Articles tagged with Brain Injuries
Multimodal neuromonitoring (MNM) tracks blood flow, pressure, oxygen and glucose levels in the brain to inform treatment decisions. MNM has improved clinical outcomes for patients with severe traumatic brain injuries at the University of Cincinnati.
A new study found that children with persisting symptoms after mild traumatic brain injury exhibited ongoing cerebral microstructural changes. The researchers used brain MRI-based metrics to detect these changes, which were more pronounced in symptomatic individuals than healthy controls.
A novel robotic system developed by USC researchers can help clinicians accurately assess a patient's rehabilitation progress. The method generates an 'arm nonuse' metric using machine learning and a socially assistive robot to track how much a patient is using their weaker arm spontaneously.
New research reveals a cocktail of approved drugs can quickly reduce brain swelling and improve outcomes in animal models of brain injury. The study suggests reopening lymph nodes as an emergency pressure release valve for the brain, addressing cerebral edema as the leading cause of TBI-related deaths.
A study published in The Lancet Neurology found that monitoring brain injury biomarkers and glucose variation over the first week of hospitalization can provide a more accurate picture of the pathological process. This allows for division into different groups with distinct disease trajectories and prognoses, enabling personalized trea...
UArizona researchers are conducting a four-year clinical trial to investigate the effectiveness of angiotensin 1-7 as a potential treatment for TBI. The study aims to address the underlying inflammatory reaction that drives long-term effects of TBI.
The Otago Community Head Impact Detection study and Elite Extension study used smart mouthguard technology to measure head acceleration events in over 17,000 players. These findings provide greater clarity and confidence than ever before into the benefits and safety of rugby.
Researchers at Ohio State University will investigate the role of microglia cells in chronic inflammation and neuronal dysfunction after TBI, with a focus on preventing long-term consequences. The $7.7 million award aims to develop innovative healthcare solutions for traumatic brain injury survivors.
A study of 54 former NFL players found increased levels of translocator protein (TSPO) indicating brain injury, as well as lower learning and memory abilities. Further research is needed to understand the persistence and progression of these signs over time.
A nationwide study by Radboud University Medical Center found that approximately 32 patients in the Netherlands are in a minimally conscious state after severe brain injury. These patients were on average 45 years old and showed signs of consciousness, such as following simple commands or showing emotions.
A brain injury expert is calling for reforms to the Uniform Determination of Death Act, citing support from 83% of medical and advocacy organizations. The expert argues that the legal definition of death should align with medical standards, including clarifying what brain functions must be lost to declare someone legally dead.
A recent study by the University of Gothenburg found no correlation between post-COVID condition and ongoing viral infection or active brain damage. The study analyzed 25 participants with confirmed post-COVID condition, six without residual symptoms, and 17 control subjects, revealing undetectable SARS-CoV-2 antigens in all samples.
A new study from UTHealth Houston has found that the posterior temporal cortex and inferior frontal cortex are crucial for semantic integration during reading. This discovery may help illuminate the inner dynamics of aphasia, a disorder affecting language expression and comprehension.
Researchers analyzed 20,335 marching band injuries from 2012-2021, finding 70% occurred in high school-age females, mostly ankle and knee injuries. Mild traumatic brain injury accounted for 6% of all encounters, highlighting the need for education on risk prevention.
A recent study found a 71% increase in injuries associated with electric scooters among children and teens aged 18 and younger. The majority of these injuries were to the head, and nearly two-thirds of head injuries were not caused by helmet use. Electric scooters are an increasingly popular mode of transportation, but their popularity...
A Graz University of Technology study found that e-scooter helmets can reduce head injuries by up to 44% and that a speed limit can bring more safety. The study also identified the importance of banning e-scooters on pavements and footpaths, which can significantly reduce serious injuries.
Scientists at University of California San Diego School of Medicine identified a new biomarker using single-cell RNA sequencing, which can predict whether neurons will regenerate after an injury. The study found that the biomarker was consistently reliable across various parts of the nervous system and developmental stages.
Researchers found that players with visible signs of concussion experienced greater head rotational velocities. Shoulder-to-head impacts were nearly four times more common than board-to-head impacts, highlighting the need for improved rink design and protective equipment to reduce any contact to the head.
Researchers found that former football players with medical and mental health conditions like depression and anxiety are at higher risk of receiving an unverified CTE diagnosis. The study highlights the need for accurate diagnoses and access to proven treatments.
A study at Ohio State University found that a combination of ibogaine hydrochloride and 5-MeO-DMT significantly improved PTSD symptoms, depression, anxiety, and cognitive functioning in special operations forces veterans. The treatment also alleviated cognitive impairment linked to traumatic brain injury.
A breakthrough technique has been developed by University of Oxford researchers to repair brain injuries using 3D printing. Neural cells can be printed to mimic the architecture of the cerebral cortex, showing structural and functional integration with host tissue.
Researchers used custom-designed headsets to evaluate headpulse biometrics among Australian Rules Football players and found brain abnormalities in 81% of those inflicted with concussion. These alterations lasted 14 days beyond expected recovery times.
Researchers propose that cerebrospinal fluid leaks could contribute to the link between traumatic brain injury and dementia. The hypothesis suggests that treating these leaks could mitigate dementia symptoms in some patients with a history of TBI. Further research is needed to confirm this potential association.
Researchers from Mass General Brigham find that traumatic brain injury increases risk of cardiovascular and cognitive dysfunction. Non-neurological conditions associated with TBI, such as hypertension and changes in the brain-gut connection, contribute to elevated cardiovascular risk.
Researchers at Western University developed a method to predict ICU patient survival rates after severe brain injury using fMRI and machine learning. They found an accuracy of 80%, surpassing current standards.
A multinational study of 62 patients found that transcranial direct current stimulation (tDCS) improved behavioral responses in specific subgroups, particularly those with traumatic brain injury. The study's results suggest a potential therapeutic strategy for treating consciousness disorders following severe brain injury.
A study of twins found that having a concussion early in life is tied to lower scores on tests of thinking and memory skills decades later. The twin who had a concussion showed faster decline in those scores compared to their identical twin with no history of TBI.
Researchers at Purdue University have developed a 'mini-brain' that tracks the effects of concussive force on brain cells, revealing a link between head trauma and Alzheimer's disease. The study found that even hours after a hit, acrolein production leads to misfolded amyloid beta protein aggregation.
A large cohort study found that post-9/11 veterans with traumatic brain injury (TBI) experienced a more than 10-fold increase in suicide rates compared to the US adult population, highlighting a significant public health concern. The study also revealed that TBI exacerbates the risk of suicidal behavior among this vulnerable population.
A new study published in JAMA Neurology found that over 40% of young contact and collision sport athletes have CTE, a degenerative brain disease caused by repetitive head impacts. The study also highlighted the importance of assessing symptoms and clinical presentation of CTE in living athletes.
Research by Kessler Foundation team found that processing speed plays a role in benefit from the modified Story Memory Technique on verbal list learning but not on prose memory tasks. This suggests that treating deficits in processing speed may lead to optimal outcomes for individuals with traumatic brain injury.
Glycosaminoglycans, complex sugars in the brain's extracellular matrix, regulate neural connectivity through sulfation patterns. This discovery could lead to treatments for neurodegenerative diseases and psychiatric disorders by manipulating these patterns.
A team of New Jersey researchers reviewed the evidence on robotic exoskeleton devices for individuals with acquired brain injury, laying out a systematic framework for future research. The review highlights the need for comprehensive approaches to evaluate these devices and their role in improving mobility in individuals with acquired ...
Researchers at Kessler Foundation are conducting novel studies on identity reconstruction, physical and mental fatigue, and upper limb function to improve the lives of individuals with TBI. The studies aim to develop scalable, accessible, and effective interventions using strength-based approaches.
Researchers have identified patterns of brain injury that underlie hidden consciousness, a phenomenon where brain-injured patients appear unconscious despite having some level of awareness. The study found that all patients with hidden consciousness had intact brain structures related to arousal and command comprehension.
A new digital headset can detect subtle forces exerted on the skull as the heart contracts, revealing brain changes even in athletes whose symptoms have subsided. The device could help clinicians and coaches make more informed decisions about when athletes are ready to return to play after a concussion.
Researchers at Duke University Medical Center have identified a fatty molecule in breast milk that triggers a process in which stem cells produce new white matter, reversing neurological damage. This finding holds promise for developing therapies to treat preterm babies with cerebral palsy.
A new review recommends raising the age of body contact in hockey leagues from 13 to 15 to reduce concussion rates. Studies show injury rates are four times higher for kids and teens with body checking, while eliminating it reduces concussion rates by over 50%.
A study of 860,000 soldiers found that individuals with military-related traumatic brain injury were at higher risk for new-onset mental health conditions. The research also showed a direct and indirect association between TBI history and increased suicide risk.
Researchers developed a blood test to detect nerve injury in MS and found it works for children, even when symptom-free. The test measures neurofilament light chain levels, which reflect nerve cell injury.
A new open-source software, NMSM Pipeline, enables clinicians and engineers to create personalized computer models of patient movement to optimize treatment designs. The software uses physics-based models to predict and optimize functional outcomes for patients with various mobility impairments.
Researchers have developed a new study showing that targeted electrical stimulation in patients with traumatic brain injury improved memory recall by 19%. The technology delivers the right stimulation at the right time, informed by the wiring of the individual's brain and that individual's successful memory retrieval.
A new study published in Pediatrics suggests that pediatric concussions do not impact intelligence or IQ levels. The research, which combined data from two cohort studies in Canada and the US, found no significant difference in IQ scores between children with concussion and those with orthopedic injuries.
Researchers developed a liquid nanofoam cushion that can absorb and dissipate high-force blows in collisions, reducing the risk of injury. The material is more flexible, comfortable to wear, and can be designed as lighter and smaller protective devices.
A team of scientists at Harvard Medical School has identified six chemical cocktails that can restore cellular aging and rejuvenate human cells. The study builds upon the discovery of Yamanaka factors, which can convert adult cells into induced pluripotent stem cells, raising hopes for treating age-related diseases and injuries. The im...
A significant rise in caesarean sections in late labour has led to an increase in impacted fetal head (IFH) injuries, resulting in minor damage, lifelong consequences, or even death. New devices like the Tydeman tube and training approaches aim to improve management of this obstetric emergency.
A mouse model of multiple sclerosis reveals evidence of inflammatory gene expression spilling over from the brain's barrier to grey matter. The study uses spatial transcriptomics to show a gradient of immune genes and inflammatory markers from meninges to surrounding brain tissue.
OU researchers discovered a correlation between cerebral blood flow regulation and prognosis following cardiac arrest. The study found that detecting this regulatory mechanism can improve management and optimize post-resuscitation care for individual patients.
Researchers found that obese patients with mild traumatic brain injuries had higher levels of inflammatory biomarkers and prolonged symptoms compared to those with healthy body mass indexes. The study suggests that obesity may mediate the inflammatory response and symptoms in mTBI patients.
A new study examining brain tissue from 631 former football players found that the cumulative force of hits, not just the number of concussions, was the strongest predictor of chronic traumatic encephalopathy (CTE). The study suggests that reducing the force and frequency of head impacts could help prevent CTE in athletes.
A new study found that football players' cumulative repetitive head impact exposure was associated with chronic traumatic encephalopathy (CTE) status and severity. The study suggests that reducing both the number of head impacts and their force could lower CTE risk.
A study found that prazosin reduced headache frequency and severity in veterans with posttraumatic headaches. Participants who received prazosin had significantly fewer headaches than those on placebo, with an average of six days of headaches per month compared to 12 days.
A pilot study suggests that high-definition cathodal transcranial direct current stimulation (HD C-tDCS) may be beneficial for acute ischemic stroke patients. In the study, patients who received HD C-tDCS showed improved blood flow and a significant rescue of threatened brain tissue, compared to those in the sham group.
A study published in Neurology found that people with TBI experience improvement and decline over time, affecting their ability to function and thinking skills. The research suggests that TBI should be recognized as a chronic condition to provide tailored care for its evolving needs.
Leading researchers discuss challenges associated with return to school for children and adolescents with TBI, highlighting the need for improved educator training and communication. Strategies for improving quality of life and outcomes are recommended by experts in this themed issue.
Research at University of South Australia finds that concussions can lead to a significant increased risk of future injury, even after recovery. The study suggests longer recovery times may be needed for youth athletes suffering from head trauma.
A new AI-based technique measures brain fluid flow with unprecedented accuracy, revealing pressures and three-dimensional flow rates. This breakthrough could lead to the development of new treatments for Alzheimer's, small vessel disease, strokes, and traumatic brain injuries.
Researchers have designed a helmet with liquid shock absorbers that could significantly reduce the impact of blows to the head, potentially cutting injuries. The helmet performed better than existing models, producing the lowest 'Helmet Performance Score' in key areas, including the side upper portion of the helmet.
Researchers confirm increased protein marker of inflammation in long COVID patients' brains, impacting depression and cognitive symptoms. CAMH study provides hope for new treatments using anti-inflammatory medications.
The study found that the immune response to spinal-cord injuries is impaired in older individuals, leading to weaker cell responses and reduced recovery. The researchers identified an essential role for the meninges surrounding the spinal cord in mounting the immune response, paving the way for new therapeutic approaches.