Articles tagged with Diabetes
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A large meta-analysis of over 2 million pregnancies has found a 53% increased risk of gestational diabetes in women who conceived through IVF compared to natural conception. The study also suggests that pregnancies achieved by assisted reproduction technologies are associated with more obstetric and perinatal complications.
A new study reveals that a protein called caveolin-1 (Cav-1) is depleted in the temporal lobe of humans with type-2 diabetes and in a diabetic mouse model, leading to increased Alzheimer's disease pathology. Restoring Cav-1 levels in mice reduced Alzheimer's pathology and improved learning and memory deficits.
The study found that men and women experience different comorbidities as having diabetes or prediabetes, including a higher rate of prediabetes among children. Prediabetic women showed a higher prevalence of osteoporosis and depression compared to men.
A new study found that Japanese-American adults with a normal body mass index have a significantly higher risk of developing diabetes compared to their non-Hispanic white counterparts. The study revealed that younger respondents, never smokers, and those with higher education levels were less likely to have diabetes.
Researchers have discovered new members of a protein complex that maintains functional beta cells in the pancreas, crucial for regulating blood glucose levels. The study reveals the complex's association with enzymes RNF20 and RNF40, which play a key role in gene expression and insulin release.
Patients with diabetes are at greater risk of developing heart failure after a heart attack, with a 56% higher risk compared to those without diabetes. The study also found that diabetic patients who develop heart failure have a much higher risk of dying in the following years.
The THEMIS trial found that ticagrelor, when added to aspirin, reduced the risk of cardiovascular death, heart attack, or stroke by 10% in patients with stable coronary artery disease and diabetes. However, patients taking dual antiplatelet therapy also experienced a greater risk of major bleeding.
A low-cost text-messaging programme improves blood sugar control in patients with diabetes and coronary heart disease. The programme, which consisted of six messages per week, resulted in a significant reduction in HbA1c levels and an increase in participants achieving the target level of less than 7%.
A new Northwestern Medicine study finds total heart disease deaths increasing since 2011, with a significant portion of deaths preventable. The study's authors call for a shift in focus towards prevention to combat cardiovascular disease.
Researchers found that postnatal overnutrition in mice leads to premature epigenetic aging in pancreatic islets, increasing the risk of diabetes. Early life overnutrition accelerates DNA methylation changes, resembling those of middle-aged mice, and contributes to impaired glucose regulation.
Researchers identified patterns in cellular behavior that could lead to diagnosis and treatment of chronic diseases. The team developed a biophysical model of energy-driven cellular machinery for understanding allostasis in cells.
A new study by Massachusetts General Hospital finds that more than one in four US adults with diabetes were not diagnosed, while nearly one in three received inadequate care. Younger, female, and non-white adults were particularly affected by disparities in meeting treatment targets.
Research published in Annals of Internal Medicine found that both general and abdominal obesity were strongly associated with mortality among Mexican adults. The study, which followed over 115,000 adults for up to 14 years, also found that waist-to-hip ratio was a major risk factor for premature death.
The Endocrine Society recommends regularly screening older adults for heart disease and diabetes risk, prioritizing lifestyle modification as the first-line therapy. Patients with at least three metabolic risk factors should be screened annually, while those with one or two risk factors should be screened every three years.
The University of Bern and Diabetes Center Berne create four tenure-track assistant professorships in diabetes technology and clinical research. The positions will focus on translating research into clinical use and improving patient outcomes.
Researchers developed a predictive risk model to identify patients with diabetes at high risk of low blood sugar. The model combines known risk factors, including recent infections, insulin use, and dementia, to help healthcare providers intervene and prevent serious adverse events.
A single viral factor released from HIV-infected cells impairs cholesterol metabolism in uninfected cells, triggering inflammation and contributing to the development of diseases such as dementia, heart disease, and diabetes. Targeted treatment may provide a longer and healthier life for people living with HIV/AIDS.
A Mediterranean-style diet rich in tree nuts like walnuts and extra virgin olive oil was found to improve maternal health outcomes during pregnancy, including a reduced risk of gestational diabetes. Women who followed the diet gained an average of 2.75 pounds less than those receiving standard prenatal care.
A team of scientists has identified a key molecular connection between diabetes and vascular disease, finding that high blood glucose activates an enzyme that constricts blood vessels. The study aims to develop new treatments targeting this pathway for reducing vascular complications of diabetes.
A study of over 900,000 VA patients found that routine blood tests with random plasma glucose levels below 200 mg/dL can accurately predict the development of diabetes. Patients with high glucose levels are more likely to be diagnosed with diabetes in the future, making this test a valuable tool for early intervention and prevention.
Research by UMass Amherst epidemiologist Youssef Oulhote found that women with gestational diabetes have a significantly higher rate of transferring synthetic chemicals to their fetus. The study examined blood and umbilical cord samples from 151 mother-newborn pairs in the Faroe Islands.
Researchers identified a molecular mechanism that may be contributing to the global obesity epidemic. The study found that a protein called RAGE on the surface of fat cells can block fat burning when stressed, leading to weight gain. Removing RAGE from fat cells reduced weight gain in mice fed a high-fat diet.
A recent analysis found that US patients with chronic kidney disease (CKD) have a high prevalence of uncontrolled hypertension and diabetes, highlighting the need for improved care. The study also reveals low use of statins in CKD patients, which is not concordant with guidelines.
Researchers found that nearly 50% of chronic kidney disease patients had uncontrolled hypertension and 40% had uncontrolled diabetes between 2006-2014. Statin use was also low, averaging only 3% over the study period.
Researchers found that a 12% calorie reduction over two years improved cholesterol, blood pressure, blood sugar levels and reduced biomarkers of chronic inflammation. Participants who maintained a 25% calorie reduction showed significant weight loss, primarily fat, and reductions in metabolic risk markers.
Researchers at the Feinstein Institutes have discovered how the vagus nerve relays signals from the periphery to the brain to regulate glucose levels. This finding could lead to new ways of measuring blood glucose levels and may uncover a new approach to managing diabetes.
A large-scale study found elevated levels of a biomarker for uranium toxicity in Kuwaiti children who developed obesity and metabolic syndrome. The study suggests that uranium exposure may contribute to the country's high rates of obesity and diabetes.
Scientists at University of Utah Health and Merck Research Laboratories found that altering the production of ceramides can reverse insulin resistance and fatty liver disease in obese mice. By deactivating an enzyme called DES1, they lowered total ceramide levels, improving metabolic health.
Researchers at Joslin Diabetes Center have identified a protein found in the eye that protects against and potentially treats diabetic eye disease. Retinol Binding Protein 3 (RBP3) prevents the development of diabetic retinopathy, and introducing it early can reverse the effects of the complication in rodent models.
A large population-based study found that antidepressants significantly reduced mortality by 35% in patients with diabetes and depression. This significant reduction highlights the importance of addressing depression in individuals with diabetes, a condition where two to three times more people are at risk of depression.
Researchers found that patients taking an additional injection of alirocumab, a PCSK9 inhibitor, had significantly reduced cholesterol levels and lower risk of heart attack. For patients with diabetes, the treatment was found to reduce cardiovascular risk by an average of 2.3%.
A recent study highlights the need to screen older individuals with HIV for diabetes mellitus, which shows a significant correlation with age and race. The study also suggests that traditional glycated haemoglobin tests may underestimate diabetes diagnosis in HIV-positive patients, emphasizing the importance of considering alternative ...
Joslin researchers will contribute to mapping specific tissues in the healthy human body using chemical imaging and single-cell sequencing. The goal is to understand how disease affects cells and develop new treatments for metabolic diseases.
Researchers found that levels of neurofilament light chain (NfL) in the blood contribute to stroke risk in diabetic patients. The study discovered a strong association between NfL levels and stroke occurrence, suggesting that adding this protein to existing stroke risk scores can increase accuracy.
Researchers at the University of Nottingham discovered that drinking coffee can stimulate 'brown fat', increasing body heat and burning calories. This could be a key to tackling obesity and diabetes. The study used thermal imaging to trace brown fat reserves and found that caffeine had a direct effect on its functions.
Researchers discovered that Veillonella bacteria in elite athletes' gut microbiomes can enhance exercise performance in mice by breaking down lactate and producing propionate, a short-chain fatty acid. This breakthrough paves the way for highly-validated performance-enhancing probiotics.
Patients managing their health via electronic patient portals had fewer emergency room visits and hospitalizations. Access to the portal was associated with more outpatient office visits, fewer emergency department visits, and fewer preventable hospital stays in patients with multiple complex chronic conditions.
A study from Penn Medicine and Stony Brook University found that language in Facebook posts can identify conditions such as diabetes, anxiety, depression, and psychosis. The researchers analyzed nearly 1,000 patient profiles and built models to predict disease using post language alone or combined with demographic data.
A study at EULAR 2019 found that RA patients with IBD and type I diabetes have higher rates of venous thromboembolism, epilepsy, and heart attacks compared to controls. These findings suggest that these conditions may be novel comorbidities for patients with RA.
Research reveals undetected glucose disorders significantly increase risk of myocardial infarction and severe periodontitis, prompting closer collaboration between dentistry and healthcare. The study emphasizes the importance of considering patients' dental health in diabetes diagnosis.
A VA study examined over 600,000 veterans with diabetes and found that health outcomes were similar regardless of whether primary providers were physicians, nurse practitioners, or physician assistants. The results suggest using these providers in primary care may improve healthcare efficiency.
Researchers have created a novel mouse model of psoriatic arthritis (PsA) by infecting non-obese diabetic mice with an adenoviral vector expressing single-chain IL-23, resulting in symptoms similar to human disease. This breakthrough model can be used to test and optimize PsA therapies.
Researchers from University of Warwick modelled effects of high blood glucose on human endothelial cells, revealing a key mechanism in blood vessel damage. The study identifies increased hexokinase-2 activity and methylglyoxal formation as drivers of metabolic dysfunction and inflammation.
A 12-year study of older adults with prediabetes found that most reverted to normal blood sugar levels, while obesity accelerated its progression to diabetes. Effective weight management and blood pressure control can help reverse prediabetes in older age.
Researchers at WVU discovered that higher exposure to perfluoroalkyl substances was associated with lower rates of coronary heart disease in adults with diabetes. The study, led by Kim Innes, used data from the C8 Health Project and found an inverse association between PFAS levels and heart disease risk.
A new study has identified several potential approaches for improving medication adherence among Latinos with diabetes, including simple measures like pillboxes and family member education. The study also highlights specific challenges faced by underserved Latino communities, such as difficulty understanding medications and managing mu...
A small-scale trial found that participants eating ultra-processed foods consumed more calories and gained weight than those on a minimally processed diet, despite similar calorie counts. The study suggests that ultra-processed foods may be a significant contributor to overeating and weight gain.
Death rates due to heart failure are increasing among younger adults under 65, with black men under age 65 facing the largest increase in premature death. The study found that an estimated 6 million adults in the US have heart failure, which is the number one reason older adults are admitted to hospital.
A new study found that closely monitoring patients with diabetic macular edema who have good vision can be an acceptable initial strategy, with prompt treatment starting if vision worsens. The two-year study showed similar visual acuity outcomes among groups receiving aflibercept injections, laser photocoagulation, or observation.
A nationwide study found patients with diabetes discharged with low glucose values have a higher risk of death and rehospitalization; physicians should avoid discharging patients until glucose levels are above 100 mg/dl
A study found that over 80% of Chinese diagnosed with hypertension and/or diabetes in 2011 were unaware of their conditions years later. Despite increased screening, disease awareness remained limited, highlighting the need for improved communication and follow-up care.
A new study led by Harvard T.H. Chan School of Public Health found that consuming propionate may trigger a cascade of metabolic events leading to insulin resistance and hyperinsulinemia. The research also showed that mice exposed to chronic propionate resulted in weight gain and insulin resistance.
A multinational study led by Vanderbilt University researchers has found that diabetes has reached epidemic proportions in Asia, dramatically increasing the risk of premature death, especially among women and middle-aged people. The study highlights the urgent need for tailored diabetes management programs for Asian populations.
The project aims to integrate diabetes and hypertension services with HIV-infection services to test their efficacy and applicability. Chronic conditions are expected to overtake infectious diseases in sub-Saharan Africa within the next decade.
A study published in Experimental Physiology found that shift work can have a long-term effect on the risk of heart disease and diabetes. Shift work was shown to negatively impact the breakdown of triglycerides and sugar utilization in the body, increasing the risk of these diseases.
A meta-analysis found that liquid meal replacements led to an average of five pounds more weight loss compared to conventional low-calorie diets. Additionally, these liquid meal replacements contributed to better reductions in body mass index and systolic blood pressure.
Researchers have shown that gene transfer therapy can improve left ventricle function and glucose disposal in mice with diabetes. A single injection of a hormone called urocortin 2 increased heart function and reduced blood sugar levels, offering a potential new treatment for cardiovascular disease.
Research presented at ENDO 2019 found that walking downhill after eating reduces bone resorption in postmenopausal women with diabetes. The study suggests combining exercise after meals with downhill walking may help reduce the need for osteoporosis medication.
A nationwide survey of Brazilian teens found that excessive screen time and unhealthy snacking are associated with an increased risk of metabolic syndrome, a cluster of risk factors for heart disease and diabetes. The study suggests that limiting screen time and avoiding snacks in front of screens may help reduce this risk.
The Endocrine Society's Clinical Practice Guideline recommends simplifying medication regimens and tailoring glycemic targets to improve compliance and prevent complications in older adults with diabetes. The guideline prioritizes blood glucose targets over hemoglobin A1c tests, aiming to reduce cardiovascular disease outcomes.