and remove cholesterol deposits from artery walls, reducing plaque burden by up to 11%. Preliminary results demonstrate the potential of non-invasive therapy to reverse atherosclerosis.
Researchers uncover clue to disease process development by identifying novel way to control innate immune response, which may translate to treatments for conditions such as atherosclerosis, autoimmunity, and heart failure. Animal studies support finding, showing mice with mutated sNASP proteins are more susceptible to septic infection.
The study found that patients with unexplained atherosclerosis had significantly higher blood levels of toxic metabolites produced by intestinal bacteria. The researchers suggest that the gut microbiome plays an important role in an individual's risk for atherosclerosis, opening the door for new treatment options.