Articles tagged with Atherosclerosis
A recent study found that about 1 in 5 people who survived an ischemic stroke had irregular heart rhythms, atrial fibrillation, due to atherosclerosis. The study suggests that these patients are at increased risk of recurrent strokes and highlights the need for continuous cardiac monitoring to detect unsuspected atrial fibrillation.
A new study by researchers from Lund University in Sweden has found that women with pregnancy complications are at an increased risk of heart disease. The study revealed that women with pre-eclampsia and gestational hypertension had visible atherosclerosis of the coronary arteries, compared to those without complications.
Researchers found that low-grade inflammation in adolescents can lead to higher blood pressure, insulin resistance, and increased risk of cardiovascular disease. The study also suggests that dietary factors, such as consumption of fruits, vegetables, and fibre-rich foods, can help prevent premature vascular damage.
According to hyperfunction theory, menopause is also a disease. Aging is a quasi-programmed disease that can be partially treatable by rapamycin. The author suggests that slowing aging may delay the onset of diseases like prostate cancer, obesity, and hypertension.
A recent study found that consuming soy flour rich in B-conglycinin can reduce LDL cholesterol levels and lower the risk of metabolic diseases. The protein inhibits HMGCR, a liver enzyme involved in triglyceride and low-density lipoprotein metabolism.
Researchers found that p53 mutations in blood cells increase the risk of developing coronary heart disease and peripheral artery disease. The study provides solid evidence for the link between acquired p53 gene mutations and cardiovascular disease, suggesting a potential new risk factor.
Researchers from Osaka University found that tricaprin supplementation leads to remarkable regression of coronary artery plaque and resolution of symptoms in patients with triglyceride deposit cardiomyovasculopathy. The study's findings provide a novel treatment concept for coronary atherosclerosis.
A recent study discovered a link between soluble urokinase plasminogen activator receptor (suPAR) and the development of atherosclerosis, a hardening of arteries that affects over a billion people worldwide. SuPAR was found to cause inflammation in blood vessels, leading to cardiovascular events and increasing risk of heart disease.
A new study published in Hypertension suggests that lipoprotein(a) cholesterol may affect the relationship between hypertension and cardiovascular disease risk. The study found that people with high levels of lipoprotein(a) and hypertension had a 24% higher risk of cardiovascular disease compared to those without hypertension.
Researchers developed a deep learning model that uses a single chest X-ray to predict the 10-year risk of death from cardiovascular disease. The model performed similarly to established clinical standards and provided incremental value in predicting major adverse cardiac events.
A study of 1779 adolescents found that early-life elevated lipids and dyslipidemia are linked to worsening subclinical atherosclerosis. Conversely, treatment at age 17 effectively halted progression and even reversed it. This critical evidence emphasizes the need for early-life screening and prevention.
Researchers at Osaka University have developed a mouse model that shows Favine protein can protect against atherosclerosis and thrombosis. The study also found that reduced levels of Favine are associated with calcification and thrombus formation, revealing a new potential therapeutic target for treating atherosclerosis.
Researchers aim to understand the role of FAK in promoting key changes in vascular smooth muscle cells that contribute to atherosclerosis. Preliminary evidence suggests that inhibiting FAK may block VSMC transdifferentiation and promote plaque stability.
A UC Riverside-led study found that acute THS exposure initiates mechanisms of inflammatory skin disease and elevates urinary biomarkers of oxidative harm. The researchers discovered elevated molecular biomarkers in blood associated with early-stage activation of contact dermatitis, psoriasis, and other skin conditions.
The Leducq Foundation has awarded $7.5 million to UVA researchers, led by Mete Civelek, to investigate sex differences in atherosclerosis and $8 million to Coleen McNamara to advance immunotherapy for cardiovascular disease. These projects aim to improve understanding of heart disease and develop new treatments.
Researchers at UVA Health have developed a new magnetic-resonance imaging (MRI) technique to track peripheral artery disease, which affects over 200 million people worldwide. The CEST approach produces comparable results to the current gold standard without requiring specialized equipment.
A study by Taiwanese researchers found that patients with atherosclerosis are at higher risk for life-threatening vascular infections from non-typhoidal Salmonella bacteremia. The study suggests the use of a scoring system to predict infection risk and identifies interleukin-1 beta as a potential biomarker.
Researchers found that DNMT3A and TET2 genes directly activate expression of a gene involved in mitochondrial inflammatory pathways. This activation leads to increased inflammation, which may exacerbate plaque buildup in atherosclerosis. Blocking these pathways could form the basis for new treatments.
Scientists at UC San Diego and Salk Institute discover link between mitochondrial function, inflammation, and DNMT3A and TET2 genes in atherosclerosis. Abnormal inflammatory signaling is triggered by low levels of these genes, leading to excessive plaque buildup.
A new analysis from the Family Heart Foundation shows that only 31.3% of individuals with familial hypercholesterolemia (FH) in its database had been diagnosed as of June 2020. This represents a significant increase since 2016, but highlights the ongoing challenge of diagnosing and managing the condition.
A study published in the European Heart Journal found that making small behavioral changes can significantly reduce cardiovascular risk. Participants who received a lifestyle intervention showed improvements in physical activity, diet, and sedentary time, leading to decreased blood pressure and cholesterol levels.
A team of researchers has discovered that malignant tumors accumulate lipid delivery molecules called LDL and attract immune suppressor cells called neutrophils, leading to tumor progression. The study also shows that targeting the LOX-1/oxidized LDL axis may be a promising strategy for treating both cancer and cardiovascular disease.
A new Mount Sinai study reveals that young Black adults are twice as likely to have atherosclerosis as their Hispanic counterparts. Researchers used comprehensive questionnaires and 3D vascular ultrasounds to determine cardiovascular risk scores, finding significant discrepancies between the groups.
A study found that around one in 500 men carry an extra sex chromosome, putting them at increased risk of several common diseases. Men with XXY or XYY chromosomes have higher risks of reproductive problems, type 2 diabetes, and other health conditions.
The study discovered that cyclic hypertensive pressure stimulation and matrix compliance regulate vascular smooth muscle cell phenotypic switch, leading to intimal thickening and early atherosclerosis progression. Cofilin is identified as the key regulator in this process.
A study published in Nature Cardiovascular Research reveals that rare T cells targeting apolipoprotein B can contribute to inflammation and atherosclerosis progression. Researchers discovered these cells resemble regulatory T cells but develop a new identity as heart disease develops.
A new device, consisting of a smart stent and printed soft sensors, can wirelessly monitor hemodynamics in real-time, detecting various vascular conditions. The system uses inductive coupling for wireless energy transfer and has the potential to replace existing clinical devices and angiograms.
A team of scientists has found that nerve signals are exchanged between arteries with plaques and the brain in atherosclerosis. This discovery sheds light on the chronic inflammatory disease of the entire artery, revealing an electrical circuit between the arteries and brain.
A study identifies new biomarkers that predict the presence of subclinical atherosclerosis, providing a non-invasive way to detect cardiovascular disease. The research team analyzed blood plasma samples and validated three proteins as biomarkers, improving the prediction of cardiovascular risk.
Researchers at Albert Einstein College of Medicine found that increasing chaperone-mediated autophagy activity can prevent atherosclerosis by protecting macrophages and smooth muscle cells from damage. The study suggests that boosting CMA could be an effective strategy for curbing atherosclerosis and halting its progression, particular...
Researchers at UConn Health found that deleting TRPM2 from macrophages in mice reduced atherosclerosis by inhibiting the TRPM2–CD36 inflammatory axis. This approach prevented foamy macrophages and alleviated inflammation in arteries.
Researchers at CNIC discover that bone marrow activation is an early event in the development of atherosclerosis, leading to inflammation and plaque formation. The study identifies metabolic syndrome as a key trigger for this process.
The American Academy of Neurology recommends using medications such as aspirin and clopidogrel, alongside statins and regular physical activity, to prevent a second stroke in people with intracranial atherosclerosis. This approach is more beneficial than placing a stent in the blood vessel.
Dr. Zhiqiang Lin has been awarded a $3.2 million NIH grant to investigate the roles of YAP and IRF2BP2 in the cardiac innate immune response, with the goal of reducing cardiac inflammation and promoting heart recovery after a heart attack.
A study published in Science Immunology reveals that a specific neurotransmitter in immune cells plays a crucial role in cholesterol accumulation and sterile inflammation in atherosclerosis. The researchers found that blocking this neurotransmitter may help reduce inflammation and develop effective treatments for the disease.
Researchers have made a significant breakthrough in predicting heart attacks and strokes by developing a non-invasive method using super-resolution ultrasound imaging. The technology aims to detect high-risk atherosclerotic plaques that are prone to rupture, allowing doctors to prescribe life-saving interventions.
A new study found that statin intolerance is over-estimated, affecting only 6-10% of patients worldwide. Researchers identified risk factors for statin intolerance, including age, sex, ethnicity, and medical conditions.
Researchers from China use digitalized flow rates to study the effect of exercise on plaque formation in carotid arteries, which carry blood to the head and neck. The study investigates how geometrical features of the arteries affect plaque formation and finds that exercising decreases reversed flow volume in older age groups.
Researchers found that Rivaroxaban reduces atherosclerosis progression by inhibiting factor Xa-PAR2 mediated macrophage autophagy and inflammasome activity. The study suggests RIV as a potential anti-atherosclerotic drug, offering hope for treating this fatal disease.
A molecule of RNA called CARMN has been found to play a crucial role in maintaining healthy smooth muscle cells in the blood vessel wall, which can help prevent atherosclerosis and angioplasty-induced restenosis. Restoring healthy CARMN levels may lead to new approaches for treating heart disease.
Researchers at La Jolla Institute for Immunology found that macrophages in artery walls can sense octanal, leading to inflammation and atherosclerosis. By blocking this detection, they reversed disease progression. Further research is needed to explore the role of olfactory receptors in cardiovascular diseases.
A study reveals a powerful subset of vascular macrophages expressing CLEC4A2 fosters 'good' macrophage behavior, limiting plaque build-up. This discovery challenges the widely held belief that macrophages only play a harmful role in cardiovascular disease.
Researchers at Karolinska Institutet discovered that omega-3 fatty acids activate the GPR32 receptor, which reduces inflammation in blood vessels and prevents atherosclerosis. This breakthrough discovery paves the way for new strategies to treat and prevent cardiovascular disease using omega-3 fatty acids.
Research published in ATVB Journal Report reveals that exposure to low-levels of toxic metals can increase the risk of plaque buildup in arteries in the neck, heart, and legs. The study focused on subclinical atherosclerosis and examined the impact of metal exposure on various artery regions.
Researchers at Karolinska Institutet found a strong link between the apoB/apoA-1 ratio and cardiovascular disease. Individuals with higher ratios had a greater risk of severe cardiovascular disease, including myocardial infarction and stroke.
A new canine mutant model mimics human cerebrovascular disease by exhibiting severe arteriosclerosis, thrombosis, and stroke. The ApoE knockout dogs show extensive and severe arteriosclerosis plaques and arterial stenosis, consistent with human cerebral arteries and coronary arteries.
A new study using SWAN data suggests that changes in menstrual cycle length during the menopause transition can predict a woman's risk of developing atherosclerosis after menopause. Women with early increase trajectories had the worst cardiometabolic risk profile.
Regular physical activity is associated with a reduced risk of obesity and heart disease, but paradoxically may hasten the build-up of calcium deposits in coronary arteries. The study found that highly active individuals had higher CAC scores, suggesting a potential link between exercise and calcification.
A new antioxidant drug, cysteamine, has been found to reverse atherosclerosis by reducing the oxidation of LDL cholesterol. This process reduces inflammation, damage, and clot formation, ultimately lowering the risk of heart attacks and strokes. Cysteamine was shown to decrease plaque size by up to 56% in mice with atherosclerosis.
Researchers at Nanyang Technological University have developed a 3D model of the human artery blood vessel wall to study atherosclerosis. The model, called an 'arterial wall-on-a-chip', helps understand how cholesterol and inflammatory cells contribute to the disease.
A new study found that increasing childhood cardiorespiratory fitness can reduce the adverse effects of metabolic syndrome traits on atherosclerosis. The researchers discovered a two-way connection between arterial health and fat mass, with healthy arteries associated with higher fat mass in children.
Researchers found that people who eat more vitamin K-rich foods have a lower risk of heart disease and peripheral artery disease. Vitamin K2 intake was also associated with reduced hospitalization rates for cardiovascular disease.
A study by Ludwig-Maximilians-Universität München's researchers found that the CD40L/CD40 interaction plays a crucial role in atherogenesis. The team showed that inhibition of this interaction can reduce atherosclerosis-associated clot formation and stabilize plaques, offering new therapeutic strategies for cardiovascular disease.
Researchers discovered that primary miRNA precursor forms are highly expressed in cell-type-specific manner, while mature miRNAs dominate common to all cell types. The study also uncovered microRNA-messenger RNA networks driving cell-type-specific responses.
Recent advances in understanding atherosclerosis have shifted traditional views on who is at risk for heart attacks and strokes, highlighting the importance of HDL cholesterol, triglycerides, and inflammation. This review paper explores these changes and their implications for treatment and prevention.
Researchers found that high blood pressure alters artery structure, facilitating atherosclerosis development and increasing accumulation of LDL cholesterol in human-like arteries. Keeping both LDL cholesterol and blood pressure low is crucial for preventing atherosclerosis.
Researchers discovered a new protein, Prosaposin, that plays a crucial role in atherosclerosis. The protein has an anti-inflammatory effect, which helps slow down the disease progression.
Researchers at Aarhus University and hospital have identified the fundamental step linking hypertension to atherosclerosis, finding that hypertension causes increased accumulation of bad cholesterol in arterial walls. This discovery may aid in developing new treatments targeting disease mechanisms.
Researchers at the University of Alberta identified a new mechanism responsible for plaque buildup on artery walls, which can restrict blood flow and lead to cardiovascular disease. They found that inhibiting this process with specific drugs could be a new strategy for treating cardiovascular disease.
Researchers have designed and synthesized short chains of amino acids that function like minimized soluble chemokine receptors, blocking atherosclerosis in animal models. These peptides selectively inhibit pathways underlying the disease while sparing beneficial physiological processes.