Articles tagged with Atherosclerosis
Researchers uncover clue to disease process development by identifying novel way to control innate immune response, which may translate to treatments for conditions such as atherosclerosis, autoimmunity, and heart failure. Animal studies support finding, showing mice with mutated sNASP proteins are more susceptible to septic infection.
The study found that patients with unexplained atherosclerosis had significantly higher blood levels of toxic metabolites produced by intestinal bacteria. The researchers suggest that the gut microbiome plays an important role in an individual's risk for atherosclerosis, opening the door for new treatment options.
Researchers at La Jolla Institute for Immunology develop a peptide vaccine that induces protective T cells and decreases plaque size in atherosclerotic mice. The vaccine targets the 'bad cholesterol' protein and expands a class of protective T cells, curbing inflammation.
Researchers have identified three distinct macrophage populations that play different roles in the development of atherosclerosis. These findings provide new insights into the disease and may lead to improved treatments. The study used single-cell RNA sequencing to analyze immune cell populations in affected vessels.
Dr. Yanqiao Zhang has received a five-year, $2.5 million grant to investigate the role of hepatic transcription factors in atherosclerosis and lipid metabolism. The award will fund research into novel genes/pathways that regulate atherogenesis.
Researchers at CNIC identified a function of the protease MT4-MMP, which increases surveillance activity of blood-patrolling monocytes. This blockade could potentiate treatments for infection or prevent metastasis, but its effects on later stages need analysis.
Researchers have developed an organ-on-a-chip device that accurately models atherosclerosis, allowing them to study inflammatory responses in cells lining blood vessels. The device can also be used to diagnose early immune responses in patients, providing a more accurate assessment of blood health.
Scientists have made breakthroughs in understanding the early stages of CAVD by studying pig valves and creating a lab model. They found that certain sugar molecules called glycosaminoglycans (GAGs) can increase blood vessel growth, but also trap low-density lipoprotein (LDL) molecules.
A new study by CNIC researchers found that LDL-C is the main predictor of atherosclerotic plaques in individuals with no risk factors, such as hypertension or smoking. The study suggests that reducing LDL-C levels can help prevent the appearance of atherosclerosis.
Researchers found that topical application of Resolvin E1 on gum tissues prevented and treated gum disease, while also reducing the likelihood of advanced arterial plaque rupture. The study suggests effective preventive and therapeutic treatments for heart disease and gum disease without unwanted side effects.
Research suggests anabolic androgenic steroid use may be associated with early coronary artery disease in healthy young individuals. The study found that steroid users had atherosclerosis, reduced HDL levels, and impaired HDL function.
A new study found that high levels of thyroid hormone FT4 are associated with an increased risk of artery disease and death. Researchers analyzed data from 9,420 participants and discovered a significant link between thyroid function and atherosclerosis.
A team of researchers, led by Tony Kim, has developed an innovative lab chip called the human-coronary-artery-on-a-chip to explore new treatments for atherosclerosis. The study aims to improve understanding of high-density lipoprotein (HDL) interactions with proinflammatory proteins and vascular tissues.
Researchers found skipping breakfast associated with increased risk of atherosclerosis and poorer cardiometabolic health. Participants who skipped breakfast had higher waist circumference, blood pressure, and fasting glucose levels.
Skipping breakfast increases the risk of atherosclerosis by up to 2.5 times, according to Spanish research. A high-energy breakfast reduces this risk, suggesting that eating habits play a crucial role in cardiovascular health.
Researchers found that PCSK9 inhibition can reverse the effects of oxidised LDL on immune activation, leading to an anti-inflammatory state that may directly influence atherosclerosis and cardiovascular disease. This new mechanism is independent of lowering LDL cholesterol.
Researchers found that healthy LDL particles become more flexible under pressure, while disease-prone particles lose flexibility. This difference in behavior may be attributed to varying lipid compositions.
A study published in the European Heart Journal shows a vaccine that lowers cholesterol may be effective in preventing cardiovascular disease. The AT04A vaccine, administered to genetically modified mice, reduced cholesterol levels by 53% and induced long-lasting antibodies against PCSK9, an enzyme contributing to high cholesterol.
Researchers found that marathon running had no association with pre-atherosclerotic changes, but age was independently linked to stiffer arteries. The study suggests that runners can complete multiple marathons without increasing their risk of atherosclerosis.
Trans-fatty acids directly activate ASK1 kinase by enhancing extracellular ATP, promoting cell death in a more direct manner than previously thought. The study identifies several trans-fatty acid types that stimulate cell death, but not their corresponding cis-fatty acids, which have health benefits.
Hyperglycemia triggers platelet production through the RAGE pathway, increasing atherosclerosis risk in diabetes. A study found that blocking RAGE receptor signaling reduced platelet production and atherogenesis.
Research suggests that exosomes derived from very obese patients' fat can accelerate biological processes leading to atherosclerosis. In contrast, those from lean patients promote cholesterol efflux and reduce 'bad' cholesterol buildup. This discovery holds promise for early detection of chronic diseases in children.
Researchers at New York Institute of Technology found that the radial artery may be useful for assessing heart disease risk, as it exhibits positive correlations with key risk factors. This discovery could lead to a new way to measure systemic atherosclerosis and improve cardiovascular health monitoring.
A systematic analysis of chemokine interactions reveals two structural types with different functional effects on inflammation. The study identifies potential therapeutic targets using specially designed peptides that selectively inhibit atherosclerosis and acute inflammation.
A study of 9,231 individuals found that those with higher free thyroxine (FT4) levels had an elevated risk of atherosclerotic morbidity and mortality independent of cardiovascular risk factors. Higher FT4 levels were also associated with greater risk of subclinical atherosclerosis.
The Tsimane people from Bolivia have the lowest levels of vascular ageing, with coronary atherosclerosis five times less common than in the US. Their diet and lifestyle, characterized by hunting, gathering, and farming, may hold the key to preventing heart disease.
The study demonstrates that pNaKtide attenuates the development of experimental nonalcoholic fatty liver disease (NAFLD) and atherosclerosis in mice fed a Western diet. The researchers found improvements in insulin sensitivity, dyslipidemia, and cholesterol levels.
A Cedars-Sinai study suggests that hormone replacement therapy is linked with lower levels of plaque buildup in the heart's arteries and improved survival rates among women. Women using HRT were found to be 30% less likely to die than those not on the therapy.
A new laser-based camera has been developed to improve the view of the carotid artery, allowing physicians to detect potential problem areas and monitor atherosclerosis. The technology uses high-resolution imaging to identify lesions and biological markers associated with increased stroke risk.
A new study links mutations in blood cells to atherosclerosis, a leading cause of death in the elderly. The research found that accumulated DNA mutations in hematopoietic cells contribute to plaque formation and inflammation.
A recent study found that mutations in blood cells of elderly humans may contribute to atherosclerosis, a leading cause of death. The research suggests that hematopoietic mutations could be an age-dependent risk factor for cardiovascular disease.
Researchers have identified an endogenous peptide that reduces cholesterol levels in mice, inhibiting the development of atherosclerosis. The protein, human neutrophil peptide 1 (HNP1), binds to LDL in the bloodstream and induces rapid uptake by the liver, reducing hypercholesterolemia.
PARP9 and PARP14 have been identified as regulators of macrophage activation, a key factor in the development of atherosclerosis. The study found that silencing these genes had opposite effects on macrophage activation, with PARP14 increasing and PARP9 decreasing activation.
Researchers found that removing aging macrophages from atherosclerosis-prone mice reduced plaque buildup by 60%, suggesting a potential cellular target for therapy. The study also showed that suppressing senescence limited disease progression and reduced markers of plaque instability.
Senescent cells drive the formation of fatty streaks in animal models of atherosclerosis. These lesions progress to larger plaques through the recruitment of immune cells, ultimately leading to unstable plaques prone to rupture. Eliminating senescent cells selectively can reduce plaque size and preserve cap integrity.
Researchers will analyze tissue samples from baboons to identify molecular mechanisms underlying early onset atherosclerosis. The study may lead to the development of early diagnostics and interventions, potentially saving millions of lives by treating the disease in its early stages.
Research led by Catherine Hedrick found that removing ATP-binding cassette transporter G1 (ABCG1) from immune cells increases regulatory T cell production, decreases pro-inflammatory T cells, and reduces atherosclerotic lesions in mice. This suggests that therapies targeting ABCG1 could help control atherosclerosis.
A study published in Circulation found that increasing IGF-1 levels in macrophages could reduce plaque buildup and lower the risk of heart disease in older adults. Higher IGF-1 levels were associated with less plaque buildup and more stable plaques.
According to new research, nearly half of all heart attacks are 'silent', with symptoms appearing so mild that they are barely noticed. Silent heart attacks increase the risk of dying from heart disease and other causes, and can be as deadly as those with classic symptoms.
Researchers found that increased insulin signaling reduces atherosclerosis development and improves aorta function in atherosclerosis-prone mice. The anti-atherogenic effects were linked to induction of nitric oxide and activation of downstream pathways, including endothelin receptor B (EDNRB).
A combined dietary supplement of marine fish oil, cocoa extract, and phytosterols could potentially prevent atherosclerosis by inhibiting key processes associated with its progression. The study found that combining these ingredients helped halt the progression of atherosclerosis in cell-based models.
Researchers at the University of Bonn discovered that cyclodextrin promotes the breakdown of cholesterol deposits in arteries, reducing inflammation and plaque formation. The ring-shaped sugar increases natural mechanisms for cholesterol breakdown and reduces inflammatory response, offering a potential new treatment for atherosclerosis.
Researchers found that taking hormone therapy within six years of menopause can slow the buildup of plaque in arteries and prevent heart disease. The study suggests that timing is crucial for the effectiveness of hormone therapy in preventing atherosclerosis progression.
Researchers found that digoxin decreased levels of total cholesterol and triglycerides by 41% and 54%, respectively, in mice treated with high-dose digoxin. Digoxin also lowered LDL-cholesterol levels by 20%. The study suggests a potential link between the drug and reduced plaque buildup.
Research by UofL professor Daniel J. Conklin found e-cigarettes may cause atherosclerosis, a plaque-causing disease leading to heart attacks and strokes. The study exposed mice to varying levels of e-cigarette aerosol, tobacco smoke, or nicotine alone, revealing that multiple constituents have cardiovascular disease-causing potential.
Researchers at LMU Munich uncover the mechanism by which crystalline deposits induce cell death, revealing a regulated process leading to necroptosis and inflammation. This discovery offers new targets for therapies and potentially improves treatment of conditions like gout and atherosclerosis.
Researchers discovered a compound that targets gut microbes to prevent heart disease by preventing the formation of toxic metabolic byproducts. This new approach may provide a whole new strategy for treating cardiovascular and metabolic diseases.
Researchers have identified a naturally occurring inhibitor that reduces TMAO levels and prevents atherosclerosis in mice, suggesting a potential new therapeutic approach for preventing heart disease and other metabolic diseases linked to gut microbes.
Researchers at Boston University School of Medicine used non-invasive Magnetic Resonance Imaging (MRI) to detect vulnerable atherosclerosis plaques, which can lead to heart attacks and strokes. The study showed that MRI can discriminate between high-risk and stable plaques at early stages.
A multicenter clinical study found that pravastatin reduced the occurrence of strokes and specific vascular events, while no difference was observed for other stroke subtypes. The study's results contribute to the establishment of guidelines for statin use in preventing strokes caused by larger artery atherosclerosis.
Researchers at University of Cincinnati discovered that a high-fat diet causes dysfunction in red blood cells, which can lead to the development of cardiovascular disease. The study found that red blood cells play a key role in fueling adipose tissue inflammation and promoting atherosclerosis.
A new tool has been developed to identify unstable atherosclerotic plaques at greatest risk of rupture, a major contributor to heart attacks and strokes. The tool uses fluorescent probes to detect the severity of plaques and shows high sensitivity and specificity in distinguishing high-risk plaques from stable ones.
A new study found that drinking cranberry juice improves vascular function and blood flow in healthy men. Cranberry polyphenols were shown to have a potent, dose-dependent relationship with these benefits, suggesting an important role for cranberries in a heart-healthy diet.
Periodontitis has been shown to increase the expression of pro-inflammatory angiopoietin 2, while decreasing anti-inflammatory angiopoietin 1 in aortic smooth muscle cells, leading to increased inflammation and atherosclerosis. This study provides new insights into the molecular mechanisms linking periodontitis to heart disease.
A sub study of the MR CLEAN trial found that patients with larger thrombi had better neurological recovery after intra arterial treatment. Thrombi size was associated with clinical outcome, and retrieving larger pieces may lead to improved patient results.
A three-year clinical trial found no link between testosterone administration and atherosclerosis progression, sexual function, or quality of life in older men. The study suggests that testosterone should not be used indiscriminately by men, as it may not provide benefits for these outcomes.
A 3-year testosterone supplementation study found no significant association between treatment and atherosclerosis progression. The trial also showed no improvements in sexual function or quality of life, despite increased hematocrit and prostate-specific antigen levels.
Researchers found that TMAO levels increase with advancing severity of kidney disease and are linked to atherosclerosis and premature death. Targeting TMAO generation by intestinal bacteria may be a novel strategy for safeguarding heart health in patients with CKD.
A study by Johns Hopkins School of Medicine found that stopping or reducing cocaine use is associated with lower levels of endothelin-1, a protein linked to coronary artery disease. Patients who stopped using cocaine had significantly reduced ET-1 levels and a lower likelihood of coronary plaque progression.
Researchers at UNC School of Medicine have discovered two biomarkers - oxidized LDL cholesterol and fructosamine - that are strongly correlated with the development of severe coronary disease in females. Elevated levels of these biomarkers were found to be a strong predictor of severe heart disease, particularly in women.