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Mount Sinai launches first-ever genetic testing program in the primary care setting

The Mount Sinai Hospital is launching the first-ever genetic testing program in primary care settings to identify genetic risk for kidney disease in patients with hypertension. This $3.7 million grant will provide genomic information to individualize treatment, testing, and monitoring, with a focus on African Americans who are four to ...

Most people with moderate kidney disease have medication-resistant hypertension

A strong association was found between worse kidney function and medication-resistant hypertension in individuals with moderate chronic kidney disease. Black patients and those with a larger waist circumference, diabetes, and a history of heart attacks or strokes were more likely to have resistant hypertension.

SourceAmerican Society of Nephrology·JournalClinical Journal of the American Society of Nephrology·DateJul 18, 2013

Greatly increased risk of stroke for patients who don't adhere to anti-hypertensive medication

A study of 73,527 high blood pressure patients found that non-adherence to anti-hypertensive medication increases the risk of stroke and hospitalization. Patients who didn't take their medication correctly had a nearly four-fold increased risk of dying from stroke in the second year after first being prescribed drugs.

SourceEuropean Society of Cardiology·JournalEuropean Heart Journal·DateJul 16, 2013

Good kidney health begins before birth

Research found that low birth weight and prematurity are linked to low nephron numbers, increasing the risk of high blood pressure and chronic kidney disease. The study suggests clinicians use birth weight as a parameter for screening patients.

SourceMonash University·JournalThe Lancet·DateMay 30, 2013

JCI early table of contents for April 24, 2013

Researchers at Cedars-Sinai Medical Center discovered that the renin angiotensin system plays a fundamental role in hypertension. They found that mice without ACE in their kidneys were resistant to high blood pressure, indicating that targeting angiotensin production may be an effective approach to treat hypertension. In contrast, stud...

SourceJCI Journals·JournalJournal of Clinical Investigation·DateApr 24, 2013

Blood pressure out of control at safety-net clinics

A Michigan State University analysis found that federally funded safety-net clinics lag behind in controlling high blood pressure among low-income patients. Only 38% of hypertensive patients had their blood pressure under control at a mid-Michigan safety-net clinic, with diabetes patients facing even greater challenges.

SourceMichigan State University·JournalJournal of Clinical Hypertension·DateApr 17, 2013

Common pregnancy conditions risk future diabetes

A Canadian study of over 1 million women found that pre-eclampsia and gestational hypertension may double the chance of being diagnosed with diabetes years after pregnancy. Women with a history of these conditions, especially combined with gestational diabetes, are at a higher risk of developing future diabetes.

SourcePLOS·JournalPLOS Medicine·DateApr 16, 2013

America: Time to shake the salt habit?

A review of literature suggests that lowering salt intake is associated with decreased cardiovascular disease and mortality. National studies in Finland and Great Britain show a significant decrease in death due to stroke and coronary heart disease after instituting a national salt-reduction program.

SourceMedical College of Wisconsin·JournalNew England Journal of Medicine·DateMar 27, 2013