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Life Sciences

Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.

447,757 articles | 2542 topics

Health and Medicine

Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.

431,843 articles | 751 topics

Social Sciences

Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.

260,756 articles | 745 topics

Physical Sciences

Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.

257,913 articles | 1552 topics

Applied Sciences and Engineering

Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.

225,386 articles | 998 topics

Scientific Community

Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.

193,043 articles | 157 topics

Space Sciences

Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.

29,662 articles | 175 topics

Research Methods

Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.

21,889 articles | 139 topics

Mathematics

Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.

3,023 articles | 113 topics

Impact of AF on stroke risk eliminated with multiple risk factors

Patients with three or more cardiovascular risk factors, including diabetes and hypertension, have a comparable stroke risk to those with atrial fibrillation. The study found that the risk of stroke associated with atrial fibrillation is eliminated in patients with five or more risk factors.

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GPs undertreat women with AF

Research shows that general practitioners underdiagnose and undertreat women with atrial fibrillation (AF), particularly those with a high stroke risk. A study of over 15,000 French patients found that women were less likely to receive anticoagulant treatment than men, regardless of their age or comorbidities.

Personalized AF management needed to close mortality gap

The European Society of Cardiology emphasizes the need for personalized AF management to close the mortality gap. Current therapies have only improved mortality by 5-10%. A new taxonomy of AF is proposed based on its pathophysiology, and biomarkers, imaging, and ECG are being studied to improve treatment.

Surgery for heart valve disorder associated with greater long-term survival

A study published in JAMA found that early surgical correction of mitral valve regurgitation was associated with greater long-term survival and lower risk of heart failure compared to initial medical management. This is particularly true for patients without American College of Cardiology guideline class I triggers.

Issue III registry defines best syncope candidates for cardiac pacing

The ISSUE III registry study found that cardiac pacing is more effective in patients with presumed neurally mediated syncope (NMS) and asystolic episodes, than in patients with positive tilt table testing. The registry showed that oral anticoagulation therapy is now widely used in patients with atrial fibrillation.

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GAP-AF study helps to define optimal approach to ablation

The GAP-AF study found that complete ablation with complete linear lesions around pulmonary veins was more effective than incomplete lesions in preventing AF recurrence. This approach resulted in higher success rates and longer periods of sinus rhythm compared to incomplete procedures.

Depression screening in AF Clinics recommended by study

Patients with paroxysmal atrial fibrillation (AF) show signs of depression, sleeping disorders, and low levels of physical activity, despite physicians rating their quality of life higher. Good communication between physicians and patients is crucial for adherence to medications and long-term prognosis.

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Routine EKG finding could signal serious heart problem

A common EKG test may predict serious cardiovascular illness in people with left anterior fascicular block (LAFB), a previously thought benign condition. The study found those with LAFB had a higher risk of atrial fibrillation, congestive heart failure and death.

New study finds digoxin safe despite recent reports

A new study published in the European Heart Journal has found no evidence that digoxin increases mortality in patients with atrial fibrillation. The study analyzed data from over 3,400 patients and found that digoxin was not associated with an increased risk of death or hospitalization.

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Symptoms and care of irregular heartbeats differ by gender

Women with atrial fibrillation experience more symptoms and a lower quality of life compared to men, according to a study analyzing over 10,000 patients. Despite this, women tend to live longer than their male peers, highlighting the need for further research into gender disparities in cardiovascular disease management.

Annals of Internal Medicine tip sheet for March 5, 2013

The American College of Physicians publishes a special supplement on patient safety strategies, featuring articles on reducing cancer risk through colonoscopy screening and increasing colorectal cancer screening adherence via electronic health records. Researchers found that colonoscopy screening reduces late-stage cancer diagnosis by ...

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Irregular heart beat elevates risk of kidney failure

Researchers at UCSF and Kaiser Permanente have found that atrial fibrillation significantly increases the risk of end-stage renal disease among patients with chronic kidney disease. The study involved over 206,000 adults and showed that those who developed atrial fibrillation were 67% more likely to progress to kidney failure.

Virtual heart sheds new light on heart defect

Researchers developed a virtual heart model to investigate atrial fibrillation, revealing electrical heterogeneity and fibre structure as key factors in the condition's initiation. The study provides new insights into the complex mechanisms underlying AF, paving the way for potential treatments.

Researchers identify new target for common heart condition

A new study found that metabolic stress can increase the onset of atrial arrhythmias, such as atrial fibrillation, by activating KATP channels in the atria. Blocking these channels with anti-diabetic drugs reversed the effects of metabolic stress and prevented atrial arrhythmia induction.

Digoxin increases deaths in patients with atrial fibrillation

A study published in the European Heart Journal found that digoxin is associated with a significant increase in deaths in patients with atrial fibrillation. High levels of digoxin in the blood have been correlated with an increased death rate in these patients.

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Gold standards of success defined for AF ablation

New guidelines set minimum acceptable success rates for catheter ablation of atrial fibrillation, with 50% success rate expected at 12 months. Long-term outcome data shows only 40-50% of patients remain free of recurrent AF after 5 years.

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PRAGUE-12 trial: Randomized open multicenter study

The PRAGUE-12 trial revealed that surgical ablation using the MAZE procedure significantly improves sinus rhythm presence one year post-operatively among patients with permanent AF. However, it had no impact on mortality, stroke or other hard clinical outcomes during a one-year follow-up.

Obesity triggers AF in fertile women

A nationwide Danish cohort study found that obese women are at a higher risk of developing atrial fibrillation than healthy weight women. The risk is more pronounced in very obese women, with a hazard ratio of over 3 times the normal risk.

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New technology improves heart rhythm treatment

Researchers have developed a new technique to detect and target tiny electrical disturbances in the heart, resulting in an 86% success rate in treating atrial fibrillation. The CONFIRM trial found that this approach significantly improved outcomes compared to conventional catheter procedures.

Safety indicators confirmed for common treatment of heart defect

A new study from the University of Manchester confirms safety indicators for people taking anticoagulant drugs to regulate atrial fibrillation, a condition that increases stroke risk. The study found that patients with high INR levels were more likely to experience bleeding episodes.

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Innovations in anticoagulation for stroke prevention

The CHA2DS2-VASc score has been validated in different populations, identifying very low risk patients who do not need antithrombotic therapy. New oral anticoagulants have a greater net clinical benefit compared to warfarin when both bleeding and stroke risks are high.

Alcohol may trigger serious palpitations in heart patients

New UCSF research establishes a stronger causal link between alcohol consumption and serious palpitations in patients with atrial fibrillation. Patients with atrial fibrillation had almost a four and a half times greater chance of having an episode if they were consuming alcohol than if they were not.

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Palpitations are predictive of future atrial fibrillation

A large cohort study found that history of palpitations and hypertension are significant risk factors for atrial fibrillation in both men and women. Palpitations increased the risk of AF by 62% in women and 91% in men, while hypertension doubled the risk in women and increased it by 40% in men.

Elderly women with irregular heart beat at higher risk for stroke

A new study published in JAMA found that elderly women with atrial fibrillation are at a higher risk of stroke than men. The study suggests that these women may need more effective stroke prevention therapy, which could be targeted towards female sex as a key risk factor.

Stroke risk high when anti-clotting drugs stopped

Researchers found that stopping anti-clotting medication in patients with irregular heartbeats increases the risk of stroke within a month. The study analyzed data from over 14,000 patients and found that both warfarin and rivaroxaban carried similar stroke risks after temporary or permanent discontinuation.

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Canadian Journal of Cardiology publishes new atrial fibrillation guidelines

The Canadian Journal of Cardiology has published new guidelines for atrial fibrillation, which provide updated guidance on stroke prevention and heart rhythm control. The guidelines are based on recent changes in drugs available to treat the condition and will have a significant impact on how doctors worldwide treat atrial fibrillation.

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Irregular heartbeat strong predictor of decline in people at risk of heart disease

A study published in Canadian Medical Association Journal found a strong link between irregular heartbeat (atrial fibrillation) and cognitive decline, dementia, and loss of independence in daily activities. Researchers analyzed data from two large trials and found that patients with atrial fibrillation were 34% more likely to experienc...

The mathematics of a heart beat could save lives

Scientists at the University of Nottingham developed a mathematical model of calcium activity in atrial heart cells, improving our understanding of heart disease and stroke. The model provides clinically relevant insights into sub-cellular calcium signals, allowing for new treatments for conditions like atrial fibrillation.

Erratic heart rhythm may account for some unexplained strokes

Research suggests that erratic heart rhythms, particularly paroxysmal atrial fibrillation (PAF), contribute to about one-fifth of unexplained strokes. Patients with stroke of unknown origin may benefit from extended monitoring and treatment with medications like dabigatran and rivaroxaban.

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Atrial arrhythmias detected by pacemakers increase risk of stroke

Researchers at McMaster University found that nearly 1 in 3 patients with pacemakers and no history of atrial fibrillation experience asymptomatic atrial arrhythmias, increasing stroke risk. These episodes were often undetected until they were picked up by the pacemaker, highlighting the importance of monitoring for silent fibrillation.

Dabigatran associated with increased risk of acute coronary events

A study published in Archives of Internal Medicine found dabigatran to be associated with a higher risk of myocardial infarction and acute coronary syndrome. The research suggests that clinicians should consider the potential cardiovascular risks when using dabigatran, particularly in high-risk populations.

Study finds warfarin underutilized in women

A large study group of Kentucky women found that only 30% were receiving warfarin for atrial fibrillation. The study suggests warfarin anticoagulation treatment is underutilized in this population, but not due to economic or educational disparities.

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$3.8 million grant investigates link between sleep apnea and atrial fibrillation

A $3.8 million grant will investigate the connection between sleep apnea and atrial fibrillation, with the goal of identifying new approaches for prevention and treatment. The study aims to characterize how sleep apnea affects the heart's structure and function, potentially leading to improved outcomes for patients with this condition.