Articles tagged with Brain Injuries
A national US study found that nearly a quarter of children with symptoms of brain injuries or concussions were not checked for the condition. Younger children were more likely to be overlooked. Routine checks can help ensure these children receive necessary care and support their mental and social well-being.
A new study by Loma Linda University reveals that mechanical bull riding is a real public health concern, especially for young riders. The study found that traumatic brain injuries are the most common outcome, and long-term consequences can be severe, including memory issues and learning disabilities.
Researchers found structural, functional, and neuroimmune brain alterations associated with higher blast exposure, impacting health-related quality of life. The frontal lobe's rostral anterior cingulate cortex (rACC) was particularly sensitive to blast waves.
Researchers at Gladstone Institutes have identified a blood coagulation protein, fibrin, as the culprit behind toxic inflammation and neuron loss after a major head injury. This finding can inform new treatment strategies for traumatic brain injuries, which often lead to dementia, depression, and difficulty concentrating.
Scientists at Salk Institute explore the clinical potential of cannabinol (CBN) in treating traumatic brain injury, Alzheimer's disease, and Parkinson's disease. They identify four CBN analogs with improved neuroprotective ability and drug-like efficacy.
A new study has identified alpha-1-antichymotrypsin as a blood protein marker that can predict delayed recovery of concussion in children. The study found that children with low levels of alpha-1-antichymotrypsin were more likely to experience delayed recovery, highlighting the potential for early diagnosis and targeted treatment.
Researchers have discovered a blood protein that may aid in detecting delayed concussion recovery in children, with lower levels of alpha-1-antichymotrypsin (alpha-1-ACT) associated with prolonged symptoms. The finding holds promise for early detection and targeted treatment of long-term concussion problems.
A traumatic brain injury quadruples the risk of developing dementia and neurodegenerative diseases like ALS. USC scientists used lab-grown human brain structures called organoids to study TBI's effects. They identified a gene, KCNJ2, that helps protect nerve cells against injury.
Researchers found TDP-43 drives nerve damage after injury and blocking cell surface protein KCNJ2 can correct faulty TDP-43, curbing nerve death. The study provides insights into traumatic brain injury and potential prevention methods.
The US Army has cleared a new whole blood rapid test for traumatic brain injury assessment, allowing clinicians to obtain lab-quality results at the bedside in 15 minutes. This improvement enables faster decision-making and reduces unnecessary medical evacuations.
A new series of essays explores the ethics and social issues raised by brain research, including post-trial obligations for human participants in neural-device trials. The studies reveal that injury and illness rob individuals of personal identity, while neuromodulation can restore it.
A study of 303 early childhood children found concussion associated with more postconcussive symptoms than typical development up to three months after injury. The study used developmentally appropriate manifestations and behaviors to track postconcussive symptoms and aid in concussion diagnosis in young children.
A new study found significant reductions in total symptom score and faster return to physical activity among concussed adolescents and young adults treated with branched chain amino acid supplementation. The study's findings provide important preliminary data for a larger trial of BCAA therapy.
The study reveals that neurological conditions are the leading cause of ill health and disability globally, with 3.4 billion people affected in 2021. The analysis shows a significant increase in disability-adjusted life years (DALYs) caused by these conditions over the past three decades.
A study published in Neurology found that middle-age veterans who experienced concussions from blasts had lower levels of amyloid-beta in their spinal fluid, a potential marker for Alzheimer's disease. The study also linked lower spinal fluid amyloid levels to poorer performance on memory and thinking tests at older ages.
A team of researchers from the Medical University of South Carolina has discovered a novel protective response by which the brain naturally repairs itself after traumatic brain injury. Protein p17 plays a crucial role in this process, triggering the restorative mechanism of mitophagy to remove damaged tissue and initiate healing.
Researchers found that pre-existing mental health diagnoses lead to a greater emotional burden and prolonged recovery time after a concussion. The study also discovered a 'dose-response' effect, where more mental health diagnoses correlate with increased emotional symptoms and longer recovery periods. Boys with prolonged recovery exper...
Researchers found a correlation between Parkinson's disease and freezing of gait in 20 studies, noting similar brain injury causes both symptoms. Sleep quality deteriorates when dopaminergic medication is stopped, suggesting treatment potential for freezing of gait.
Researchers identified a novel bicarbonate-sensing GPCR, GPR30, that regulates reperfusion injury in ischemic stroke. GPR30 deficiency showed significant protection against cerebral ischemia-reperfusion injury.
A national multicenter survey found that up to one-third of children who were hospitalized due to COVID-19 did not fully recover and experienced persistent symptoms. Children who had not recovered were more likely to have neurological symptoms, including headache and weakness.
A new study published in eClinicalMedicine found that the iTalkBetter app significantly improved patients' ability to talk after six weeks of use. The app provided digital speech therapy for over 200 commonly used words, with a 13% increase in naming items and improvements in spontaneous speech.
Neural stem cells developed into nerve cells when adhering to hydrogels with high positive charge, while those on lower positively charged gels became glial cells. The ability to influence differentiation could aid in nerve and glial cell regeneration and treatment of diseases like multiple sclerosis.
A new blood test uses the biomarker BD-tau to predict functional outcomes in patients after ischemic stroke. Higher levels of BD-tau are associated with more severe outcomes.
A study of over 1.9 million US veterans found moderate to severe traumatic brain injuries associated with later brain cancer diagnoses, while mild TBI showed no link. The research highlights the need for further investigation into long-term health effects of TBI on war veterans.
Researchers at Tufts University School of Medicine found that traumatic brain injuries lead to widespread changes in neural connections throughout the brain. The study used imaging technology to track neuronal activity after a brain injury, revealing new pathways formed by both hemispheres.
A narrative review article in NeuroRehabilitation addresses the medicolegal challenges of litigating cases involving patients with disorders of consciousness. Clinicians and neurolitigators must be aware of the nuances, including terminology, assessment, prognosis, treatment, and patient rights.
A new study has shown that AT2R activation alleviates blood-brain barrier leakage, inhibits proinflammatory cytokines, and benefits cardiac function after TBI. This finding suggests that activation of AT2R may serve as a feasible strategy to benefit the long-term prognosis of TBI patients.
Researchers developed a drug that targets the p17 protein to prevent brain damage after concussions. The treatment, LCL768, restores mitochondrial function and prevents secondary axonal degeneration in mouse models and human CTE cases.
Researchers found that turbans greatly reduced the risk of skull fractures in areas covered with thick fabric, while different turban styles affected head injury risk. The study recommends covering larger areas with thicker fabric and reducing friction to minimize brain injuries.
A new study suggests that high-intensity training (HIT) may be beneficial for individuals with chronic traumatic brain injury (TBI), improving walking ability and potentially secondary benefits such as aerobic capacity and cognition. The study found greater increases in 6-minute walk test and peak treadmill speed during exercise testin...
A study published in Brain Injury found that processing speed deficits significantly impair delayed verbal recall and overall memory in people with acquired brain injuries. Researchers recommend cognitive rehabilitation techniques to improve processing speed and enhance quality of life.
Researchers found that low-dose X-ray irradiation reduced lesion size and reversed motor deficits in TBI and ischemic stroke mice, demonstrating its potential as a therapeutic strategy. The treatment also accelerated substantial motor function recovery and promoted brain rewiring after stroke.
This study found that sports-related traumatic brain injuries (TBI) result in higher rates of functional limitations six months after injury. In contrast, patients with non-sports related TBI exhibit better mental health and post-concussion symptom recovery. The findings highlight the need for a more nuanced understanding of TBI outcomes.
A new large national study of collegiate student-athletes in the US finds no sex difference in concussion recovery, with similar recovery patterns on cognitive function, symptoms and mental health. Women reported more problems with eye and inner ear function after injury, but there was no significant delay in return to play.
Researchers found that bone marrow mononuclear cell infusion in children within 48 hours of severe traumatic brain injury reduced intensive care needs and preserved white matter. The treatment also enhanced connectivity in the corpus callosum, a midline structure in the brain.
Researchers at Kennedy Krieger and Boston Children's Hospital have discovered a new way to decrease early seizure likelihood among infants with Sturge-Weber Syndrome. Presymptomatic treatment involving anti-seizure medication and low-dose aspirin improves neurologic outcomes.
Scooter-related injuries in the US nearly tripled from 2016 to 2020, resulting in more severe injuries and higher healthcare costs. The study found that scooter riders were more likely to experience long bone fractures and paralysis than bicycle riders.
Stanford researchers found that ibogaine safely improves depression, anxiety and functioning among veterans with TBI. The study included 30 veterans who experienced significant improvements in PTSD symptoms, depression and anxiety after treatment.
Researchers at the Wyss Institute have created a new treatment for traumatic brain injury (TBI) that leverages macrophages to deliver localized anti-inflammatory treatment. The approach reduced lesion size by 56% and significantly decreased local inflammation levels in pigs, offering a promising new direction for TBI treatment.
A new study published in The Journal of Head Trauma Rehabilitation found that approximately 60% of people living with traumatic brain injury (TBI) experience chronic pain, even up to 30 years after injury. Chronic pain can significantly worsen outcomes for individuals with TBI, and medications are often the most frequently used treatment.
A new study found that COVID-19 infection can lead to persistent brain injury markers in the blood even months after recovery from hospitalization. Patients with neurological complications during the acute phase of the illness showed robust biomarker evidence of ongoing neuroglial injury.
Researchers investigated cognitive fatigue across multiple sclerosis, traumatic brain injury, and controls using two tasks, finding that fatigue was consistent across participants regardless of task. Cognitive fatigue correlated with longer response times and activation in the caudate nucleus and thalamus.
A Kessler Foundation study found that spatial neglect affects a substantial percentage of people with traumatic brain injury, with an incidence rate of 38% post-TBI. The study also revealed that right brain damage is more likely to result in spatial neglect, highlighting the need for timely treatment and screening guidelines.
A recent study published in EBioMedicine found that yellow fever virus causes myocardial fibrosis, cardiomyocyte hypertrophy, and vascular endothelium alterations, leading to cardiac conduction system disruption. The research provides new insights into the pathogenesis of YF-associated heart injury.
A NSF-funded project, MABLE, is developing a digital app using crowdsensing, AI, and robotics to empower individuals with responsive maps and turn-by-turn instructions. The app aims to improve accessibility and navigation for persons with visual or mobility impairments, such as those with low vision and wheelchair users.
Researchers have identified promising treatment candidates for morphine tolerance and cancer, as well as a biomarker for kidney injury. A monoclonal antibody targeting the mu-opioid receptor has been shown to alleviate morphine tolerance and physical dependence, while inducing excessive mitochondrial fission in tumor cells. Additionall...
Researchers at George Washington University discover protein Snail plays key role in coordinating brain cell responses after injury, with potential to minimize damage and enhance recovery. Additional studies are needed to show increased Snail production could curtail injury or promote healing of the brain.
Researchers from the University of Technology Sydney have developed a portable, non-invasive system that can decode silent thoughts and turn them into text. The technology has been shown to achieve state-of-the-art performance in EEG translation, with an accuracy score of around 40% on BLEU-1.
Researchers at Helmholtz Munich have identified a new source of stem cells in the brains of patients with brain injuries, which could lead to improved treatments for neurological disorders. The discovery involves specific astrocyte cells that exhibit properties of neural stem cells and can be regulated by a protein called Galectin 3.
A study by Southern Methodist University researchers found that tennis ball head injuries can cause traumatic brain injuries, although they are rare. The study used computational modeling to simulate the impact of a tennis ball on a person's head, and found that high-speed impacts could lead to concussions or worse.
A study found increased brain inflammation and structural changes in special operations personnel exposed to blasts, potentially increasing the risk of long-term brain-related disease. The research suggests that repetitive exposure to low-level blasts may cause brain injuries and highlights the need for better protective measures.
Researchers developed a new technique using deep brain stimulation that restored cognitive abilities in patients with moderate to severe traumatic brain injuries. The study, published in Nature Medicine, exceeded expectations and showed promise against long-lasting impairments from brain injuries.
A new decision rule has been developed to identify patients who can safely forgo a head CT scan after falling, reducing unnecessary imaging and costs. The Falls Decision Rule can be applied to all older adults who have fallen, regardless of sustaining a head injury or recalling the fall.
A new meta-analysis found that intravenous fluid therapy using balanced solutions can reduce the risk of in-hospital death in critically ill patients by four percent. Balanced solutions are more closely matched to human blood chemistry than commonly used saline, and may be associated with lower mortality rates.
Researchers found high levels of a repair protein in the brains of former NFL athletes up to 12 years after they stopped playing, indicating persistent brain inflammation and long-term cognitive problems. The study suggests that repeated collision sports like football may have a direct link to long-term inflammation in the brain.
A study found that non-deployed veterans with moderate or severe traumatic brain injury (TBI) are more likely to develop epilepsy due to the 'healthy warrior effect', where good health is required for deployment. Deployed veterans also had a higher risk of epilepsy, especially those with penetrating TBI.
Researchers at the University of Birmingham have created a novel diagnostic device using eye-safe laser technology to detect traumatic brain injury. The device uses Raman spectroscopy to analyze biochemical and structural properties of molecules in the eye, providing information on the severity of trauma.
Researchers found that acoustic stimulation improved postconcussive symptoms in individuals with mild traumatic brain injury, although the benefits were largely sustained. The study's results suggest that listening to acoustic stimulation based on brain electrical activity may not improve symptoms more than randomly generated sound sti...
Researchers argue that the brain does not create new functions in previously unrelated areas but instead utilizes existing latent capacities. They provide alternative explanations for observed changes in brain activity following injury or deficit.
A study found that only 60% of ED patients with fall-related head injury followed up with their PCP, while 56% adopted a fall prevention strategy. Physical therapy was the most common intervention, used by 68% of patients.