Articles tagged with Diabetes
Researchers found that CNOT3 protein silences genes that cause insulin-producing cells to malfunction, leading to diabetes. Knocking out CNOT3 in mice results in the development of diabetes due to the activation of normally silenced genes.
Children born to obese mothers face higher risk of developing non-alcoholic fatty liver disease due to microbiome disruption, which can be influenced by maternal diet during pregnancy. The study aims to investigate the role of pyrroloquinoline quinone in improving the microbiome and lowering the risk for NAFLD.
A study of over 86,000 Japanese couples found that wives with similar cardiovascular disease risk factors as their husbands are more likely to suffer from the same disorders. The researchers emphasize the importance of considering spouses' health in medical treatment and recommending family-based interventions.
A new Tulane University study found that patients hospitalized with COVID-19 who had metabolic syndrome were over three times more likely to die from the disease. The study also showed that patients with metabolic syndrome were nearly five times more likely to be admitted to an ICU, need a ventilator, or develop ARDS.
Researchers found that women who deliver preterm or extremely preterm have a higher risk of dying from any cause, with 1.7-fold and 2.2-fold increased risks compared to full-term deliveries. The excess deaths associated with preterm delivery persist for up to 40 years after birth.
Researchers found an association between recent weight loss and increased pancreatic cancer risk among individuals with diabetes, especially those with a longer duration of diabetes. The study suggests that maintaining weight loss may be crucial in reducing the risk of pancreatic cancer in people with diabetes.
Researchers found that patients with diabetes and gout are at a higher risk of undergoing amputations compared to those without the conditions. The combined condition was associated with an amputation rate of 0.77 percent, significantly higher than the 0.03 percent in those without either disease.
Scientists have developed a protocol to measure mitochondrial activity in living animals using a bioluminescent molecule found in fireflies. This method reveals impaired mitochondrial functions in diseases such as diabetes and cancer.
Researchers develop a new mouse model of permanent neonatal diabetes using the Kuma mutation, which exhibits severe insulin-deficiency and beta-cell dysfunction in an immune deficient background. The study successfully reverses hyperglycemia with insulin implants, making it suitable for islet transplantation research.
Researchers at Children's Hospital of Philadelphia found that youth who are involved in the decision to start continuous glucose monitoring (CGM) are more likely to continue using the technology consistently. Having a role in the decision increases satisfaction and consistent use of CGM.
Researchers have developed a bioengineered scaffold using human mesenchymal stem cells and timolol, which significantly improved wound epithelialization and reduced inflammatory response in diabetic mice. The combination therapy resulted in more than a 70% increase in tissue repair compared to the control group.
A new study published in Neurology found that midlife thinking skills may suffer from high blood pressure, diabetes, and smoking. Five percent of participants experienced accelerated cognitive decline over five years, while those with high blood pressure had a 7.5% faster decline rate compared to non-hypertensive individuals.
A new study by The George Institute for Global Health found that prediabetes is associated with a higher risk of cardiovascular disease and death. Researchers analyzed over 10 million people and found that early detection and proper treatment can have significant benefits in reducing the burden of these conditions.
A new Northwestern Medicine remote weight-loss program, Opt-IN, helped participants lose 11-13 pounds, matching the success rate of the gold-standard National Diabetes Prevention Program. The program is cheaper and less burdensome than traditional treatments, making it more accessible and affordable.
The article discusses challenges faced by older adults with diabetes and ways to care for them during the pandemic. Key findings include the importance of close monitoring, medication management, and addressing social determinants of health.
A new UCL-led study reveals that people in their 40s and 50s are likely to suffer more years of ill health than older generations. The study found a greater prevalence of ill health among those born later, with conditions such as diabetes and obesity affecting people earlier.
Researchers from Staffordshire University found that optimised cushioning in diabetic footwear can significantly reduce plantar pressure, leading to ulcers and painful complications. The study used made-to-measure 3D-printed insoles to change the stiffness of the sole, finding a clear relationship between BMI and optimal stiffness.
A recent study found that nearly half of veteran nursing home residents with limited life expectancy or dementia were overtreated for diabetes, suggesting that deintensification may be beneficial. Lowering diabetes treatment could prevent unnecessary hospitalizations and increase patient comfort without compromising health outcomes.
A massive genomic analysis has found hundreds of new genetic variants associated with type-2 diabetes, as well as those tied to related conditions like coronary heart disease and chronic kidney disease. The discovery may lead to personalized treatments for patients at high risk of developing the disease.
A new study from Veterans Affairs Research Communications used predictive modeling techniques on over 275,000 patients with diabetes to identify factors that impact mortality. The results placed patients in three time frames for expected death and provide a framework for clinicians to make informed treatment decisions.
A recent study found that consuming calories later in the day can worsen glucose tolerance and reduce fat burned. The effects were more pronounced in people with obesity or diabetes, who already have compromised metabolism.
Hospitalized COVID-19 patients with diabetes require comprehensive glucose management to minimize complications and death. The new guidance emphasizes the importance of limiting direct contact between clinicians and patients, using remote monitoring devices, and considering diabetes self-management for knowledgeable patients.
Research at Kobe University reveals that metformin causes blood sugar to be excreted in the stool, promoting its removal from the intestine. This discovery contributes to understanding the mechanism of metformin's biological effects and may lead to the development of new drugs for diabetes.
Researchers created a mini-insulin molecule that combines human insulin's potency with the fast-acting potential of cone snail venom, potentially improving blood sugar control. The hybrid insulin has the same potency as human insulin but acts faster, making it a prime candidate for new diabetes treatments.
A study found that no-deductible preventive drugs reduced out-of-pocket costs by $612 per year, leading to a significant increase in medication use among low-income diabetes patients. The results showed that lower-income patients benefited the most from these policies.
A hybrid sensor is being developed to detect diabetes from exhaled breath using nanoparticles loaded on 1D metal oxides. This innovative technology aims to provide a non-invasive, affordable, and rapid detection method for continuous diabetes monitoring, potentially reducing serious health problems and life-threatening side effects.
A study by the University of Bonn shows that smartphone-based fundus imaging can detect diabetic retinopathy with high accuracy, even in early stages. The method allows for efficient screening and diagnosis, enabling trained laypersons to examine patients, reducing hospital visits.
A study revealed that insufficient insulin action in adipocytes leads to the development of diabetes and NASH by hyperactivating the protein FoxO1. This finding could serve as a potential target for new drug development for these conditions.
A new study has found that high blood glucose levels before pregnancy can increase the risk of severe maternal morbidity and death, even in women without diabetes. The study analyzed data from over 31,000 women and found that elevated hemoglobin A1c levels were associated with a higher risk of adverse outcomes
A large international study found that consuming at least two daily servings of dairy products is associated with lower risks of diabetes and high blood pressure. Full-fat dairy products showed the strongest associations, particularly in countries with low dairy intakes.
Researchers found that virtual care did not negatively impact glycemic outcomes for diabetes patients, improving hospital exposure and transmission risk. The study's results have broader implications for telehealth implementation in remote locations.
Researchers surveyed patients with diabetes on their understanding of sharing medical data, finding they prefer a digital consent application that offers empowerment and control. The Dovetail Digital consent application, using blockchain infrastructure, received favorable responses for its transparency and traceability.
Researchers at Joslin Diabetes Center have discovered two subtypes of human white subcutaneous fat cells with distinct patterns of gene expression, which may help control whether cells become mature fat cells. This study highlights the potential of bringing together biology, artificial intelligence, and data analysis to better understa...
Researchers at Salk Institute discover two genes that regulate levels of healthy fats called FAHFAs, which decrease inflammation and increase insulin sensitivity. An experimental drug successfully increases FAHFA levels by blocking the activity of these genes, offering new insights into therapies for metabolic and inflammatory diseases.
Research highlights age-related muscle loss as a contributing factor to diabetes in the elderly. Men with lower lean body mass are more prone to developing diabetes, but not women.
A study by Korean researchers found that breastfeeding lowers maternal postpartum diabetes incidence and improves metabolic health through serotonin production. The research showed sustained improvements in pancreatic beta cells lasting years after lactation cessation, reducing the risk of developing diabetes.
Researchers at Pohang University of Science & Technology developed smart contact lenses that can detect diabetes and treat diabetic retinopathy by controlling insulin secretion with electrical signals. The lenses verified accurate glucose level detection in tears of diabetic rabbits.
The North Carolina Diabetes Research Center will provide educational programs, pilot grants, and research infrastructure support to investigators in diabetes research. As one of only 12 NIH Diabetes Research Centers, the grant aims to connect investigators with collaborators to expand project scope.
Researchers from DZD and Boston Children's Hospital highlight the importance of body weight and metabolic health in understanding COVID-19 severity. Studies suggest that obesity may increase the risk of severe illness, independent of cardiometabolic diseases.
Research team finds that high-altitude adaptations in the Himalayas may lower risk for hypertension and diabetes-associated anemia. The study, led by Katherine Wander of Binghamton University, found that a Tibetan-descended population living in Southwest China had lower rates of these conditions compared to low-altitude Han populations.
A new study from Aarhus University shows that a motivational interview with a GP can have a preventative effect on cardiovascular disease. The study found a 13% reduction in cardiovascular disease risk among patients without diabetes who talked to a GP trained in motivational interviewing.
Understanding interactions between metal ions and peptides may lead to improved treatments for diabetes, Alzheimer's, and other diseases. Researchers found that copper can impede the aggregation of pramlintide, but not rat amylin.
Researchers at Houston Methodist have developed a fatty acid-based platform for biological drug delivery, demonstrating high absorption rates in mice models. The study published in Science Advances may pave the way for oral delivery of more biological drugs, including those used to treat rheumatoid arthritis and autoimmune diseases.
Individuals taking glucocorticoid medications for conditions like asthma and arthritis are at high risk of severe COVID-19 due to suppressed immune systems. Injectable supplemental therapy can reverse adrenal failure and is crucial in managing patients with primary or secondary adrenal insufficiency.
Researchers used machine learning to analyze nationwide health checkup records and identified a reliable method for predicting diabetes patients. The model accurately predicted future incidence of diabetes with an overall accuracy of 94.9%.
A recent study suggests that bariatric surgery performed before developing diabetes results in greater weight loss. Patients without diabetes achieved a higher chance of successful weight loss compared to those with diabetes, with diabetes diminishing weight loss by 1.2 BMI points.
Researchers from Kumamoto University found that Melinjo seed extract activates the beneficial hormone adiponectin, improving obesity and diabetes. The study discovered individual genotype differences affect efficacy.
A study by Singapore researchers found that underweight diabetics have an eight-fold increase in risk of contracting active TB compared to obese individuals. The study highlights the importance of early diagnosis and targeted screening for this vulnerable population.
Researchers developed a mathematical model to predict the behavior of glucose-responsive insulins in humans and rodents. The model identified optimal designs that could work well in both species, with about 13% predicted to be effective in both, and 14% in humans alone.
A new study from the Joslin Diabetes Center reveals that ultra-wide field (UWF) fluorescein angiography detects over three times more microaneurysms than UWF color imaging, highlighting the need for cautious use of these techniques when evaluating and treating diabetic retinopathy. The research also suggests that AI can automate the gr...
Research suggests that middle-aged individuals who walk the most steps per day have a significantly lower risk of developing diabetes and high blood pressure. Women in particular see a substantial reduction in obesity risk, with the highest step count linked to a 61% lower likelihood.
A new Yale study suggests that consuming low-calorie sweeteners with carbohydrates impairs metabolism. The research challenges the 'uncoupling hypothesis' and instead finds that sucralose can cause problematic metabolic responses when paired with carbs.
A study found that older adults who experience excessive daytime sleepiness are at increased risk of developing diabetes, cancer, and heart disease. Researchers analyzed data from over 10,000 participants and discovered a significant link between daytime sleepiness and the development of these conditions.
A new technology developed at Purdue University has shown promise in treating obesity and diabetes by converting bad fat into good fat. The Adipo Therapeutics team is seeking additional funding to further develop their technology and submit it to the FDA.
A study found that people become less confident in their choices when faced with new information related to familiar topics like finances and health, suggesting a critical gap in understanding how new information interacts with prior knowledge. This highlights the need for tailored information based on individual mental models.
Researchers have discovered a new drug combination that can restore beta cell function in an animal model, showing promise for diabetes remission. The treatment, which combines GLP-1/estrogen with insulin, was found to be more effective than single-treatments and increase pancreatic insulin content and beta cell numbers.
A Kaiser Permanente study found that diabetes patients who used the patient portal and mobile phone app showed significant improvements in health outcomes. The use of these online tools was associated with increased medication adherence and lower blood glucose levels, particularly among patients with higher baseline HbA1c levels.
Researchers found that morning versus evening dosing of warfarin has insignificant effect on anticoagulant stability, suggesting patients can take medication at any regular time. A separate study showed that home blood pressure monitoring in cases of clinical uncertainty can improve hypertension control and patient understanding.
A peer-delivered program incorporating cognitive behavioral approaches improved health outcomes in rural adults with diabetes. Participants showed significant improvements in functional status, pain, and quality of life compared to a control group.
A systematic review and meta-analysis found significant reductions in body mass index (BMI), body weight, waist circumference, and fat mass in children and adolescents treated with metformin. However, the treatment did not affect lean body mass or have a significant impact on those who were already overweight or obese.