Articles tagged with Atherosclerosis
A two-year study led by Ben-Gurion University researchers found that moderate weight loss significantly reverses carotid artery atherosclerosis, reducing the risk of strokes and heart attacks. The study compared low-carbohydrate, low-fat and Mediterranean diets, showing improved results for those with greater weight loss.
Research by USDA scientists found that oat compounds called avenanthramides decrease inflammatory molecules and inhibit proinflammatory cytokines. This suggests potential health benefits for heart disease prevention beyond lowering blood cholesterol levels.
Researchers at Imperial College London have identified TLR-2 as the trigger that leads to inflammation and damage in atherosclerosis, a condition causing heart attacks and strokes. Blocking this molecule could potentially treat atherosclerosis and reduce the risk of these diseases.
Hardening of the arteries has been detected in ancient Egyptian mummies, dating back to 3,500 years ago. Atherosclerosis, a build-up of fat and cholesterol in blood vessels, was found in four out of 20 mummies.
Researchers have discovered that ancient Egyptian mummies, some as old as 3,500 years, exhibited significant calcification in their arteries, indicating the presence of atherosclerosis. This finding suggests that heart attack and stroke may not be exclusively modern diseases.
Researchers found that oral activated charcoal lessens atherosclerotic lesions in experimental mice with kidney damage. This effect appears to be related to reduced inflammation in the blood vessels, regardless of treatment timing or changes in blood pressure or cholesterol levels.
Researchers found that SPAK silencing may promote cancer progression in B-cell lymphomas by crippling genotoxic stress signaling. In contrast, macrophage migration contributes to impaired peritoneal fluid drainage and lymphatic dysfunction in the diaphragm. Additionally, urokine plasminogen activator (uPA) is instrumental in the early ...
A study led by Beth Israel Deaconess Medical Center found that mice on low-carb diets developed significantly more atherosclerosis and had impaired ability to form new blood vessels compared to those on Western or standard diets. Standard markers of cardiovascular risk, including cholesterol, were not affected.
A recent study found that adherence to the Dietary Guidelines for Americans slows the progression of atherosclerosis in women. The study's results highlight the importance of whole-grain, total fat, and cholesterol intake in reducing cardiovascular disease risk.
A new study finds that blocking the muscle growth-limiting hormone myostatin can decrease body fat and promote resistance to atherosclerosis in mice. The results show significant reductions in obesity-related biomarkers, including fasting blood sugar, insulin levels, and cholesterol levels.
Researchers Narayanan Parameswaran and Gregory Fink at MSU have received nearly $400,000 to study the molecular aspects of chronic diseases like atherosclerosis and high blood pressure.
A new study suggests that cytomegalovirus (CMV) is a cause of high blood pressure, a leading risk factor for heart disease, stroke and kidney disease. The virus can lead to the development of atherosclerosis, or hardening of the arteries, when coupled with other risk factors.
Researchers found that eliminating the gene for cyclophilin A from mice prevented the development of abdominal aortic aneurysm and atherosclerosis. The study suggests that targeting cyclophilin A could potentially address both conditions, which are linked by shared biochemical pathways.
A new urine screening test has shown promise in predicting coronary artery disease by identifying specific protein patterns associated with the condition. The test uses proteome analysis to detect collagen fragments found on the surface of atherosclerotic plaques, achieving an accuracy rate of 84%.
A team of researchers has identified a class of drugs that may enhance the therapeutic effects of imatinib mesylate in treating chronic myeloid leukemia. They also developed a zebrafish model for screening potential therapies for Alzheimer's disease and identified a molecular mechanism underlying aggressive prostate cancer.
A study published in JAMA found that pactimibe did not slow the progression of atherosclerosis in patients with familial hypercholesterolemia, but was associated with increased cardiovascular events. The treatment also led to significant increases in low-density lipoprotein cholesterol levels.
Two studies found that SOX9 renders melanomas sensitive to retinoic acid, stopping tumor growth and offering new hope for effective treatment. Additionally, researchers identified two enzymes crucial for ureter-bladder connection during development, which may hold key to treating congenital anomalies.
Researchers developed a synthetic atherosclerosis drug, DMHCA, which targets the Liver X Receptors and reduces plaque formation without increasing fat levels. The study found significant therapeutic promise, with DMHCA significantly reducing arterial lesions in mice by 45-48%.
A new study has found a possible connection between shorter menopause and faster progression of atherosclerosis, which can lead to heart disease. Women who transitioned more quickly through menopause were at higher risk for a higher rate of progression of preclinical atherosclerosis.
A new study reveals that younger individuals defined as low risk by conventional risk stratification methods may actually have a higher lifetime risk of heart disease. Those in the high-risk group had a greater subclinical disease burden and incidence of atherosclerotic progression, even at younger ages.
A new study published in The FASEB Journal suggests that infected gums may be a source of inflammation leading to heart disease. Proper dental hygiene can greatly reduce the risk of atherosclerosis, stroke, and heart disease independently.
Researchers at Vanderbilt University Medical Center have identified prostaglandin-E2 receptors as crucial players in atherosclerosis development. Mice with impaired EP4 receptors showed reduced atherosclerosis and increased macrophage programmed cell death, highlighting the importance of these signaling pathways in disease progression.
A study found that high-normal phosphate levels are associated with increased calcium in coronary arteries, a key indicator of atherosclerosis. The research suggests that phosphate levels may represent a previously unidentified cardiovascular risk factor.
Retired NFL players had a lower prevalence of diabetes and hypertension compared to control groups, but higher rates of elevated cholesterol and impaired fasting glucose. Staying physically active may help protect against these health risks in former athletes.
Research finds urokinase plasminogen activator promotes atherosclerosis growth and dilation, while plasminogen loss protects against disease. The study suggests new ideas for preventing or treating artery disease.
A recent study found that aspirin increases the expression of paraoxonase 1 and apolipoprotein A1, two proteins that help remove bad cholesterol from the bloodstream. This increase can lead to reduced risk of atherosclerosis, a condition characterized by the buildup of plaque in arteries.
Researchers have developed a new class of heart disease medication that reduces the development of high-risk blockages in arteries. The study found that darapladib, which specifically inhibits lipoprotein-associated phospholipase A2, decreased the size and number of advanced plaques that cause heart attacks and strokes.
Research reveals a common connection between cellular innate immunity and human chronic inflammatory diseases, including atherosclerosis, Type 2 Diabetes, and neurodegenerative diseases. A critical signaling network involving IRAK-1 has been identified as a potential target for diagnosis and treatment.
A study published in Sleep found that heavy snoring is an independent risk factor for early carotid atherosclerosis. The prevalence of carotid atherosclerosis increases significantly with the severity of snoring, affecting up to 64% of heavy snorers.
Researchers explore new treatments for psoriasis, revealing a potential therapeutic option in AEB071, while cautioning further clinical trials are needed. Additionally, studies uncover the reasons behind gene therapy complications in SCID patients, shedding light on insertional oncogenesis and acquired somatic mutations.
A study published in the journal AIDS has found that long-term antiretroviral therapy for HIV may offer protection against atherosclerosis. The Multicenter AIDS Cohort Study measured coronary artery calcification in nearly 950 HIV-positive and HIV-negative men, finding CAC scores were almost 60% lower in those on HAART.
Researchers have identified low levels of naturally occurring antibodies as an increased risk factor for cardiovascular disease, particularly stroke in men. This breakthrough finding suggests that anti-PC antibodies play a crucial role in the development of cardiovascular disease.
A study found that high omega-3 fatty acid intake from eating large quantities of fish may explain Japan's very low levels of heart disease. This is due to a strong anti-atherogenic effect observed in Japanese men, who consume an average of 100g of fish daily.
Arthritis treatment drugs show promise in treating atherosclerosis and other autoimmune diseases by targeting cytokines, protein messaging molecules released by immune cells. The discovery of anti-cytokine therapy holds potential for treating multiple biological processes and unmet medical needs.
Researchers found Alaskan Eskimo adults had higher rates of fatty artery plaque than the general US population due to unhealthy lifestyle habits. The study suggests that traditional heart-healthy diet and exercise may not be enough to counteract the effects of smoking.
A meta-analysis found the ankle brachial index (ABI) improves accuracy of cardiovascular risk prediction by identifying individuals at high risk for atherosclerosis. The ABI may help modify treatment recommendations in approximately 19% of men and 36% of women.
Two studies in the FASEB Journal describe key findings on atherosclerosis, including the role of ROCK1 protein in reducing inflammation. Targeting lipid mediators and mechanisms used to make them could lead to new anti-atherosclerosis therapies.
Researchers found that increasing pro-resolution signals can cool down inflammation and slow down atherosclerosis. However, clamping down on these signals would fan the fire of inflammation and speed up its progression.
A new study published in JAMA found that patients with depression are more likely to develop type-2 diabetes, and those with type-2 diabetes are also at a higher risk for developing depression. The study used data from the Multi-Ethnic Study of Atherosclerosis (MESA) to investigate this connection.
A new study published in Molecular Nutrition and Food Research found that apples and apple juice have similar cardiovascular protective properties to grapes. The researchers observed that processing the fruit into juice increases the bioavailability of antioxidants and phenolic compounds, which can help prevent early atherosclerosis.
Researchers link atherosclerosis to widespread organ damage and discover potential targets for treatment. The study found that biochemical signals in arteries can contribute to harm in the lungs, liver, and other organs.
A new study suggests that taking pioglitazone can help slow the progression of plaque build-up in coronary arteries, which is particularly aggressive in patients with diabetes. The findings have important implications for managing patients with type 2 diabetes and coronary artery disease.
A gluten-free vegan diet has been shown to lower blood levels of oxidized LDL-cholesterol and increase anti-PC antibodies, providing atheroprotective effects. This study suggests that diet can impact the immune system and reduce disease incidence.
Researchers discovered that diabetes drives inflammation and slows blood flow, accelerating atherosclerosis through interference with ERK5 signaling. The study identifies advanced glycation end products (AGEs) as key molecules sabotaging this protective mechanism.
Scientists at the Salk Institute have identified PPAR delta as a powerful anti-inflammatory agent that can slow down lesion progression and reduce plaque buildup in arteries. Activating this protein may offer a novel approach to treating metabolic syndrome and its associated cardiovascular risks.
A new viewpoint published in The Lancet suggests that age is not an unmodifiable risk factor for cardiovascular disease, but rather a combination of factors that can be modified through early intervention. The authors argue that conventional wisdom prioritizes age over modifiable risk factors like lipid levels and blood pressure.
Researchers say a solution for atherosclerosis is many years away due to the complex disease process, which involves genetics, metabolism, and inflammation. Huge investments of time and money are needed to develop effective therapies.
Researchers found that treatment with myriocin can significantly inhibit the progress of established atherosclerosis in mice, coinciding with decreases in sphingomyelin, cholesterol, and triglycerides. In contrast, statins may increase PCSK9 levels, which limits their benefit.
Researchers find a direct link between visceral fat and atherosclerosis, a condition that causes blood vessels to harden and narrow. The study suggests that anti-inflammatory medication could be used to reverse the process and reduce heart disease risk.
Researchers found that lipoic acid supplements reduced atherosclerotic lesion formation by 55% in mice, lowered triglycerides, and helped normalize metabolic processes. The supplements may be useful as a preventive mechanism before advanced cardiovascular disease develops.
A study by Yale School of Medicine identified a genetic mutation that expands lesions in the aorta and promotes coronary atherosclerosis. The researchers found that mice lacking the Akt1 gene developed more severe aortic atherosclerosis, highlighting the importance of this gene in regulating endothelial cell development
A new study reveals secretoneurin's neuroprotective role in a rat model of stroke. SN treatment improved survival of primary brain cell cultures and reduced cerebral tissue death in rats with ischemia-induced stroke.
Researchers have identified histone deacetylase HDAC9 as a potential target for treating premature atherosclerosis in lupus patients. They also found that elevated microRNA-16 levels contribute to abnormal cell death in lupus patients, and reducing these levels may lead to targeted treatments.
Researchers found that treating OSA patients with CPAP significantly decreases atherosclerosis markers in just months. This study links OSA directly to artery hardening, providing new evidence for the causal connection between OSA and cardiovascular events.
Researchers found that cholesterol limits the activity of a key protective protein called transforming growth factor-beta (TGF-beta), allowing atherosclerosis to develop. Statins, which lower cholesterol levels, enhance TGF-beta's protective qualities.
A multidisciplinary team of researchers at Columbia University Medical Center will investigate the link between type 2 diabetes and heart disease using a $10.8 million NIH grant. They aim to understand how insulin resistance contributes to accelerated atherosclerotic lesion progression in diabetics.
A Weill Cornell study finds that nicotine in cigarettes accelerates atherosclerosis, even at low levels, by activating the sympathetic nervous system and increasing heart rate. Mice exposed to low-nicotine cigarettes showed smaller atherosclerotic lesions than those exposed to regular cigarettes.
A new experimental drug blocks a protein linked to metabolic diseases, preventing and treating type 2 diabetes and atherosclerosis in genetically predisposed mice. The compound's effectiveness suggests it may be protective against other metabolic disorders, including asthma.
A study finds that cytomegalovirus infection triggers an autoimmune response, causing endothelial cell damage and exacerbating atherosclerosis. The immune system mistakenly attacks healthy cells, leading to inflammation and further disease progression.
A study of coronary artery surgery survivors found that patients with inflammatory rheumatic diseases like rheumatoid arthritis and lupus had more chronic inflammatory cell infiltration in their aortic walls. Smoking was also independently associated with increased inflammation, particularly in the inner adventitia.