Articles tagged with Atherosclerosis
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Researchers Narayanan Parameswaran and Gregory Fink at MSU have received nearly $400,000 to study the molecular aspects of chronic diseases like atherosclerosis and high blood pressure.
A new study suggests that cytomegalovirus (CMV) is a cause of high blood pressure, a leading risk factor for heart disease, stroke and kidney disease. The virus can lead to the development of atherosclerosis, or hardening of the arteries, when coupled with other risk factors.
Researchers found that eliminating the gene for cyclophilin A from mice prevented the development of abdominal aortic aneurysm and atherosclerosis. The study suggests that targeting cyclophilin A could potentially address both conditions, which are linked by shared biochemical pathways.
A new urine screening test has shown promise in predicting coronary artery disease by identifying specific protein patterns associated with the condition. The test uses proteome analysis to detect collagen fragments found on the surface of atherosclerotic plaques, achieving an accuracy rate of 84%.
A team of researchers has identified a class of drugs that may enhance the therapeutic effects of imatinib mesylate in treating chronic myeloid leukemia. They also developed a zebrafish model for screening potential therapies for Alzheimer's disease and identified a molecular mechanism underlying aggressive prostate cancer.
A study published in JAMA found that pactimibe did not slow the progression of atherosclerosis in patients with familial hypercholesterolemia, but was associated with increased cardiovascular events. The treatment also led to significant increases in low-density lipoprotein cholesterol levels.
Two studies found that SOX9 renders melanomas sensitive to retinoic acid, stopping tumor growth and offering new hope for effective treatment. Additionally, researchers identified two enzymes crucial for ureter-bladder connection during development, which may hold key to treating congenital anomalies.
Researchers developed a synthetic atherosclerosis drug, DMHCA, which targets the Liver X Receptors and reduces plaque formation without increasing fat levels. The study found significant therapeutic promise, with DMHCA significantly reducing arterial lesions in mice by 45-48%.
A new study reveals that younger individuals defined as low risk by conventional risk stratification methods may actually have a higher lifetime risk of heart disease. Those in the high-risk group had a greater subclinical disease burden and incidence of atherosclerotic progression, even at younger ages.
A new study has found a possible connection between shorter menopause and faster progression of atherosclerosis, which can lead to heart disease. Women who transitioned more quickly through menopause were at higher risk for a higher rate of progression of preclinical atherosclerosis.
A new study published in The FASEB Journal suggests that infected gums may be a source of inflammation leading to heart disease. Proper dental hygiene can greatly reduce the risk of atherosclerosis, stroke, and heart disease independently.
Researchers at Vanderbilt University Medical Center have identified prostaglandin-E2 receptors as crucial players in atherosclerosis development. Mice with impaired EP4 receptors showed reduced atherosclerosis and increased macrophage programmed cell death, highlighting the importance of these signaling pathways in disease progression.
A study found that high-normal phosphate levels are associated with increased calcium in coronary arteries, a key indicator of atherosclerosis. The research suggests that phosphate levels may represent a previously unidentified cardiovascular risk factor.
Retired NFL players had a lower prevalence of diabetes and hypertension compared to control groups, but higher rates of elevated cholesterol and impaired fasting glucose. Staying physically active may help protect against these health risks in former athletes.
Research finds urokinase plasminogen activator promotes atherosclerosis growth and dilation, while plasminogen loss protects against disease. The study suggests new ideas for preventing or treating artery disease.
Researchers have developed a new class of heart disease medication that reduces the development of high-risk blockages in arteries. The study found that darapladib, which specifically inhibits lipoprotein-associated phospholipase A2, decreased the size and number of advanced plaques that cause heart attacks and strokes.
A recent study found that aspirin increases the expression of paraoxonase 1 and apolipoprotein A1, two proteins that help remove bad cholesterol from the bloodstream. This increase can lead to reduced risk of atherosclerosis, a condition characterized by the buildup of plaque in arteries.
Research reveals a common connection between cellular innate immunity and human chronic inflammatory diseases, including atherosclerosis, Type 2 Diabetes, and neurodegenerative diseases. A critical signaling network involving IRAK-1 has been identified as a potential target for diagnosis and treatment.
A study published in Sleep found that heavy snoring is an independent risk factor for early carotid atherosclerosis. The prevalence of carotid atherosclerosis increases significantly with the severity of snoring, affecting up to 64% of heavy snorers.
Researchers explore new treatments for psoriasis, revealing a potential therapeutic option in AEB071, while cautioning further clinical trials are needed. Additionally, studies uncover the reasons behind gene therapy complications in SCID patients, shedding light on insertional oncogenesis and acquired somatic mutations.
A study published in the journal AIDS has found that long-term antiretroviral therapy for HIV may offer protection against atherosclerosis. The Multicenter AIDS Cohort Study measured coronary artery calcification in nearly 950 HIV-positive and HIV-negative men, finding CAC scores were almost 60% lower in those on HAART.
Researchers have identified low levels of naturally occurring antibodies as an increased risk factor for cardiovascular disease, particularly stroke in men. This breakthrough finding suggests that anti-PC antibodies play a crucial role in the development of cardiovascular disease.
A study found that high omega-3 fatty acid intake from eating large quantities of fish may explain Japan's very low levels of heart disease. This is due to a strong anti-atherogenic effect observed in Japanese men, who consume an average of 100g of fish daily.
Arthritis treatment drugs show promise in treating atherosclerosis and other autoimmune diseases by targeting cytokines, protein messaging molecules released by immune cells. The discovery of anti-cytokine therapy holds potential for treating multiple biological processes and unmet medical needs.
Researchers found Alaskan Eskimo adults had higher rates of fatty artery plaque than the general US population due to unhealthy lifestyle habits. The study suggests that traditional heart-healthy diet and exercise may not be enough to counteract the effects of smoking.
A meta-analysis found the ankle brachial index (ABI) improves accuracy of cardiovascular risk prediction by identifying individuals at high risk for atherosclerosis. The ABI may help modify treatment recommendations in approximately 19% of men and 36% of women.
Researchers found that increasing pro-resolution signals can cool down inflammation and slow down atherosclerosis. However, clamping down on these signals would fan the fire of inflammation and speed up its progression.
Two studies in the FASEB Journal describe key findings on atherosclerosis, including the role of ROCK1 protein in reducing inflammation. Targeting lipid mediators and mechanisms used to make them could lead to new anti-atherosclerosis therapies.
A new study published in JAMA found that patients with depression are more likely to develop type-2 diabetes, and those with type-2 diabetes are also at a higher risk for developing depression. The study used data from the Multi-Ethnic Study of Atherosclerosis (MESA) to investigate this connection.
A new study published in Molecular Nutrition and Food Research found that apples and apple juice have similar cardiovascular protective properties to grapes. The researchers observed that processing the fruit into juice increases the bioavailability of antioxidants and phenolic compounds, which can help prevent early atherosclerosis.
Researchers link atherosclerosis to widespread organ damage and discover potential targets for treatment. The study found that biochemical signals in arteries can contribute to harm in the lungs, liver, and other organs.
A new study suggests that taking pioglitazone can help slow the progression of plaque build-up in coronary arteries, which is particularly aggressive in patients with diabetes. The findings have important implications for managing patients with type 2 diabetes and coronary artery disease.
A gluten-free vegan diet has been shown to lower blood levels of oxidized LDL-cholesterol and increase anti-PC antibodies, providing atheroprotective effects. This study suggests that diet can impact the immune system and reduce disease incidence.
Researchers discovered that diabetes drives inflammation and slows blood flow, accelerating atherosclerosis through interference with ERK5 signaling. The study identifies advanced glycation end products (AGEs) as key molecules sabotaging this protective mechanism.
Scientists at the Salk Institute have identified PPAR delta as a powerful anti-inflammatory agent that can slow down lesion progression and reduce plaque buildup in arteries. Activating this protein may offer a novel approach to treating metabolic syndrome and its associated cardiovascular risks.
A new viewpoint published in The Lancet suggests that age is not an unmodifiable risk factor for cardiovascular disease, but rather a combination of factors that can be modified through early intervention. The authors argue that conventional wisdom prioritizes age over modifiable risk factors like lipid levels and blood pressure.
Researchers say a solution for atherosclerosis is many years away due to the complex disease process, which involves genetics, metabolism, and inflammation. Huge investments of time and money are needed to develop effective therapies.
Researchers found that treatment with myriocin can significantly inhibit the progress of established atherosclerosis in mice, coinciding with decreases in sphingomyelin, cholesterol, and triglycerides. In contrast, statins may increase PCSK9 levels, which limits their benefit.
Researchers find a direct link between visceral fat and atherosclerosis, a condition that causes blood vessels to harden and narrow. The study suggests that anti-inflammatory medication could be used to reverse the process and reduce heart disease risk.
Researchers found that lipoic acid supplements reduced atherosclerotic lesion formation by 55% in mice, lowered triglycerides, and helped normalize metabolic processes. The supplements may be useful as a preventive mechanism before advanced cardiovascular disease develops.
A study by Yale School of Medicine identified a genetic mutation that expands lesions in the aorta and promotes coronary atherosclerosis. The researchers found that mice lacking the Akt1 gene developed more severe aortic atherosclerosis, highlighting the importance of this gene in regulating endothelial cell development
A new study reveals secretoneurin's neuroprotective role in a rat model of stroke. SN treatment improved survival of primary brain cell cultures and reduced cerebral tissue death in rats with ischemia-induced stroke.
Researchers have identified histone deacetylase HDAC9 as a potential target for treating premature atherosclerosis in lupus patients. They also found that elevated microRNA-16 levels contribute to abnormal cell death in lupus patients, and reducing these levels may lead to targeted treatments.
Researchers found that treating OSA patients with CPAP significantly decreases atherosclerosis markers in just months. This study links OSA directly to artery hardening, providing new evidence for the causal connection between OSA and cardiovascular events.
Researchers found that cholesterol limits the activity of a key protective protein called transforming growth factor-beta (TGF-beta), allowing atherosclerosis to develop. Statins, which lower cholesterol levels, enhance TGF-beta's protective qualities.
A multidisciplinary team of researchers at Columbia University Medical Center will investigate the link between type 2 diabetes and heart disease using a $10.8 million NIH grant. They aim to understand how insulin resistance contributes to accelerated atherosclerotic lesion progression in diabetics.
A Weill Cornell study finds that nicotine in cigarettes accelerates atherosclerosis, even at low levels, by activating the sympathetic nervous system and increasing heart rate. Mice exposed to low-nicotine cigarettes showed smaller atherosclerotic lesions than those exposed to regular cigarettes.
A new experimental drug blocks a protein linked to metabolic diseases, preventing and treating type 2 diabetes and atherosclerosis in genetically predisposed mice. The compound's effectiveness suggests it may be protective against other metabolic disorders, including asthma.
A study finds that cytomegalovirus infection triggers an autoimmune response, causing endothelial cell damage and exacerbating atherosclerosis. The immune system mistakenly attacks healthy cells, leading to inflammation and further disease progression.
A study of coronary artery surgery survivors found that patients with inflammatory rheumatic diseases like rheumatoid arthritis and lupus had more chronic inflammatory cell infiltration in their aortic walls. Smoking was also independently associated with increased inflammation, particularly in the inner adventitia.
A recent study failed to validate the association of 85 genetic variants with increased risk for acute coronary syndromes (ACS), including heart attack and angina. The research included 811 patients with ACS, but found no conclusive evidence supporting the use of these gene variants as risk factors in clinical care.
Researchers found that reconstituted HDL infusion reduced atheroma volume by 3.4% and 5.3 mm³ compared to placebo, but the differences were not statistically significant. The study suggests potential favorable vascular effects of CSL-111 on coronary atherosclerosis.
A new study found that CSL-111, a drug that mimics HDL, did not significantly reduce plaque in coronary arteries, but showed improvement in two indexes assessing blood vessel changes. The trial involved 183 patients with acute coronary syndromes and used intravenous ultrasound to assess coronary artery changes.
The study found that Crestor arrested the progression of thickened carotid arteries in participants with moderately elevated cholesterol levels. The therapy also lowered low-density lipoprotein and increased high-density lipoprotein, as well as reduced triglycerides.
Studies found that ramipril and rosiglitazone slow atherosclerosis progression, while rosuvastatin treatment reduces arterial plaque buildup in low-risk individuals. Additionally, high-dose atorvastatin improves outcomes in patients with acute coronary syndromes undergoing percutaneous coronary intervention
A study published in JAMA found that rosuvastatin reduces the rate of progression of arterial thickening and stops but does not reverse atherosclerotic disease in middle-aged individuals with low Framingham risk scores and evidence of subclinical atherosclerosis. The medication also showed a similar safety profile to placebo.
Clinical trials show statin therapy promotes regression of coronary atherosclerosis through significant reductions in LDL-C and increases in HDL-C. Patients experiencing substantial decreases in LDL-C (<87.5 mg/dL) and percentage increases in HDL-C (>7.5%) exhibit notable atheroma regression.
Researchers aim to discover genetic predispositions for atherosclerosis, which can lead to heart disease and stroke. The multi-year study will analyze DNA data from two large-scale studies to pinpoint specific genes contributing to the condition.
Researchers are using computed tomography to study the effects of fat stored around the heart and its potential contribution to atherosclerosis. The study aims to investigate whether fat deposits in the arteries increase the risk of fatty deposits and inflammation, leading to heart attacks.
A new clinical trial, CHICAGO, demonstrated that pioglitazone (ACTOS) reduced the progression of carotid intima-media thickness (CIMT), a surrogate marker for heart attack and stroke, by 0.013 mm. The study also showed improved glycemic control, decreased triglycerides, and increased HDL-C levels with ACTOS treatment.