Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
A new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism uses machine learning to predict gestational diabetes in Chinese women. The researchers analyzed nearly 17,000 electronic health records and found that low body mass was associated with an increased risk of gestational diabetes.
A research group at Graz University of Technology is developing an interactive and adaptive health information system that uses machine learning and cognitive psychology to provide personalized content. The system aims to improve doctor-patient communication, enhance health literacy, and make decisions beneficial to users' health.
A new drug combination combining a widely used diabetes treatment with an experimental cancer drug has shown significant improvements in blood glucose control and weight loss in mice. The combination treatment enhanced insulin secretion and reduced body weight, paving the way for clinical studies.
A lipid metabolite called 12,13-diHOME is found in human breast milk and appears to be associated with beneficial infant weight gain and body composition. Maternal exercise may boost levels of the metabolite, potentially benefiting offspring growth and development.
Researchers at Temple University Health System develop improved models to predict 30-day readmission risk among patients with diabetes based on electronic health record data. The new tool, eDERRI TM, aims to accurately identify risk factors and improve care for vulnerable patients.
A standardized 'Artificial Pancreas (AP) Dashboard' is proposed to improve glycemic control and reduce hypoglycemia in insulin requiring patients with diabetes. The dashboard provides a single-page report of seven main components, including glucose metrics, insulin management, and user experience.
A study revealed that incretin-based drugs act on the Gq signaling pathway to promote insulin secretion and improve blood glucose levels in diabetic patients. The researchers found that a switch from Gs to Gq signaling occurs in pancreatic β-cells due to continuous cell excitation.
Researchers discover anthraquinone-forming enzyme in plants, enabling mass production of plant-based medicines. The breakthrough could lead to more efficient and sustainable methods for producing these valuable compounds.
A new study finds that Medicaid expansion increases health insurance coverage, ability to see a physician, and foot examinations among patients with diabetes. However, it does not improve follow-up examinations, care, or treatment for diabetes, highlighting the need for additional structural changes.
A recent study of over 11,000 hospital patients in Spain found that high blood sugar levels were associated with a higher chance of death from COVID-19. Patients with abnormally high glucose levels were more than twice as likely to die from the virus compared to those with normal readings.
High levels of GIP are linked to an increased risk of early arteriosclerosis signs, while GLP-1 is associated with a lower risk. The study suggests a potential link between raised GIP levels and cardiovascular disease in diabetic patients, highlighting the need for further investigation.
The Endocrine Society's virtual annual meeting, ENDO 2021, offers journalists the opportunity to discuss groundbreaking research with world-renowned experts in diverse fields. The event features over 70 live sessions, 20 oral sessions, and six plenaries, covering topics such as diabetes, obesity, reproductive health, and more.
Patients with chronic kidney disease can proactively manage their health by receiving tailored guidance on diet and lifestyle. Effective communication with doctors and strong family support are also crucial in empowering patients to take a more active role in their care. This study highlights the importance of clearer information, bett...
Researchers find that Staphylococcus aureus thrives in glucose-rich diabetic conditions, triggering virulent features and unchecked infection. Understanding this mechanism could lead to treatments targeting the bacteria's glucose hunger.
Potentially preventable hospitalizations among older adults are more common among Black and Hispanic Americans. Researchers found that increasing primary care access and affordable healthcare can reduce these hospitalizations.
A study found that weight and blood pressure were reduced regardless of when participants ate, challenging the idea that eating earlier affects energy usage. Researchers followed 41 overweight adults for 12 weeks and saw no difference in weight loss between those who ate most calories early or later.
A study using genome sequencing and CRISPR gene editing tools has uncovered a new biological pathway essential for insulin production in the YIPF5 gene. The research shows that genetic changes in this gene result in high stress levels, leading to cell death in insulin-producing cells.
Dr. Ann Marie Schmidt has made critical contributions to understanding the connections between heart disease and diabetes through her discovery of the RAGE receptor. Her work aims to develop targeted treatments for obesity and its complications, with the potential to impact hundreds of millions of lives worldwide.
A team of researchers from CNIO describes how the enterovirus coxsackievirus type B4 can induce diabetes by deregulating the URI protein and silencing the Pdx1 gene. This finding has potential implications for understanding the relationship between SARS-CoV-2 infection and diabetes.
The COVID-19 pandemic has accelerated adoption of innovative diabetes care models, including telehealth, to improve medical outcomes and patient experience. Despite challenges such as lack of insurance coverage and workforce shortages, these models have the potential to transform diabetes care for millions worldwide.
Researchers at University of Chicago Medicine are launching a four-year trial to test two interventions for personalized diabetes care in older adults. The 'My Diabetes, My Community' trial incorporates personalized sugar control goals, telephonic care management, and community-based resource access.
A new study has found that non-obese Vietnamese Americans are 60% more likely to have diabetes than non-obese, non-Hispanic White Americans. Only 9% of Vietnamese Americans with diabetes were obese, compared to half of all non-Hispanic White Americans.
A new study by Mount Sinai researchers found that a person's risk of uncontrolled chronic disease increases after moving to a place where the condition is more common. The study analyzed millions of adults who moved to new neighborhoods, counties, and states, tracing how their health changed after the move.
A new study found that continuous positive airway pressure (CPAP) treatment can lower daytime resting heart rates in patients with prediabetes who have obstructive sleep apnea, reducing their risk of cardiovascular disease. Optimal CPAP treatment also lowers heart rates during the day, similar to regular exercise.
Researchers found a strong correlation between glycoalbumin levels in tears and blood, suggesting potential for non-invasive diabetes monitoring. The study of 100 subjects with diabetes indicates that tear analysis could provide a reliable alternative to current invasive methods.
A prospective cohort study found that cycling was associated with lower all-cause and cardiovascular mortality risk among people with diabetes. The study analyzed data from over 7,500 adults and showed that even short periods of cycling per week can significantly reduce the risk of premature death.
This observational study found that preterm delivery, gestational diabetes, and low birth weight are associated with an increased risk of atherosclerotic cardiovascular disease in postmenopausal women. The study controlled for traditional risk factors, highlighting the importance of considering pregnancy outcomes in cardiovascular health.
Researchers estimate that diagnosing and treating high-risk cardiovascular conditions in England could prevent 3.4 million cases of heart disease and stroke, saving £68 billion over 25 years. Identifying undiagnosed diabetes would yield the greatest benefits, while following NICE guidelines would further increase health outcomes.
Children born to mothers with gestational diabetes in pregnancy are at increased risk for accelerated aging and poor health outcomes later in life. The study found a link between epigenetic age and higher weight, body mass index, blood pressure, and cardiovascular risks.
A study of 270 overweight women found no link between gut microbiota composition and the incidence of gestational diabetes. However, the combination of fish oil and probiotics was shown to modulate gut microbiota in women who did not develop gestational diabetes. Further research is needed to confirm these findings.
Researchers have identified 48 significant risk factors for mortality in diabetic patients discharged from hospital, grouped into nine categories. The most common risk factor is age, and co-morbidity burden and BMI are also significant, with heavier individuals at higher risk.
A cardiac biomarker was found to have stronger associations with kidney disease progression than blood pressure in both diabetic and nondiabetic individuals. Higher levels of NTproBNP, urine NGAL, and troponin T were linked to increased rates of CKD progression.
Researchers found that CNOT3 protein silences genes that cause insulin-producing cells to malfunction, leading to diabetes. Knocking out CNOT3 in mice results in the development of diabetes due to the activation of normally silenced genes.
Children born to obese mothers face higher risk of developing non-alcoholic fatty liver disease due to microbiome disruption, which can be influenced by maternal diet during pregnancy. The study aims to investigate the role of pyrroloquinoline quinone in improving the microbiome and lowering the risk for NAFLD.
A study of over 86,000 Japanese couples found that wives with similar cardiovascular disease risk factors as their husbands are more likely to suffer from the same disorders. The researchers emphasize the importance of considering spouses' health in medical treatment and recommending family-based interventions.
A new Tulane University study found that patients hospitalized with COVID-19 who had metabolic syndrome were over three times more likely to die from the disease. The study also showed that patients with metabolic syndrome were nearly five times more likely to be admitted to an ICU, need a ventilator, or develop ARDS.
Researchers found that women who deliver preterm or extremely preterm have a higher risk of dying from any cause, with 1.7-fold and 2.2-fold increased risks compared to full-term deliveries. The excess deaths associated with preterm delivery persist for up to 40 years after birth.
Researchers found an association between recent weight loss and increased pancreatic cancer risk among individuals with diabetes, especially those with a longer duration of diabetes. The study suggests that maintaining weight loss may be crucial in reducing the risk of pancreatic cancer in people with diabetes.
Researchers found that patients with diabetes and gout are at a higher risk of undergoing amputations compared to those without the conditions. The combined condition was associated with an amputation rate of 0.77 percent, significantly higher than the 0.03 percent in those without either disease.
Scientists have developed a protocol to measure mitochondrial activity in living animals using a bioluminescent molecule found in fireflies. This method reveals impaired mitochondrial functions in diseases such as diabetes and cancer.
Researchers develop a new mouse model of permanent neonatal diabetes using the Kuma mutation, which exhibits severe insulin-deficiency and beta-cell dysfunction in an immune deficient background. The study successfully reverses hyperglycemia with insulin implants, making it suitable for islet transplantation research.
Researchers at Children's Hospital of Philadelphia found that youth who are involved in the decision to start continuous glucose monitoring (CGM) are more likely to continue using the technology consistently. Having a role in the decision increases satisfaction and consistent use of CGM.
Researchers have developed a bioengineered scaffold using human mesenchymal stem cells and timolol, which significantly improved wound epithelialization and reduced inflammatory response in diabetic mice. The combination therapy resulted in more than a 70% increase in tissue repair compared to the control group.
A new study published in Neurology found that midlife thinking skills may suffer from high blood pressure, diabetes, and smoking. Five percent of participants experienced accelerated cognitive decline over five years, while those with high blood pressure had a 7.5% faster decline rate compared to non-hypertensive individuals.
A new study by The George Institute for Global Health found that prediabetes is associated with a higher risk of cardiovascular disease and death. Researchers analyzed over 10 million people and found that early detection and proper treatment can have significant benefits in reducing the burden of these conditions.
A new Northwestern Medicine remote weight-loss program, Opt-IN, helped participants lose 11-13 pounds, matching the success rate of the gold-standard National Diabetes Prevention Program. The program is cheaper and less burdensome than traditional treatments, making it more accessible and affordable.
The article discusses challenges faced by older adults with diabetes and ways to care for them during the pandemic. Key findings include the importance of close monitoring, medication management, and addressing social determinants of health.
A new UCL-led study reveals that people in their 40s and 50s are likely to suffer more years of ill health than older generations. The study found a greater prevalence of ill health among those born later, with conditions such as diabetes and obesity affecting people earlier.
Researchers from Staffordshire University found that optimised cushioning in diabetic footwear can significantly reduce plantar pressure, leading to ulcers and painful complications. The study used made-to-measure 3D-printed insoles to change the stiffness of the sole, finding a clear relationship between BMI and optimal stiffness.
A recent study found that nearly half of veteran nursing home residents with limited life expectancy or dementia were overtreated for diabetes, suggesting that deintensification may be beneficial. Lowering diabetes treatment could prevent unnecessary hospitalizations and increase patient comfort without compromising health outcomes.
A massive genomic analysis has found hundreds of new genetic variants associated with type-2 diabetes, as well as those tied to related conditions like coronary heart disease and chronic kidney disease. The discovery may lead to personalized treatments for patients at high risk of developing the disease.
A new study from Veterans Affairs Research Communications used predictive modeling techniques on over 275,000 patients with diabetes to identify factors that impact mortality. The results placed patients in three time frames for expected death and provide a framework for clinicians to make informed treatment decisions.
A recent study found that consuming calories later in the day can worsen glucose tolerance and reduce fat burned. The effects were more pronounced in people with obesity or diabetes, who already have compromised metabolism.
Hospitalized COVID-19 patients with diabetes require comprehensive glucose management to minimize complications and death. The new guidance emphasizes the importance of limiting direct contact between clinicians and patients, using remote monitoring devices, and considering diabetes self-management for knowledgeable patients.
Research at Kobe University reveals that metformin causes blood sugar to be excreted in the stool, promoting its removal from the intestine. This discovery contributes to understanding the mechanism of metformin's biological effects and may lead to the development of new drugs for diabetes.
Researchers created a mini-insulin molecule that combines human insulin's potency with the fast-acting potential of cone snail venom, potentially improving blood sugar control. The hybrid insulin has the same potency as human insulin but acts faster, making it a prime candidate for new diabetes treatments.
A study found that no-deductible preventive drugs reduced out-of-pocket costs by $612 per year, leading to a significant increase in medication use among low-income diabetes patients. The results showed that lower-income patients benefited the most from these policies.
A hybrid sensor is being developed to detect diabetes from exhaled breath using nanoparticles loaded on 1D metal oxides. This innovative technology aims to provide a non-invasive, affordable, and rapid detection method for continuous diabetes monitoring, potentially reducing serious health problems and life-threatening side effects.
A study by the University of Bonn shows that smartphone-based fundus imaging can detect diabetic retinopathy with high accuracy, even in early stages. The method allows for efficient screening and diagnosis, enabling trained laypersons to examine patients, reducing hospital visits.
A study revealed that insufficient insulin action in adipocytes leads to the development of diabetes and NASH by hyperactivating the protein FoxO1. This finding could serve as a potential target for new drug development for these conditions.